TDR Targets

Basic information

Technical information

TDR Targets ID: 894594
Name: N-(3,5-dimethoxyphenyl)-4-nitrobenzenesulfona mide
MW: 338.336 | Formula: C14H14N2O6S
H donors: 1 H acceptors: 4 LogP: 2.22 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1)OC)NS(=O)(=O)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C14H14N2O6S/c1-21-12-7-10(8-13(9-12)22-2)15-23(19,20)14-5-3-11(4-6-14)16(17)18/h3-9,15H,1-2H3
InChiKey: VABRMTSOEUUNLO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(3,5-dimethoxyphenyl)-4-nitro-benzenesulfonamide
STK119858
ZINC00449703
BIM-0011498.P001
CBMicro_011356

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0044	0.0126
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0011	0.0047	0.0071
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0019	0.0279	0.0113
Echinococcus multilocularis	cpg binding protein	0.0028	0.0515	0.0515
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0245	0.1593
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0019	0.0279	0.0113
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0065	0.154	0.1981
Mycobacterium ulcerans	acyl-CoA synthetase	0.0065	0.154	0.2053
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0245	0.4284
Echinococcus multilocularis	jumonji domain containing protein	0.0038	0.0814	0.0814
Onchocerca volvulus	Alhambra homolog	0.0028	0.0515	0.1879
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0019	0.0279	0.2493
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.0019	0.0279	0.009
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0717	0.0717
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0076	0.0907
Echinococcus granulosus	dna polymerase eta	0.0039	0.0836	0.0836
Schistosoma mansoni	hypothetical protein	0.0009	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0279	0.0797
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0047	0.0071
Mycobacterium ulcerans	long-chain-acyl-CoA synthetase	0.0019	0.0279	0.009
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0515	0.4614
Loa Loa (eye worm)	hypothetical protein	0.0065	0.154	0.4404
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.025	0.6646	1
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.0009	0.0003	0.0028
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.0019	0.0279	0.009
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Toxoplasma gondii	propionate-CoA ligase	0.0019	0.0279	0.2493
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0245	0.0245
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0019	0.0279	0.0797
Trypanosoma cruzi	DNA polymerase eta, putative	0.0039	0.0836	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0048	0.1088	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.1016	0.1257
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1059	0.303
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.1016	0.1257
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.001	0.0041	0.0041
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0019	0.0279	0.3333
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.009	0.2247	0.2247
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0015	0.0182	0.0182
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0065	0.154	1
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0245	0.4284
Schistosoma mansoni	DNA polymerase eta	0.0039	0.0836	0.0836
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0065	0.154	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0065	0.154	1
Echinococcus multilocularis	dnaJ subfamily B	0.0371	1	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0019	0.0279	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1088	0.3113
Brugia malayi	jmjC domain containing protein	0.009	0.2247	0.6428
Mycobacterium ulcerans	hypothetical protein	0.0065	0.154	0.2053
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0019	0.0279	0.0797
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Schistosoma mansoni	jumonji domain containing protein	0.0072	0.1735	0.1735
Echinococcus multilocularis	dna polymerase eta	0.0039	0.0836	0.0836
Trypanosoma brucei	unspecified product	0.0012	0.0076	0.0907
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0065	0.154	0.2053
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.009	0.2247	0.2247
Schistosoma mansoni	cpg binding protein	0.0028	0.0515	0.0515
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0019	0.0279	0.3333
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Brugia malayi	jmjC domain containing protein	0.0035	0.0717	0.205
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0055	0.128	0.128
Schistosoma mansoni	hypothetical protein	0.016	0.4178	0.4178
Brugia malayi	AMP-binding enzyme family protein	0.0065	0.154	0.4404
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0009	0.0003	0.0037
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0017	0.022	0.1432
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0279	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3496	1
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0065	0.154	0.2053
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0017	0.022	0.022
