Detailed information for compound 916989

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.692 | Formula: C12H10ClN5O4
  • H donors: 4 H acceptors: 4 LogP: 1.67 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)NNC(=O)c1[nH]cc(c1)[N+](=O)[O-]
  • InChi: 1S/C12H10ClN5O4/c13-7-1-3-8(4-2-7)15-12(20)17-16-11(19)10-5-9(6-14-10)18(21)22/h1-6,14H,(H,16,19)(H2,15,17,20)
  • InChiKey: VHISSHHZLZBOON-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis microtubule associated protein 2 0.0722 0.901 0.9008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0243 0.051
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.051
Schistosoma mansoni microtubule-associated protein tau 0.0722 0.901 0.9007
Echinococcus granulosus tar DNA binding protein 0.007 0.0689 0.067
Schistosoma mansoni tar DNA-binding protein 0.007 0.0689 0.0657
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4768 1
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0018 0.0035 0.0014
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0058 0.0539 0.1064
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Schistosoma mansoni hypothetical protein 0.0081 0.0835 0.0802
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Schistosoma mansoni hypothetical protein 0.035 0.427 0.4249
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0058 0.0539 0.1064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0408 0.0374
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0243 0.1605
Loa Loa (eye worm) transcription factor SMAD2 0.0372 0.4542 0.9524
Brugia malayi transcriptional regulator, Sir2 family protein 0.0018 0.0035 0.0074
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0835 0.0815
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0835 0.0815
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.1156 1
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0389 0.4768 1
Echinococcus granulosus smad 0.0025 0.0123 0.0102
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Loa Loa (eye worm) hypothetical protein 0.0256 0.3071 0.6426
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0316 0.0282
Schistosoma mansoni cpg binding protein 0.0056 0.0516 0.0482
Brugia malayi MH1 domain containing protein 0.0025 0.0123 0.0257
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4768 1
Onchocerca volvulus 0.0056 0.0516 0.0602
Brugia malayi beta-lactamase 0.0035 0.0243 0.051
Schistosoma mansoni Smad4 0.0025 0.0123 0.0088
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.012 0.1327 0.9968
Mycobacterium ulcerans NAD-dependent deacetylase 0.0058 0.0539 0.1064
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0058 0.0539 0.0988
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Loa Loa (eye worm) transcriptional regulator 0.0018 0.0035 0.003
Echinococcus granulosus geminin 0.035 0.427 0.4258
Loa Loa (eye worm) hypothetical protein 0.0018 0.0035 0.003
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Echinococcus multilocularis geminin 0.035 0.427 0.4258
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0123 0.0088
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0018 0.0035 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0058 0.0539 1
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.011 0.1487
Loa Loa (eye worm) hypothetical protein 0.0175 0.2036 0.4245
Brugia malayi hypothetical protein 0.0024 0.011 0.0231
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.3428 0.7178
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0058 0.0539 0.3888
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0053 0.0474 0.0454
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0058 0.0539 0.3888
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.1331 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.011 0.1487
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0058 0.0539 0.3888
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0243 0.044
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Mycobacterium ulcerans lipase LipD 0.0035 0.0243 0.044
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0286 0.053
Loa Loa (eye worm) sirtuin 4 0.0018 0.0035 0.003
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1139 0.2332
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0269 0.3236 1
Schistosoma mansoni hypothetical protein 0.0081 0.0835 0.0802
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.044
Schistosoma mansoni tar DNA-binding protein 0.007 0.0689 0.0657
Echinococcus multilocularis tumor protein p63 0.0353 0.4309 0.4298
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0018 0.0035 0.0014
Brugia malayi NAD-dependent deacetylase SIRT1 0.0018 0.0035 0.0074
Schistosoma mansoni tar DNA-binding protein 0.007 0.0689 0.0657
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4768 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Schistosoma mansoni hypothetical protein 0.0175 0.2036 0.2008
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Brugia malayi Smad1 0.0025 0.0123 0.0257
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0835 0.175
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Plasmodium vivax NAD-dependent deacetylase, putative 0.0058 0.0539 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0123 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0408 0.0387
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2309 0.4803
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.012 0.1327 0.1309
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0209
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0835 0.175
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0286 0.053
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0243 0.0209
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0243 0.4129
Loa Loa (eye worm) hypothetical protein 0.0053 0.0474 0.0954
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.0593
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0316 0.0295
