TDR Targets

Basic information

Technical information

TDR Targets ID: 907143
Name: N-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-4- nitrobenzamide
MW: 393.78 | Formula: C20H12ClN3O4
H donors: 1 H acceptors: 4 LogP: 4.72 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc2c(c1)nc(o2)c1cccc(c1)NC(=O)c1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C20H12ClN3O4/c21-14-6-9-18-17(11-14)23-20(28-18)13-2-1-3-15(10-13)22-19(25)12-4-7-16(8-5-12)24(26)27/h1-11H,(H,22,25)
InChiKey: SHBBPAVZNIKWEA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[3-(5-chloro-1,3-benzoxazol-2-yl)phenyl]-4-nitro-benzamide
Oprea1_822058

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hsp90 protein	0.0075	0.0158	0.0155
Onchocerca volvulus	Fxna peptidase homolog	0.0719	0.1584	0.1574
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0719	0.1584	0.1581
Trypanosoma brucei	Heat shock protein 83, putative	0.0074	0.0156	0.0968
Onchocerca volvulus	Glutaminyl cyclase homolog	0.4516	1	1
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Onchocerca volvulus		0.0719	0.1584	0.1574
Trypanosoma brucei	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0009	0.0012	0.0056
Schistosoma mansoni	endoplasmin	0.0074	0.0156	0.0156
Leishmania major	mitochondrial DNA topoisomerase II	0.0009	0.0012	0.0056
Echinococcus multilocularis	heat shock protein	0.0074	0.0156	0.0153
Schistosoma mansoni	DNA mismatch repair protein PMS2	0.0005	0.0003	0.0003
Brugia malayi	heat shock protein 90	0.0074	0.0156	0.0153
Schistosoma mansoni	pyruvate dehydrogenase	0.0009	0.0012	0.0012
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Echinococcus granulosus	glutaminyl peptide cyclotransferase	0.4516	1	1
Leishmania major	glutaminyl cyclase, putative	0.0719	0.1584	1
Loa Loa (eye worm)	heat shock protein 75	0.0075	0.0158	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Leishmania major	developmentally regulated phosphoprotein-like protein	0.0009	0.0012	0.0056
Toxoplasma gondii	peptidase, M28 family protein	0.0719	0.1584	1
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Trichomonas vaginalis	conserved hypothetical protein	0.0719	0.1584	1
Trichomonas vaginalis	heat shock protein, putative	0.0065	0.0135	0.0835
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0043	0.0088	0.5515
Trichomonas vaginalis	sensory transduction histidine kinase, putative	0.0009	0.0012	0.0056
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.007	0.0147	1
Loa Loa (eye worm)	histone methyltransferase	0.0008	0.001	0.0007
Trypanosoma brucei	DNA topoisomerase II beta, putative	0.0009	0.0012	0.0056
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0006	0.0003
Schistosoma mansoni	glutaminyl cyclase (M28 family)	0.4516	1	1
Echinococcus granulosus	heat shock protein 90	0.0074	0.0156	0.0153
Echinococcus multilocularis	glutaminyl peptide cyclotransferase	0.4516	1	1
Trichomonas vaginalis	Clan MH, family M28, aminopeptidase S-like metallopeptidase	0.0719	0.1584	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0005	0.0011
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.0009	0.0012	0.0056
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0065	0.0135	0.8629
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.007	0.0147	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0009	0.0012	0.0056
Brugia malayi	Probable DNA topoisomerase II	0.0009	0.0012	0.0009
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Schistosoma mansoni	Microrchidia 2a	0.0005	0.0003	0.0003
Plasmodium vivax	hypothetical protein, conserved	0.0009	0.0012	0.0576
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0009	0.0012	0.0009
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Toxoplasma gondii	hypothetical protein	0.0719	0.1584	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0009	0.0012	0.0056
Plasmodium vivax	DNA topoisomerase II, putative	0.0009	0.0012	0.0576