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0279	0.0113
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0279	0.0113
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0048	0.1088	0.1371
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Brugia malayi	AF-10 protein	0.0009	0.0003	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Echinococcus multilocularis	dna polymerase kappa	0.0017	0.022	0.022
Schistosoma mansoni	hypothetical protein	0.0028	0.0515	0.0515
Trypanosoma brucei	DNA polymerase IV, putative	0.0017	0.022	0.2638
Leishmania major	DNA polymerase kappa, putative	0.0017	0.022	0.1432
Trypanosoma brucei	unspecified product	0.0017	0.022	0.2638
Toxoplasma gondii	exonuclease III APE	0.0018	0.0245	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0279	0.0797
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0245	0.5
Mycobacterium ulcerans	O-succinylbenzoic acid--CoA ligase	0.0019	0.0279	0.009
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0019	0.0279	0.0113
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.1016	0.1257
Treponema pallidum	hypothetical protein	0.025	0.6646	1
Brugia malayi	F/Y-rich N-terminus family protein	0.0017	0.0223	0.0637
Schistosoma mansoni	hypothetical protein	0.0371	1	1
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.025	0.6646	1
Mycobacterium ulcerans	bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase	0.0019	0.0279	0.009
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Brugia malayi	ImpB/MucB/SamB family protein	0.0017	0.022	0.0631
Echinococcus granulosus	geminin	0.016	0.4178	0.4178
Echinococcus granulosus	cpg binding protein	0.0028	0.0515	0.0515
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.0019	0.0279	0.009
Loa Loa (eye worm)	oxidoreductase	0.0019	0.0279	0.0797
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0019	0.0279	0.0113
Loa Loa (eye worm)	hypothetical protein	0.0136	0.3496	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0076	0.0907
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0028	0.0515	0.0515
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.025	0.6646	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0065	0.154	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0065	0.154	0.2053
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0046	0.1016	0.1257
Toxoplasma gondii	PHD-finger domain-containing protein	0.0028	0.0515	0.4614
Toxoplasma gondii	PHD-finger domain-containing protein	0.0009	0.0003	0.0028
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0245	0.0702
Loa Loa (eye worm)	PHD-finger family protein	0.0028	0.0515	0.1474
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0245	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0065	0.154	0.4404
Leishmania major	long-chain-fatty-acid-CoA ligase, putative	0.0019	0.0279	0.1809
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1088	0.3113
Onchocerca volvulus		0.0065	0.154	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0065	0.154	1
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0065	0.154	0.2053
Giardia lamblia	PHD finger protein 15	0.0028	0.0515	1
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.025	0.6646	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0017	0.022	0.0631
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0019	0.0279	0.0113
Trichomonas vaginalis	antibiotic synthetase, putative	0.0019	0.0279	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0245	0.0245
Echinococcus granulosus	jumonji domain containing protein	0.0038	0.0814	0.0814
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0048	0.1088	0.1351
Leishmania major	acetyl-CoA synthetase, putative	0.0019	0.0279	0.1809
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0017	0.022	0.022
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0245	0.0062
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0245	0.0369
Echinococcus granulosus	dna polymerase kappa	0.0017	0.022	0.022
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0019	0.0279	0.009
Brugia malayi	AMP-binding enzyme family protein	0.0065	0.154	0.4404
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0028	0.0514	0.4603
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Mycobacterium ulcerans	acyl-CoA synthetase	0.0065	0.154	0.2053
Echinococcus multilocularis	muscleblind protein	0.0136	0.3496	0.3496
Brugia malayi	PHD-finger family protein	0.0028	0.0515	0.1474
Schistosoma mansoni	cpg binding protein	0.0028	0.0515	0.0515
Schistosoma mansoni	hypothetical protein	0.016	0.4178	0.4178
Echinococcus multilocularis	peregrin	0.0028	0.0515	0.0515
Echinococcus multilocularis	lysine specific demethylase 5A	0.0033	0.0676	0.0676
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Schistosoma mansoni	ap endonuclease	0.0018	0.0245	0.0245
Plasmodium vivax	acyl-CoA synthetase, putative	0.0048	0.1088	0.1638
Plasmodium vivax	hypothetical protein, conserved	0.0028	0.0515	0.0776
Entamoeba histolytica	long-chain-fatty-acid--CoA ligase, putative	0.0019	0.0279	0.044
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0245	0.0189
Echinococcus multilocularis	muscleblind protein 1	0.0136	0.3496	0.3496
