Detailed information for compound 882589

Basic information

Technical information
  • TDR Targets ID: 882589
  • Name: 1-(4-ethoxyphenyl)-7-methyl-2-(4-methyl-1,3-t hiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-di one
  • MW: 432.492 | Formula: C24H20N2O4S
  • H donors: 0 H acceptors: 3 LogP: 4.52 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C1N(c2scc(n2)C)C(=O)c2c1c(=O)c1c(o2)ccc(c1)C
  • InChi: 1S/C24H20N2O4S/c1-4-29-16-8-6-15(7-9-16)20-19-21(27)17-11-13(2)5-10-18(17)30-22(19)23(28)26(20)24-25-14(3)12-31-24/h5-12,20H,4H2,1-3H3
  • InChiKey: KHIOKGZPCZVYEJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-ethoxyphenyl)-7-methyl-2-(4-methylthiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-(4-ethoxyphenyl)-7-methyl-2-(4-methyl-2-thiazolyl)-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • 1-(4-ethoxyphenyl)-7-methyl-2-(4-methylthiazol-2-yl)-1H-chromeno[2,3-c]pyrrole-3,9-quinone
  • STOCK4S-44224

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Brugia malayi protein-tyrosine kinase 0.0028 0.0117 0.0109
Brugia malayi hypothetical protein 0.0022 0.0053 0.0045
Echinococcus granulosus cpg binding protein 0.0027 0.0103 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.002 0.0012
Echinococcus multilocularis tar DNA binding protein 0.0115 0.0917 0.091
Brugia malayi Protein kinase domain containing protein 0.0028 0.0117 0.0109
Schistosoma mansoni tyrosine kinase 0.0035 0.018 0.0378
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.0139
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Brugia malayi Protein kinase domain containing protein 0.0028 0.0117 0.0109
Loa Loa (eye worm) WEE protein kinase 0.0226 0.1943 0.1936
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.002 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.002 0.0012
Brugia malayi glutathione reductase 0.0034 0.0164 0.0156
Schistosoma mansoni tyrosine kinase 0.0177 0.1492 0.3124
Echinococcus multilocularis casein kinase i 0.0056 0.0374 0.0366
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0043 0.0248 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0128 0.1034 0.1027
Echinococcus granulosus casein kinase I alpha 0.0056 0.0374 0.0366
Entamoeba histolytica hypothetical protein 0.007 0.0499 0.5143
Trypanosoma cruzi casein kinase, putative 0.0056 0.0374 0.0366
Brugia malayi Immunoglobulin I-set domain containing protein 0.0018 0.0019 0.0011
Echinococcus multilocularis tyrosine protein kinase Srms 0.0028 0.0117 0.0109
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Onchocerca volvulus 0.0028 0.0117 0.0205
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0023 0.0015
Echinococcus multilocularis Immunoglobulin 0.0017 0.0015 0.0007
Echinococcus multilocularis tyrosine protein kinase Abl 0.0035 0.018 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.002 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.002 0.0012
Echinococcus granulosus mitogen activated protein kinase 0.0128 0.1034 0.1027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.0166
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0099 0.0773 0.0765
Echinococcus multilocularis rho associated protein kinase 0.0178 0.1495 0.1488
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.002 0.0012
Echinococcus multilocularis mitogen activated protein kinase 14 0.1098 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0092 0.0706 0.0698
Trypanosoma brucei aurora B kinase 0.0077 0.0565 0.0557
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0018 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Echinococcus granulosus titin 0.0018 0.0019 0.0011
Echinococcus granulosus neuroglian 0.0017 0.0015 0.0007
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Brugia malayi RhoGAP domain containing protein 0.0018 0.0023 0.0015
Trypanosoma brucei protein kinase, putative 0.0128 0.1034 0.1027
Brugia malayi hypothetical protein 0.007 0.0499 0.0491
Brugia malayi Dual specificity mitogen-activated protein kinase kinase 6 0.021 0.1794 0.1787
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0034 0.0164 0.2467
Schistosoma mansoni tyrosine kinase 0.0089 0.068 0.1423
Brugia malayi MAP kinase sur-1 0.0128 0.1034 0.1027
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Schistosoma mansoni protein kinase 0.0056 0.0374 0.0783
Echinococcus multilocularis SH2 motif 0.0018 0.0023 0.0015
Schistosoma mansoni protein kinase 0.0024 0.0075 0.0157
Echinococcus granulosus cyclin dependent kinase 0.0062 0.0426 0.0419
Trichomonas vaginalis STE family protein kinase 0.0072 0.0517 0.5
Onchocerca volvulus 0.0028 0.0117 0.0205
Trypanosoma brucei cdc2-related kinase 1 0.0062 0.0426 0.0419
Trypanosoma cruzi polo-like protein kinase, putative 0.012 0.0963 0.0955
Loa Loa (eye worm) RNA binding protein 0.0115 0.0917 0.091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0212 0.1814 0.1808
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0419 0.3724 0.3719
Echinococcus multilocularis titin 0.0018 0.0019 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0426 0.0893
Echinococcus multilocularis activin receptor type 0.0024 0.0075 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0008 0.0071
Echinococcus multilocularis 0.0018 0.0023 0.0015
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0043 0.0248 0.024
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0018 0.0023 0.0015
Toxoplasma gondii aurora kinase 0.0077 0.0565 0.5426
Schistosoma mansoni cell adhesion molecule 0.0022 0.0053 0.011
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.0139
