TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 370.508 | Formula: C21H26N2O2S
H donors: 0 H acceptors: 2 LogP: 3.82 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)CC=Cc1ccccc1
InChi: 1S/C21H26N2O2S/c1-2-19-10-12-21(13-11-19)26(24,25)23-17-15-22(16-18-23)14-6-9-20-7-4-3-5-8-20/h3-13H,2,14-18H2,1H3/b9-6-
InChiKey: DWEPBASMACUICX-TWGQIWQCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine kinase	0.0036	0.0039	0.0039
Trypanosoma cruzi	hypothetical protein, conserved	0.0172	0.1021	1
Schistosoma mansoni	protein tyrosine phosphatase	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0036	0.0039	0.0039
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus multilocularis	snurportin 1	0.0346	0.2271	0.2271
Trypanosoma cruzi	hypothetical protein, conserved	0.0172	0.1021	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0176	0.0176
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0559	0.3802	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0559	0.3802	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0055	0.0176	0.0176
Onchocerca volvulus		0.005	0.0142	0.0374
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0176	0.0176
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.007	0.0283	0.0283
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	glutamate receptor 2	0.007	0.0283	0.0283
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0172	0.1021	0.2543
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.005	0.0142	0.0142
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.007	0.0283	0.0283
Schistosoma mansoni	glutamate receptor AMPA	0.007	0.0283	0.0283
Echinococcus granulosus	snurportin 1	0.0346	0.2271	0.2271
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0176	0.0176
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0039	0.0039
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus multilocularis	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	beta-lactamase family protein	0.004	0.0073	0.0073
Mycobacterium leprae	Probable lipase LipE	0.004	0.0073	0.5
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0559	0.3802	0.3802
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0172	0.1021	0.2543
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0055	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Brugia malayi	Receptor family ligand binding region containing protein	0.0036	0.0039	0.0039
Schistosoma mansoni	hypothetical protein	0.019	0.1152	0.1152
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0036	0.0039	0.0039
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein tyrosine phosphatase	0.005	0.0142	0.0142
Brugia malayi	hypothetical protein	0.005	0.0142	0.0142
Onchocerca volvulus		0.0036	0.0039	0.0102
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Plasmodium vivax	hypothetical protein, conserved	0.004	0.0073	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	nmda type glutamate receptor	0.0248	0.1567	0.1567
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0073	0.0073
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.005	0.0142	0.0275
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0036	0.0039	0.0039
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0142	0.1054
Brugia malayi	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Brugia malayi	Glutamate receptor 2 precursor	0.007	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0105	0.054	0.054
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0142	0.1054
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.142	1	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.005	0.0142	0.0142
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0105	0.054	0.054
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.005	0.0142	0.0142
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0176	0.0176
Schistosoma mansoni	hypothetical protein	0.007	0.0283	0.0283
Brugia malayi	Importin beta-1 subunit	0.0032	0.0015	0.0015
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0055	0.0176	0.0176
Brugia malayi	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.005	0.0142	0.0142
Schistosoma mansoni	glutamate receptor AMPA	0.007	0.0283	0.0283
Chlamydia trachomatis	glutamine binding protein	0.0178	0.1066	0.5
Onchocerca volvulus		0.0559	0.3802	1
Echinococcus multilocularis	importin subunit beta 1	0.0032	0.0015	0.0015
Schistosoma mansoni	importin beta-1	0.0032	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0666	0.0666
Brugia malayi	beta-lactamase family protein	0.004	0.0073	0.0073
Schistosoma mansoni	glutamate receptor NMDA	0.0105	0.054	0.054
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.004	0.0073	0.0073
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0178	0.1066	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Schistosoma mansoni	metabotropic glutamate receptor	0.0036	0.0039	0.0039
Brugia malayi	beta-lactamase	0.004	0.0073	0.0073
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0178	0.1066	0.3987
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.142	1	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.004	0.0073	0.0073
Echinococcus multilocularis	tyrosine kinase	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0306	0.0306
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0055	0.0176	0.0176
Onchocerca volvulus		0.005	0.0142	0.0374
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0036	0.0039	0.0039
Onchocerca volvulus		0.005	0.0142	0.0374
Brugia malayi	metabotropic glutamate receptor type 2	0.0036	0.0039	0.0039
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0055	0.0176	0.0176
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Echinococcus granulosus	glutamate receptor 2	0.0036	0.0039	0.0039
Schistosoma mansoni	glutamate receptor kainate	0.007	0.0283	0.0283
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0386	0.2563	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.004	0.0073	0.0073
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0105	0.054	0.054
Onchocerca volvulus		0.0077	0.034	0.0893
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0559	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Leishmania major	hypothetical protein, conserved	0.004	0.0073	0.0349
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0105	0.054	0.054
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0559	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0055	0.0176	0.0176
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Schistosoma mansoni	protein kinase	0.0036	0.0039	0.0039
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Echinococcus granulosus	nmda type glutamate receptor	0.0036	0.0039	0.0039
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.005	0.0142	0.0142
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0559	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus granulosus	receptor type guanylyl cyclase	0.0036	0.0039	0.0039
Trypanosoma brucei	hypothetical protein, conserved	0.004	0.0073	0.0576
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.007	0.0283	0.0283
Echinococcus granulosus	beta LACTamase domain containing family member	0.004	0.0073	0.0073
Echinococcus multilocularis	glutamate receptor 2	0.007	0.0283	0.0283
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0105	0.054	0.054
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.142	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Onchocerca volvulus		0.004	0.0073	0.0192
Echinococcus granulosus	protein tyrosine phosphatase n9	0.005	0.0142	0.0142
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0015	0.0015
