TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 360.366 | Formula: C20H16N4O3
H donors: 1 H acceptors: 4 LogP: 2.62 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cnn(c1O)C)c1ccc2c(c1)c(=O)n(c(n2)C)c1ccccc1
InChi: 1S/C20H16N4O3/c1-12-22-17-9-8-13(18(25)16-11-21-23(2)19(16)26)10-15(17)20(27)24(12)14-6-4-3-5-7-14/h3-11,26H,1-2H3
InChiKey: SWEQWYFWMUNIGV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	4-hydroxyphenylpyruvate dioxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448
Onchocerca volvulus	Putative protein	Get druggable targets OG5_129448	All targets in OG5_129448
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	Get druggable targets OG5_129448	All targets in OG5_129448
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448
Candida albicans	similar to HPPD a 4-hydroxyphenylpyruvate dioxygenase	Get druggable targets OG5_129448	All targets in OG5_129448

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Cadmium inducible protein CadI	0.0054	0.045	1
Brugia malayi	Sugar transporter family protein	0.0029	0.016	0.0346
Loa Loa (eye worm)	sugar transporter	0.0206	0.2221	0.5426
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0567	0.1973
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.016	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0543	0.1326
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Schistosoma mansoni	lamin	0.0031	0.0189	0.0032
Leishmania major	lysyl-tRNA synthetase, putative	0.0046	0.0358	0.395
Mycobacterium leprae	conserved hypothetical protein	0.0054	0.045	0.6505
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0662	1
Brugia malayi	hypothetical protein	0.0029	0.016	0.0346
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0358	0.0219
Toxoplasma gondii	lysine-tRNA ligase	0.0046	0.0358	0.0308
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0567	0.1973
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0332	0.3698	0.3595
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0567	0.8107
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0189	0.0417
Brugia malayi	4-hydroxyphenylpyruvate dioxygenase family protein	0.0366	0.4093	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0206	0.2221	0.3201
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.016	0.0175
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0072	0.0662	0.0779
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.016	0.0346
Toxoplasma gondii	protein kinase, putative	0.0581	0.6598	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0558	0.044
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0063	0.0558	0.0617
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.016	0.0175
Onchocerca volvulus	Putative protein	0.0366	0.4093	1
Echinococcus multilocularis	microtubule associated protein 2	0.0804	0.9193	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0567	0.1973
Echinococcus granulosus	lamin	0.0031	0.0189	0.0206
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Echinococcus granulosus	microtubule associated protein 2	0.0804	0.9193	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0567	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0063	0.0558	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Schistosoma mansoni	protein kinase	0.0063	0.0558	0.044
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0358	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Plasmodium falciparum	proline--tRNA ligase	0.0072	0.0662	0.051
Plasmodium vivax	lysine--tRNA ligase, putative	0.0046	0.0358	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Plasmodium falciparum	glyoxalase I	0.0054	0.045	0.0294
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0054	0.045	1
Echinococcus multilocularis	solute carrier family 22	0.0029	0.016	0.0175
Brugia malayi	Sugar transporter family protein	0.0206	0.2221	0.5404
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0189	0.0032
Schistosoma mansoni	gynecophoral canal protein	0.0054	0.045	0.0321
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.016	0.0392
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.016	0.0346
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0567	0.1973
Leishmania major	protein kinase, putative	0.0063	0.0558	0.7919
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0046	0.0358	0.3046
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Schistosoma mansoni	hypothetical protein	0.0206	0.2221	0.2281
Schistosoma mansoni	microtubule-associated protein tau	0.0804	0.9193	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0662	1
Loa Loa (eye worm)	sugar transporter	0.0029	0.016	0.0392
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0567	0.8107
Echinococcus granulosus	lysyl tRNA synthetase	0.0046	0.0358	0.039
Mycobacterium tuberculosis	Conserved protein	0.0054	0.045	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0062	0.0543	0.1284
Toxoplasma gondii	glyoxalase I, putative	0.0054	0.045	0.045