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.1034 0.1027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.002 0.0012
Echinococcus granulosus suppressor of cytokine signaling 6 0.0018 0.0023 0.0015
Brugia malayi cell division control protein 2 homolog 0.0062 0.0426 0.0419
Echinococcus granulosus tyrosine protein kinase Src64B 0.0035 0.018 0.0173
Brugia malayi Variant SH3 domain containing protein 0.0018 0.0023 0.0015
Echinococcus granulosus hypothetical protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) STE/STE7/MEK4 protein kinase 0.0182 0.1538 0.1531
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0135 0.11 0.1093
Echinococcus multilocularis cyclin dependent kinase 1 0.0062 0.0426 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0174 0.1681
Loa Loa (eye worm) hypothetical protein 0.0025 0.0087 0.0079
Entamoeba histolytica protein kinase, putative 0.0077 0.0565 0.5831
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0028 0.0117 0.0109
Echinococcus multilocularis insulin receptor 0.0063 0.0434 0.0427
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.002 0.0012
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0018 0.0023 0.0015
Echinococcus granulosus c-Jun N-terminal kinases 0.0533 0.4775 0.477
Brugia malayi chromobox protein homolog 3 0.0035 0.0174 0.0166
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0045
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0565 0.5458
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0054 0.0354 0.0741
Onchocerca volvulus 0.0018 0.0023 0.0009
Echinococcus granulosus mitogen activated protein kinase 3 0.0128 0.1034 0.1027
Entamoeba histolytica casein kinase, putative 0.0056 0.0374 0.3832
Echinococcus multilocularis N chimaerin 0.0018 0.0023 0.0015
Echinococcus granulosus epidermal growth factor receptor 0.0099 0.0773 0.0765
Brugia malayi Protein kinase domain containing protein 0.0533 0.4775 0.477
Plasmodium falciparum serine/threonine protein kinase, putative 0.0077 0.0565 1
Echinococcus granulosus MAM 0.0032 0.0147 0.0139
Brugia malayi SRC-1 0.0035 0.018 0.0173
Leishmania major protein kinase, putative 0.0072 0.0517 0.051
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0533 0.4775 0.477
Schistosoma mansoni tyrosine kinase 0.0063 0.0434 0.091
Echinococcus granulosus tyrosine kinase 0.0028 0.0117 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.1034 1
Loa Loa (eye worm) TK protein kinase 0.0028 0.0117 0.0109
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0199 0.1917
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.002 0.0001
Echinococcus granulosus signal transduction protein lnk realted 0.0018 0.0023 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0048 0.03 0.2851
Echinococcus multilocularis mitogen activated protein kinase 11 0.1098 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.0018 0.0023 0.0015
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0017 0.0015 0.0032
Echinococcus granulosus roundabout 2 0.0022 0.0053 0.0045
Brugia malayi serine/threonine-protein kinase plk-2 0.012 0.0963 0.0955
Schistosoma mansoni tyrosine kinase 0.0035 0.018 0.0378
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0017 0.0015 0.0007
Schistosoma mansoni tyrosine kinase 0.0089 0.068 0.1423
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0917 0.1921
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0077 0.0565 0.5831
Echinococcus granulosus casein kinase I delta 0.0056 0.0374 0.0366
Brugia malayi Protein kinase domain containing protein 0.0028 0.0117 0.0109
Echinococcus granulosus epidermal growth factor receptor 0.0177 0.1492 0.1485
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0565 0.0557
Echinococcus multilocularis thyroid hormone receptor alpha 0.0018 0.002 0.0012
Brugia malayi serine/threonine kinase 12 0.0077 0.0565 0.0557
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0135 0.11 0.1093
Mycobacterium tuberculosis Probable reductase 0.0077 0.0562 0.8751
Echinococcus granulosus tensin 0.0018 0.0023 0.0015
Toxoplasma gondii casein kinase I 0.0056 0.0374 0.3566
Echinococcus multilocularis mitogen activated protein kinase 3 0.0128 0.1034 0.1027
Echinococcus multilocularis MAM 0.0032 0.0147 0.0139
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0499 0.0491
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0081 0.0774
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Echinococcus granulosus Immunoglobulin 0.0017 0.0015 0.0007
Echinococcus multilocularis tyrosine protein kinase Blk 0.0028 0.0117 0.0109
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0025 0.0087 0.0079
Trichomonas vaginalis STE family protein kinase 0.0097 0.075 0.7256
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0019 0.0011
Leishmania major casein kinase, putative 0.0056 0.0374 0.0366
Schistosoma mansoni coup transcription factor 0.0018 0.002 0.0041
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.002 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0043 0.0248 0.024
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Schistosoma mansoni hypothetical protein 0.0043 0.0248 0.0519
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Echinococcus multilocularis casein kinase I alpha 0.0056 0.0374 0.0366
Trypanosoma cruzi cdc2-related kinase 1 0.0062 0.0426 0.0419
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0025 0.0087 0.0183
Giardia lamblia Kinase, CK1 Casein kinase 0.0056 0.0374 0.3566
Brugia malayi casein kinase 1, delta 0.0056 0.0374 0.0366
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0028 0.0117 0.1139
Schistosoma mansoni hypothetical protein 0.0043 0.0248 0.0519
