Detailed information for compound 898137

Basic information

Technical information
  • TDR Targets ID: 898137
  • Name: ethyl 2-[(2-chlorobenzoyl)amino]-5-ethylthiop hene-3-carboxylate
  • MW: 337.821 | Formula: C16H16ClNO3S
  • H donors: 1 H acceptors: 2 LogP: 5 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cc(sc1NC(=O)c1ccccc1Cl)CC
  • InChi: 1S/C16H16ClNO3S/c1-3-10-9-12(16(20)21-4-2)15(22-10)18-14(19)11-7-5-6-8-13(11)17/h5-9H,3-4H2,1-2H3,(H,18,19)
  • InChiKey: OSHDXVJPNQJVBO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 2-[(2-chlorobenzoyl)amino]-5-ethyl-thiophene-3-carboxylate
  • 2-[[(2-chlorophenyl)-oxomethyl]amino]-5-ethyl-3-thiophenecarboxylic acid ethyl ester
  • 2-[(2-chlorobenzoyl)amino]-5-ethyl-thiophene-3-carboxylic acid ethyl ester
  • ethyl 2-[(2-chlorophenyl)carbonylamino]-5-ethyl-thiophene-3-carboxylate
  • STOCK1S-71389
  • AE-848/11419388
  • ZINC00266461
  • Oprea1_773671

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Onchocerca volvulus 0.0063 0.1411 0.3901
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.009 0.2105 0.7637
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0016 0.0233 0.0277
Schistosoma mansoni tar DNA-binding protein 0.0055 0.1219 0.1309
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0041 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0041 0.0044
Echinococcus multilocularis FTZ F1 alpha 0.0009 0.0041 0.0048
Schistosoma mansoni gabp alpha 0.0123 0.2944 0.3162
Echinococcus granulosus beta LACTamase domain containing family member 0.0063 0.1411 0.1675
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.1411 0.1515
Schistosoma mansoni 6-phosphofructokinase 0.009 0.2105 0.226
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.009 0.2105 1
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0426 0.0458
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Trypanosoma brucei unspecified product 0.0017 0.0237 0.0841
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.1411 0.4672
Loa Loa (eye worm) hypothetical protein 0.0015 0.0189 0.0203
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0123 0.2944 0.3162
Schistosoma mansoni 6-phosphofructokinase 0.009 0.2105 0.226
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0018 0.0271 0.0291
Echinococcus multilocularis beta LACTamase domain containing family member 0.0063 0.1411 0.1675
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0149 0.3616 0.3884
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0009 0.0041 0.0044
Schistosoma mansoni dep domain containing protein 0.0007 0.0004 0.0004
Brugia malayi DNA-binding protein D-ETS-3 0.0018 0.0271 0.0291
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0007 0.0004 0.0005
Schistosoma mansoni ap endonuclease 0.0016 0.0233 0.0251
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0007 0.0004 0.0004
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0018 0.0271 0.0291
Echinococcus multilocularis GA binding protein alpha chain 0.0123 0.2944 0.3494
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0704 0.254
Echinococcus granulosus dna polymerase eta 0.0024 0.0426 0.0506
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0009 0.0041 0.0048
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0048 0.1047 0.3789
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0017 0.0253 0.0079
Loa Loa (eye worm) ets-domain-containing protein 0.0018 0.0271 0.0291
Brugia malayi eukaryotic initiation factor 4A 0.0017 0.0253 0.0272
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0017 0.0253 0.354
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.008 0.1839 0.2183
Brugia malayi CXXC zinc finger family protein 0.0024 0.0421 0.0453
Toxoplasma gondii 6-phosphofructokinase 0.0024 0.0435 0.1568
Echinococcus granulosus Pleckstrin G protein interacting region 0.0007 0.0004 0.0005
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.008 0.1839 0.1976
Brugia malayi Fli-1 protein 0.0373 0.931 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0041 0.0044
Entamoeba histolytica phosphofructokinase, putative 0.009 0.2105 0.7424
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0009 0.0041 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0068 0.1545 0.7336
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0009 0.0041 0.0044
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0024 0.0435 0.08
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0009 0.0041 0.0048
Echinococcus granulosus ecdysone induced protein 78C 0.0009 0.0041 0.0048
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.008 0.1839 0.2183
