Detailed information for compound 883322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.092 | Formula: C13H9Cl4NO3S
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C(Cl)C(=O)C(C(C1=NS(=O)(=O)c1ccccc1)Cl)(Cl)Cl
  • InChi: 1S/C13H9Cl4NO3S/c1-7-9(14)12(19)13(16,17)11(15)10(7)18-22(20,21)8-5-3-2-4-6-8/h2-6,11H,1H3/b18-10+
  • InChiKey: YSPGGQPHFYOSNN-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121 0.0967 0.1429
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121 0.0967 0.1429
Echinococcus granulosus Ankyrin 0.0048 0.0125 0.0184
Brugia malayi PAS domain containing protein 0.0102 0.0749 0.1078
Brugia malayi nuclear receptor NHR-67 0.0057 0.0229 0.0329
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0229 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121 0.0967 0.1391
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.1117 1
Echinococcus granulosus death domain containing protein 0.0048 0.012 0.0177
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.2675 0.3953
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Brugia malayi ecdysone receptor 0.0057 0.0229 0.0329
Loa Loa (eye worm) hypothetical protein 0.0048 0.0125 0.0156
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Onchocerca volvulus Bile acid receptor homolog 0.0121 0.0967 0.4286
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0967 0.1391
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.017 0.0245
Echinococcus multilocularis peroxidasin 0.0082 0.0509 0.0753
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0906 1 1
Schistosoma mansoni lipoxygenase 0.0437 0.4601 0.6799
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0957 0.1414
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121 0.0967 0.137
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Echinococcus granulosus tar DNA binding protein 0.0068 0.0349 0.0516
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0048 0.0125 0.0184
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0443 0.0637
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121 0.0967 0.1429
Brugia malayi Cytochrome P450 family protein 0.0154 0.1346 0.1937
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi hypothetical protein 0.0064 0.0308 0.0443
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.0344 0.3528 0.5065
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0308 0.0455
Schistosoma mansoni hypothetical protein 0.0329 0.3361 0.4966
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0349 0.048
Schistosoma mansoni netrin receptor unc5 0.0048 0.012 0.0177
Schistosoma mansoni hypothetical protein 0.0039 0.0017 0.0025
Brugia malayi RNA, U transporter 1 0.0088 0.0579 0.0833
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121 0.0967 0.1429
Brugia malayi hypothetical protein 0.0219 0.2096 0.3015
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Schistosoma mansoni hypothetical protein 0.0104 0.0772 0.1142
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121 0.0967 0.4286
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.1346 0.1917
Brugia malayi hypothetical protein 0.0057 0.0229 0.0329
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Schistosoma mansoni single-minded 0.0102 0.0749 0.1107
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Schistosoma mansoni RAR-like nuclear receptor 0.0121 0.0967 0.1429
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0967 0.1391
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0229 0.0338
Brugia malayi steroid hormone receptor 0.0121 0.0967 0.1391
Onchocerca volvulus 0.0104 0.0772 0.3302
Echinococcus multilocularis Polycystic kidney disease protein 0.0104 0.0772 0.1142
Brugia malayi Steroid receptor seven-up type 2 0.0121 0.0967 0.1391
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0308 0.0419
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0967 0.1391
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0957 0.0538
Mycobacterium ulcerans proteasome PrcA 0.0906 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.0967 0.1391
Schistosoma mansoni peroxidasin 0.0082 0.0509 0.0753
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0229 0.0329
Echinococcus granulosus jun protein 0.0279 0.2787 0.4118
Brugia malayi Protein kinase domain containing protein 0.0048 0.012 0.0173
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121 0.0967 0.1429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121 0.0967 0.1429
Onchocerca volvulus 0.0082 0.0509 0.197
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0224 0.0299
Schistosoma mansoni aryl hydrocarbon receptor 0.0102 0.0749 0.1107
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0308 0.0455
Onchocerca volvulus Chorion peroxidase homolog 0.0082 0.0509 0.197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Loa Loa (eye worm) hypothetical protein 0.0104 0.0772 0.109
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0967 0.1429
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0451 0.476 0.7034
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121 0.0967 0.1429
Schistosoma mansoni nuclear receptor 0.0057 0.0229 0.0338
Onchocerca volvulus 0.0082 0.0509 0.197
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Plasmodium vivax multidomain scavenger receptor, putative 0.0104 0.0772 0.5
Brugia malayi hypothetical protein 0.0104 0.0772 0.1111
Brugia malayi photoreceptor-specific nuclear receptor 0.0121 0.0967 0.1391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Schistosoma mansoni loxhd1 0.0104 0.0772 0.1142
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121 0.0967 0.1429
Echinococcus multilocularis snurportin 1 0.0329 0.3361 0.4966