Mycobacterium ulcerans	glyoxalase GloA	0.0054	0.045	1
Brugia malayi	intermediate filament protein	0.0031	0.0189	0.0417
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Echinococcus multilocularis	lamin dm0	0.0031	0.0189	0.0206
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0189	0.0463
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.016	0.5
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0063	0.0558	0.1362
Loa Loa (eye worm)	4-hydroxyphenylpyruvate dioxygenase	0.0366	0.4093	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0063	0.0558	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0358	0.0876
Giardia lamblia	Prolyl-tRNA synthetase	0.0062	0.0543	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0072	0.0662	0.051
Leishmania major	glucose transporter, lmgt2	0.0064	0.0567	0.8107
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0063	0.0558	0.0404
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0063	0.0558	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0054	0.045	0.11
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0662	1
Echinococcus granulosus	calcium dependent protein kinase	0.0059	0.0512	0.0557
Entamoeba histolytica	protein kinase, putative	0.0063	0.0558	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0063	0.0558	0.7919
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0054	0.045	0.5777
Mycobacterium ulcerans	biphenyl-2,3-diol 1,2-dioxygenase	0.0054	0.045	1
Echinococcus multilocularis	General substrate transporter	0.0177	0.1884	0.2049
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0063	0.0558	0.0404
Echinococcus granulosus	General substrate transporter	0.0177	0.1884	0.2049
Echinococcus multilocularis	solute carrier family 22	0.0029	0.016	0.0175
Schistosoma mansoni	4-hydroxyphenylpyruvate dioxygenase	0.0054	0.045	0.0321
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0662	1
Echinococcus granulosus	lamin dm0	0.0031	0.0189	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.004	0.0293	0.0641
Schistosoma mansoni	protein kinase	0.0063	0.0558	0.044
Schistosoma mansoni	glucose transport protein	0.0206	0.2221	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0558	0.1362
Brugia malayi	Cam kinase protein 1	0.0063	0.0558	0.1321
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0046	0.0358	0.395
Trypanosoma brucei	glucose transporter 2A	0.0064	0.0567	0.8107
Brugia malayi	hypothetical protein	0.0029	0.016	0.0346
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.045	0.1406
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.016	0.0175
Plasmodium falciparum	hexose transporter	0.0206	0.2221	0.2094
Echinococcus multilocularis	solute carrier family 22	0.0029	0.016	0.0175
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0567	0.1973
Brugia malayi	major facilitator superfamily protein	0.0029	0.016	0.0346
Schistosoma mansoni	glucose transport protein	0.0206	0.2221	0.2281
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Echinococcus multilocularis	lamin	0.0031	0.0189	0.0206
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0873	1	1
Mycobacterium tuberculosis	Conserved protein TB27.3	0.0054	0.045	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0064	0.0567	0.8107
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0077	0.5
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0332	0.3698	0.3595
Echinococcus granulosus	solute carrier family 22	0.0029	0.016	0.0175
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0063	0.0558	0.1362
Trypanosoma cruzi	lactoylglutathione lyase-like protein, putative	0.0054	0.045	0.5777
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0062	0.0543	1
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.016	0.2228
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0332	0.3698	0.5495
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0662	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0189	0.0463
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0567	0.8107
Brugia malayi	lactoylglutathione lyase	0.0054	0.045	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Plasmodium falciparum	protein kinase 7	0.0581	0.6598	0.6542
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Echinococcus multilocularis	lysyl tRNA synthetase	0.0046	0.0358	0.039
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0358	0.7542
Trichomonas vaginalis	conserved hypothetical protein	0.0054	0.045	0.1406
Onchocerca volvulus		0.0031	0.0189	0.0074
Echinococcus granulosus	solute carrier family 22	0.0029	0.016	0.0175
Trypanosoma cruzi	hexose transporter	0.0064	0.0567	0.8107
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.016	0.2228
Brugia malayi	major facilitator superfamily protein	0.0029	0.016	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0189	0.0463
Brugia malayi	lysyl-tRNA synthetase	0.0046	0.0358	0.0832
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0046	0.0358	0.395
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.2221	1