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Mycobacterium tuberculosis Conserved protein 0.0063 0.1411 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Loa Loa (eye worm) X11 protein 0.0057 0.1263 0.1356
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.008 0.1839 0.2183
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0426 0.0335
Onchocerca volvulus Bile acid receptor homolog 0.0009 0.0041 0.0113
Brugia malayi 6-phosphofructokinase 0.009 0.2105 0.226
Echinococcus granulosus FTZ F1 alpha 0.0009 0.0041 0.0048
Schistosoma mansoni hypothetical protein 0.0147 0.3568 0.3832
Schistosoma mansoni regulator of G protein signaling 0.0007 0.0004 0.0004
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0115 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0115 0.2754 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0017 0.0253 0.0272
Entamoeba histolytica phosphofructokinase, putative 0.009 0.2105 0.7424
Leishmania major eukaryotic initiation factor 4a, putative 0.0017 0.0253 0.0899
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0016 0.0233 0.0827
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0041 0.0044
Toxoplasma gondii phosphofructokinase PFKII 0.0024 0.0435 0.1568
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0435 0.1561
Loa Loa (eye worm) fli-1 protein 0.0373 0.931 1
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0115 0.2754 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0009 0.0041 0.0044
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0041 0.0048
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0017 0.0253 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0009 0.0041 0.0044
Echinococcus multilocularis 6 phosphofructokinase 0.009 0.2105 0.2498
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.024 0.0285
Trypanosoma brucei unspecified product 0.0017 0.0237 0.0841
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0061 0.0072
Loa Loa (eye worm) hypothetical protein 0.0024 0.0426 0.0458
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08
Schistosoma mansoni steroid hormone receptor ad4bp 0.0009 0.0041 0.0044
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0017 0.0253 0.0906
Mycobacterium ulcerans DNA polymerase IV 0.0068 0.1545 0.7336
Echinococcus multilocularis dna polymerase eta 0.0024 0.0426 0.0506
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0007 0.0007
Loa Loa (eye worm) voltage-dependent calcium channel 0.0017 0.024 0.0258
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0017 0.0253 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0024 0.0435 0.1568
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0009 0.0041 0.0048
Loa Loa (eye worm) 6-phosphofructokinase 0.009 0.2105 0.226
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0149 0.3616 1
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0061 0.0065
Trichomonas vaginalis esterase, putative 0.0063 0.1411 0.4672
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0115 0.2754 0.2958
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0016 0.0233 0.0827
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0024 0.0426 0.0458
Schistosoma mansoni coup transcription factor 0.0009 0.0041 0.0044
Mycobacterium ulcerans esterase/lipase LipP 0.0063 0.1411 0.6694
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0017 0.0253 0.0079
Toxoplasma gondii ABC1 family protein 0.0063 0.1411 0.5116
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0024 0.0426 0.0506
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0061 0.0065
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0024 0.0426 0.0506
Echinococcus multilocularis protein C ets 2 0.0018 0.0271 0.0321
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0017 0.0253 0.0899
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0063 0.1411 0.6694
Echinococcus multilocularis ETS transcription factor Elf 2 0.0018 0.0271 0.0321
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0115 0.2754 0.2958
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0063 0.1411 0.1515
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0291
Plasmodium vivax hypothetical protein, conserved 0.0063 0.1411 0.5112
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0017 0.0253 0.03
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0065
Entamoeba histolytica deoxycytidyl transferase, putative 0.0024 0.0426 0.0766
Schistosoma mansoni cpg binding protein 0.0024 0.0421 0.0453
Echinococcus granulosus ETS transcription factor Elf 1 0.0018 0.0271 0.0321
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.1411 0.4672
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0009 0.0041 0.0044