Entamoeba histolytica protein kinase , putative 0.0077 0.0565 0.5831
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0426 0.4121
Entamoeba histolytica protein kinase, putative 0.0077 0.0565 0.5831
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0019 0.004
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0097 0.075 0.0743
Echinococcus multilocularis epidermal growth factor receptor 0.0177 0.1492 0.1485
Echinococcus multilocularis SH2 domain containing protein 7 0.0018 0.0023 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.002 0.0012
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0308
Onchocerca volvulus 0.0056 0.0374 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Echinococcus granulosus dual specificity mitogen activated protein 0.0097 0.075 0.0743
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1098 1 1
Plasmodium vivax casein kinase 1, putative 0.0056 0.0374 0.6572
Trypanosoma cruzi cdc2-related kinase 1 0.0062 0.0426 0.0419
Schistosoma mansoni titin 0.0018 0.0019 0.004
Brugia malayi Serine/threonine-protein kinase F42G10.2 0.0182 0.1538 0.1531
Echinococcus multilocularis NCK adaptor protein 0.0025 0.0087 0.0079
Echinococcus multilocularis tensin 0.0018 0.0023 0.0015
Trichomonas vaginalis CK1 family protein kinase 0.0056 0.0374 0.3612
Echinococcus granulosus titin 0.0018 0.0019 0.0011
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Echinococcus granulosus mitogen activated protein kinase 11 0.1098 1 1
Plasmodium falciparum thioredoxin reductase 0.0034 0.0164 0.2807
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Schistosoma mansoni nck2/grb4 0.0025 0.0087 0.0183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.002 0.0012
Echinococcus multilocularis serine:threonine protein kinase 3 0.0265 0.2301 0.2295
Echinococcus granulosus aurora kinase A 0.0077 0.0565 0.0557
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0056 0.0374 0.0366
Schistosoma mansoni GTPase activating protein 0.0018 0.0023 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0178 0.1495 0.3132
Echinococcus granulosus dual specificity mitogen activated protein 0.0152 0.1258 0.1251
Onchocerca volvulus 0.0018 0.0023 0.0009
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0085 0.0641 1
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0565 0.5458
Echinococcus granulosus tar DNA binding protein 0.0115 0.0917 0.091
Trichomonas vaginalis STE family protein kinase 0.0097 0.075 0.7256
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0077 0.0562 0.8751
Loa Loa (eye worm) hypothetical protein 0.0135 0.11 0.1093
Plasmodium falciparum protein kinase 5 0.0062 0.0426 0.7516
Loa Loa (eye worm) STE/STE7/MEK3 protein kinase 0.021 0.1794 0.1787
Echinococcus granulosus tyrosine protein kinase ABL1 0.0028 0.0117 0.0109
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.002 0.0012
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0056 0.0374 0.0366
Schistosoma mansoni ste20-related kinase 0.0207 0.1765 0.3698
Echinococcus multilocularis cyclin dependent kinase 0.0062 0.0426 0.0419
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0018 0.0023 0.0015
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0077 0.0562 0.8751
Echinococcus granulosus SH2 domain containing adapter protein F 0.0018 0.0023 0.0015
Trypanosoma cruzi casein kinase, putative 0.0056 0.0374 0.0366
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0097 0.075 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.002 0.0012
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0533 0.4775 0.477
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.002 0.0012
Loa Loa (eye worm) SRC-1 0.0035 0.018 0.0173
Schistosoma mansoni serine/threonine protein kinase 0.0128 0.1034 0.2165
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.1034 1
Echinococcus multilocularis SH2 motif 0.0018 0.0023 0.0015
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0072 0.0517 0.5335
Onchocerca volvulus 0.0018 0.0023 0.0009
Echinococcus multilocularis chromobox protein 1 0.0062 0.0426 0.0418
Echinococcus multilocularis neuroglian 0.0017 0.0015 0.0007
Loa Loa (eye worm) TK/INSR protein kinase 0.0063 0.0434 0.0427
Trichomonas vaginalis STE family protein kinase 0.0097 0.075 0.7256
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Echinococcus multilocularis tyrosine protein kinase shark 0.0507 0.4541 0.4537
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0018 0.0023 0.0015
Onchocerca volvulus 0.0021 0.0045 0.0055
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.0053 0.0045
Loa Loa (eye worm) TK/EGFR protein kinase 0.0177 0.1492 0.1485
Echinococcus granulosus dual specificity mitogen activated protein 0.0182 0.1538 0.1531
Giardia lamblia Kinase, PLK 0.012 0.0963 0.9306
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0097 0.075 0.0743
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.002 0.0012
Onchocerca volvulus Kinase homolog 0.0182 0.1538 0.3194
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0018 0.0023 0.0015
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0008 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0426 0.4121
Echinococcus multilocularis dual specificity mitogen activated protein 0.0182 0.1538 0.1531
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.002 0.0012
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0018 0.0023 0.0049
Entamoeba histolytica hypothetical protein 0.007 0.0499 0.5143
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0115 0.0917 0.091
Echinococcus multilocularis cpg binding protein 0.0027 0.0103 0.0095
