Detailed information for compound 882267

Basic information

Technical information
  • TDR Targets ID: 882267
  • Name: N-(4-chloro-3-nitrophenyl)-3-(2,4-dimethoxyph enyl)prop-2-enamide
  • MW: 362.764 | Formula: C17H15ClN2O5
  • H donors: 1 H acceptors: 3 LogP: 3.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(c(c1)OC)C=CC(=O)Nc1ccc(c(c1)[N+](=O)[O-])Cl
  • InChi: 1S/C17H15ClN2O5/c1-24-13-6-3-11(16(10-13)25-2)4-8-17(21)19-12-5-7-14(18)15(9-12)20(22)23/h3-10H,1-2H3,(H,19,21)/b8-4+
  • InChiKey: IHEKQRZLKIBIND-XBXARRHUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-(4-chloro-3-nitrophenyl)-3-(2,4-dimethoxyphenyl)prop-2-enamide
  • (E)-N-(4-chloro-3-nitro-phenyl)-3-(2,4-dimethoxyphenyl)prop-2-enamide
  • N-(4-chloro-3-nitro-phenyl)-3-(2,4-dimethoxyphenyl)prop-2-enamide
  • (E)-N-(4-chloro-3-nitro-phenyl)-3-(2,4-dimethoxyphenyl)acrylamide
  • N-(4-chloro-3-nitro-phenyl)-3-(2,4-dimethoxyphenyl)acrylamide
  • ZINC00936302
  • ST5199141

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RUN 0.0058 0.2341 0.2341
Brugia malayi nuclear receptor NHR-88 0.0033 0.0898 0.1396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.2959 0.2959
Loa Loa (eye worm) TK/EGFR protein kinase 0.0059 0.2412 0.375
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.2959 0.4601
Loa Loa (eye worm) hypothetical protein 0.0058 0.2341 0.3639
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.2959 0.4601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.2959 0.4601
Entamoeba histolytica cysteine proteinase, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Schistosoma mansoni rab6-interacting 0.0058 0.2341 0.2341
Loa Loa (eye worm) hypothetical protein 0.0024 0.0402 0.0625
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.2959 0.4601
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Entamoeba histolytica cysteine proteinase, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.2959 0.4601
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.2959 0.2959
Echinococcus multilocularis Polycystic kidney disease protein 0.0058 0.2341 0.2341
Loa Loa (eye worm) doublecortin family protein 0.0058 0.2341 0.3639
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.3176 0.3176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.2959 0.4601
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.3176 0.3849
Brugia malayi bZIP transcription factor family protein 0.0083 0.3754 0.5837
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0898 0.1396
Echinococcus multilocularis slit 2 protein 0.0024 0.0402 0.0402
Schistosoma mansoni tyrosine kinase 0.0059 0.2412 0.2412
Brugia malayi Doublecortin family protein 0.0058 0.2341 0.3639
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0131 0.6431 0.7795
Schistosoma mansoni tyrosine kinase 0.0058 0.2352 0.2352
Brugia malayi hypothetical protein 0.0058 0.2341 0.3639
Echinococcus multilocularis 0.0017 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.2959 0.4601
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.2959 0.3586
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.1118 0.1118
Schistosoma mansoni tyrosine kinase 0.0131 0.6431 0.6431
Loa Loa (eye worm) hypothetical protein 0.0024 0.0402 0.0625
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.2959 0.4601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Plasmodium vivax multidomain scavenger receptor, putative 0.0058 0.2341 1
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0024 0.0402 0.0402
Schistosoma mansoni cell polarity protein 0.0024 0.0402 0.0402
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.1118 0.1739
Schistosoma mansoni lipoxygenase 0.0058 0.2341 0.2341
Schistosoma mansoni zinc finger protein 0.0033 0.0898 0.0898
Brugia malayi Furin-like cysteine rich region family protein 0.0059 0.2412 0.375
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.2959 0.2959
Schistosoma mansoni loxhd1 0.0058 0.2341 0.2341
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0898 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.2959 0.3586
Leishmania major cathepsin L-like protease 0.0064 0.2649 1
Brugia malayi steroid hormone receptor 0.0069 0.2959 0.4601
Onchocerca volvulus 0.0069 0.2959 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0898 0.0898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0898 0.1396
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.2959 0.2959
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.2959 0.4601
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.2959 0.2959
Leishmania major cathepsin L-like protease 0.0064 0.2649 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0402 0.0625
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0898 0.1396
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0898 0.1088
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.2959 0.4601
Brugia malayi nuclear receptor RXR 0.0033 0.0898 0.1396
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.2341 0.2837
Brugia malayi hypothetical protein 0.0037 0.1118 0.1739
Echinococcus granulosus Polycystic kidney disease protein 0.0058 0.2341 0.2837
Echinococcus granulosus RUN 0.0058 0.2341 0.2837
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0898 0.1088
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.2959 0.4601