Schistosoma mansoni amyloid beta A4 protein related 0.0057 0.1263 0.1356
Echinococcus multilocularis ets variant gene 4 0.0018 0.0271 0.0321
Brugia malayi Steroid receptor seven-up type 2 0.0009 0.0041 0.0044
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.0004 0.0005
Mycobacterium ulcerans lipase LipD 0.0063 0.1411 0.6694
Schistosoma mansoni z-protein (S1r protein) 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0024 0.0435 0.6147
Echinococcus granulosus cpg binding protein 0.0025 0.0456 0.0541
Schistosoma mansoni voltage-gated cation channel 0.008 0.1839 0.1976
Schistosoma mansoni ets-related 0.0373 0.931 1
Brugia malayi TAR-binding protein 0.0055 0.1219 0.1309
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0435 0.5
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.009 0.2105 1
Brugia malayi regulator of G-protein signaling egl-10 0.0007 0.0004 0.0004
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08
Brugia malayi RasGEF domain containing protein 0.0007 0.0007 0.0007
Echinococcus granulosus 6 phosphofructokinase 0.009 0.2105 0.2498
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0009 0.0041 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0009 0.0041 0.0044
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0017 0.0253 0.0272
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0515 0.1852
Echinococcus multilocularis ETS transcription factor Elf 2 0.0018 0.0271 0.0321
Toxoplasma gondii exonuclease III APE 0.0016 0.0233 0.0834
Trypanosoma brucei DNA polymerase eta, putative 0.0024 0.0426 0.1529
Mycobacterium ulcerans 6-phosphofructokinase 0.009 0.2105 1
Schistosoma mansoni cpg binding protein 0.0025 0.0456 0.049
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Echinococcus multilocularis sodium channel protein 0.0034 0.0675 0.0801
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0009 0.0041 0.0048
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0007 0.0004 0.0004
Brugia malayi nuclear receptor NHR-88 0.0009 0.0041 0.0044
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0041 0.0044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0009 0.0041 0.0044
Mycobacterium ulcerans hypothetical protein 0.0063 0.1411 0.6694
Loa Loa (eye worm) 6-phosphofructokinase 0.009 0.2105 0.226
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0115 0.2754 1
Onchocerca volvulus 0.0063 0.1411 0.3901
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0068 0.1545 0.5206
Brugia malayi Ets-domain containing protein 0.0123 0.2944 0.3162
Brugia malayi N-terminal motif family protein 0.0149 0.3616 0.3884
Echinococcus granulosus dna polymerase kappa 0.0068 0.1545 0.1834
Giardia lamblia DINP protein human, muc B family 0.0035 0.0704 1
Echinococcus multilocularis dna polymerase kappa 0.0068 0.1545 0.1834
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0024 0.0435 0.1078
Loa Loa (eye worm) hypothetical protein 0.0051 0.1125 0.1209
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0009 0.0041 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Loa Loa (eye worm) calcium channel 0.008 0.1839 0.1976
Echinococcus multilocularis ETS transcription factor Elf 5 0.0018 0.0271 0.0321
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.008 0.1839 0.2183
Brugia malayi 6-phosphofructokinase 0.009 0.2105 0.226
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.1411 0.4672
Schistosoma mansoni DNA polymerase eta 0.0024 0.0426 0.0458
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0018 0.0271 0.0321
Schistosoma mansoni cpg binding protein 0.0025 0.0456 0.049
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0009 0.0041 0.0044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.005 0.1099 0.118
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.008 0.1839 0.2183
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0115 0.2754 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0055 0.1219 0.1309
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0016 0.0233 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Schistosoma mansoni elf1 0.0018 0.0271 0.0291
Leishmania major DNA polymerase eta, putative 0.0024 0.0426 0.1529
Onchocerca volvulus 0.0009 0.0041 0.0113
Echinococcus multilocularis ewsr:fli fusion protein type 0.0018 0.0271 0.0321
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0035 0.0704 0.0615
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0009 0.0041 0.0044
Echinococcus granulosus protein C ets 2 0.0018 0.0271 0.0321
Schistosoma mansoni tar DNA-binding protein 0.0055 0.1219 0.1309
Loa Loa (eye worm) D-ets-2 protein 0.0018 0.0271 0.0291