Entamoeba histolytica protein kinase, putative 0.0032 0.0152 0.1504
Schistosoma mansoni tensin 0.0018 0.0023 0.0049
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0917 0.1921
Schistosoma mansoni chromobox protein 0.0062 0.0426 0.0892
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0072 0.0517 0.051
Leishmania major protein kinase, putative 0.0024 0.0075 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.0426 0.0893
Echinococcus multilocularis 0.0052 0.0334 0.0327
Schistosoma mansoni hypothetical protein 0.007 0.0499 0.1045
Echinococcus multilocularis Immunoglobulin 0.0017 0.0015 0.0007
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0426 0.4115
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0028 0.0117 0.0109
Onchocerca volvulus 0.0032 0.0147 0.0269
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.002 0.0012
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0008 0.5
Onchocerca volvulus 0.0164 0.1367 0.2835
Echinococcus granulosus SH2 motif 0.0018 0.0023 0.0015
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.002 0.0012
Echinococcus multilocularis myosin iiia 0.0072 0.0517 0.051
Trypanosoma cruzi cdc2-related kinase 3 0.0062 0.0426 0.0419
Loa Loa (eye worm) TK/ALK protein kinase 0.0275 0.2397 0.2391
Brugia malayi protein unc-22 0.0018 0.0019 0.0011
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0565 0.0557
Echinococcus granulosus thioredoxin glutathione reductase 0.0034 0.0168 0.016
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0087 0.0079
Brugia malayi Fibronectin type III domain containing protein 0.0022 0.0053 0.0045
Schistosoma mansoni hypothetical protein 0.0092 0.0706 0.1478
Echinococcus multilocularis dual specificity mitogen activated protein 0.0097 0.075 0.0743
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0085 0.0641 1
Schistosoma mansoni tyrosine kinase 0.0489 0.4371 0.9155
Schistosoma mansoni growth factor receptor-bound protein 0.0025 0.0087 0.0183
Brugia malayi STAT protein, DNA binding domain containing protein 0.0018 0.0023 0.0015
Brugia malayi SH2 domain containing protein 0.0028 0.0117 0.0109
Schistosoma mansoni kinase 0.0068 0.0479 0.1002
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0072 0.0517 0.051
Brugia malayi STE20-like kinase MST 0.0265 0.2301 0.2295
Brugia malayi Protein kinase domain containing protein 0.0275 0.2398 0.2392
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0128 0.1034 0.1027
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0018 0.0023 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.002 0.0012
Echinococcus granulosus geminin 0.0157 0.1307 0.13
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0056 0.0374 0.0366
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0056 0.0374 0.0366
Brugia malayi Dual specificity mitogen-activated protein kinase kinase 7. -TRUNCATED- 0.0152 0.1258 0.1251
Leishmania major protein kinase, putative 0.0077 0.0565 0.0557
Echinococcus granulosus SHC transforming protein 3 0.0018 0.0023 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.001 0.0022
Loa Loa (eye worm) SH2 domain-containing protein 0.0018 0.0023 0.0015
Onchocerca volvulus 0.0027 0.0105 0.0181
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.002 0.0012
Echinococcus multilocularis mitogen activated protein kinase 11 0.1098 1 1
Trichomonas vaginalis CK1 family protein kinase 0.0056 0.0374 0.3612
Plasmodium falciparum protein kinase, putative 0.0024 0.0075 0.1201
Schistosoma mansoni protein kinase 0.0077 0.0565 0.1182
Onchocerca volvulus 0.0028 0.0117 0.0205
Trypanosoma cruzi casein kinase, putative 0.0056 0.0374 0.0366
Schistosoma mansoni tyrosine kinase 0.0507 0.4541 0.9511
Mycobacterium tuberculosis Probable dehydrogenase 0.0077 0.0562 0.8751
Echinococcus granulosus N chimaerin 0.0018 0.0023 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.002 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0135 0.11 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.002 0.0012
Trypanosoma cruzi cdc2-related kinase 3 0.0062 0.0426 0.0419
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0917 0.1921
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0466 0.45
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0128 0.1034 1
Schistosoma mansoni tyrosine kinase 0.0099 0.0773 0.1619
Onchocerca volvulus 0.0036 0.0184 0.0348
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0043 0.0248 0.024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.002 0.0041
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0077 0.0565 0.0557
Brugia malayi steroid hormone receptor 0.0018 0.002 0.0012
Schistosoma mansoni protein kinase 0.0024 0.0075 0.0157
Onchocerca volvulus 0.0028 0.0117 0.0205
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.002 0.0041
Onchocerca volvulus 0.0018 0.0023 0.0009
Echinococcus multilocularis tyrosine kinase 0.0028 0.0117 0.0109
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0017 0.0015 0.0032
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.012 0.0963 0.0955
Brugia malayi hypothetical protein 0.0032 0.0147 0.0139
Echinococcus granulosus FTZ F1 alpha 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Echinococcus multilocularis GPCR, family 2 0.0043 0.0248 0.024
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0035 0.018 0.0173
Giardia lamblia Kinase, CMGC MAPK 0.0128 0.1034 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.0139
Brugia malayi casein kinase I 0.0056 0.0374 0.0366
Brugia malayi nuclear hormone receptor 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.002 0.0012
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0018 0.0019 0.0011