Schistosoma mansoni retinoic acid receptor RXR 0.0069 0.2959 0.2959
Schistosoma mansoni jun-related protein 0.0068 0.2874 0.2874
Brugia malayi nuclear hormone receptor 0.0033 0.0898 0.1396
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.2959 0.2959
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.2959 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0898 0.1088
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Schistosoma mansoni nuclear receptor 0.0033 0.0898 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0 0.5
Schistosoma mansoni lipoxygenase 0.0163 0.8251 0.8251
Brugia malayi hypothetical protein 0.0033 0.0898 0.1396
Toxoplasma gondii cathepsin CPL 0.0017 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Schistosoma mansoni nuclear receptor 0.0033 0.0898 0.0898
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.2412 0.2412
Schistosoma mansoni rab6-interacting 0.0058 0.2341 0.2341
Schistosoma mansoni nuclear hormone receptor 0.0069 0.2959 0.2959
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Brugia malayi conserved hypotetical protein 0.0033 0.0898 0.1396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Brugia malayi nuclear receptor NHR-88 0.0069 0.2959 0.4601
Brugia malayi nuclear hormone receptor 0.0069 0.2959 0.4601
Echinococcus granulosus lipoxygenase domain containing protein 0.0058 0.2341 0.2837
Loa Loa (eye worm) hypothetical protein 0.0058 0.2341 0.3639
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.3754 0.455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Echinococcus multilocularis epidermal growth factor receptor 0.0059 0.2412 0.2412
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.2959 0.2959
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.2649 1
Brugia malayi hypothetical protein 0.0033 0.0898 0.1396
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0069 0.2959 0.3586
Echinococcus granulosus pikachurin 0.0024 0.0402 0.0487
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.6098 0.7391
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0163 0.8251 0.8251
Echinococcus granulosus slit 2 protein 0.0024 0.0402 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.2959 0.4601
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.2959 0.3586
Brugia malayi laminin alpha chain 0.0024 0.0402 0.0625
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.2959 0.3586
Brugia malayi laminin-like protein K08C7.3 precursor 0.0024 0.0402 0.0625
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0898 0.1396
Onchocerca volvulus 0.0058 0.2341 0.7911
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.2959 0.2959
Echinococcus granulosus FTZ F1 alpha 0.0069 0.2959 0.3586
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0898 0.0898
Echinococcus multilocularis neurogenic locus notch protein 0.0024 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0071 0.3077 0.4784
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.2959 0.3586
Schistosoma mansoni laminin gamma-3 chain 0.0024 0.0402 0.0402
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0898 0.1396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Brugia malayi Protein kinase domain containing protein 0.0131 0.6431 1
Echinococcus multilocularis jun protein 0.0083 0.3754 0.3754
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0898 0.3034
Schistosoma mansoni polycystin 1-related 0.0058 0.2341 0.2341
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.2959 0.4601
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0033 0.0898 0.0898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0898 0.1396
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.2959 0.4601
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0898 0.1088
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.2959 0.2959
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0898 0.0898
Onchocerca volvulus 0.0058 0.2341 0.7911
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.1118 0.1739
Onchocerca volvulus 0.0033 0.0898 0.3034
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.2959 0.2959
Brugia malayi hypothetical protein 0.0037 0.1118 0.1739
Schistosoma mansoni hypothetical protein 0.0125 0.6098 0.6098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.2341 0.2341
Loa Loa (eye worm) hypothetical protein 0.0037 0.1118 0.1739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.2959 0.2959
Brugia malayi hypothetical protein 0.0065 0.2745 0.4269
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.2959 0.3586
Schistosoma mansoni hypothetical protein 0.0068 0.2874 0.2874
Leishmania major cathepsin L-like protease 0.0064 0.2649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Brugia malayi hypothetical protein 0.0058 0.2341 0.3639
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Plasmodium falciparum LCCL domain-containing protein 0.0058 0.2341 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.1118 0.1739
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Schistosoma mansoni coup transcription factor 0.0069 0.2959 0.2959
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.1881 0.7098
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.2959 0.4601
Echinococcus granulosus insulin receptor 0.0131 0.6431 0.7795