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0408 0.0855
Echinococcus multilocularis smad 0.0025 0.0123 0.0102
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0286 0.4978
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0123 0.0102
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0053 0.0474 0.0994
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.011 0.0578
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0082 0.084 0.1701
Mycobacterium leprae Probable NAD-dependent deacetylase NpdA (Regulatory protein SIR2 homolog) 0.0039 0.0303 1
Schistosoma mansoni hypothetical protein 0.0081 0.0835 0.0802
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0188
Loa Loa (eye worm) TAR-binding protein 0.007 0.0689 0.1408
Echinococcus granulosus microtubule associated protein 2 0.0722 0.901 0.9008
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0408 0.0374
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.011 0.1487
Schistosoma mansoni hypothetical protein 0.0081 0.0835 0.0802
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0123 0.0214
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0038 0.0286 0.0143
Loa Loa (eye worm) beta-lactamase 0.0035 0.0243 0.0468
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0053 0.0474 0.0454
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0474 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0058 0.0539 0.1064
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0389 0.4768 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0123 0.0102
Mycobacterium ulcerans beta-lactamase 0.0035 0.0243 0.044
Trichomonas vaginalis conserved hypothetical protein 0.012 0.1327 0.2729
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.1319 0.1288
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0058 0.0539 0.3888
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.1331 0.2738
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0474 0.0927
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Loa Loa (eye worm) hypothetical protein 0.0052 0.046 0.0924
Onchocerca volvulus 0.0052 0.046 0.0478
Brugia malayi CXXC zinc finger family protein 0.0056 0.0516 0.1081
Brugia malayi RNA binding protein 0.007 0.0689 0.1446
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0516 0.1042
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Toxoplasma gondii hypothetical protein 0.0038 0.0286 0.2237
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0243 0.044
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Brugia malayi RNA recognition motif domain containing protein 0.007 0.0689 0.1446
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.0593
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0286 0.7137
Schistosoma mansoni tar DNA-binding protein 0.007 0.0689 0.0657
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Echinococcus multilocularis dnaJ subfamily B 0.0799 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0243 0.0223
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0053 0.0474 0.044
Toxoplasma gondii hypothetical protein 0.0038 0.0286 0.2237
Schistosoma mansoni chromatin regulatory protein sir2 0.0058 0.0539 0.0506
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.044
Brugia malayi MH2 domain containing protein 0.0025 0.0123 0.0257
Echinococcus multilocularis cpg binding protein 0.0059 0.0556 0.0537
Toxoplasma gondii hypothetical protein 0.0105 0.1139 0.9847
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.011 0.0578
Echinococcus granulosus tumor protein p63 0.0353 0.4309 0.4298
Echinococcus multilocularis tar DNA binding protein 0.007 0.0689 0.067
Brugia malayi MH1 domain containing protein 0.0025 0.0123 0.0257
Brugia malayi transcriptional regulator, Sir2 family protein 0.0018 0.0035 0.0074
Echinococcus granulosus GPCR family 2 0.0081 0.0835 0.0815
Loa Loa (eye worm) transcriptional regulator 0.0018 0.0035 0.003
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0082 0.084 0.1701
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0038 0.0286 0.0143
Loa Loa (eye worm) transcriptional regulator 0.0018 0.0035 0.003
Loa Loa (eye worm) hypothetical protein 0.0038 0.0286 0.0558
Echinococcus multilocularis Smad4 0.0025 0.0123 0.0102
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0243 0.0468
Loa Loa (eye worm) RNA binding protein 0.007 0.0689 0.1408
Schistosoma mansoni cpg binding protein 0.0059 0.0556 0.0523
Schistosoma mansoni hypothetical protein 0.035 0.427 0.4249
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.011 0.0668
Leishmania major hypothetical protein, conserved 0.0024 0.011 0.0578
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0389 0.4768 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2635 0.7992
Trypanosoma cruzi hypothetical protein, conserved 0.012 0.1331 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0835 0.1714
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0408 0.0387
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0408 0.0374
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0474 0.0927
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0123 0.0102
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.012 0.1327 0.2729
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0408 0.0387
Loa Loa (eye worm) MH2 domain-containing protein 0.0372 0.4542 0.9524
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0243 0.044
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.0593
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0088
Schistosoma mansoni smad 0.0025 0.0123 0.0088
Schistosoma mansoni smad1 5 8 and 0.0025 0.0123 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0243 0.1605
Giardia lamblia Transcriptional regulator, Sir2 family 0.0058 0.0539 0.1064
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.012 0.1331 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Echinococcus granulosus Smad4 0.0025 0.0123 0.0102