Echinococcus multilocularis cyclin dependent kinase 1 0.0062 0.0426 0.0419
Brugia malayi Thioredoxin reductase 0.0034 0.0164 0.0156
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Brugia malayi Latrophilin receptor protein 2 0.0043 0.0248 0.024
Echinococcus granulosus casein kinase i 0.0056 0.0374 0.0366
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.0152 0.1258 0.1251
Entamoeba histolytica protein kinase, putative 0.0056 0.0374 0.3836
Echinococcus multilocularis casein kinase I delta 0.0056 0.0374 0.0366
Brugia malayi Tyrosine-protein kinase abl-1 0.0035 0.018 0.0173
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0056 0.0374 0.0366
Brugia malayi Variant SH3 domain containing protein 0.0025 0.0087 0.0079
Echinococcus granulosus insulin receptor 0.0063 0.0434 0.0427
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.002 0.0012
Echinococcus multilocularis geminin 0.0157 0.1307 0.13
Entamoeba histolytica serine/threonine protein kinase, putative 0.012 0.0963 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.0426 0.4121
Brugia malayi Variant SH3 domain containing protein 0.002 0.0038 0.003
Trypanosoma cruzi polo-like protein kinase, putative 0.012 0.0963 0.0955
Brugia malayi hypothetical protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) STE/STE7/MEK7 protein kinase 0.0152 0.1258 0.1251
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0419 0.3724 0.3719
Brugia malayi MH2 domain containing protein 0.0212 0.1814 0.1808
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0128 0.1034 0.1027
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0072 0.0517 0.051
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0523 0.469 0.4686
Giardia lamblia Kinase, STE STE20 0.0097 0.075 0.7236
Trypanosoma brucei trypanothione reductase 0.0034 0.0164 0.0156
Brugia malayi tRNA modification GTPase TrmE family protein 0.0018 0.0023 0.0015
Schistosoma mansoni tyrosine kinase 0.0099 0.0773 0.1619
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0075 0.0067
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0097 0.075 0.0743
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0018 0.0023 0.0049
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0062 0.0426 0.4078
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Loa Loa (eye worm) IKK protein kinase 0.0533 0.4775 0.477
Schistosoma mansoni vav2 0.002 0.0038 0.0079
Schistosoma mansoni tyrosine kinase 0.0089 0.068 0.1423
Echinococcus multilocularis tensin 0.0018 0.0023 0.0015
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0043 0.0248 0.024
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0077 0.0565 0.5831
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0018 0.0023 0.0015
Trypanosoma brucei polo-like protein kinase 0.012 0.0963 0.0955
Brugia malayi Protein kinase domain containing protein 0.0226 0.1943 0.1936
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0062 0.0426 0.0419
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0565 0.5458
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.002 0.0001
Brugia malayi nuclear receptor NHR-88 0.0018 0.002 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.002 0.0012
Brugia malayi TAR-binding protein 0.0115 0.0917 0.091
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0062 0.0426 0.0419
Echinococcus granulosus serine:threonine protein kinase PLK1 0.012 0.0963 0.0955
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0128 0.1034 0.1027
Echinococcus multilocularis thioredoxin glutathione reductase 0.0034 0.0168 0.016
Loa Loa (eye worm) hypothetical protein 0.0233 0.201 0.2004
Loa Loa (eye worm) thioredoxin reductase 0.0034 0.0164 0.0156
Echinococcus granulosus tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Schistosoma mansoni growth factor receptor-bound protein 0.0025 0.0087 0.0183
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0077 0.0565 0.0557
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0008 0.0071
Echinococcus granulosus chromobox protein 1 0.0062 0.0426 0.0418
Brugia malayi Protein kinase domain containing protein 0.0028 0.0117 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.012 0.0963 0.2016
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.1034 1
Brugia malayi cytokine inducible SH2-containing protein 5 0.0018 0.0023 0.0015
Brugia malayi Stress-activated protein kinase jnk-1 0.0533 0.4775 0.477
Entamoeba histolytica casein kinase 1, putative 0.0056 0.0374 0.3832
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0062 0.0426 0.0419
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0072 0.0517 0.5335
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0199 0.1917
Schistosoma mansoni protein kinase 0.0152 0.1258 0.2635
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0018 0.0023 0.0015
Echinococcus multilocularis c src tyrosine kinase 0.0035 0.018 0.0173
Echinococcus granulosus mitogen activated protein kinase 14 0.1098 1 1
Echinococcus granulosus expressed conserved protein 0.0018 0.0023 0.0015
Echinococcus multilocularis mitogen activated protein kinase 0.0128 0.1034 0.1027
Schistosoma mansoni kinase 0.0182 0.1538 0.3221
Trichomonas vaginalis AGC family protein kinase 0.0077 0.0565 0.5458
Trypanosoma brucei casein kinase I, isoform 2 0.0056 0.0374 0.0366
Trichomonas vaginalis CK1 family protein kinase 0.0056 0.0374 0.3612
Plasmodium vivax glutathione reductase, putative 0.0034 0.0164 0.2807
Loa Loa (eye worm) SH2 domain-containing protein 0.0018 0.0023 0.0015
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0077 0.0565 0.5831
