Detailed information for compound 883322

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 401.092 | Formula: C13H9Cl4NO3S
  • H donors: 0 H acceptors: 3 LogP: 4.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C(Cl)C(=O)C(C(C1=NS(=O)(=O)c1ccccc1)Cl)(Cl)Cl
  • InChi: 1S/C13H9Cl4NO3S/c1-7-9(14)12(19)13(16,17)11(15)10(7)18-22(20,21)8-5-3-2-4-6-8/h2-6,11H,1H3/b18-10+
  • InChiKey: YSPGGQPHFYOSNN-VCHYOVAHSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0055 0.0203 0.0418
Brugia malayi ecdysteroid receptor 0.0121 0.0967 0.1391
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.017 0.0221
Brugia malayi Cytochrome P450 family protein 0.0154 0.1346 0.1937
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Brugia malayi hypothetical protein 0.0064 0.0308 0.0443
Schistosoma mansoni loxhd1 0.0104 0.0772 0.1142
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0121 0.0967 0.1429
Brugia malayi hypothetical protein 0.0104 0.0772 0.1111
Loa Loa (eye worm) hypothetical protein 0.0641 0.695 1
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0121 0.0967 0.1429
Brugia malayi RNA, U transporter 1 0.0088 0.0579 0.0833
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0057 0.0229 0.0329
Trypanosoma cruzi cruzipain precursor, putative 0.0134 0.1117 1
Brugia malayi Uncoordinated protein 44 0.0048 0.012 0.0173
Loa Loa (eye worm) steroid hormone receptor 0.0121 0.0967 0.137
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Brugia malayi Doublecortin family protein 0.0104 0.0772 0.1111
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.017 0.1523 0.2251
Loa Loa (eye worm) hypothetical protein 0.0104 0.0772 0.109
Schistosoma mansoni peroxidasin 0.0082 0.0509 0.0753
Loa Loa (eye worm) hypothetical protein 0.0344 0.3528 0.5065
Brugia malayi nuclear receptor NHR-88 0.0121 0.0967 0.1391
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0048 0.0125 0.0184
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Echinococcus granulosus survival motor neuron protein 1 0.027 0.2675 0.3953
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0121 0.0957 0.1414
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Echinococcus granulosus netrin receptor unc 5 0.0048 0.012 0.0177
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Brugia malayi steroid hormone receptor 0.0121 0.0967 0.1391
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0057 0.0229 0.0338
Brugia malayi nuclear receptor RXR 0.0057 0.0229 0.0329
Schistosoma mansoni zinc finger protein 0.0057 0.0229 0.0338
Onchocerca volvulus Peroxidase homolog 0.0082 0.0509 0.197
Onchocerca volvulus 0.0104 0.0772 0.3302
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.0224 0.0322
Echinococcus granulosus thyroid hormone receptor alpha 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0349 0.048
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Brugia malayi RNA binding protein 0.0068 0.0349 0.0503
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0957 0.0538
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Schistosoma mansoni hypothetical protein 0.0039 0.0017 0.0025
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0121 0.0967 0.4286
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0121 0.0967 0.1391
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0121 0.0967 0.1391
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni nuclear receptor 0.0057 0.0229 0.0338
Plasmodium falciparum LCCL domain-containing protein 0.0104 0.0772 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0121 0.0957 0.1377
Onchocerca volvulus Dual oxidase homolog 0.0082 0.0509 0.197
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0967 0.1429
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0121 0.0967 0.1429
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0279 0.2787 0.4118
Loa Loa (eye worm) DR-78 0.0057 0.0229 0.0305
Brugia malayi hypothetical protein 0.027 0.2675 0.3849
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0229 0.0329
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0967 0.1391
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Brugia malayi Steroid receptor seven-up type 2 0.0121 0.0967 0.1391
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Echinococcus multilocularis survival motor neuron protein 1 0.027 0.2675 0.3953
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0967 0.1391
Onchocerca volvulus Protein ultraspiracle homolog 0.0121 0.0967 0.4286
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0048 0.012 0.0149
Plasmodium vivax multidomain scavenger receptor, putative 0.0104 0.0772 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.104 0.1475