Leishmania major	DNA topoisomerase ii	0.0009	0.0012	0.0056
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0075	0.0158	0.0155
Brugia malayi	nicalin	0.0719	0.1584	0.1581
Trypanosoma brucei	DNA topoisomerase ii	0.0009	0.0012	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0719	0.1584	1
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0719	0.1584	0.1581
Schistosoma mansoni	microrchidia 2a	0.0005	0.0003	0.0003
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0009	0.0012	0.0619
Trypanosoma cruzi	heat shock protein 90, putative	0.0036	0.0072	0.0434
Plasmodium falciparum	heat shock protein 90, putative	0.0043	0.0088	0.5515
Leishmania major	heat shock protein, putative	0.0075	0.0158	0.0979
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Schistosoma mansoni	glutaminyl-peptide cyclotransferase-related	0.0719	0.1584	0.1584
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	TOPoisomerase family member	0.0009	0.0012	0.0009
Schistosoma mansoni	NAALADASE L peptidase (M28 family)	0.0719	0.1584	0.1584
Onchocerca volvulus		0.0027	0.0052	0.004
Schistosoma mansoni	heat shock protein	0.0075	0.0158	0.0158
Schistosoma mansoni	Fxna peptidase (M28 family)	0.0719	0.1584	0.1584
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Echinococcus multilocularis	heat shock protein 90	0.0074	0.0156	0.0153
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Loa Loa (eye worm)	leucyl aminopeptidase	0.0719	0.1584	0.1581
Loa Loa (eye worm)	hypothetical protein	0.4516	1	1
Chlamydia trachomatis	DNA gyrase subunit B	0.0009	0.0012	1
Plasmodium vivax	endoplasmin, putative	0.0074	0.0156	0.988
Leishmania major	hypothetical protein, conserved	0.0009	0.0012	0.0056
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Brugia malayi	FXNA	0.0719	0.1584	0.1581
Trypanosoma brucei	heat shock protein 84, putative	0.0075	0.0158	0.0979
Plasmodium falciparum	DNA gyrase subunit B	0.0009	0.0012	0.0583
Trichomonas vaginalis	heat shock protein, putative	0.0074	0.0156	0.0968
Schistosoma mansoni	nicalin (M28 family)	0.0719	0.1584	0.1584
Plasmodium vivax	heat shock protein 90, putative	0.0075	0.0158	1
Entamoeba histolytica	heat shock protein 90, putative	0.0074	0.0156	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Schistosoma mansoni	heat shock protein	0.0074	0.0156	0.0156
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0006	0.0003
Schistosoma mansoni	endoplasmin	0.0074	0.0156	0.0156
Entamoeba histolytica	heat shock protein 90, putative	0.0074	0.0156	1
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0074	0.0156	1
Echinococcus multilocularis	heat shock protein 90	0.0065	0.0135	0.0132
Schistosoma mansoni	cpg binding protein	0.0029	0.0056	0.0056
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0009	0.0012	0.0619
Chlamydia trachomatis	DNA gyrase subunit B	0.0009	0.0012	1
Echinococcus granulosus	endoplasmic reticulum metallopeptidase 1	0.0719	0.1584	0.1581
Schistosoma mansoni	hypothetical protein	0.0005	0.0003	0.0003
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0052	0.0106	0.0652
Toxoplasma gondii	Hsp90 domain-containing protein	0.0043	0.0088	0.0534
Echinococcus multilocularis	n acetylated alpha linked acidic dipeptidase 2	0.0719	0.1584	0.1581
Trypanosoma cruzi	heat shock protein 90, putative	0.0065	0.0135	0.0835
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Plasmodium falciparum	endoplasmin, putative	0.0048	0.0097	0.6098
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0009	0.0012	0.0009
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0009
Trypanosoma cruzi	heat shock protein 85, putative	0.0065	0.0135	0.0835
Trichomonas vaginalis	helicase, putative	0.0006	0.0005	0.0011
Schistosoma mansoni	DNA mismatch repair protein MLH1	0.0005	0.0003	0.0003
Loa Loa (eye worm)	heat shock protein 90	0.0074	0.0156	0.0153
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Trichomonas vaginalis	receptor histidine kinase, putative	0.0009	0.0012	0.0056