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0004
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0035 0.0704 0.254
Trypanosoma brucei hypothetical protein, conserved 0.0063 0.1411 0.5112
Brugia malayi DIX domain containing protein 0.001 0.0061 0.0065
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0004 0.0004
Brugia malayi beta-lactamase 0.0063 0.1411 0.1515
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0061 0.0072
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0017 0.0253 0.07
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0063 0.1411 0.1329
Brugia malayi hypothetical protein 0.0007 0.0004 0.0004
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1125 0.4073
Echinococcus multilocularis thyroid hormone receptor alpha 0.0009 0.0041 0.0048
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0018 0.0271 0.0291
Echinococcus multilocularis cpg binding protein 0.0025 0.0456 0.0541
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0009 0.0041 0.0044
Brugia malayi RNA recognition motif domain containing protein 0.0055 0.1219 0.1309
Onchocerca volvulus 0.0024 0.0421 0.1165
Schistosoma mansoni ets-related 0.0018 0.0271 0.0291
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0017 0.0253 0.016
Mycobacterium tuberculosis Conserved protein 0.0063 0.1411 0.1329
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0515 0.1852
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0016 0.0233 0.0251
Schistosoma mansoni tar DNA-binding protein 0.0055 0.1219 0.1309
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0515 0.1852
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0016 0.0233 0.0277
Loa Loa (eye worm) hypothetical protein 0.0018 0.0271 0.0291
Loa Loa (eye worm) steroid hormone receptor 0.0009 0.0041 0.0044
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0284 0.1017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0016 0.0233 0.3256
Echinococcus granulosus ETS domain containing protein Elk 1 0.0018 0.0271 0.0321
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0233 0.0827
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Loa Loa (eye worm) phosphofructokinase 0.009 0.2105 0.226
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0016 0.0233 0.0827
Onchocerca volvulus 0.0007 0.0004 0.0011
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0061 0.0072
Brugia malayi nuclear hormone receptor 0.0009 0.0041 0.0044
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0435 0.1561
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0063 0.1411 0.1515
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.2105 0.7424
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0016 0.0233 0.5
Schistosoma mansoni hypothetical protein 0.0018 0.0271 0.0291
Schistosoma mansoni dishevelled 0.001 0.0061 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0063 0.1411 0.4672
Toxoplasma gondii histone lysine methyltransferase SET1 0.0045 0.0962 0.3484
Trypanosoma brucei unspecified product 0.0057 0.1268 0.4592
Trypanosoma brucei DNA polymerase IV, putative 0.0068 0.1545 0.5602
Schistosoma mansoni ets 0.0018 0.0271 0.0291
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0017 0.0253 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.1411 0.5112
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0147 0.3568 0.3832
Entamoeba histolytica phosphofructokinase, putative 0.009 0.2105 0.7424
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0009 0.0041 0.0048
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0115 0.2754 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0017 0.0253 0.03
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.008 0.1839 0.1976
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.008 0.1839 0.2183
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0009 0.0041 0.0048
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08
Mycobacterium tuberculosis Probable lipase LipE 0.0063 0.1411 0.1329
Schistosoma mansoni ap endonuclease 0.0016 0.0233 0.0251
Mycobacterium tuberculosis Conserved protein 0.0063 0.1411 0.1329
Echinococcus multilocularis voltage dependent calcium channel 0.008 0.1839 0.2183
Loa Loa (eye worm) hypothetical protein 0.0105 0.249 0.2675
Brugia malayi beta-lactamase family protein 0.0063 0.1411 0.1515
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0115 0.2754 0.2958
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Echinococcus granulosus tar DNA binding protein 0.0055 0.1219 0.1447
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0009 0.0041 0.0048
Brugia malayi hypothetical protein 0.0007 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0063 0.1411 0.5112