Schistosoma mansoni aryl hydrocarbon receptor 0.0102 0.0749 0.1107
Brugia malayi hypoxia-induced factor 1 0.0317 0.3222 0.4635
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0349 0.048
Onchocerca volvulus 0.0082 0.0509 0.197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0121 0.0967 0.137
Brugia malayi hypothetical protein 0.0057 0.0229 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Echinococcus granulosus tar DNA binding protein 0.0068 0.0349 0.0516
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0048 0.012 0.0177
Brugia malayi hypothetical protein 0.0344 0.3528 0.5077
Brugia malayi Blistered cuticle protein 3 0.0082 0.0509 0.0733
Schistosoma mansoni steroid hormone receptor ad4bp 0.0121 0.0967 0.1429
Loa Loa (eye worm) doublecortin family protein 0.0104 0.0772 0.109
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0121 0.0967 0.1391
Brugia malayi conserved hypotetical protein 0.0057 0.0229 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.017 0.0251
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0048 0.012 0.0177
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0017 0.0024
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0064 0.0308 0.0455
Onchocerca volvulus 0.0076 0.0443 0.1633
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0121 0.0967 0.1391
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni lipoxygenase 0.0625 0.6767 1
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Echinococcus granulosus peroxidasin 0.0082 0.0509 0.0753
Loa Loa (eye worm) nuclear hormone receptor 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Schistosoma mansoni rab6-interacting 0.0104 0.0772 0.1142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0234 0.2262 0.3342
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Brugia malayi tailless protein 0.0057 0.0229 0.0329
Onchocerca volvulus 0.0082 0.0509 0.197
Loa Loa (eye worm) hypothetical protein 0.0048 0.012 0.0149
Loa Loa (eye worm) hypothetical protein 0.0104 0.0772 0.109
Brugia malayi small heat shock protein 0.0641 0.695 1
Onchocerca volvulus 0.0121 0.0967 0.4286
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0957 0.1414
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0121 0.0967 0.1391
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Schistosoma mansoni thyroid hormone receptor 0.0121 0.0967 0.1429
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0967 0.1391
Brugia malayi MH2 domain containing protein 0.0128 0.104 0.1496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Schistosoma mansoni nuclear hormone receptor 0.0121 0.0967 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0121 0.0967 0.137
Echinococcus granulosus ecdysone induced protein 78C 0.0121 0.0967 0.1429
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0329 0.3361 0.4823
Schistosoma mansoni lipoxygenase 0.0437 0.4601 0.6799
Echinococcus granulosus Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.027 0.2675 0.3834
Echinococcus multilocularis peroxidasin 0.0082 0.0509 0.0753
Echinococcus multilocularis snurportin 1 0.0329 0.3361 0.4966
Loa Loa (eye worm) RNA binding protein 0.0068 0.0349 0.048
Brugia malayi Animal haem peroxidase family protein 0.0082 0.0509 0.0733
Echinococcus granulosus single minded 2 0.0076 0.0443 0.0654
Brugia malayi hypothetical protein 0.0104 0.0772 0.1111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0121 0.0967 0.1429
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0121 0.0967 0.1391
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0308 0.0443
Brugia malayi TAR-binding protein 0.0068 0.0349 0.0503
Brugia malayi nuclear receptor NHR-67 0.0057 0.0229 0.0329
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0279 0.2787 0.4118
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0906 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0121 0.0967 0.1429
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0272 0.2699 0.3868
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0121 0.0967 0.1429
Loa Loa (eye worm) blistered cuticle protein 3 0.0082 0.0509 0.071
Schistosoma mansoni jun-related protein 0.0227 0.2184 0.3227
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Echinococcus granulosus Ankyrin 0.0048 0.0125 0.0184
Echinococcus multilocularis RUN 0.0104 0.0772 0.1142
Onchocerca volvulus Chorion peroxidase homolog 0.0082 0.0509 0.197
Brugia malayi Protein kinase domain containing protein 0.0048 0.012 0.0173
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0451 0.476 0.7034
