Detailed information for compound 886431

Basic information

Technical information
  • TDR Targets ID: 886431
  • Name: 2-(4-chlorophenyl)-3-(2-methoxyethyl)chromeno [3,2-e]pyrimidine-4,5-dione
  • MW: 382.797 | Formula: C20H15ClN2O4
  • H donors: 0 H acceptors: 2 LogP: 3.06 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCn1c(nc2c(c1=O)c(=O)c1c(o2)cccc1)c1ccc(cc1)Cl
  • InChi: 1S/C20H15ClN2O4/c1-26-11-10-23-18(12-6-8-13(21)9-7-12)22-19-16(20(23)25)17(24)14-4-2-3-5-15(14)27-19/h2-9H,10-11H2,1H3
  • InChiKey: HJCCTRIMCSFWQH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-chlorophenyl)-3-(2-methoxyethyl)chromeno[3,2-e]pyrimidine-4,5-quinone
  • ZINC02341268

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0378 0.0375
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.039 0.4709 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.128 0.2692
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0258 0.4788
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0813 0.0811
Loa Loa (eye worm) MH2 domain-containing protein 0.0376 0.453 0.9621
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.3044 0.6465
Echinococcus granulosus cpg binding protein 0.006 0.0539 0.0537
Loa Loa (eye worm) hypothetical protein 0.0258 0.3044 0.6463
Mycobacterium ulcerans lipase LipD 0.0035 0.0226 0.0445
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0104 0.0216
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Brugia malayi hypothetical protein 0.0041 0.0298 0.0633
Brugia malayi TAR-binding protein 0.007 0.0672 0.1428
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0298 0.0281
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0226 0.0209
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0378 0.0802
Loa Loa (eye worm) hypothetical protein 0.0052 0.0442 0.0932
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0104 0.0102
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi MH2 domain containing protein 0.0376 0.453 0.9621
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.004 0.0285 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.1626
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0226 0.0223
Echinococcus granulosus smad 0.0026 0.0104 0.0102
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0104 0.0102
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0059 0.0521 1
Schistosoma mansoni smad 0.0026 0.0104 0.0088
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2622 0.8086
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Toxoplasma gondii hypothetical protein 0.0038 0.0258 0.215
Echinococcus multilocularis GPCR, family 2 0.0082 0.0813 0.0811
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0019 0.0017 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0104 0.0102
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0038 0.0258 0.0111
Mycobacterium ulcerans beta-lactamase 0.0035 0.0226 0.0445
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0672 0.1428
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0287 0.3415 0.7252
Schistosoma mansoni cpg binding protein 0.006 0.0539 0.0523
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0092 0.067
Brugia malayi NAD-dependent deacetylase SIRT1 0.0019 0.0017 0.0036
Onchocerca volvulus 0.039 0.4709 1
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.2293 0.4852
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0226 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni hypothetical protein 0.0041 0.0298 0.0281
Toxoplasma gondii GAF domain-containing protein 0.0038 0.0258 0.215
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0052 0.0443 0.0908
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Echinococcus multilocularis dnaJ subfamily B 0.0808 1 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Schistosoma mansoni cpg binding protein 0.006 0.0539 0.0523
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Brugia malayi MH2 domain containing protein 0.0026 0.0104 0.0222
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0813 0.0811
Echinococcus multilocularis geminin 0.0354 0.4258 0.4257
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Echinococcus multilocularis chromatin regulatory protein sir2 0.0019 0.0017 0.0014
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0104 0.0216
Mycobacterium ulcerans hypothetical protein 0.0035 0.0226 0.0445
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0119 0.128 0.1278
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.039 0.4709 1
Onchocerca volvulus Glucosylceramidase homolog 0.0189 0.2165 0.4326
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0059 0.0521 0.1075
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0813 0.0811
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0672 0.1422
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0119 0.128 0.1278
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis esterase, putative 0.0035 0.0226 0.0445
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0226 0.1626
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0226 0.0479
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.003
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0119 0.128 0.1265
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0019 0.0017 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0226 0.0445
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.9 0.9
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0019 0.0017 0.0014
Leishmania major hypothetical protein, conserved 0.012 0.13 1
Loa Loa (eye worm) sirtuin 4 0.0019 0.0017 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0019 0.0017 0.0014
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.027 0.319 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Entamoeba histolytica protein tyrosine phosphatase, putative 0.039 0.4709 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Brugia malayi MH1 domain containing protein 0.0026 0.0104 0.0222
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0813 0.1722
Echinococcus granulosus GPCR family 2 0.0082 0.0813 0.0811
Entamoeba histolytica protein tyrosine phosphatase, putative 0.039 0.4709 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0038 0.0258 0.0515
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 0.2734
Loa Loa (eye worm) hypothetical protein 0.0176 0.2012 0.4269
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0052 0.0443 0.094
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 1
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Schistosoma mansoni tar DNA-binding protein 0.007 0.0672 0.0656
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0258 0.0515
Loa Loa (eye worm) hypothetical protein 0.0038 0.0258 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Schistosoma mansoni hypothetical protein 0.0808 1 1
Brugia malayi MH2 domain containing protein 0.0026 0.0104 0.0222
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0019 0.0017 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0378 0.0796
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0226 0.0223
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0298 0.0295
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0226 0.0473
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.039 0.4709 1
Brugia malayi beta-lactamase family protein 0.0035 0.0226 0.0479
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0092 0.1492
Giardia lamblia Transcriptional regulator, Sir2 family 0.0059 0.0521 0.1075
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.1303 0.1288