Schistosoma mansoni	glutamate receptor kainate	0.007	0.0283	0.0283
Mycobacterium leprae	conserved hypothetical protein	0.004	0.0073	0.5
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0055	0.0176	0.0176
Toxoplasma gondii	ABC1 family protein	0.004	0.0073	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0142	0.0142
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0105	0.054	0.054
Echinococcus granulosus	glutamate receptor 2	0.0105	0.054	0.054
Echinococcus multilocularis	glutamate receptor 2	0.0036	0.0039	0.0039
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0105	0.054	0.054
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.005	0.0142	0.1054
Echinococcus multilocularis	geminin	0.019	0.1152	0.1152
Echinococcus multilocularis	nmda type glutamate receptor	0.0036	0.0039	0.0039
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0248	0.1567	0.1567
Onchocerca volvulus		0.0036	0.0039	0.0102
Brugia malayi	Glutamate receptor 1 precursor	0.007	0.0283	0.0283
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.019	0.1152	0.1152
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Schistosoma mansoni	glutamate receptor kainate	0.007	0.0283	0.0283
Echinococcus granulosus	glutamate receptor subunit protein glur	0.007	0.0283	0.0283
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0559	0.3802	1
Leishmania major	tyrosine specific protein phosphatase, putative	0.005	0.0142	0.1054
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.005	0.0142	0.0142
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.005	0.0142	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0073	0.0349
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0036	0.0039	0.0039
Leishmania major	hypothetical protein, conserved	0.0172	0.1021	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Schistosoma mansoni	metabotropic glutamate receptor	0.0036	0.0039	0.0039
Schistosoma mansoni	protein tyrosine phosphatase	0.0055	0.0176	0.0176
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0346	0.2271	0.2271
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0306	0.0306
Schistosoma mansoni	pcd6 interacting protein-related	0.005	0.0142	0.0142
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus granulosus	nmda type glutamate receptor	0.0248	0.1567	0.1567
Schistosoma mansoni	glutamate receptor NMDA	0.007	0.0283	0.0283
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0036	0.0039	0.0102
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Schistosoma mansoni	hypothetical protein	0.0346	0.2271	0.2271
Schistosoma mansoni	protein tyrosine phosphatase	0.005	0.0142	0.0142
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0178	0.1066	0.2662
Trypanosoma brucei	protein tyrosine phosphatase 1	0.005	0.0142	0.1264
Loa Loa (eye worm)	beta-lactamase	0.004	0.0073	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0306	0.0306
Plasmodium falciparum	importin beta, putative	0.0032	0.0015	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0559	0.3802	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.142	1	1
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0559	0.3802	0.3802
Brugia malayi	Receptor family ligand binding region containing protein	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0036	0.0039	0.0039
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0176	0.0176
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Echinococcus granulosus	geminin	0.019	0.1152	0.1152
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0036	0.0039	0.0039
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.005	0.0142	0.1054
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0036	0.0039	0.0039
Brugia malayi	hypothetical protein	0.005	0.0142	0.0142
Schistosoma mansoni	ATP-binding cassette transporter	0.007	0.0283	0.0283
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0055	0.0176	0.0176
Brugia malayi	RNA, U transporter 1	0.0092	0.0445	0.0445
Echinococcus multilocularis		0.005	0.0142	0.0142
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.005	0.0142	0.0275
Echinococcus granulosus	importin subunit beta 1	0.0032	0.0015	0.0015
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0036	0.0039	0.0039
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0559	0.3802	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase 1	0.005	0.0142	0.0142
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0178	0.1066	0.5
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.007	0.0283	0.0283
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0559	0.3802	1
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0073	0.0349
Onchocerca volvulus		0.004	0.0073	0.0192
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.005	0.0142	0.0142
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.005	0.0142	0.0142
Onchocerca volvulus		0.004	0.0073	0.0192
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0039	0.0039
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.007	0.0283	0.0283
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Onchocerca volvulus	4.1 G protein, putative homolog	0.005	0.0142	0.0374
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.005	0.0142	0.0142
Brugia malayi	Guanylyl cyclase protein 23	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Schistosoma mansoni	tyrosine kinase	0.0036	0.0039	0.0039
Trichomonas vaginalis	pten, drome, putative	0.005	0.0142	0.0186
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.005	0.0142	0.0142
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0055	0.0176	0.0176
Brugia malayi	hypothetical protein	0.0036	0.0039	0.0039
Echinococcus multilocularis	NMDA receptor	0.007	0.0283	0.0283
Brugia malayi	Protein-tyrosine phosphatase	0.0128	0.07	0.07
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0036	0.0039	0.0039
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0036	0.0039	0.0039
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.005	0.0142	0.0142
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0039	0.0039
Onchocerca volvulus		0.005	0.0142	0.0374
Loa Loa (eye worm)	glutamate receptor	0.0036	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.005	0.0142	0.0142
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0036	0.0039	0.0039
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0105	0.054	0.054
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0055	0.0176	0.0176
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.005	0.0142	0.0142
Loa Loa (eye worm)	hypothetical protein	0.004	0.0073	0.0073
Echinococcus multilocularis	glutamate receptor 2	0.0105	0.054	0.054
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0178	0.1066	0.5
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0559	0.3802	1
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	beta LACTamase domain containing family member	0.004	0.0073	0.0073
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.007	0.0283	0.0283
Loa Loa (eye worm)	glutamate receptor 1	0.007	0.0283	0.0283
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0172	0.1021	1
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.007	0.0283	0.0283
Schistosoma mansoni	tyrosine kinase	0.0036	0.0039	0.0039
Onchocerca volvulus		0.005	0.0142	0.0374
Onchocerca volvulus		0.005	0.0142	0.0374
Echinococcus granulosus	glutamate NMDA receptor subunit	0.007	0.0283	0.0283
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.005	0.0142	0.0142
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0258	0.1642	0.63

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 885598