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0057 0.0229 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0229 0.0549
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.017 0.0251
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.104 0.1475
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Brugia malayi nuclear hormone receptor family member nhr-6 0.0057 0.0229 0.0329
Schistosoma mansoni coup transcription factor 0.0121 0.0967 0.1429
Onchocerca volvulus Peroxidase homolog 0.0082 0.0509 0.197
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.0224 0.0322
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0057 0.0229 0.0338
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0121 0.0967 0.137
Echinococcus granulosus nuclear factor of activated T cells 5 0.0245 0.2391 0.3533
Echinococcus multilocularis thyroid hormone receptor alpha 0.0121 0.0967 0.1429
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0121 0.0967 0.137
Echinococcus granulosus nuclear receptor nhr 48 0.0057 0.0229 0.0338
Schistosoma mansoni polycystin 1-related 0.0104 0.0772 0.1142
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0121 0.0957 0.0538
Brugia malayi nuclear hormone receptor 0.0121 0.0967 0.1391
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0064 0.0308 0.0455
Schistosoma mansoni hypothetical protein 0.0329 0.3361 0.4966
Brugia malayi orphan nuclear receptor NR2E1 0.0057 0.0229 0.0329
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0349 0.0503
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.017 0.0251
Schistosoma mansoni hypothetical protein 0.0104 0.0772 0.1142
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Brugia malayi photoreceptor-specific nuclear receptor 0.0121 0.0967 0.1391
Trypanosoma cruzi cysteine peptidase, putative 0.0134 0.1117 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0057 0.0229 0.0305
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0057 0.0229 0.0338
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Brugia malayi hypothetical protein 0.0057 0.0229 0.0329
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Echinococcus granulosus lipoxygenase domain containing protein 0.0104 0.0772 0.1142
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0229 0.0338
Schistosoma mansoni nuclear hormone receptor 0.0057 0.0229 0.0338
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0625 0.6767 1
Brugia malayi bHLH-PAS transcription factor 0.0076 0.0443 0.0637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0121 0.0967 0.4286
Brugia malayi Death domain containing protein 0.0048 0.012 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Echinococcus granulosus RUN 0.0104 0.0772 0.1142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Brugia malayi hypothetical protein 0.0219 0.2096 0.3015
Loa Loa (eye worm) hypoxia-induced factor 1 0.0317 0.3222 0.4622
Brugia malayi nuclear hormone receptor 0.0057 0.0229 0.0329
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.017 0.0245
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0509 0.197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0121 0.0967 0.137
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.012 0.0173
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0121 0.0967 0.137
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Echinococcus multilocularis nuclear receptor nhr 48 0.0057 0.0229 0.0338
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0625 0.6767 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0121 0.0967 0.1429
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0349 0.0516
Schistosoma mansoni retinoic acid receptor RXR 0.0234 0.2262 0.3342
Echinococcus multilocularis Ankyrin 0.0048 0.0125 0.0184
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0121 0.0967 0.1429
Brugia malayi nuclear hormone receptor family member odr-7 0.0057 0.0229 0.0329
Schistosoma mansoni RAR-like nuclear receptor 0.0121 0.0967 0.1429
Brugia malayi Peroxidasin 0.0082 0.0509 0.0733
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.0224 0.0299
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0121 0.0967 0.1429
Echinococcus multilocularis FTZ F1 alpha 0.0121 0.0967 0.1429
Brugia malayi bZIP transcription factor family protein 0.0279 0.2787 0.401
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni survival motor neuron protein 0.0055 0.0203 0.0299
Brugia malayi nuclear receptor NHR-88 0.0057 0.0229 0.0329
Onchocerca volvulus 0.0057 0.0229 0.0549
Schistosoma mansoni hypothetical protein 0.0048 0.012 0.0177
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0121 0.0967 0.1429
