Detailed information for compound 908316

Basic information

Technical information
  • TDR Targets ID: 908316
  • Name: 1-methyl-2,4-dinitroimidazole
  • MW: 172.099 | Formula: C4H4N4O4
  • H donors: 0 H acceptors: 5 LogP: 0.34 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cn(c(n1)[N+](=O)[O-])C
  • InChi: 1S/C4H4N4O4/c1-6-2-3(7(9)10)5-4(6)8(11)12/h2H,1H3
  • InChiKey: GHLBJBRVTJECDP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-methyl-2,4-dinitro-imidazole
  • 5213-50-3
  • 1-METHYL-2,4-DINITRO-1H-IMIDAZOLE
  • NSC342705
  • EU-0004986

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0193 0.0193
Schistosoma mansoni lamin 0.0025 0.0157 0.0157
Onchocerca volvulus 0.0219 0.2718 0.2718
Brugia malayi Doublecortin family protein 0.0018 0.0068 0.0068
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0028 0.0193 0.0193
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0267 0.0267
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0047 0.0453 0.0786
Echinococcus multilocularis neuropeptide s receptor 0.0427 0.5469 0.5469
Mycobacterium leprae Probable lipase LipE 0.0033 0.0267 0.1768
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0245 0.3062 0.3062
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0267 0.0267
Schistosoma mansoni microtubule-associated protein tau 0.0453 0.5813 0.5813
Schistosoma mansoni intermediate filament proteins 0.0025 0.0157 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0028 0.0193 0.0193
Echinococcus multilocularis neuropeptide receptor A26 0.0427 0.5469 0.5469
Leishmania major hexokinase, putative 0.077 1 1
Onchocerca volvulus 0.0018 0.0068 0.0068
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0047 0.0453 0.4744
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0245 0.3062 0.3062
Schistosoma mansoni nuclear hormone receptor 0.0028 0.0193 0.0193
Echinococcus granulosus tar DNA binding protein 0.0058 0.0601 0.0601
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0192 0.0192
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0028 0.0193 0.0193
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 1
Loa Loa (eye worm) hexokinase 0.0483 0.6209 0.6209
Loa Loa (eye worm) hypothetical protein 0.0525 0.6766 0.6766
Echinococcus multilocularis lamin 0.0025 0.0157 0.0157
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0039 0.0348 0.0194
Onchocerca volvulus 0.0025 0.0157 0.0157
Loa Loa (eye worm) doublecortin family protein 0.0018 0.0068 0.0068
Brugia malayi Steroid receptor seven-up type 2 0.0028 0.0193 0.0193
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0039 0.0348 0.0194
Brugia malayi Pre-SET motif family protein 0.0192 0.2367 0.2367
Schistosoma mansoni rab6-interacting 0.0018 0.0068 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0193 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0386 0.0386
Echinococcus multilocularis microtubule associated protein 2 0.0453 0.5813 0.5813
Schistosoma mansoni peptidase Clp (S14 family) 0.0072 0.0782 0.0782
Onchocerca volvulus 0.077 1 1
Schistosoma mansoni thyroid hormone receptor 0.0028 0.0193 0.0193
Brugia malayi RNA binding protein 0.0058 0.0601 0.0601
Brugia malayi Pre-SET motif family protein 0.0028 0.0192 0.0192
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0028 0.0193 0.0193
Loa Loa (eye worm) hexokinase 0.077 1 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0212 0.2634 1
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.0305 0.5
Brugia malayi beta-lactamase family protein 0.0033 0.0267 0.0267
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0192 0.0036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0028 0.0193 0.0193
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0068 0.0068
Schistosoma mansoni retinoic acid receptor RXR 0.0028 0.0193 0.0193
Loa Loa (eye worm) steroid hormone receptor 0.0028 0.0193 0.0193
Plasmodium vivax hexokinase, putative 0.077 1 1
Schistosoma mansoni polycystin 1-related 0.0018 0.0068 0.0068
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0753 0.0753
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0157 0.0157
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 0.0718
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0192 0.0192
Brugia malayi nuclear receptor RXR 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Schistosoma mansoni hexokinase 0.077 1 1
Schistosoma mansoni lamin 0.0025 0.0157 0.0157
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.0068 0.0068
Loa Loa (eye worm) hexokinase type II 0.077 1 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0028 0.0193 0.0193
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0068 0.0068
Onchocerca volvulus 0.0033 0.0267 0.0267
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0157 0.0157
Loa Loa (eye worm) hexokinase 0.0238 0.2975 0.2975
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0028 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0156 0.1895 0.1895
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0072 0.0782 1
Echinococcus granulosus intermediate filament protein 0.0025 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0028 0.0193 0.0193
Trypanosoma brucei hexokinase, putative 0.077 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Echinococcus granulosus FTZ F1 alpha 0.0028 0.0193 0.0193
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.0386 0.0386
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0028 0.0193 0.0193
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0028 0.0193 0.0193
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.0068 0.0068
Trichomonas vaginalis bromodomain-containing protein, putative 0.0039 0.0348 0.033