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0917 0.1921
Entamoeba histolytica hypothetical protein 0.007 0.0499 0.5143
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0056 0.0374 0.0366
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0024 0.0075 0.0067
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0062 0.0426 0.0419
Echinococcus granulosus cyclin dependent kinase 1 0.0062 0.0426 0.0419
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0045
Schistosoma mansoni tensin-related 0.0018 0.0023 0.0049
Schistosoma mansoni hypothetical protein 0.0157 0.1307 0.2737
Plasmodium vivax thioredoxin reductase, putative 0.0034 0.0164 0.2807
Loa Loa (eye worm) hypothetical protein 0.0048 0.0298 0.029
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0018 0.0023 0.0015
Schistosoma mansoni tyrosine kinase 0.0178 0.1499 0.3139
Schistosoma mansoni thyroid hormone receptor 0.0018 0.002 0.0041
Echinococcus multilocularis chromobox protein 1 0.0062 0.0426 0.0418
Loa Loa (eye worm) TK/ABL protein kinase 0.0028 0.0117 0.0109
Echinococcus multilocularis growth factor receptor bound protein 2 0.0025 0.0087 0.0079
Schistosoma mansoni suppressor of cytokine signaling 0.0018 0.0023 0.0049
Echinococcus multilocularis dual specificity mitogen activated protein 0.0152 0.1258 0.1251
Entamoeba histolytica SH2 domain containing protein 0.0018 0.0023 0.0162
Trichomonas vaginalis CMGC family protein kinase 0.0128 0.1034 1
Echinococcus granulosus c src tyrosine kinase 0.0035 0.018 0.0173
Echinococcus granulosus cyclin dependent kinase 5 0.0062 0.0426 0.0419
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0308 0.0301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0053 0.0045
Brugia malayi hypothetical protein 0.0028 0.0117 0.0109
Echinococcus granulosus dual specificity mitogen activated protein 0.021 0.1794 0.1787
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0265 0.2301 0.2295
Schistosoma mansoni tensin-related 0.0018 0.0023 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.002 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.002 0.0001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0043 0.0248 0.024
Schistosoma mansoni vesicular amine transporter 0.0017 0.0015 0.0032
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0185 0.1562 0.1556
Schistosoma mansoni thyroid hormone receptor 0.0018 0.002 0.0041
Schistosoma mansoni tar DNA-binding protein 0.0115 0.0917 0.1921
Brugia malayi Sex muscle abnormal protein 5 0.0025 0.0087 0.0079
Echinococcus granulosus tyrosine kinase 0.0028 0.0117 0.0109
Schistosoma mansoni serine/threonine protein kinase 0.0419 0.3724 0.78
Schistosoma mansoni hypothetical protein 0.0018 0.0023 0.0049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.002 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.002 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.002 0.0012
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0077 0.0565 1
Trypanosoma brucei cdc2-related kinase 3 0.0062 0.0426 0.0419
Echinococcus granulosus chromobox protein 1 0.0062 0.0426 0.0418
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0018 0.0023 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0008 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0174 0.1681
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.018 0.0173
Trichomonas vaginalis CAMK family protein kinase 0.0066 0.0466 0.45
Leishmania major trypanothione reductase 0.0034 0.0164 0.0156
Schistosoma mansoni cpg binding protein 0.0027 0.0103 0.0215
Schistosoma mansoni shc transforming protein 0.0018 0.0023 0.0049
Echinococcus multilocularis casein kinase I alpha 0.0056 0.0374 0.0366
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0025 0.0087 0.0079
Loa Loa (eye worm) CXXC zinc finger family protein 0.0026 0.0089 0.0081
Plasmodium vivax protein kinase Crk2 0.0062 0.0426 0.7516
Onchocerca volvulus 0.0533 0.4775 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0038 0.003
Schistosoma mansoni adapter molecule crk 0.0025 0.0087 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0374 0.0783
Loa Loa (eye worm) variant SH3 domain-containing protein 0.002 0.0038 0.003
Echinococcus granulosus twitchin 0.0031 0.0143 0.0135
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0018 0.0023 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0077 0.0565 0.5831
Echinococcus granulosus casein kinase I delta 0.0056 0.0374 0.0366
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.1098 1 1
Echinococcus granulosus NCK adaptor protein 0.0025 0.0087 0.0079
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0035 0.018 0.0378
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0037 0.0199 0.0378
Brugia malayi SH2 domain containing protein 0.0028 0.0117 0.0109
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.002 0.0041
Schistosoma mansoni hypothetical protein 0.0032 0.0147 0.0308
Echinococcus multilocularis casein kinase I delta 0.0056 0.0374 0.0366
Schistosoma mansoni nuclear hormone receptor 0.0018 0.002 0.0041
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0035 0.018 0.0173
Brugia malayi serine/threonine protein kinase 6 0.0077 0.0565 0.0557
Loa Loa (eye worm) STAT protein 0.0018 0.0023 0.0015
Brugia malayi Protein kinase domain containing protein 0.0063 0.0434 0.0427
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0024 0.0075 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Schistosoma mansoni hypothetical protein 0.0043 0.0248 0.0519
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0067 0.0472 0.0464
Onchocerca volvulus 0.0018 0.0023 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0108 0.01