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0009	0.0012	0.0056
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Trypanosoma cruzi	Heat shock protein 83, putative	0.0074	0.0156	0.0968
Trypanosoma cruzi	heat shock protein, putative	0.0075	0.0158	0.0979
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.007	0.0147	0.086
Trichomonas vaginalis	receptor histidine kinase, putative	0.0009	0.0012	0.0056
Onchocerca volvulus	Fxna peptidase homolog	0.0719	0.1584	0.1574
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Treponema pallidum	heat shock protein 90	0.007	0.0147	1
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0009	0.0012	0.0009
Echinococcus multilocularis	cpg binding protein	0.0029	0.0056	0.0052
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Trichomonas vaginalis	heat shock protein, putative	0.0048	0.0097	0.059
Schistosoma mansoni	cpg binding protein	0.0029	0.0056	0.0056
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Leishmania major	hypothetical protein, conserved	0.0719	0.1584	1
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0009	0.0012	0.0009
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0009	0.0012	0.0583
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0009
Onchocerca volvulus	Fxna peptidase homolog	0.0719	0.1584	0.1574
Trypanosoma cruzi	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative	0.0009	0.0012	0.0056
Plasmodium falciparum	heat shock protein 90, putative	0.007	0.0146	0.9334
Plasmodium vivax	DNA gyrase subunit B, putative	0.0009	0.0012	0.0576
Trichomonas vaginalis	heat shock protein, putative	0.0038	0.0076	0.0457
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0719	0.1584	1
Echinococcus multilocularis	endoplasmin	0.007	0.0147	0.0144
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0075	0.0158	0.0146
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0009	0.0012	0.0619
Trypanosoma brucei	DNA topoisomerase II alpha, putative	0.0009	0.0012	0.0056
Toxoplasma gondii	heat shock protein HSP90	0.0074	0.0156	0.0968
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.001	0.0007
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0009	0.0012	0.0056
Toxoplasma gondii	heat shock protein 75, putative	0.0075	0.0158	0.0979
Toxoplasma gondii	heat shock protein 90, putative	0.0074	0.0156	0.0968
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Mycobacterium ulcerans	heat shock protein 90	0.007	0.0147	0.086
Echinococcus granulosus	cpg binding protein	0.0029	0.0056	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Mycobacterium tuberculosis	Conserved protein	0.0719	0.1584	1
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0009	0.0012	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.0005	0.0011
Trichomonas vaginalis	DNA topoisomerase II, putative	0.0009	0.0012	0.0056
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0075	0.0158	0.0155
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0009	0.0012	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.0005	0.0011
Trypanosoma cruzi	glutaminyl cyclase, putative	0.0719	0.1584	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0006	0.0003
Trypanosoma cruzi	heat shock protein 85, putative	0.0074	0.0156	0.0968
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.0005	0.0011
Brugia malayi	Endoplasmin precursor	0.0074	0.0156	0.0153
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.0009	0.0012	0.0056
Brugia malayi	leucyl aminopeptidase	0.0719	0.1584	0.1581
Trichomonas vaginalis	sensory transduction histidine kinase bacterial, putative	0.0009	0.0012	0.0056
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0009	0.0012	0.0009
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	endoplasmin	0.0074	0.0156	0.0153
Trypanosoma brucei	heat shock protein 90, putative	0.0074	0.0156	0.0968
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0052	0.0049