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Echinococcus granulosus FTZ F1 alpha 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0121 0.0967 0.137
Schistosoma mansoni hypothetical protein 0.0227 0.2184 0.3227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0121 0.0967 0.1391
Brugia malayi nuclear receptor RXR 0.0064 0.0308 0.0443
Brugia malayi Nuclear hormone receptor-like 1 0.0121 0.0967 0.1391
Echinococcus granulosus snurportin 1 0.0329 0.3361 0.4966
Leishmania major cathepsin L-like protease 0.0134 0.1117 1
Schistosoma mansoni nuclear receptor nhr-48 0.0057 0.0229 0.0338
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0064 0.0308 0.0419
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Onchocerca volvulus 0.0057 0.0229 0.0549
Brugia malayi Nuclear hormone receptor-like 1 0.0064 0.0308 0.0443
Schistosoma mansoni ankyrin 23/unc44 0.0048 0.012 0.0177
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0109 0.0823 0.1163
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0121 0.0967 0.1429
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Loa Loa (eye worm) nuclear receptor NHR-67 0.0057 0.0229 0.0305
Onchocerca volvulus 0.0219 0.2096 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0123 0.0982 0.5946
Schistosoma mansoni hypothetical protein 0.0055 0.0203 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.017 0.0251
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0064 0.0308 0.0455
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Echinococcus granulosus Polycystic kidney disease protein 0.0104 0.0772 0.1142
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0203 0.0292
Brugia malayi ecdysone receptor 0.0057 0.0229 0.0329
Mycobacterium ulcerans proteasome PrcA 0.0906 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.017 0.0251
Schistosoma mansoni nuclear receptor 0.0057 0.0229 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0121 0.0967 0.1391
Brugia malayi hypothetical protein 0.0064 0.0308 0.0443
Echinococcus granulosus jun protein 0.0279 0.2787 0.4118
Entamoeba histolytica hypothetical protein 0.0037 0 0.5
Echinococcus granulosus death domain containing protein 0.0048 0.012 0.0177
Loa Loa (eye worm) animal heme peroxidase 0.0082 0.0509 0.071
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0121 0.0967 0.1391
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.0443 0.0654
Onchocerca volvulus 0.0104 0.0772 0.3302
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0064 0.0308 0.0419
Onchocerca volvulus 0.0082 0.0509 0.197
Brugia malayi PAS domain containing protein 0.0102 0.0749 0.1078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0121 0.0967 0.137
Loa Loa (eye worm) cytochrome P450 family protein 0.0154 0.1346 0.1917
Loa Loa (eye worm) hypothetical protein 0.0057 0.0229 0.0305
Loa Loa (eye worm) hypothetical protein 0.0057 0.0224 0.0299
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0245 0.2391 0.3533
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0057 0.0229 0.0338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Schistosoma mansoni rab6-interacting 0.0104 0.0772 0.1142
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Schistosoma mansoni peroxidasin 0.0082 0.0509 0.0753
Loa Loa (eye worm) hypothetical protein 0.0048 0.0125 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0121 0.0967 0.1391
Schistosoma mansoni netrin receptor unc5 0.0048 0.012 0.0177
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0064 0.0308 0.0455
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0349 0.0516
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0134 0.1117 0.5
Loa Loa (eye worm) hypothetical protein 0.0082 0.0509 0.071
Brugia malayi hypothetical protein 0.0082 0.0509 0.0733
Schistosoma mansoni single-minded 0.0102 0.0749 0.1107
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0057 0.0229 0.0338
Echinococcus multilocularis jun protein 0.0279 0.2787 0.4118
Echinococcus multilocularis netrin receptor unc 5 0.0048 0.012 0.0177
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0121 0.0967 0.1429
Echinococcus multilocularis Polycystic kidney disease protein 0.0104 0.0772 0.1142
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0121 0.0967 0.1429
Brugia malayi Nuclear hormone receptor E75 0.0057 0.0229 0.0329
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0121 0.0957 0.1414
Onchocerca volvulus Peroxidasin homolog 0.0082 0.0509 0.197
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0057 0.0229 0.0549

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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