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.0019	0.0279	0.009
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0017	0.022	0.0023
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.0009	0.0003	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0515	0.1474
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0065	0.154	0.2071
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0245	0.2936
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0017	0.022	0.0023
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0245	0.0702
Trichomonas vaginalis	antibiotic synthetase, putative	0.0019	0.0279	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0474	0.1355
Mycobacterium ulcerans	acetyl-CoA synthetase	0.0019	0.0279	0.009
Echinococcus multilocularis	geminin	0.016	0.4178	0.4178
Leishmania major	4-coumarate:coa ligase-like protein	0.0065	0.154	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0019	0.0279	0.0113
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0019	0.0279	0.3333
Brugia malayi	AMP-binding enzyme family protein	0.0065	0.154	0.4404
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0035	0.0717	0.0717
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0019	0.0279	0.0419
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0028	0.0515	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1088	0.3113
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0065	0.154	0.2071
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Brugia malayi	ImpB/MucB/SamB family protein	0.0039	0.0836	0.239
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0019	0.0279	0.3333
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0019	0.0279	0.3333
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0019	0.0279	0.0279
Brugia malayi	Bromodomain containing protein	0.0028	0.0515	0.1474
Loa Loa (eye worm)	jmjC domain-containing protein	0.0035	0.0717	0.205
Trypanosoma cruzi	DNA polymerase eta, putative	0.0028	0.0514	0.6153
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.025	0.6646	1
Echinococcus granulosus	PHD finger protein rhinoceros	0.0028	0.0515	0.0515
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0017	0.022	0.022
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.001	0.0041	0.0041
Plasmodium falciparum	phd finger protein, putative	0.0028	0.0515	0.0776
Brugia malayi	Muscleblind-like protein	0.0136	0.3496	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0012	0.0076	0.0907
Schistosoma mansoni	acetyl-CoA synthetase	0.0019	0.0279	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1088	0.3113
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0245	0.0369
Brugia malayi	PHD-finger family protein	0.0011	0.0044	0.0126
Schistosoma mansoni	cpg binding protein	0.0026	0.0474	0.0474
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0019	0.0279	0.2493
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Echinococcus granulosus	peregrin	0.0028	0.0515	0.0515
Trypanosoma brucei	unspecified product	0.0012	0.0076	0.0907
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0019	0.0279	0.3333
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0065	0.154	0.1981
Trypanosoma brucei	DNA polymerase IV, putative	0.0017	0.022	0.2638
Trypanosoma brucei	DNA polymerase kappa, putative	0.0017	0.022	0.2638
Loa Loa (eye worm)	jmjC domain-containing protein	0.0057	0.1326	0.3793
Plasmodium falciparum	acyl-CoA synthetase	0.0048	0.1088	0.1638
Trypanosoma brucei	DNA polymerase eta, putative	0.0039	0.0836	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1088	0.3113
Brugia malayi	AMP-binding enzyme family protein	0.0019	0.0279	0.0797
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0836	0.239
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0245	0.0844
Echinococcus granulosus	muscleblind protein	0.0136	0.3496	0.3496
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0019	0.0279	0.0279
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0049	0.1117	1
Loa Loa (eye worm)	hypothetical protein	0.0065	0.154	0.4404
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0245	0.0245
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0017	0.022	0.022
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0474	0.1355
Trypanosoma brucei	DNA polymerase IV, putative	0.0017	0.022	0.2638
Leishmania major	DNA polymerase eta, putative	0.0028	0.0514	0.334
Mycobacterium ulcerans	acyl-CoA synthetase	0.0065	0.154	0.2053
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0019	0.0279	0.0113
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0245	0.2936
Mycobacterium ulcerans	acyl-CoA synthetase	0.0019	0.0279	0.009
Leishmania major	acetyl-CoA synthetase, putative	0.0019	0.0279	0.1809
Leishmania major	DNA polymerase eta, putative	0.0039	0.0836	0.5427
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0245	0.2936
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0019	0.0279	0.0419
Onchocerca volvulus		0.0026	0.0474	0.1547
Echinococcus granulosus	lysine specific demethylase 5A	0.0035	0.0717	0.0717
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0017	0.022	0.2638

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 894594