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0128 0.1034 0.1027
Echinococcus multilocularis epidermal growth factor receptor 0.0099 0.0773 0.0765
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0854 0.774 0.7738
Brugia malayi Furin-like cysteine rich region family protein 0.0177 0.1492 0.1485
Echinococcus multilocularis SH2 motif 0.0018 0.0023 0.0015
Plasmodium falciparum glutathione reductase 0.0034 0.0164 0.2807
Echinococcus granulosus GPCR family 2 0.0043 0.0248 0.024
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0028 0.0108 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Schistosoma mansoni protein kinase 0.0024 0.0075 0.0157
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.002 0.0041
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0185 0.1562 0.1556
Loa Loa (eye worm) heterochromatin protein 1 0.0062 0.0426 0.0418
Echinococcus granulosus tyrosine protein kinase Srms 0.0028 0.0117 0.0109
Schistosoma mansoni ap endonuclease 0.0017 0.0008 0.0017
Brugia malayi RNA binding protein 0.0115 0.0917 0.091
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0023 0.0015
Echinococcus granulosus growth factor receptor bound protein 2 0.0025 0.0087 0.0079
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0028 0.0117 0.0109
Loa Loa (eye worm) TAR-binding protein 0.0115 0.0917 0.091
Echinococcus granulosus defective proboscis extension response 0.0017 0.0015 0.0007
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.1098 1 1
Schistosoma mansoni chromobox protein 0.0062 0.0426 0.0892
Brugia malayi Protein kinase domain containing protein 0.0028 0.0117 0.0109
Loa Loa (eye worm) hypothetical protein 0.0028 0.0117 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.002 0.0012
Trypanosoma brucei protein kinase, putative 0.0024 0.0075 0.0067
Giardia lamblia Kinase, STE STE20 0.0072 0.0517 0.4965
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0097 0.075 0.0743
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0032 0.0152 0.1504
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0105 0.0097
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Echinococcus multilocularis casein kinase I alpha 0.0056 0.0374 0.0366
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0499 0.0491
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) hypothetical protein 0.0092 0.0706 0.0698
Entamoeba histolytica cell division protein kinase 2, putative 0.0062 0.0426 0.4383
Schistosoma mansoni hypothetical protein 0.0043 0.0248 0.0519
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0075 0.0067
Giardia lamblia Aurora kinase 0.0077 0.0565 0.5426
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0023 0.0015
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.1098 1 1
Onchocerca volvulus 0.0028 0.0117 0.0205
Echinococcus granulosus casein kinase I alpha 0.0056 0.0374 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.002 0.0012
Echinococcus granulosus rho-associated protein kinase 1 0.0178 0.1495 0.1488
Brugia malayi RNA recognition motif domain containing protein 0.0115 0.0917 0.091
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0035 0.018 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0081 0.0774
Echinococcus granulosus activin receptor type 0.0024 0.0075 0.0067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.002 0.0012
Echinococcus granulosus tyrosine protein kinase shark 0.0507 0.4541 0.4537
Schistosoma mansoni protein kinase 0.0097 0.075 0.1571
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.012 0.0963 0.0955
Brugia malayi Protein kinase domain containing protein 0.0062 0.0426 0.0419
Entamoeba histolytica hypothetical protein 0.007 0.0499 0.5143
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0056 0.0374 0.0366
Onchocerca volvulus 0.0028 0.0117 0.0205
Brugia malayi Tensin 0.0018 0.0023 0.0015
Echinococcus multilocularis cyclin dependent kinase 5 0.0062 0.0426 0.0419
Onchocerca volvulus 0.0042 0.0246 0.0477
Brugia malayi serine/threonine-protein kinase 6 0.0077 0.0565 0.0557
Loa Loa (eye worm) AUR protein kinase 0.0077 0.0565 0.0557
Brugia malayi Protein kinase domain containing protein 0.0523 0.469 0.4686
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.002 0.0012
Onchocerca volvulus 0.0018 0.0023 0.0009
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0018 0.0023 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Mycobacterium tuberculosis Probable oxidoreductase 0.0085 0.0641 1
Giardia lamblia Kinase, CMGC CDK 0.0062 0.0426 0.4078
Trichomonas vaginalis chromobox protein, putative 0.0062 0.0426 0.4115
Echinococcus granulosus SH2 motif 0.0018 0.0023 0.0015
Trypanosoma cruzi casein kinase, putative 0.0056 0.0374 0.0366
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.002 0.0012
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0035 0.018 0.0173
Schistosoma mansoni hypothetical protein 0.0018 0.0023 0.0049
Schistosoma mansoni serine/threonine protein kinase 0.0056 0.0374 0.0784
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.012 0.0963 0.0955
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0012
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.1098 1 1
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0499 0.1045
Plasmodium falciparum casein kinase 1 0.0056 0.0374 0.6572
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0062 0.0426 0.0419
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.002 0.0041
Echinococcus granulosus tyrosine protein kinase Blk 0.0028 0.0117 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.002 0.0041
