Detailed information for compound 886431

Basic information

Technical information
  • TDR Targets ID: 886431
  • Name: 2-(4-chlorophenyl)-3-(2-methoxyethyl)chromeno [3,2-e]pyrimidine-4,5-dione
  • MW: 382.797 | Formula: C20H15ClN2O4
  • H donors: 0 H acceptors: 2 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(nc2c(c1=O)c(=O)c1c(o2)cccc1)c1ccc(cc1)Cl
  • InChi: 1S/C20H15ClN2O4/c1-26-11-10-23-18(12-6-8-13(21)9-7-12)22-19-16(20(23)25)17(24)14-4-2-3-5-15(14)27-19/h2-9H,10-11H2,1H3
  • InChiKey: HJCCTRIMCSFWQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-chlorophenyl)-3-(2-methoxyethyl)chromeno[3,2-e]pyrimidine-4,5-quinone
  • ZINC02341268

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0226 0.0223
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0019 0.0017 0.0014
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.0802 0.1674
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0813 0.1727
Onchocerca volvulus 0.0057 0.0498 0.0608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0052 0.0443 0.0908
Brugia malayi MH1 domain containing protein 0.0026 0.0104 0.0222
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.13 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.004 0.0285 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.039 0.4709 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0104 0.0216
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.1626
Schistosoma mansoni cpg binding protein 0.006 0.0539 0.0523
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.453 0.9621
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Toxoplasma gondii hypothetical protein 0.0038 0.0258 0.215
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0226 0.0473
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0019 0.0017 0.0014
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni hypothetical protein 0.0354 0.4258 0.4249
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0038 0.0258 0.0515
Onchocerca volvulus 0.0052 0.0442 0.0482
Loa Loa (eye worm) hypothetical protein 0.0052 0.0443 0.0935
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Mycobacterium ulcerans beta-lactamase 0.0035 0.0226 0.0445
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0226 0.0223
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0298 0.0295
Echinococcus granulosus chromatin regulatory protein sir2 0.0019 0.0017 0.0014
Brugia malayi CXXC zinc finger family protein 0.0057 0.0498 0.1058
Echinococcus granulosus tar DNA binding protein 0.007 0.0672 0.067
Echinococcus multilocularis cpg binding protein 0.006 0.0539 0.0537
Echinococcus granulosus tumor protein p63 0.0357 0.4295 0.4293
Loa Loa (eye worm) sirtuin 4 0.0019 0.0017 0.003
Brugia malayi beta-lactamase family protein 0.0035 0.0226 0.0479
Echinococcus multilocularis dnaJ subfamily B 0.0808 1 1
Schistosoma mansoni cpg binding protein 0.0057 0.0498 0.0482
Schistosoma mansoni Smad4 0.0026 0.0104 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus multilocularis tumor protein p63 0.0357 0.4295 0.4293
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Loa Loa (eye worm) beta-lactamase 0.0035 0.0226 0.0473
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0038 0.0258 0.0111
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.2293 0.4852
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.128 0.2692
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0813 0.1722
Brugia malayi beta-lactamase family protein 0.0035 0.0226 0.0479
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0672 0.1428
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0258 0.0515
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0052 0.0443 0.044
Brugia malayi TAR-binding protein 0.007 0.0672 0.1428
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.128 0.9845
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0813 0.0811
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi MH1 domain containing protein 0.0026 0.0104 0.0222
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0378 0.0375
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1303 0.1288
Echinococcus multilocularis GPCR, family 2 0.0082 0.0813 0.0811
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0104 0.0216
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Schistosoma mansoni cpg binding protein 0.006 0.0539 0.0523
Brugia malayi NAD-dependent deacetylase SIRT1 0.0019 0.0017 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0378 0.0375
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0052 0.0443 0.0426
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0443 0.0908
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Toxoplasma gondii GAF domain-containing protein 0.0038 0.0258 0.215
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi beta-lactamase 0.0035 0.0226 0.0479
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0258 0.5512
Mycobacterium ulcerans hypothetical protein 0.0035 0.0226 0.0445
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0226 0.0479
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0521 0.0505
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0059 0.0521 0.0998
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0019 0.0017 0.0014
Toxoplasma gondii hypothetical protein 0.0104 0.1096 0.9604
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0226 0.0445
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.114 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2622 0.8086
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0052 0.0443 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0378 0.0375
Loa Loa (eye worm) TAR-binding protein 0.007 0.0672 0.1422
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0038 0.0258 0.0111
Echinococcus multilocularis chromatin regulatory protein sir2 0.0019 0.0017 0.0014
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Plasmodium vivax NAD-dependent deacetylase, putative 0.0059 0.0521 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0052 0.0443 0.094
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.3044 0.6465
Echinococcus granulosus GPCR family 2 0.0082 0.0813 0.0811
Brugia malayi RNA binding protein 0.007 0.0672 0.1428
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0498 0.1053
Schistosoma mansoni smad 0.0026 0.0104 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.039 0.4709 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0298 0.0295
Loa Loa (eye worm) hypothetical protein 0.0082 0.0813 0.1722
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 0.2734
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0226 0.0445
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Brugia malayi Smad1 0.0026 0.0104 0.0222
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0543
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0813 0.1727