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0024 0.0435 0.1561
Trypanosoma brucei DNA polymerase IV, putative 0.0068 0.1545 0.5602
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0061 0.0072
Echinococcus multilocularis regulator of G protein signaling 7 0.0007 0.0004 0.0005
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0115 0.2754 0.2958
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0009 0.0041 0.0044
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0051 0.111 0.1192
Brugia malayi polk-prov protein 0.0051 0.1125 0.1209
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0017 0.0253 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0055 0.1219 0.1309
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0009 0.0041 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0009 0.0041 0.0044
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0061 0.0167
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Brugia malayi ecdysteroid receptor 0.0009 0.0041 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0051 0.1125 0.4073
Brugia malayi photoreceptor-specific nuclear receptor 0.0009 0.0041 0.0044
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.008 0.1839 0.1976
Mycobacterium tuberculosis Probable lipase LipD 0.0063 0.1411 0.1329
Brugia malayi beta-lactamase family protein 0.0063 0.1411 0.1515
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.2105 0.7424
Echinococcus multilocularis ETS transcription factor Elf 1 0.0018 0.0271 0.0321
Trypanosoma cruzi DNA polymerase eta, putative 0.0024 0.0426 0.1529
Brugia malayi F/Y-rich N-terminus family protein 0.0007 0.0002 0.0002
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0009 0.0041 0.0113
Echinococcus multilocularis geminin 0.0147 0.3568 0.4234
Brugia malayi exodeoxyribonuclease III family protein 0.0016 0.0233 0.0251
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0063 0.1411 0.1515
Brugia malayi hypothetical protein 0.0055 0.1206 0.1295
Schistosoma mansoni tar DNA-binding protein 0.0055 0.1219 0.1309
Brugia malayi transcription factor E74 isoform 0.0018 0.0271 0.0291
Schistosoma mansoni DNA polymerase IV / kappa 0.0007 0.0006 0.0007
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0115 0.2754 0.3268
Brugia malayi steroid hormone receptor 0.0009 0.0041 0.0044
Leishmania major DNA polymerase kappa, putative 0.0035 0.0704 0.254
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0009 0.0041 0.0044
Echinococcus granulosus ewsr:fli fusion protein type 0.0018 0.0271 0.0321
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0063 0.1411 0.1329
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0006 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0253 0.0272
Schistosoma mansoni hypothetical protein 0.0338 0.8425 0.9049
Echinococcus multilocularis ecdysone induced protein 78C 0.0009 0.0041 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Plasmodium vivax 6-phosphofructokinase, putative 0.0024 0.0435 0.1561
Loa Loa (eye worm) hypothetical protein 0.0015 0.0189 0.0203
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0009 0.0041 0.0048
Schistosoma mansoni retinoic acid receptor RXR 0.0009 0.0041 0.0044
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0009 0.0041 0.0044
Echinococcus granulosus ETS transcription factor Elf 2 0.0018 0.0271 0.0321
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0034 0.0675 0.0801
Loa Loa (eye worm) TAR-binding protein 0.0055 0.1219 0.1309
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0016 0.0233 0.0827
Toxoplasma gondii hypothetical protein 0.0015 0.0189 0.0674
Brugia malayi phosphofructokinase 0.009 0.2105 0.226
Schistosoma mansoni RAR-like nuclear receptor 0.0009 0.0041 0.0044
Mycobacterium tuberculosis Probable hydrolase 0.0063 0.1411 0.1329
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0016 0.0233 0.0827
Brugia malayi Ets-domain containing protein 0.0123 0.2944 0.3162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0009 0.0041 0.0044
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.009 0.2105 0.2029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0009 0.0041 0.0044
Echinococcus granulosus ETS transcription factor Elf 5 0.0018 0.0271 0.0321
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0115 0.2754 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0048 0.1047 0.3789
Trichomonas vaginalis D-aminoacylase, putative 0.0063 0.1411 0.4672
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0024 0.0426 0.0458
Mycobacterium tuberculosis Probable esterase LipL 0.0063 0.1411 0.1329