Loa Loa (eye worm) hypothetical protein 0.0024 0.0151 0.0151
Toxoplasma gondii ABC1 family protein 0.0033 0.0267 0.0112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.0386 0.0386
Echinococcus multilocularis lamin dm0 0.0025 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0068 0.0068
Brugia malayi ecdysteroid receptor 0.0028 0.0193 0.0193
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0193 0.0193
Echinococcus granulosus hexokinase 0.077 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0601 0.0601
Echinococcus granulosus geminin 0.0156 0.1895 0.1895
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.0305 0.0238
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0192 0.0192
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0051 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0028 0.0193 0.0193
Schistosoma mansoni lipoxygenase 0.0051 0.0501 0.0501
Echinococcus multilocularis hexokinase 0.077 1 1
Onchocerca volvulus 0.0483 0.6209 0.6209
Onchocerca volvulus 0.077 1 1
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0601 0.0601
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0193 0.0193
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0072 0.0782 0.0718
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0028 0.0193 0.0193
Echinococcus granulosus neuropeptide s receptor 0.0427 0.5469 0.5469
Onchocerca volvulus 0.0028 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0028 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0018 0.0068 0.0068
Echinococcus multilocularis peptidase Clp (S14 family) 0.0047 0.0453 0.0453
Onchocerca volvulus 0.0033 0.0267 0.0267
Brugia malayi hypothetical protein 0.0015 0.0021 0.0021
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0015 0.0021 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0386
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0025 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0753 0.9431
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0753 0.0753
Brugia malayi Hexokinase family protein 0.0483 0.6209 0.6209
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0753 0.2051
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0532 0.686 0.686
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0028 0.0193 0.0193
Echinococcus multilocularis FTZ F1 alpha 0.0028 0.0193 0.0193
Plasmodium vivax SET domain protein, putative 0.0028 0.0192 0.0124
Loa Loa (eye worm) RNA binding protein 0.0058 0.0601 0.0601
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.0068 0.0068
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0753 0.0753
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0051 0.0501 0.0501
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0386
Brugia malayi intermediate filament protein 0.0025 0.0157 0.0157
Onchocerca volvulus 0.0025 0.0157 0.0157
Trypanosoma cruzi hexokinase, putative 0.077 1 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0047 0.0453 0.0786
Entamoeba histolytica hexokinase 1 0.077 1 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0028 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0028 0.0193 0.0193
Brugia malayi nuclear receptor NHR-88 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0753 0.0605
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0028 0.0193 0.0193
Echinococcus multilocularis hexokinase type 2 0.077 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Schistosoma mansoni steroid hormone receptor ad4bp 0.0028 0.0193 0.0193
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0028 0.0193 0.0193
Brugia malayi Hexokinase family protein 0.0238 0.2975 0.2975
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0782 0.0635
Loa Loa (eye worm) beta-lactamase 0.0033 0.0267 0.0267
Schistosoma mansoni coup transcription factor 0.0028 0.0193 0.0193
Brugia malayi Probable ClpP-like protease 0.0072 0.0782 0.0782
Leishmania major hexokinase, putative 0.077 1 1
Brugia malayi TAR-binding protein 0.0058 0.0601 0.0601
Echinococcus granulosus histone acetyltransferase KAT2B 0.013 0.1546 0.1546
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0753 0.0753
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0028 0.0193 0.0193
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0267 0.0267
Echinococcus granulosus microtubule associated protein 2 0.0453 0.5813 0.5813
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Loa Loa (eye worm) acetyltransferase 0.0134 0.1596 0.1596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.0386 0.0386
Echinococcus multilocularis thyroid hormone receptor alpha 0.0028 0.0193 0.0193
Echinococcus multilocularis musashi 0.0025 0.0157 0.0157
Brugia malayi hypothetical protein 0.0018 0.0068 0.0068
Trichomonas vaginalis set domain proteins, putative 0.0219 0.2718 1
Schistosoma mansoni lipoxygenase 0.0018 0.0068 0.0068
Echinococcus granulosus hexokinase 0.077 1 1
Onchocerca volvulus Bile acid receptor homolog 0.0028 0.0193 0.0193
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0386 0.0386
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0192 0.0192
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0039 0.0348 0.0281
Trypanosoma cruzi hexokinase, putative 0.077 1 1
Onchocerca volvulus 0.0028 0.0193 0.0193
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0157 0.0157
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0601 0.0601
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0025 0.0157 0.0089
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0028 0.0193 0.0193
Onchocerca volvulus Hexokinase homolog 0.0483 0.6209 0.6209
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0134 0.1596 0.1596