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0048 0.012 0.0177
Loa Loa (eye worm) hypothetical protein 0.027 0.2675 0.3834
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0509 0.197
Brugia malayi bZIP transcription factor family protein 0.0279 0.2787 0.401
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0279 0.2787 0.4118
Onchocerca volvulus Peroxidase homolog 0.0082 0.0509 0.197
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121 0.0967 0.1429
Echinococcus granulosus netrin receptor unc 5 0.0048 0.012 0.0177
Echinococcus granulosus snurportin 1 0.0329 0.3361 0.4966
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Schistosoma mansoni peroxidasin 0.0082 0.0509 0.0753
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0224 0.0322
Brugia malayi small heat shock protein 0.0641 0.695 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121 0.0967 0.1429
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Brugia malayi Death domain containing protein 0.0048 0.012 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) doublecortin family protein 0.0104 0.0772 0.109
Brugia malayi RNA binding protein 0.0068 0.0349 0.0503
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0349 0.048
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121 0.0967 0.1391
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Onchocerca volvulus 0.0219 0.2096 1
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0234 0.2262 0.3342
Loa Loa (eye worm) blistered cuticle protein 3 0.0082 0.0509 0.071
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121 0.0967 0.1391
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Onchocerca volvulus 0.0055 0.0203 0.0418
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0349 0.0503
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0967 0.1429
Echinococcus granulosus FTZ F1 alpha 0.0121 0.0967 0.1429
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.0967 0.1391
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0229 0.0338
Loa Loa (eye worm) RNA binding protein 0.0068 0.0349 0.048
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0509 0.197
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3361 0.4823
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0229 0.0549
Brugia malayi Doublecortin family protein 0.0104 0.0772 0.1111
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni nuclear receptor 0.0057 0.0229 0.0338
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0308 0.0455
Loa Loa (eye worm) hypoxia-induced factor 1 0.0317 0.3222 0.4622
Loa Loa (eye worm) hypothetical protein 0.0641 0.695 1
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Brugia malayi hypothetical protein 0.0064 0.0308 0.0443
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Schistosoma mansoni ankyrin 23/unc44 0.0048 0.012 0.0177
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.104 0.1475
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Brugia malayi TAR-binding protein 0.0068 0.0349 0.0503
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Brugia malayi hypothetical protein 0.0057 0.0229 0.0329
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0121 0.0957 0.1414
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0048 0.012 0.0177
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0229 0.0338
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Schistosoma mansoni retinoic acid receptor RXR 0.0234 0.2262 0.3342
Onchocerca volvulus Protein ultraspiracle homolog 0.0121 0.0967 0.4286
Loa Loa (eye worm) steroid hormone receptor 0.0121 0.0967 0.137
Brugia malayi Peroxidasin 0.0082 0.0509 0.0733
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0048 0.012 0.0149
Brugia malayi conserved hypotetical protein 0.0057 0.0229 0.0329
Brugia malayi hypoxia-induced factor 1 0.0317 0.3222 0.4635
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0625 0.6767 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0982 0.5946
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0957 0.0538
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0308 0.0455
Brugia malayi hypothetical protein 0.027 0.2675 0.3849
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0229 0.0329
Brugia malayi Uncoordinated protein 44 0.0048 0.012 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0308 0.0443
Brugia malayi MH2 domain containing protein 0.0128 0.104 0.1496
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0308 0.0443
Echinococcus granulosus single minded 2 0.0076 0.0443 0.0654
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0957 0.1414
Echinococcus granulosus nuclear factor of activated T cells 5 0.0245 0.2391 0.3533
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.017 0.1523 0.2251
Schistosoma mansoni survival motor neuron protein 0.0055 0.0203 0.0299
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121 0.0967 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121 0.0967 0.137
Brugia malayi nuclear receptor RXR 0.0064 0.0308 0.0443
Plasmodium falciparum LCCL domain-containing protein 0.0104 0.0772 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni polycystin 1-related 0.0104 0.0772 0.1142
Brugia malayi nuclear hormone receptor 0.0121 0.0967 0.1391
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0229 0.0329
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.017 0.0221
Brugia malayi tailless protein 0.0057 0.0229 0.0329
Echinococcus granulosus peroxidasin 0.0082 0.0509 0.0753
Brugia malayi Blistered cuticle protein 3 0.0082 0.0509 0.0733
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0229 0.0329
