Detailed information for compound 891588

Basic information

Technical information
  • TDR Targets ID: 891588
  • Name: N-[(4-dimethylaminophenyl)methylideneamino]-2 -(2-methylimidazol-1-yl)acetamide
  • MW: 285.344 | Formula: C15H19N5O
  • H donors: 1 H acceptors: 2 LogP: 1.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1ccnc1C)N/N=C/c1ccc(cc1)N(C)C
  • InChi: 1S/C15H19N5O/c1-12-16-8-9-20(12)11-15(21)18-17-10-13-4-6-14(7-5-13)19(2)3/h4-10H,11H2,1-3H3,(H,18,21)/b17-10+
  • InChiKey: KTLFEUVDZHOXNW-LICLKQGHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-dimethylaminophenyl)methyleneamino]-2-(2-methylimidazol-1-yl)acetamide
  • N-[(4-dimethylaminophenyl)methyleneamino]-2-(2-methyl-1-imidazolyl)acetamide
  • N-[(4-dimethylaminobenzylidene)amino]-2-(2-methylimidazol-1-yl)acetamide
  • N-[(4-dimethylaminophenyl)methylideneamino]-2-(2-methylimidazol-1-yl)ethanamide
  • STOCK4S-97501

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0657 0.2429 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Echinococcus multilocularis transient receptor potential ion channel A 0.08 0.2985 0.2985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0229 0.0224
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0325 0.0325
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0281 0.0969 0.2095
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2603 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0657 0.2429 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Echinococcus granulosus cysteine protease 0.0657 0.2429 0.2429
Echinococcus multilocularis cysteine protease 0.1208 0.4572 0.4572
Schistosoma mansoni cathepsin F (C01 family) 0.1208 0.4572 0.4569
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2603 1 1
Echinococcus multilocularis cathepsin b 0.2603 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.2429 0.53
Brugia malayi Cathepsin L-like precursor 0.0375 0.1335 0.1335
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Echinococcus multilocularis cathepsin L 0.0281 0.0969 0.0969
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.0832 0.3111 0.3111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0657 0.2429 0.53
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Trypanosoma cruzi cruzipain precursor, putative 0.0375 0.1335 0.1323
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1208 0.4572 0.4572
Entamoeba histolytica cysteine protease, putative 0.1208 0.4572 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0281 0.0969 0.0969
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0005 0.0005
Schistosoma mansoni cathepsin F (C01 family) 0.0832 0.3111 0.3108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Onchocerca volvulus 0.1208 0.4572 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.0969 0.0964
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) hypothetical protein 0.0188 0.0606 0.0606
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Echinococcus multilocularis cysteine protease 0.1208 0.4572 0.4572
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0657 0.2429 0.2426
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0999 0.3762 0.3759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0657 0.2429 0.2419
Toxoplasma gondii cathepsin B 0.0999 0.3762 0.8222
Schistosoma mansoni transient receptor potential channel 4 0.0832 0.3111 0.3108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Toxoplasma gondii cathepsin CPL 0.1208 0.4572 1
Plasmodium vivax vivapain-3 0.0657 0.2429 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0657 0.2429 0.53
Brugia malayi fibroinase precursor 0.0281 0.0969 0.0969
Schistosoma mansoni cathepsin S (C01 family) 0.0281 0.0969 0.0964
Trypanosoma cruzi cysteine peptidase, putative 0.1208 0.4572 0.4565
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.0969 0.2095
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.0969 0.0969
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0229 0.0224
Loa Loa (eye worm) hypothetical protein 0.0049 0.0066 0.0066
Echinococcus granulosus cathepsin b 0.2603 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Schistosoma mansoni inositol monophosphatase 0.0036 0.0013 0.0008
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Entamoeba histolytica cysteine proteinase, putative 0.0657 0.2429 0.53
Trypanosoma cruzi cysteine peptidase, putative 0.0657 0.2429 0.2419
Entamoeba histolytica cysteine proteinase, putative 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.1335 0.1335
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1208 0.4572 1
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) cysteine protease 0.1208 0.4572 0.4572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.0969 0.0964
Trypanosoma cruzi cruzipain precursor, putative 0.1208 0.4572 0.4565
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0281 0.0969 0.2095
Plasmodium falciparum cysteine proteinase falcipain 3 0.1208 0.4572 1
Plasmodium vivax vivapain-2 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.0969 0.0964
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0229 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.0611 0.2252 0.2252
Schistosoma mansoni transient receptor potential channel 0.1277 0.4841 0.4838
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0066 0.0066
Brugia malayi cathepsin F-like cysteine proteinase 0.0375 0.1335 0.1335