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 0.5
Echinococcus multilocularis geminin 0.0156 0.1895 0.1895
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 0.0635
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0193 0.0193
Toxoplasma gondii hexokinase 0.077 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0028 0.0193 0.0193
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0267 0.0267
Mycobacterium leprae conserved hypothetical protein 0.0033 0.0267 0.1768
Echinococcus granulosus RUN 0.0018 0.0068 0.0068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0028 0.0193 0.0193
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0192 0.0192
Schistosoma mansoni loxhd1 0.0018 0.0068 0.0068
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0028 0.0193 0.0193
Schistosoma mansoni RAR-like nuclear receptor 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0028 0.0193 0.0193
Echinococcus granulosus lamin dm0 0.0025 0.0157 0.0157
Brugia malayi steroid hormone receptor 0.0028 0.0193 0.0193
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0039 0.0348 0.033
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0025 0.0157 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0192 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0193 0.0193
Loa Loa (eye worm) hexokinase 0.077 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 0.5
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0015 0.0021 0.0021
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0015 0.0021 0.0021
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Brugia malayi hypothetical protein 0.0018 0.0068 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0753 0.9431
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0072 0.0782 0.0782
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0601 0.0601
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0028 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0072 0.0782 0.0782
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0015 0.0021 0.0021
Brugia malayi acetyltransferase, GNAT family protein 0.0134 0.1596 0.1596
Brugia malayi hexokinase type II 0.0245 0.3062 0.3062
Echinococcus granulosus lamin 0.0025 0.0157 0.0157
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0753 0.0499
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0021 0.0021
Brugia malayi Hexokinase family protein 0.077 1 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0028 0.0193 0.0193
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.0068 0.0068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0179 0.0179
Trypanosoma brucei hexokinase 0.077 1 1
Entamoeba histolytica hexokinase 2 0.077 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0047 0.0453 0.0453
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0193 0.0193
Onchocerca volvulus 0.077 1 1
Schistosoma mansoni rab6-interacting 0.0018 0.0068 0.0068
Onchocerca volvulus 0.0018 0.0068 0.0068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0028 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0028 0.0193 0.0193
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.0386 0.0386
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0134 0.1596 0.1596
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.2367 0.2367
Echinococcus granulosus neuropeptide receptor A26 0.0427 0.5469 0.5469
Echinococcus granulosus ecdysone induced protein 78C 0.0028 0.0193 0.0193
Brugia malayi nuclear hormone receptor 0.0028 0.0193 0.0193
Echinococcus granulosus hexokinase 0.077 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0028 0.0193 0.0193
Echinococcus multilocularis hexokinase 0.077 1 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0267 0.0267
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0028 0.0193 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0028 0.0193 0.0193
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0072 0.0782 0.0635
Echinococcus multilocularis hexokinase 0.077 1 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0072 0.0782 0.5
Plasmodium falciparum hexokinase 0.077 1 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0039 0.0348 0.0348
Brugia malayi hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0601 0.0601
Onchocerca volvulus 0.0033 0.0267 0.0267
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0267 0.0267
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0028 0.0193 0.0193
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0072 0.0782 0.0782
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0028 0.0193 0.0193
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0753 0.9431
Treponema pallidum hexokinase (hxk) 0.077 1 1
Echinococcus multilocularis RUN 0.0018 0.0068 0.0068
Schistosoma mansoni hypothetical protein 0.0156 0.1895 0.1895
Trypanosoma brucei hexokinase 0.077 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0267 0.0267
Brugia malayi Nuclear hormone receptor-like 1 0.0015 0.0021 0.0021
Echinococcus multilocularis ecdysone induced protein 78C 0.0028 0.0193 0.0193
Echinococcus granulosus hexokinase type 2 0.077 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.0386 0.0386
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0028 0.0193 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0267 0.02
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0028 0.0193 0.0193
Brugia malayi photoreceptor-specific nuclear receptor 0.0028 0.0193 0.0193
Brugia malayi beta-lactamase family protein 0.0033 0.0267 0.0267
Brugia malayi beta-lactamase 0.0033 0.0267 0.0267

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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