Brugia malayi Protein kinase domain containing protein 0.0072 0.3137 0.4877
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0033 0.0898 0.3034
Loa Loa (eye worm) hypothetical protein 0.0037 0.1118 0.1739
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0898 0.1396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0898 0.0898
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0898 0.0898
Schistosoma mansoni tyrosine kinase 0.0058 0.2352 0.2352
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.2959 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0131 0.6431 1
Onchocerca volvulus 0.0065 0.2745 0.9278
Schistosoma mansoni tyrosine kinase 0.0131 0.6431 0.6431
Onchocerca volvulus 0.0033 0.0898 0.3034
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0898 0.0898
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0898 0.1088
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0163 0.8251 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.2959 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.2959 0.4601
Loa Loa (eye worm) hypothetical protein 0.0037 0.1118 0.1739
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Brugia malayi tailless protein 0.0033 0.0898 0.1396
Echinococcus granulosus jun protein 0.0083 0.3754 0.455
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Loa Loa (eye worm) hypothetical protein 0.0081 0.3625 0.5637
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.1118 0.1118
Loa Loa (eye worm) abnormal epIthelia family member 0.0024 0.0402 0.0625
Schistosoma mansoni hypothetical protein 0.0058 0.2341 0.2341
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.2649 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.2959 0.2959
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0024 0.0402 0.0625
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.1118 0.1118
Brugia malayi ecdysteroid receptor 0.0069 0.2959 0.4601
Brugia malayi EGF-like domain containing protein 0.0024 0.0402 0.0625
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.6098 0.6098
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0898 0.1396
Loa Loa (eye worm) hypothetical protein 0.0037 0.1118 0.1739
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.2959 0.4601
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.2959 0.2959
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.3754 0.3754
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.2412 0.2923
Loa Loa (eye worm) hypothetical protein 0.0069 0.2959 0.4601
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0898 0.0898
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.2649 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.2959 0.4601
Entamoeba histolytica cysteine protease, putative 0.0017 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0059 0.2412 0.2923
Echinococcus multilocularis lipoxygenase domain containing protein 0.0058 0.2341 0.2341
Schistosoma mansoni tyrosine kinase 0.0058 0.2352 0.2352
Schistosoma mansoni tyrosine kinase 0.0059 0.2412 0.2412
Schistosoma mansoni slit 0.0024 0.0402 0.0402
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.2959 0.4601
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.2649 1
Schistosoma mansoni thyroid hormone receptor 0.0194 1 1
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0898 0.0898
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0898 0.1396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.2959 0.4601
Schistosoma mansoni tyrosine kinase 0.0059 0.2412 0.2412
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.2959 0.4601
Brugia malayi nuclear receptor NHR-67 0.0033 0.0898 0.1396
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.2959 0.4601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.2649 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.1118 0.1739
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.2959 0.4601
Brugia malayi ecdysone receptor 0.0033 0.0898 0.1396
Loa Loa (eye worm) hypothetical protein 0.0033 0.0898 0.1396
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0898 0.1088
Brugia malayi nuclear receptor RXR 0.0037 0.1118 0.1739
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.2959 0.4601
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.2959 0.2959
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.1118 0.1355
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.2959 0.2959
Echinococcus granulosus neurogenic locus notch protein 0.0024 0.0402 0.0487
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0 0.5
Loa Loa (eye worm) DR-78 0.0033 0.0898 0.1396
Echinococcus multilocularis insulin receptor 0.0131 0.6431 0.6431
Echinococcus granulosus epidermal growth factor receptor 0.0059 0.2412 0.2923
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.2338 0.8824
Schistosoma mansoni thyroid hormone receptor 0.0194 1 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0898 0.0898
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0131 0.6431 0.6431
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.2959 0.2959
Echinococcus multilocularis pikachurin 0.0024 0.0402 0.0402
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.2959 0.3586

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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