Detailed information for compound 911498

Basic information

Technical information
  • TDR Targets ID: 911498
  • Name: 3-(3,4-dichlorophenyl)-2-(3-nitrophenyl)-1,3- thiazolidin-4-one
  • MW: 369.223 | Formula: C15H10Cl2N2O3S
  • H donors: 0 H acceptors: 3 LogP: 4.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(N1c1ccc(c(c1)Cl)Cl)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C15H10Cl2N2O3S/c16-12-5-4-10(7-13(12)17)18-14(20)8-23-15(18)9-2-1-3-11(6-9)19(21)22/h1-7,15H,8H2
  • InChiKey: RHVUOTYPPILBBF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,4-dichlorophenyl)-2-(3-nitrophenyl)thiazolidin-4-one
  • 3-(3,4-dichlorophenyl)-2-(3-nitrophenyl)-4-thiazolidinone
  • Oprea1_657820

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.0079 0.0234 0.0202
Toxoplasma gondii NAC domain-containing protein 0.0069 0.0178 0.0996
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.05 0.2809 0.4328
Toxoplasma gondii melibiase subfamily protein 0.0102 0.0379 0.2279
Brugia malayi hypothetical protein 0.0079 0.0234 0.0202
Trypanosoma cruzi endonuclease G, putative 0.03 0.1589 1
Echinococcus granulosus transcription factor btf3 0.0069 0.0178 0.0284
Brugia malayi beta-NAC-like protein 0.0069 0.0178 0.0112
Echinococcus granulosus transferase 0.0079 0.0234 0.0386
Giardia lamblia Fructose-bisphosphate aldolase 0.0615 0.3515 1
Brugia malayi Melibiase family protein 0.0068 0.0171 0.01
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0171 0.01
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.05 0.2809 0.4328
Echinococcus multilocularis gpi ethanolamine phosphate transferase 3 0.0079 0.0234 0.0127
Brugia malayi AEL166Cp 0.0079 0.0234 0.0202
Loa Loa (eye worm) hypothetical protein 0.0079 0.0234 0.0202
Trypanosoma brucei GPI ethanolamine phosphate transferase 3, putative 0.0079 0.0234 0.0396
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.3515 1
Loa Loa (eye worm) type I phosphodiesterase/nucleotide pyrophosphatase 0.0079 0.0234 0.0202
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0379 0.0434
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.03 0.1589 1
Schistosoma mansoni hypothetical protein 0.0079 0.0234 0.0202
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0079 0.0234 0.0127
Plasmodium vivax basic transcription factor 3b, putative 0.0069 0.0178 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.5079
Echinococcus multilocularis gpi ethanolamine phosphate transferase 1 0.0079 0.0234 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0667 0.0565
Trypanosoma brucei endonuclease G, putative 0.03 0.1589 1
Schistosoma mansoni hypothetical protein 0.0079 0.0234 0.0202
Loa Loa (eye worm) hypothetical protein 0.0068 0.0171 0.01
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.012 0.0177
Brugia malayi hypothetical protein 0.0157 0.0711 0.0966
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0079 0.0234 0.0667
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0102 0.0379 0.0274
Mycobacterium ulcerans hypothetical protein 0.0079 0.0234 0.0779
Onchocerca volvulus 0.05 0.2809 0.4211
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0079 0.0234 0.0202
Echinococcus multilocularis Endonuclease G 0.03 0.1589 0.1497
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.05 0.2809 0.4328
Echinococcus granulosus gpi ethanolamine phosphate transferase 3 0.0079 0.0234 0.0386
Trypanosoma cruzi DNA/RNA non-specific endonuclease protein-like, putative 0.03 0.1589 1
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0667 0.0896
Schistosoma mansoni hypothetical protein 0.0079 0.0234 0.0202
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0108 0.0157
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0379 0.0434
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0301 0.1591 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0667 0.0896
Trypanosoma brucei endonuclease G, putative 0.03 0.1589 1
Echinococcus granulosus neuropeptide s receptor 0.0941 0.5509 1
Brugia malayi Type I phosphodiesterase / nucleotide pyrophosphatase family protein 0.0079 0.0234 0.0202
Brugia malayi hypothetical protein 0.0079 0.0234 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Echinococcus granulosus Endonuclease G 0.03 0.1589 0.2856
Plasmodium falciparum GPI ethanolamine phosphate transferase 3, putative 0.0079 0.0234 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0079 0.0234 0.0386
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0102 0.0379 0.0274
Loa Loa (eye worm) hypothetical protein 0.05 0.2809 0.4328
Loa Loa (eye worm) acetyltransferase 0.0149 0.0667 0.0896
Onchocerca volvulus 0.1079 0.6349 1
Toxoplasma gondii DNA/RNA non-specific endonuclease 0.03 0.1589 1
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.05 0.2809 0.4328
