Detailed information for compound 919087

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 316.31 | Formula: C14H9FN4O2S
  • H donors: 1 H acceptors: 4 LogP: 1.52 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cncc(c1)Oc1cncc(n1)NC(=O)c1ccsc1
  • InChi: 1S/C14H9FN4O2S/c15-10-3-11(5-16-4-10)21-13-7-17-6-12(18-13)19-14(20)9-1-2-22-8-9/h1-8H,(H,18,19,20)
  • InChiKey: HURBZZSEKQOPOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Metabotropic glutamate receptor 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Metabotropic glutamate receptor precursor, putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum ko:K04606 glutamate receptor, metabotropic 3, putative Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 5 Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi Metabotropic glutamate receptor precursor. Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus granulosus metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) Get druggable targets OG5_127095 All targets in OG5_127095
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative Get druggable targets OG5_127095 All targets in OG5_127095
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127095 All targets in OG5_127095
Echinococcus multilocularis metabotropic glutamate receptor 2 Get druggable targets OG5_127095 All targets in OG5_127095
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0065 0.0867 0.7575
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.1144 0.1144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.1252 0.1252
Brugia malayi beta-lactamase family protein 0.0081 0.1144 0.2506
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1144 1
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.1144 0.1144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1144 0.3658
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0284 0.4567 1
Brugia malayi beta-lactamase 0.0081 0.1144 0.2506
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0062 0.0199
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0062 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.1252 0.1252
Mycobacterium ulcerans beta-lactamase 0.0081 0.1144 0.1144
Mycobacterium tuberculosis Conserved protein 0.0081 0.1144 0.1144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0148 0.1292
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0062 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0243 0.2127
Loa Loa (eye worm) hypothetical protein 0.006 0.0792 0.1619
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.1515 0.4842
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.1144 0.1144
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0423 0.3694
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1818 0.3897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Echinococcus multilocularis cysteine protease 0.0017 0.0062 0.0199
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0062 0.1471
Trypanosoma brucei trypanothione reductase 0.0038 0.0423 0.3694
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0062 0.0543
Mycobacterium ulcerans two component transcriptional regulator 0.0606 1 1
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0423 0.3694
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0814 0.2603
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0148 0.1292
Plasmodium vivax glutathione reductase, putative 0.0038 0.0423 0.3694
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.1515 0.4842
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.1144 0.1144
Schistosoma mansoni ap endonuclease 0.0022 0.0148 0.0473
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0148 0.1292
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0041 0.0467 0.1493
Mycobacterium tuberculosis Conserved protein 0.0081 0.1144 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Echinococcus granulosus metabotropic glutamate receptor 2 0.0041 0.0467 0.1493
Loa Loa (eye worm) glutamate receptor 0.0049 0.0601 0.1196
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Schistosoma mansoni hypothetical protein 0.0199 0.3128 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.1144 0.1144
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0062 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1515 0.4842
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.0814 0.2603
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0062 0.1471
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.1144 0.1144
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.1144 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0148 0.0473
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Schistosoma mansoni ap endonuclease 0.0022 0.0148 0.0473
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0148 0.0324
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0423 0.0423
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Brugia malayi Metabotropic glutamate receptor precursor. 0.0049 0.0601 0.1316
Leishmania major hypothetical protein, conserved 0.0081 0.1144 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0431 0.1379
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.0814 0.0814
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Loa Loa (eye worm) glutamate receptor 0.0019 0.01 0.0085
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.1144 0.3658
Mycobacterium tuberculosis Possible transcriptional regulatory protein 0.0606 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Mycobacterium ulcerans lipase LipD 0.0081 0.1144 0.1144
Leishmania major cathepsin L-like protease 0.0017 0.0062 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0062 0.0136
Plasmodium vivax vivapain-2 0.0017 0.0062 0.0543
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Leishmania major cathepsin L-like protease 0.0017 0.0062 0.0543
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0148 0.1292
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0518 0.852 0.852
Mycobacterium ulcerans hypothetical protein 0.0606 1 1
Mycobacterium tuberculosis Conserved protein 0.0081 0.1144 0.1144
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0103 0.1515 0.4842
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0056 0.0714 0.2282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1818 0.3897
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1144 0.2506
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Leishmania major trypanothione reductase 0.0038 0.0423 0.3694
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0867 0.7575
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.0814 0.0814
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0148 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.1416 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Toxoplasma gondii thioredoxin reductase 0.0038 0.0423 0.3694
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0 0.5
Schistosoma mansoni metabotropic glutamate receptor 0.0024 0.0178 0.0569
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Mycobacterium tuberculosis Possible two component transcriptional regulatory protein (probably LuxR-family) 0.0606 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1144 0.2506
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.1252 0.1252
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0431 0.1379
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0867 0.7575
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0148 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0148 0.1292
Echinococcus multilocularis cysteine protease 0.0017 0.0062 0.0199
Mycobacterium tuberculosis Probable transcriptional regulatory protein 0.0606 1 1
Echinococcus multilocularis geminin 0.0199 0.3128 1
Schistosoma mansoni metabotropic glutamate receptor 0.0041 0.0467 0.1493