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Leishmania major hypothetical protein, conserved 0.012 0.13 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.039 0.4709 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus granulosus geminin 0.0354 0.4258 0.4257
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0813 0.0811
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0442 0.0932
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Echinococcus granulosus smad 0.0026 0.0104 0.0102
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0019 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0019 0.0017 0.0014
Echinococcus granulosus microtubule associated protein 2 0.0729 0.9 0.9
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Schistosoma mansoni hypothetical protein 0.0808 1 1
Brugia malayi MH2 domain containing protein 0.0026 0.0104 0.0222
Onchocerca volvulus 0.039 0.4709 1
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.2165 0.4326
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Echinococcus multilocularis geminin 0.0354 0.4258 0.4257
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.9 0.9
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0052 0.0443 0.0908
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0226 0.0209
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.9 0.8998
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.027 0.319 1
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Echinococcus granulosus Smad4 0.0026 0.0104 0.0102
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0052 0.0443 0.094
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0287 0.3415 0.7252
Brugia malayi hypothetical protein 0.0025 0.0092 0.0196
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0587
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0442 0.0425
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0119 0.128 0.1265
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0672 0.1422
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0378 0.0796
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0081 0.0802 0.6122
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0019 0.0017 0.0014
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0226 0.0209
Toxoplasma gondii hypothetical protein 0.0038 0.0258 0.215
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0258 0.4788
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0587
Echinococcus multilocularis smad 0.0026 0.0104 0.0102
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 0.2734
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 1
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0119 0.128 0.1278
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Mycobacterium ulcerans NAD-dependent deacetylase 0.0059 0.0521 0.1075
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0104 0.0102
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0104 0.0102
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.2293 0.4852
Brugia malayi MH2 domain containing protein 0.0376 0.453 0.9621
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0226 0.0445
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.3044 0.6463
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0019 0.0017 0.0014
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.13 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0059 0.0521 1
Trichomonas vaginalis esterase, putative 0.0035 0.0226 0.0445
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.453 0.9621
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0378 0.0375
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0019 0.0017 0.0014
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0119 0.128 0.1278
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0298 0.0281
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0378 0.0802
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0287 0.3415 0.725
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0226 0.4137
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0092 0.0587
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Loa Loa (eye worm) Smad1 0.0026 0.0104 0.0216
Toxoplasma gondii ABC1 family protein 0.0035 0.0226 0.1857
Plasmodium falciparum GAF domain-related protein, putative 0.0038 0.0258 0.4788
Entamoeba histolytica protein tyrosine phosphatase, putative 0.039 0.4709 1
Echinococcus granulosus cpg binding protein 0.006 0.0539 0.0537
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Schistosoma mansoni hypothetical protein 0.0041 0.0298 0.0281
Brugia malayi MH2 domain containing protein 0.0026 0.0104 0.0222
Loa Loa (eye worm) RNA binding protein 0.007 0.0672 0.1422
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.3044 0.6465
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0059 0.0521 0.1075
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0813 0.0811
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) hypothetical protein 0.0258 0.3044 0.6463
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0587
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0104 0.0102
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) hypothetical protein 0.0176 0.2012 0.4269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0813 0.0811
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0092 0.067
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0104 0.0088
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0226 0.0445
Schistosoma mansoni hypothetical protein 0.0176 0.2012 0.1998
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.039 0.4709 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.1626
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.039 0.4709 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni hypothetical protein 0.0354 0.4258 0.4249
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Mycobacterium ulcerans lipase LipD 0.0035 0.0226 0.0445
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.2012 0.4272
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0059 0.0521 0.3931
Giardia lamblia Transcriptional regulator, Sir2 family 0.0059 0.0521 0.1075
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0081 0.0802 0.1674
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0258 0.0515
Toxoplasma gondii histone deacetylase SIR2 0.0059 0.0521 0.449
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi hypothetical protein 0.0041 0.0298 0.0633
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.019
Leishmania major hypothetical protein, conserved 0.0035 0.0226 0.1626
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus multilocularis Smad4 0.0026 0.0104 0.0102
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.128 0.9845
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus multilocularis tar DNA binding protein 0.007 0.0672 0.067
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0226 0.1626

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.