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2165 0.4579
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0587
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0287 0.3415 0.725
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0059 0.0521 0.3931
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0052 0.0443 0.0426
Plasmodium vivax NAD-dependent deacetylase, putative 0.0059 0.0521 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.128 0.9845
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0059 0.0521 0.0998
Toxoplasma gondii ABC1 family protein 0.0035 0.0226 0.1857
Loa Loa (eye worm) hypothetical protein 0.0025 0.0092 0.019
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0258 0.5512
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0226 0.0445
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0019 0.0017 0.0014
Schistosoma mansoni cpg binding protein 0.0057 0.0498 0.0482
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0226 0.1626
Loa Loa (eye worm) Smad1 0.0026 0.0104 0.0216
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni chromatin regulatory protein sir2 0.0059 0.0521 0.0505
Mycobacterium ulcerans NAD-dependent deacetylase 0.0059 0.0521 0.1075
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus granulosus geminin 0.0354 0.4258 0.4257
Echinococcus granulosus chromatin regulatory protein sir2 0.0019 0.0017 0.0014
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0019 0.0017 0.0014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0104 0.0102
Schistosoma mansoni hypothetical protein 0.0354 0.4258 0.4249
Leishmania major hypothetical protein, conserved 0.0035 0.0226 0.1626
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0378 0.0375
Schistosoma mansoni hypothetical protein 0.0354 0.4258 0.4249
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0813 0.1727
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0813 0.0811
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Echinococcus granulosus tumor protein p63 0.0357 0.4295 0.4293
Brugia malayi beta-lactamase 0.0035 0.0226 0.0479
Toxoplasma gondii hypothetical protein 0.0104 0.1096 0.9604
Loa Loa (eye worm) transcription factor SMAD2 0.0376 0.453 0.9621
Brugia malayi Smad1 0.0026 0.0104 0.0222
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.13 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.3044 0.6463
Brugia malayi CXXC zinc finger family protein 0.0057 0.0498 0.1058
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Schistosoma mansoni Smad4 0.0026 0.0104 0.0088
Echinococcus granulosus microtubule associated protein 2 0.0729 0.9 0.9
Brugia malayi beta-lactamase family protein 0.0035 0.0226 0.0479
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0226 0.0445
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Loa Loa (eye worm) RNA binding protein 0.007 0.0672 0.1422
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.039 0.4709 1
Echinococcus multilocularis cpg binding protein 0.006 0.0539 0.0537
Brugia malayi transcriptional regulator, Sir2 family protein 0.0019 0.0017 0.0036
Onchocerca volvulus 0.0057 0.0498 0.0608
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.13 1
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.114 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.13 0.2734
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0059 0.0521 0.3931
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0052 0.0443 0.094
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0498 0.1053
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0052 0.0443 0.0908
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0052 0.0443 0.044
Echinococcus multilocularis tar DNA binding protein 0.007 0.0672 0.067
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0442 0.0425
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0258 0.0515
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.9 0.8998
Leishmania major hypothetical protein, conserved 0.0025 0.0092 0.0587
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0081 0.0802 0.6122
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0092 0.0587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0378 0.0375
Plasmodium falciparum GAF domain-related protein, putative 0.0038 0.0258 0.4788
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0226 0.0445
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0052 0.0443 0.0908
Loa Loa (eye worm) hypothetical protein 0.0052 0.0443 0.0935
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0059 0.0521 0.1075
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.039 0.4709 1
Echinococcus granulosus Smad4 0.0026 0.0104 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0226 0.0473
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0226 0.0445
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0226 0.0209
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0298 0.0295
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0052 0.0443 0.044
Entamoeba histolytica hypothetical protein 0.0041 0.0298 0.0599
Echinococcus multilocularis Smad4 0.0026 0.0104 0.0102
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0378 0.0361
Schistosoma mansoni hypothetical protein 0.0082 0.0813 0.0798
Toxoplasma gondii hypothetical protein 0.0038 0.0258 0.215
Onchocerca volvulus 0.0052 0.0442 0.0482
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0104 0.0088
Brugia malayi hypothetical protein 0.0025 0.0092 0.0196
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0038 0.0258 0.0111
Loa Loa (eye worm) hypothetical protein 0.0082 0.0813 0.1722
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0092 0.0587
Loa Loa (eye worm) TAR-binding protein 0.007 0.0672 0.1422
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.3044 0.6465
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1096 0.2299
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0226 0.4137
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0813 0.1727
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.128 0.9845
Echinococcus multilocularis tumor protein p63 0.0357 0.4295 0.4293
Echinococcus granulosus tar DNA binding protein 0.007 0.0672 0.067
Loa Loa (eye worm) transcriptional regulator 0.0019 0.0017 0.003
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.039 0.4709 1
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.2012 0.4272
Trichomonas vaginalis glucosylceramidase, putative 0.0287 0.3415 0.7242
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0019 0.0017 0.0014
Brugia malayi RNA binding protein 0.007 0.0672 0.1428
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.128 0.9845
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0081 0.0802 0.1674
Brugia malayi MH1 domain containing protein 0.0026 0.0104 0.0222
Schistosoma mansoni hypothetical protein 0.0176 0.2012 0.1998
Echinococcus multilocularis smad 0.0026 0.0104 0.0102
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.128 0.2692
Toxoplasma gondii histone deacetylase SIR2 0.0059 0.0521 0.449
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0378 0.0375
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.128 0.2692
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.128 0.2692
Trichomonas vaginalis glucosylceramidase, putative 0.0199 0.2293 0.4852
Schistosoma mansoni smad1 5 8 and 0.0026 0.0104 0.0088
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0081 0.0802 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0258 0.0515

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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