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.5079
Echinococcus multilocularis ectonucleotide 0.0421 0.2328 0.2244
Schistosoma mansoni hypothetical protein 0.019 0.0913 0.1289
Loa Loa (eye worm) hypothetical protein 0.05 0.2809 0.4328
Echinococcus granulosus geminin 0.019 0.0913 0.1623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Loa Loa (eye worm) hypothetical protein 0.0421 0.2328 0.3558
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.5079
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0301 0.1591 1
Onchocerca volvulus 0.0157 0.0711 0.0779
Echinococcus multilocularis geminin 0.019 0.0913 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0447
Trypanosoma cruzi endonuclease G, putative 0.03 0.1589 1
Schistosoma mansoni hypothetical protein 0.019 0.0913 0.1289
Leishmania major endonuclease G, putative 0.03 0.1589 1
Echinococcus multilocularis neuropeptide receptor A26 0.0941 0.5509 0.546
Echinococcus multilocularis transcription factor btf3 0.0069 0.0178 0.0071
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.012 0.0012
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0108 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0447
Giardia lamblia Phosphatidylinositol-glycan biosynthesis, class O protein 0.0079 0.0234 0.0667
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Loa Loa (eye worm) ICD-1 protein 0.0069 0.0178 0.0112
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0102 0.0379 0.0651
Loa Loa (eye worm) hypothetical protein 0.0157 0.0711 0.0966
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0171 0.01
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0421 0.2328 0.2244
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0642 0.1129
Echinococcus multilocularis Alkaline phosphatase, core domain 0.0079 0.0234 0.0127
Schistosoma mansoni transcription factor btf3 0.0069 0.0178 0.0112
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0379 0.0434
Schistosoma mansoni ectonucleotide pyrophosphatase/phosphodiesterase 0.05 0.2809 0.4328
Entamoeba histolytica transcription factor BTF3, putative 0.0069 0.0178 0.0507
Loa Loa (eye worm) hypothetical protein 0.0079 0.0234 0.0202
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Brugia malayi endonuclease G, mitochondrial precursor 0.03 0.1589 0.2373
Echinococcus granulosus ectonucleotide 0.0421 0.2328 0.4203
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.273
Loa Loa (eye worm) hypothetical protein 0.0079 0.0234 0.0202
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.5079
Loa Loa (eye worm) thrombospondin type 1 domain-containing protein 0.1079 0.6349 1
Leishmania major ethanolamine phosphotransferase, putative 0.0079 0.0234 0.078
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.0421 0.2328 0.4203
Onchocerca volvulus 0.05 0.2809 0.4211
Echinococcus multilocularis neuropeptide s receptor 0.0941 0.5509 0.546
Leishmania major DNA/RNA non-specific endonuclease-like protein 0.03 0.1589 1
Schistosoma mansoni hypothetical protein 0.0079 0.0234 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Entamoeba histolytica phosphatidylinositol-glycan biosynthesis class O protein, putative 0.0079 0.0234 0.0667
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.012 0.0018
Entamoeba histolytica hypothetical protein 0.0069 0.0178 0.0507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Schistosoma mansoni endonuclease related 0.03 0.1589 0.2373
Brugia malayi Thrombospondin type 1 domain containing protein 0.1079 0.6349 1
Schistosoma mansoni hypothetical protein 0.1079 0.6349 1
Echinococcus granulosus neuropeptide receptor A26 0.0941 0.5509 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0069 0.0178 0.7613
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0178 0.0447
Leishmania major basic transcription factor 3a, putative 0.0069 0.0178 0.0399
Loa Loa (eye worm) hypothetical protein 0.05 0.2809 0.4328
Trypanosoma brucei endonuclease G, putative 0.03 0.1589 1
Echinococcus multilocularis transferase 0.0079 0.0234 0.0127
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0615 0.3515 1
Echinococcus granulosus ectonucleotide pyrophosphatase:phosphodiesterase 0.05 0.2809 0.5079
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.012 0.0621
Treponema pallidum fructose-bisphosphate aldolase 0.0615 0.3515 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0615 0.3515 1
Echinococcus multilocularis ectonucleotide pyrophosphatase:phosphodiesterase 0.0079 0.0234 0.0127
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0171 0.0425
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0102 0.0379 0.0434
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0301 0.1591 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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