Schistosoma mansoni hypothetical protein 0.0227 0.2184 0.3227
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0121 0.0957 0.1377
Echinococcus multilocularis RUN 0.0104 0.0772 0.1142
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Brugia malayi nuclear hormone receptor 0.0057 0.0229 0.0329
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121 0.0967 0.137
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.017 0.0251
Brugia malayi nuclear receptor NHR-88 0.0121 0.0967 0.1391
Schistosoma mansoni rab6-interacting 0.0104 0.0772 0.1142
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0279 0.2787 0.4118
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Brugia malayi hypothetical protein 0.0082 0.0509 0.0733
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) DR-78 0.0057 0.0229 0.0305
Schistosoma mansoni lipoxygenase 0.0625 0.6767 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.012 0.0173
Schistosoma mansoni hypothetical protein 0.0055 0.0203 0.0299
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0229 0.0338
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0229 0.0549
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0299
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0229 0.0338
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0823 0.1163
Onchocerca volvulus 0.0076 0.0443 0.1633
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.017 0.0251
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0229 0.0329
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0625 0.6767 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0967 0.1391
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.104 0.1475
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Schistosoma mansoni zinc finger protein 0.0057 0.0229 0.0338
Brugia malayi hypothetical protein 0.0344 0.3528 0.5077
Schistosoma mansoni rab6-interacting 0.0104 0.0772 0.1142
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0229 0.0338
Echinococcus multilocularis FTZ F1 alpha 0.0121 0.0967 0.1429
Onchocerca volvulus 0.0057 0.0229 0.0549
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0224 0.0322
Echinococcus multilocularis netrin receptor unc 5 0.0048 0.012 0.0177
Brugia malayi hypothetical protein 0.0104 0.0772 0.1111
Brugia malayi nuclear receptor NHR-88 0.0057 0.0229 0.0329
Echinococcus multilocularis ecdysone induced protein 78C 0.0121 0.0967 0.1429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0229 0.0329
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.0967 0.1429
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0245 0.2391 0.3533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0967 0.1391
Echinococcus granulosus RUN 0.0104 0.0772 0.1142
Onchocerca volvulus Peroxidase homolog 0.0082 0.0509 0.197
Brugia malayi nuclear receptor RXR 0.0057 0.0229 0.0329
Onchocerca volvulus 0.0082 0.0509 0.197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.0967 0.137
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.0967 0.1429
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121 0.0967 0.1391
Echinococcus granulosus ecdysone induced protein 78C 0.0121 0.0967 0.1429
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.0967 0.1429
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0443 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121 0.0967 0.1391
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0349 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Echinococcus granulosus Polycystic kidney disease protein 0.0104 0.0772 0.1142
Onchocerca volvulus 0.0057 0.0229 0.0549
Schistosoma mansoni coup transcription factor 0.0121 0.0967 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121 0.0967 0.137
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0149
Onchocerca volvulus Dual oxidase homolog 0.0082 0.0509 0.197
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0229 0.0338
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0229 0.0305
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121 0.0967 0.1429
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Onchocerca volvulus 0.0104 0.0772 0.3302
Schistosoma mansoni jun-related protein 0.0227 0.2184 0.3227
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Onchocerca volvulus 0.0121 0.0967 0.4286
Schistosoma mansoni hypothetical protein 0.0048 0.012 0.0177
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.017 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Schistosoma mansoni nuclear hormone receptor 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.017 0.0251
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121 0.0967 0.1429
Echinococcus multilocularis jun protein 0.0279 0.2787 0.4118
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0229 0.0305
Brugia malayi ecdysteroid receptor 0.0121 0.0967 0.1391
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0203 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121 0.0967 0.1391
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0017 0.0024
Echinococcus multilocularis Ankyrin 0.0048 0.0125 0.0184
Loa Loa (eye worm) hypothetical protein 0.0104 0.0772 0.109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0967 0.1391
Loa Loa (eye worm) hypothetical protein 0.0272 0.2699 0.3868
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121 0.0967 0.137
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121 0.0967 0.137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0229 0.0338
Echinococcus granulosus survival motor neuron protein 1 0.027 0.2675 0.3953

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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