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.024 0.086
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0063 0.1411 0.1329
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0115 0.2754 0.2958
Echinococcus multilocularis voltage dependent calcium channel 0.008 0.1839 0.2183
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0005
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0115 0.2754 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.1206 0.1295
Plasmodium vivax RNA helicase-1, putative 0.0017 0.0253 0.0899
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0009 0.0041 0.0044
Onchocerca volvulus 0.0063 0.1411 0.3901
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0041 0.0044
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.009 0.2105 0.7637
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0041 0.0048
Loa Loa (eye worm) beta-lactamase 0.0063 0.1411 0.1515
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0009 0.0041 0.0048
Echinococcus granulosus geminin 0.0147 0.3568 0.4234
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0063 0.1411 0.1515
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0007 0.0004 0.0004
Schistosoma mansoni terminal deoxycytidyl transferase 0.0024 0.0426 0.0458
Echinococcus multilocularis dnaJ subfamily B 0.0338 0.8425 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0016 0.0233 0.1083
Echinococcus granulosus dnaJ subfamily B 0.0338 0.8425 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0041 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0024 0.0426 0.0458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0009 0.0041 0.0044
Echinococcus granulosus amyloid beta A4 protein 0.0057 0.1263 0.1499
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0024 0.0435 0.08
Plasmodium falciparum eukaryotic initiation factor 4A 0.0017 0.0253 0.0899
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0017 0.0253 0.0899
Echinococcus granulosus voltage dependent calcium channel 0.008 0.1839 0.2183
Onchocerca volvulus Protein ultraspiracle homolog 0.0009 0.0041 0.0113
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0041 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0024 0.0421 0.0453
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08
Brugia malayi RNA binding protein 0.0055 0.1219 0.1309
Loa Loa (eye worm) hypothetical protein 0.0009 0.0041 0.0044
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0024 0.0435 0.5
Trichomonas vaginalis DNA polymerase eta, putative 0.0068 0.1545 0.5206
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0004
Echinococcus multilocularis amyloid beta A4 protein 0.0057 0.1263 0.1499
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.2105 0.7424
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0009 0.0041 0.0044
Trichomonas vaginalis phosphofructokinase, putative 0.009 0.2105 0.7424
Loa Loa (eye worm) hypothetical protein 0.0017 0.024 0.0258
Loa Loa (eye worm) RNA binding protein 0.0055 0.1219 0.1309
Mycobacterium ulcerans beta-lactamase 0.0063 0.1411 0.6694
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0115 0.2754 1
Brugia malayi Ets-domain containing protein 0.0018 0.0271 0.0291
Schistosoma mansoni dishevelled 0.001 0.0061 0.0065
Leishmania major ATP-dependent phosphofructokinase 0.009 0.2105 0.7637
Echinococcus granulosus regulator of G protein signaling 7 0.0007 0.0004 0.0005
Treponema pallidum ATP-dependent RNA helicase 0.0017 0.0253 0.0106
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0115 0.2754 0.3268
Echinococcus granulosus eukaryotic initiation factor 4A 0.0017 0.0253 0.03
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0115 0.2754 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0017 0.0253 0.0899
Schistosoma mansoni hypothetical protein 0.0018 0.0271 0.0291
Loa Loa (eye worm) hypothetical protein 0.008 0.1839 0.1976
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0007 0.0006 0.0008
Leishmania major hypothetical protein, conserved 0.0063 0.1411 0.5112
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.1268 0.4592
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.008 0.1839 0.2183
Trypanosoma brucei DNA polymerase kappa, putative 0.0068 0.1545 0.5602
Echinococcus multilocularis tar DNA binding protein 0.0055 0.1219 0.1447
Echinococcus granulosus GA binding protein alpha chain 0.0123 0.2944 0.3494
Echinococcus granulosus ETS transcription factor Elf 2 0.0018 0.0271 0.0321
Trichomonas vaginalis phosphofructokinase, putative 0.0024 0.0435 0.08

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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