Brugia malayi glutathione reductase 0.0038 0.0423 0.0926
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1515 0.4842
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0423 0.0801
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.1252 0.0121
Echinococcus granulosus metabotropic glutamate receptor 5 0.006 0.0792 0.253
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0148 0.0324
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0243 0.5757
Plasmodium vivax hypothetical protein, conserved 0.0081 0.1144 1
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.1144 0.1144
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0148 0.3498
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0062 0.0199
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.1252 0.1252
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0772 0.6748
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0062 0.0543
Onchocerca volvulus 0.0081 0.1144 0.3788
Brugia malayi beta-lactamase family protein 0.0081 0.1144 0.2506
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Plasmodium falciparum ataxin-2 like protein, putative 0.0028 0.0243 0.5757
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0062 0.0199
Leishmania major cathepsin L-like protease 0.0017 0.0062 0.0543
Mycobacterium tuberculosis Possible nitrate/nitrite response transcriptional regulatory protein NarL 0.0606 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0867 0.7575
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Echinococcus granulosus geminin 0.0199 0.3128 1
Mycobacterium tuberculosis Probable transcriptional regulatory protein (LuxR-family) 0.0606 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.3089 0.6763
Brugia malayi hypothetical protein 0.0028 0.0243 0.0533
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.0814 0.7115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.1416 0.1416
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.0814 0.2603
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.1144 0.2506
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.1416 0.1416
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0103 0.1515 0.4842
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.1416 0.1416
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Leishmania major cathepsin L-like protease 0.0065 0.0867 0.7575
Toxoplasma gondii LsmAD domain-containing protein 0.0028 0.0243 0.2127
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0867 0.7575
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.1144 0.3658
Echinococcus multilocularis metabotropic glutamate receptor 5 0.006 0.0792 0.253
Loa Loa (eye worm) beta-lactamase 0.0081 0.1144 0.2403
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Schistosoma mansoni hypothetical protein 0.0199 0.3128 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1144 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0044 0.0523 0.1146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.1144 0.2403
Brugia malayi hypothetical protein 0.0018 0.0078 0.017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.1144 0.1144
Onchocerca volvulus 0.0081 0.1144 0.3788
Mycobacterium ulcerans two component transcriptional regulatory protein DevR 0.0606 1 1
Brugia malayi Thioredoxin reductase 0.0038 0.0423 0.0926
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.1144 0.1144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0028 0.0243 0.2127
Plasmodium vivax ataxin-2 like protein, putative 0.0028 0.0243 0.2127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0062 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0062 0.0199
Plasmodium vivax vivapain-2 0.0017 0.0062 0.0543
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Leishmania major cathepsin L-like protease 0.0017 0.0062 0.0543
Echinococcus granulosus cathepsin l1 0.0017 0.0062 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis esterase, putative 0.0081 0.1144 0.2506
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.0814 0.2603
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0148 0.0473
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.2919 1
Plasmodium falciparum glutathione reductase 0.0038 0.0423 1
Trichomonas vaginalis glucosylceramidase, putative 0.0284 0.4567 1
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0148 0.0324
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0148 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0148 0.019
Trypanosoma brucei PAB1-binding protein , putative 0.0028 0.0243 0.2127
Mycobacterium tuberculosis Probable transcriptional regulatory protein (probably LuxR/UhpA-family) 0.0606 1 1
Mycobacterium tuberculosis Probable reductase 0.0087 0.1252 0.1252
Leishmania major cathepsin L-like protease 0.0065 0.0867 0.7575
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0103 0.1515 0.4842
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1144 0.2506
Toxoplasma gondii exonuclease III APE 0.0022 0.0148 0.1292
Leishmania major hypothetical protein, conserved 0.0028 0.0243 0.2127
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0633 0.5534
Toxoplasma gondii cathepsin CPL 0.0017 0.0062 0.0543
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0062 0.1471
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.1144 0.2506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Brugia malayi Cathepsin L-like precursor 0.0017 0.0062 0.0136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.1144 0.3658
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.1144 0.2506
Plasmodium falciparum thioredoxin reductase 0.0038 0.0423 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0062 0.0199
Loa Loa (eye worm) glutathione reductase 0.0038 0.0423 0.0801
Leishmania major cathepsin L-like protease 0.0017 0.0062 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2919 0.6392
Mycobacterium ulcerans nitrate/nitrite response regulator protein NarL 0.0606 1 1
Onchocerca volvulus 0.0081 0.1144 0.3788
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0867 0.7575
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Loa Loa (eye worm) hypothetical protein 0.0081 0.1144 0.2403
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.0814 0.7115
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0103 0.1515 0.3317
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0062 0.0199
Loa Loa (eye worm) hypothetical protein 0.0028 0.0243 0.0402
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0284 0.4567 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0103 0.1515 0.3224
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0148 1
Mycobacterium ulcerans hypothetical protein 0.0081 0.1144 0.1144
Brugia malayi metabotropic glutamate receptor type 2 0.0024 0.0178 0.039
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.1252 0.1252
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0062 0.0136
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0062 0.0136
Toxoplasma gondii ABC1 family protein 0.0081 0.1144 1
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.3089 0.6763
Brugia malayi MH2 domain containing protein 0.0121 0.1818 0.398
Mycobacterium ulcerans putative regulatory protein 0.0606 1 1

Activities

Activity type Activity value Assay description Source Reference
%max (binding) = 0.1 % Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in 100 uM glutamate-induced calcium mobilization at 30 uM ChEMBL. 24969015
IC50 (binding) = 5.5 Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization ChEMBL. 24969015
IC50 (binding) = 3450 nM Negative allosteric modulator activity at rat mGlu5 expressed in HEK293A cells assessed as reduction in glutamate-induced calcium mobilization ChEMBL. 24969015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.