Mycobacterium ulcerans	lipoprotein aminopeptidase LpqL	0.0719	0.1584	1
Brugia malayi	kinase, mitochondrial precursor	0.0009	0.0012	0.0009
Trypanosoma brucei	heat shock protein 90, putative	0.0074	0.0156	0.0968
Trypanosoma brucei	glutaminyl cyclase, putative	0.0719	0.1584	1
Trypanosoma brucei	developmentally regulated phosphoprotein	0.0009	0.0012	0.0056
Plasmodium falciparum	DNA topoisomerase 2	0.0009	0.0012	0.0583
Echinococcus granulosus	heat shock protein	0.0074	0.0156	0.0153
Trypanosoma cruzi	heat shock protein 85, putative	0.0074	0.0156	0.0968
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0006	0.0003
Trichomonas vaginalis	heat shock protein, putative	0.007	0.0147	0.0911
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0052	0.0049
Mycobacterium ulcerans	hypothetical protein	0.0719	0.1584	1
Echinococcus granulosus	heat shock protein 90	0.0065	0.0135	0.0132
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0012	0.0009
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0065	0.0135	0.0132
Trichomonas vaginalis	two component sensor and regulator histidine kinase bacteria, putative	0.0009	0.0012	0.0056
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1584	0.1581
Plasmodium vivax	heat shock protein, putative	0.0043	0.0088	0.5449
Trypanosoma cruzi	DNA topoisomerase II, putative	0.0009	0.0012	0.0056
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0009	0.0012	0.0056
Giardia lamblia	Grp94/Hsp90	0.007	0.0147	0.9417
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1584	0.1581
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.0009	0.0012	0.0009
Giardia lamblia	Pms1-like protein	0.0009	0.0012	0.0583
Trichomonas vaginalis	endoplasmin, putative	0.0048	0.0097	0.059
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1584	0.1581
Toxoplasma gondii	DNA topoisomerase 2, putative	0.0009	0.0012	0.0056
Schistosoma mansoni	hypothetical protein	0.0005	0.0003	0.0003
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Trichomonas vaginalis	heat shock protein, putative	0.007	0.0147	0.0911
Plasmodium vivax	heat shock protein 86, putative	0.0074	0.0156	0.988
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0719	0.1584	0.1581
Plasmodium falciparum	heat shock protein 90	0.0074	0.0156	1
Trichomonas vaginalis	sensor histidine kinase, putative	0.0009	0.0012	0.0056
Leishmania major	heat shock protein 83-1	0.0074	0.0156	0.0968
Schistosoma mansoni	DNA topoisomerase II	0.0009	0.0012	0.0012
Trypanosoma cruzi	heat shock protein 85, putative	0.0074	0.0156	0.0968
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.012	0.012
Echinococcus multilocularis	endoplasmic reticulum metallopeptidase 1	0.0719	0.1584	0.1581
Trypanosoma cruzi	heat shock protein 90, putative	0.0074	0.0156	0.0968
Trichomonas vaginalis	conserved hypothetical protein	0.0719	0.1584	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0006	0.0006
Echinococcus granulosus	endoplasmin	0.007	0.0147	0.0144
Mycobacterium tuberculosis	Probable lipoprotein aminopeptidase LpqL	0.0719	0.1584	1
Schistosoma mansoni	heat shock protein	0.0074	0.0156	0.0156
Trichomonas vaginalis	mismatch repair protein Mlh1C (mutL homolog)	0.0009	0.0012	0.0056
Entamoeba histolytica	DNA topoisomerase II, putative	0.0009	0.0012	0.0583
Brugia malayi	F/Y-rich N-terminus family protein	0.0008	0.001	0.0007
Trypanosoma cruzi	mitochondrial DNA topoisomerase II, putative	0.0009	0.0012	0.0056
Trypanosoma brucei	heat shock protein, putative	0.0074	0.0156	0.0968
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.0009	0.0012	0.0009
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.001	0.0007
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0009	0.0012	0.0619
Schistosoma mansoni	cpg binding protein	0.0027	0.0052	0.0052
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.007	0.0147	0.0911

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 907143