Echinococcus granulosus serine:threonine protein kinase 3 0.0265 0.2301 0.2295
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.002 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0533 0.4775 1
Brugia malayi SH2 domain containing protein 0.0018 0.0023 0.0015
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0028 0.0117 0.0109
Schistosoma mansoni tyrosine kinase 0.0035 0.018 0.0378
Echinococcus multilocularis roundabout 2 0.0022 0.0053 0.0045
Echinococcus granulosus SH2 domain containing protein 7 0.0018 0.0023 0.0015
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Brugia malayi Heterochromatin protein 1 0.0062 0.0426 0.0418
Schistosoma mansoni ap endonuclease 0.0017 0.0008 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.012 0.0963 0.9311
Schistosoma mansoni tensin 0.0018 0.0023 0.0049
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0017 0.0015 0.0007
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0035 0.018 0.0173
Echinococcus multilocularis mitogen activated protein kinase 14 0.1098 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.002 0.0012
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0419 0.3724 0.3719
Echinococcus multilocularis signal transduction protein lnk realted 0.0018 0.0023 0.0015
Entamoeba histolytica protein kinase domain containing protein 0.0024 0.0075 0.07
Schistosoma mansoni signal transduction protein lnk-related 0.0018 0.0023 0.0049
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0077 0.0562 0.8751
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0056 0.0374 0.0366
Schistosoma mansoni tyrosine kinase 0.0035 0.018 0.0378
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0023 0.0015
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0023 0.0015
Loa Loa (eye worm) glutathione reductase 0.0034 0.0164 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.002 0.0012
Schistosoma mansoni nephrin 0.0022 0.0053 0.011
Brugia malayi CXXC zinc finger family protein 0.0026 0.0089 0.0081
Trypanosoma cruzi aurora B kinase, putative 0.0077 0.0565 0.0557
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0164 0.0156
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0128 0.1034 0.1027
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0023 0.0049
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0035 0.018 0.0173
Echinococcus multilocularis SHC transforming protein 3 0.0018 0.0023 0.0015
Onchocerca volvulus 0.0026 0.0089 0.0148
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0077 0.0562 0.8751
Schistosoma mansoni suppressor of cytokine signaling 0.0018 0.0023 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.002 0.0012
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0565 0.1182
Schistosoma mansoni tyrosine kinase 0.0063 0.0434 0.091
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0035 0.0174 0.0326
Onchocerca volvulus 0.0018 0.002 0.0001
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.018 0.0173
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0018 0.0023 0.0049
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0035 0.018 0.0173
Loa Loa (eye worm) hypothetical protein 0.0043 0.0248 0.024
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0018 0.0023 0.0009
Onchocerca volvulus 0.0178 0.1495 0.3104
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0128 0.1034 0.1027
Echinococcus multilocularis dual specificity mitogen activated protein 0.021 0.1794 0.1787
Entamoeba histolytica protein kinase, putative 0.0056 0.0374 0.3836
Loa Loa (eye worm) transcription factor SMAD2 0.0212 0.1814 0.1808
Echinococcus multilocularis aurora kinase A 0.0077 0.0565 0.0557
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0007
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0067 0.0472 0.0464
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0028 0.0117 0.0109
Toxoplasma gondii thioredoxin reductase 0.0034 0.0164 0.1523
Schistosoma mansoni cpg binding protein 0.0027 0.0103 0.0215
Brugia malayi map kinase activated protein kinase protein 2 0.0419 0.3724 0.3719
Onchocerca volvulus Serine\/threonine kinase homolog 0.012 0.0963 0.1984
Echinococcus granulosus suppressor of cytokine signaling 7 0.0018 0.0023 0.0015
Entamoeba histolytica cell division protein kinase 2, putative 0.0062 0.0426 0.4383
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0023 0.0015
Echinococcus granulosus casein kinase I alpha 0.0056 0.0374 0.0366
Brugia malayi ecdysteroid receptor 0.0018 0.002 0.0012
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0062 0.0426 0.0419
Trypanosoma cruzi casein kinase, putative 0.0056 0.0374 0.0366
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0024 0.0075 0.0067
Schistosoma mansoni tensin 0.0018 0.0023 0.0049
Schistosoma mansoni cpg binding protein 0.0026 0.0089 0.0187
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0042 0.0246 0.0238
Giardia lamblia Kinase, CMGC CDK 0.0062 0.0426 0.4078
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0035 0.018 0.0173
Schistosoma mansoni SH2A 0.0018 0.0023 0.0049
Loa Loa (eye worm) TK/FER protein kinase 0.0028 0.0117 0.0109
Schistosoma mansoni hypothetical protein 0.0157 0.1307 0.2737
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.002 0.0041
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0024 0.0075 0.0652
Loa Loa (eye worm) CAMK protein kinase 0.0018 0.0019 0.0011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0085 0.0641 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0018 0.0023 0.0015

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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