Plasmodium vivax	glyoxalase I, putative	0.0054	0.045	0.0294
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0358	0.7542
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0063	0.0558	0.0606
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0063	0.0558	0.0617
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0206	0.2221	0.2416
Leishmania major	glucose transporter, lmgt3	0.0064	0.0567	0.8107
Schistosoma mansoni	lamin	0.0031	0.0189	0.0032
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0567	0.1973
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0046	0.0358	0.0961
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0062	0.0543	0.9253
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0567	0.8107
Entamoeba histolytica	protein kinase, putative	0.0063	0.0558	1
Onchocerca volvulus		0.0031	0.0189	0.0074
Toxoplasma gondii	glyoxalase family protein	0.0054	0.045	0.045
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0543	0.0423
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0543	0.059
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0063	0.0558	0.0404
Schistosoma mansoni	protein kinase	0.0063	0.0558	0.044
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0063	0.0558	0.0404
Echinococcus granulosus	intermediate filament protein	0.0031	0.0189	0.0206
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0062	0.0543	0.1284
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0063	0.0558	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2221	0.2416
Onchocerca volvulus	Lactoylglutathione lyase homolog	0.0054	0.045	0.0736
Mycobacterium ulcerans	hypothetical protein	0.0054	0.045	1
Leishmania major	glyoxalase I,trypanothione-dependent glyoxalase I	0.0054	0.045	0.5777
Plasmodium vivax	hexose transporter	0.0206	0.2221	0.2094
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Plasmodium vivax	glyoxalase I, putative	0.0054	0.045	0.0294
Brugia malayi	hypothetical protein	0.0029	0.016	0.0346
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0063	0.0558	0.1321
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0039	0.0278	0.4053
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0183	0.0446
Trichomonas vaginalis	CAMK family protein kinase	0.0063	0.0558	0.1927
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0543	0.059
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Mycobacterium tuberculosis	Conserved protein	0.0054	0.045	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0567	0.8107
Plasmodium falciparum	lysine--tRNA ligase	0.0046	0.0358	0.0201
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Echinococcus multilocularis	calcium dependent protein kinase	0.0059	0.0512	0.0557
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0278	0.4053
Echinococcus granulosus	solute carrier family 22	0.0029	0.016	0.0175
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0025	0.0119	0.029
Brugia malayi	Sugar transporter family protein	0.0029	0.016	0.0346
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0567	0.8107
Plasmodium falciparum	glyoxalase I	0.0054	0.045	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0029	0.016	0.0392
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.016	0.0346
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.023	0.1383
Trypanosoma brucei	glucose transporter 1E	0.0064	0.0567	0.8107
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0062	0.0543	0.1855
Leishmania major	glucose transporter, lmgt1	0.0064	0.0567	0.8107
Mycobacterium ulcerans	sugar transporter	0.0029	0.016	0.2228
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.016	0.0175
Echinococcus multilocularis	musashi	0.0031	0.0189	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0543	0.1326
Echinococcus granulosus	solute carrier family 22	0.0029	0.016	0.0175
Mycobacterium ulcerans	glyoxalase GloA	0.0054	0.045	1
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0567	0.1973
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.016	0.2228
Loa Loa (eye worm)	hypothetical protein	0.005	0.0408	0.0996
Chlamydia trachomatis	lysine--tRNA ligase	0.0046	0.0358	1
Echinococcus multilocularis	solute carrier family 22	0.0029	0.016	0.0175
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0019	0.0048
Giardia lamblia	Lysyl-tRNA synthetase	0.0046	0.0358	0.5182
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0063	0.0558	0.0404
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0558	0.0606
Schistosoma mansoni	glucose transport protein	0.0206	0.2221	0.2281
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0063	0.0558	0.0404
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0543	0.0423

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 19 nM	Inhibition of purified His6-tagged recombinant human HPPD assessed as inhibition of maleylacetoacetate formation after 30 mins by UV/visible spectrophotometry	ChEMBL.	25182962

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3342431

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 935470