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0281 0.0969 0.2095
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Plasmodium vivax vivapain-2 0.1208 0.4572 1
Schistosoma mansoni cathepsin B (C01 family) 0.0281 0.0969 0.0964
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1208 0.4572 0.4572
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0221 0.0733 0.0733
Brugia malayi cathepsin Z-like cysteine proteinase 0.0281 0.0969 0.0969
Trypanosoma cruzi cysteine proteinase, putative 0.0657 0.2429 0.2419
Echinococcus granulosus short transient receptor potential channel 6 0.0644 0.2378 0.2378
Echinococcus granulosus cathepsin L cysteine proteinase 0.1208 0.4572 0.4572
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0281 0.0969 0.0964
Loa Loa (eye worm) inositol-1 0.0036 0.0013 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0066 0.0066
Plasmodium vivax vivapain-1 0.0657 0.2429 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.0969 0.0964
Onchocerca volvulus 0.1208 0.4572 1
Trypanosoma cruzi cysteine protease, putative 0.0657 0.2429 0.2419
Onchocerca volvulus 0.1208 0.4572 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) hypothetical protein 0.0832 0.3111 0.3111
Schistosoma mansoni inositol monophosphatase 0.0036 0.0013 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0229 0.0224
Brugia malayi Cathepsin L-like precursor 0.0832 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0657 0.2429 0.2426
Brugia malayi Papain family cysteine protease containing protein 0.0657 0.2429 0.2429
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Echinococcus granulosus cathepsin L 0.0657 0.2429 0.2429
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0803 0.2998 0.2998
Loa Loa (eye worm) cathepsin B 0.0999 0.3762 0.3762
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Echinococcus granulosus cathepsin l1 0.0832 0.3111 0.3111
Echinococcus granulosus cathepsin L cysteine protease 0.0657 0.2429 0.2429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) hypothetical protein 0.0375 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.1208 0.4572 0.4572
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2603 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1208 0.4572 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Schistosoma mansoni cathepsin F (C01 family) 0.1208 0.4572 0.4569
Echinococcus granulosus cathepsin b 0.2603 1 1
Brugia malayi POT family protein 0.004 0.0028 0.0028
Echinococcus multilocularis cathepsin L 0.0657 0.2429 0.2429
Plasmodium vivax unspecified product 0.0657 0.2429 0.4054
Trypanosoma cruzi cysteine peptidase, putative 0.1208 0.4572 0.4565
Loa Loa (eye worm) ctsf protein 0.1208 0.4572 0.4572
Echinococcus granulosus cathepsin l1 0.1208 0.4572 0.4572
Giardia lamblia Cathepsin B precursor 0.0999 0.3762 1
Leishmania major cysteine peptidase A (CPA) 0.1208 0.4572 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0281 0.0969 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Brugia malayi Transient-receptor-potential like protein 0.0221 0.0733 0.0733
Echinococcus multilocularis short transient receptor potential channel 6 0.0644 0.2378 0.2378
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Toxoplasma gondii cathepsin CPC1 0.0281 0.0969 0.2095
Entamoeba histolytica hypothetical protein 0.0281 0.0969 0.2095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1208 0.4572 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0375 0.1335 0.1335
Trichomonas vaginalis conserved hypothetical protein 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0832 0.3111 0.6795
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0832 0.3111 0.6795
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0281 0.0969 0.2095
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0999 0.3762 0.3754
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Echinococcus granulosus TRP transient receptor potential channel 0.0221 0.0733 0.0733
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1208 0.4572 1
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0281 0.0969 0.2095
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Onchocerca volvulus Cathepsin F homolog 0.1208 0.4572 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0229 0.0229
Brugia malayi Papain family cysteine protease containing protein 0.1208 0.4572 0.4572
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Brugia malayi Papain family cysteine protease containing protein 0.0281 0.0969 0.0969
Trypanosoma cruzi cysteine peptidase, putative 0.1208 0.4572 0.4565
Plasmodium vivax unspecified product 0.0375 0.1335 0.1016
Plasmodium falciparum cysteine proteinase falcipain 1 0.0657 0.2429 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0657 0.2429 0.53
Brugia malayi Cathepsin L-like precursor 0.0832 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Entamoeba histolytica cysteine proteinase, putative 0.0657 0.2429 0.53
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0281 0.0969 0.0969
Brugia malayi MH2 domain containing protein 0.0116 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0034 0.0005 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0229 0.0229
Echinococcus granulosus transient receptor potential ion channel A 0.08 0.2985 0.2985
Schistosoma mansoni transient receptor potential channel 0.0644 0.2378 0.2375
Trypanosoma cruzi cysteine peptidase, putative 0.0375 0.1335 0.1323