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0058 0.0539 0.1064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0256 0.3071 0.6426
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.046 0.0426
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.012 0.1327 0.2729
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.012 0.1327 0.1296
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0389 0.4768 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4768 1
Leishmania major hypothetical protein, conserved 0.012 0.1331 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0408 0.0814
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0286 0.053
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0256 0.3071 0.6441
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0082 0.084 0.6213
Brugia malayi MH2 domain containing protein 0.0372 0.4542 0.9526
Echinococcus granulosus cpg binding protein 0.0059 0.0556 0.0537
Loa Loa (eye worm) Smad1 0.0025 0.0123 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0256 0.3071 0.6441
Leishmania major hypothetical protein, conserved 0.0035 0.0243 0.1605
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0018 0.0038
Entamoeba histolytica hypothetical protein 0.004 0.0316 0.0593
Brugia malayi TAR-binding protein 0.007 0.0689 0.1446
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0316 0.0295
Schistosoma mansoni hypothetical protein 0.004 0.0316 0.0282
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0038 0.0286 0.053
Plasmodium falciparum GAF domain-related protein, putative 0.0038 0.0286 0.4978
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Schistosoma mansoni hypothetical protein 0.0799 1 1
Brugia malayi MH2 domain containing protein 0.0025 0.0123 0.0257
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0018 0.0035 0.0014
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.012 0.1331 0.2738
Brugia malayi hypothetical protein 0.004 0.0316 0.0662
Trichomonas vaginalis esterase, putative 0.0035 0.0243 0.044
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0408 0.0387
Echinococcus granulosus chromatin regulatory protein sir2 0.0018 0.0035 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0243 0.044
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0389 0.4768 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0389 0.4768 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.012 0.1327 0.9968
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0243 0.044
Onchocerca volvulus 0.0389 0.4768 1
Schistosoma mansoni cpg binding protein 0.0059 0.0556 0.0523
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0123 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0187 0.218 0.4532
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1139 0.2332
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0835 0.0815
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0389 0.4768 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0835 0.0815
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.011 0.0578
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.2036 0.427
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Toxoplasma gondii GAF domain-containing protein 0.0038 0.0286 0.2237
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0474 0.0994
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.012 0.1327 0.1309
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.007 0.0689 0.1408
Loa Loa (eye worm) hypothetical protein 0.0081 0.0835 0.1714
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1139 0.2332
Brugia malayi beta-lactamase family protein 0.0035 0.0243 0.051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0243 0.0223
Brugia malayi transcriptional regulator, Sir2 family protein 0.0018 0.0035 0.0074
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.012 0.1327 0.2729
Trypanosoma brucei cAMP-specific phosphodiesterase 0.012 0.1327 0.9968
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0018 0.0035 0.0014
Loa Loa (eye worm) hypothetical protein 0.0035 0.0243 0.0468
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.9867 0.9866
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0018 0.0035 0.0014
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0018 0.0035 0.0014
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0018 0.0035 0.0014
Echinococcus multilocularis chromatin regulatory protein sir2 0.0018 0.0035 0.0014
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.3428 0.719
Onchocerca volvulus Glucosylceramidase homolog 0.0187 0.218 0.4281
Toxoplasma gondii ABC1 family protein 0.0035 0.0243 0.1856
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0243 0.1605
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0389 0.4768 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.3428 0.7169
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.2309 0.4803
Toxoplasma gondii histone deacetylase SIR2 0.0058 0.0539 0.4494
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.012 0.1327 0.9968
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.012 0.1327 0.9968
Echinococcus multilocularis GPCR, family 2 0.0081 0.0835 0.0815
Schistosoma mansoni tar DNA-binding protein 0.007 0.0689 0.0657
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.012 0.1327 0.2729
Mycobacterium ulcerans hypothetical protein 0.0035 0.0243 0.044

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 2 ug ml-1 Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 days by Resazurin micro titer assay ChEMBL. 24878195
MIC (functional) = 3.125 ug ml-1 Antimicrobial activity against Escherichia coli ATCC 25922 after 48 hrs by broth dilution technique ChEMBL. 24878195
MIC (functional) = 3.125 ug ml-1 Antimicrobial activity against Candida albicans after 48 hrs by agar dilution method ChEMBL. 24878195

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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