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0281 0.0969 0.2095
Loa Loa (eye worm) hypothetical protein 0.0281 0.0969 0.0969
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0229 0.0229
Trypanosoma cruzi major cysteine proteinase, putative 0.0281 0.0969 0.0957
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0066 0.0066
Echinococcus multilocularis cathepsin L cysteine protease 0.1208 0.4572 0.4572
Loa Loa (eye worm) hypothetical protein 0.0375 0.1335 0.1335
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0013 0.5
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1208 0.4572 0.4572
Trypanosoma cruzi cysteine peptidase, putative 0.1208 0.4572 0.4565
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0281 0.0969 0.0964
Brugia malayi Inositol-1 0.0036 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2603 1 1
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0375 0.1335 0.1335
Brugia malayi cathepsin L-like precursor 0.0832 0.3111 0.3111
Echinococcus granulosus short transient receptor potential channel 6 0.1277 0.4841 0.4841
Toxoplasma gondii cathepsin CPC2 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Giardia lamblia Cathepsin B precursor 0.0999 0.3762 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1208 0.4572 1
Echinococcus multilocularis cathepsin L cysteine protease 0.1208 0.4572 0.4572
Loa Loa (eye worm) hypothetical protein 0.0832 0.3111 0.3111
Onchocerca volvulus Cathepsin L homolog 0.1208 0.4572 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0229 0.0229
Trypanosoma brucei cysteine peptidase C (CPC) 0.0999 0.3762 0.8222
Entamoeba histolytica cysteine protease, putative 0.0281 0.0969 0.2095
Trypanosoma cruzi cysteine proteinase, putative 0.0657 0.2429 0.2419
Onchocerca volvulus Cathepsin L homolog 0.1208 0.4572 1
Echinococcus multilocularis cathepsin b 0.2603 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0657 0.2429 0.2426
Entamoeba histolytica cysteine proteinase, putative 0.0832 0.3111 0.6795
Echinococcus multilocularis short transient receptor potential channel 6 0.1277 0.4841 0.4841
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0999 0.3762 0.8222
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Onchocerca volvulus 0.1208 0.4572 1
Echinococcus granulosus cathepsin L 0.0281 0.0969 0.0969
Onchocerca volvulus 0.0832 0.3111 0.5946
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1208 0.4572 0.4572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Giardia lamblia Cathepsin B precursor 0.0999 0.3762 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Brugia malayi Papain family cysteine protease containing protein 0.0657 0.2429 0.2429
Entamoeba histolytica cysteine proteinase 2 0.0657 0.2429 0.53
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2603 1 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0832 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Loa Loa (eye worm) POT family protein 0.004 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0221 0.0733 0.0733
Brugia malayi cathepsin L precursor 0.0281 0.0969 0.0969
Loa Loa (eye worm) fibroinase 0.1208 0.4572 0.4572
Loa Loa (eye worm) hypothetical protein 0.0832 0.3111 0.3111
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Onchocerca volvulus 0.1208 0.4572 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0832 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.0969 0.2095
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0832 0.3111 0.3102
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0999 0.3762 0.8222
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0281 0.0969 0.0964
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0013 0.5
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Onchocerca volvulus 0.1208 0.4572 1
Loa Loa (eye worm) hypothetical protein 0.2603 1 1
Echinococcus granulosus transient receptor potential gamma protein 0.0832 0.3111 0.3111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Schistosoma mansoni cathepsin C 0.0281 0.0969 0.0964
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0229 0.0229
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Schistosoma mansoni cathepsin s 0.0375 0.1335 0.133
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.1208 0.4572 0.4572
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1208 0.4572 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0281 0.0969 0.0957
Entamoeba histolytica cysteine proteinase, putative 0.1208 0.4572 1
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Onchocerca volvulus 0.1208 0.4572 1
Entamoeba histolytica cysteine proteinase, putative 0.0657 0.2429 0.53
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0281 0.0969 0.0964
Leishmania major cathepsin L-like protease 0.1208 0.4572 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1208 0.4572 1
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0013 0.0013
Brugia malayi Cathepsin L-like precursor 0.1208 0.4572 0.4572
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0281 0.0969 0.2095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0281 0.0969 0.2095
Schistosoma mansoni transient receptor potential channel 0.0832 0.3111 0.3108
Brugia malayi cathepsin F-like cysteine proteinase 0.0281 0.0969 0.0969
Entamoeba histolytica cysteine protease, putative 0.0657 0.2429 0.53

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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