Detailed information for compound 936428

Basic information

Technical information
  • TDR Targets ID: 936428
  • Name: [(2S)-1-(cyclohexanecarbonyl)pyrrolidin-2-yl] -[4-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3,17-di hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12, 14,15,16,17-tetradecahydro-1H-cyclopenta[a]ph enanthren-2-yl]piperazin-1-yl]methanone
  • MW: 583.845 | Formula: C35H57N3O4
  • H donors: 2 H acceptors: 4 LogP: 5.34 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1N1CCN(CC1)C(=O)[C@@H]1CCCN1C(=O)C1CCCCC1)C)CC[C@]1([C@H]3CC[C@@H]1O)C
  • InChi: 1S/C35H57N3O4/c1-34-15-14-27-25(26(34)12-13-31(34)40)11-10-24-21-30(39)29(22-35(24,27)2)36-17-19-37(20-18-36)33(42)28-9-6-16-38(28)32(41)23-7-4-3-5-8-23/h23-31,39-40H,3-22H2,1-2H3/t24-,25-,26-,27-,28-,29-,30-,31-,34-,35-/m0/s1
  • InChiKey: JGWZRKHVYBWTRR-CMDDEGKBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [(2S)-1-(cyclohexyl-oxomethyl)-2-pyrrolidinyl]-[4-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]-1-piperazinyl]methanone
  • [(2S)-1-cyclohexylcarbonylpyrrolidin-2-yl]-[4-[(2S,3S,5S,8R,9S,10S,13S,14S,17S)-3,17-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-2-yl]piperazin-1-yl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.021 0.0675 0.0644
Loa Loa (eye worm) phosphatidylinositol 3 0.25 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0501 0.1861 0.1833
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.25 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0876 0.3387 0.3365
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0229 0.0753 0.0722
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0296 0.1025 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0865 0.3345 0.3322
Schistosoma mansoni voltage-gated potassium channel 0.0165 0.0495 0.0495
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0375 0.1348 0.1348
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0522 0.1946 0.1946
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0355 0.1266 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.1622 0.6425 0.6413
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0152 0.0438 0.0438
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.019 0.0595 0.0563
Loa Loa (eye worm) phosphatidylinositol kinase 0.0171 0.0518 0.0518
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0052 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.1495 0.5911 0.5897
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.019 0.0595 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0672 0.2558 0.2533
Giardia lamblia Hypothetical protein 0.0171 0.0518 0.0485
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0229 0.0753 0.0722
Toxoplasma gondii FATC domain-containing protein 0.049 0.1818 0.1881
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.5393 0.5378
Trichomonas vaginalis PIKK family atypical protein kinase 0.1996 0.7951 0.7944
Schistosoma mansoni phosphatidylinositol 4-kinase 0.019 0.0595 0.0595
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.0485
Echinococcus multilocularis serine protein kinase ATM 0.049 0.1818 0.1818
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0876 0.3387 0.3365
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0229 0.0753 0.0753
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.25 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0171 0.0518 0.0485
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.019 0.0595 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.5393 0.5378
Brugia malayi FAT domain containing protein 0.0375 0.1348 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.049 0.1818 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0501 0.1861 0.1833
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.0518 0.5
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0171 0.0518 0.8616
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0288 0.0995 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0518 0.0485
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0319 0.1122 0.1092
Trichomonas vaginalis PIKK family atypical protein kinase 0.1996 0.7951 0.7944
Mycobacterium leprae conserved hypothetical protein 0.0171 0.0518 0.5
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.019 0.0595 0.0595
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1175 0.4607 0.4589
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.019 0.0595 0.0595
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0595 0.0112
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0052 0.0034 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.8474 0.8469
Echinococcus multilocularis Zinc finger, PHD finger 0.019 0.0595 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0876 0.3387 0.3365
Leishmania major phosphatidylinositol 3-kinase, putative 0.019 0.0595 0.0563
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.25 1 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1998 0.7959 0.7952
Trichomonas vaginalis PIKK family atypical protein kinase 0.0319 0.1122 0.1092
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0595 0.0563
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0375 0.1348 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.1495 0.5908 0.5894
Loa Loa (eye worm) phosphatidylinositol 3 0.0483 0.1789 0.1789
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.019 0.0595 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0052 0.0034 0.0034
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0355 0.1266 0.1237
Entamoeba histolytica hypothetical protein 0.0316 0.1109 0.1079
Schistosoma mansoni voltage-gated potassium channel 0.0165 0.0495 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.1366 0.5385 0.537
Schistosoma mansoni immunophilin 0.0052 0.0034 0.0034
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0171 0.0518 0.8616
Trichomonas vaginalis PIKK family atypical protein kinase 0.1495 0.5908 0.5894
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0171 0.0518 0.0485
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.0398 0.0365
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0229 0.0753 0.0722
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.25 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0171 0.0518 0.0485
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0052 0.0034 0.0034
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0316 0.1109 0.1079
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.019 0.0595 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.5393 0.5378
Entamoeba histolytica hypothetical protein 0.0171 0.0518 0.0485
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0355 0.1266 0.1266
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.049 0.1818 0.1818
Schistosoma mansoni immunophilin 0.0045 0.0005 0.0005
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0171 0.0518 0.0485
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0171 0.0518 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1996 0.7951 0.7944
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0355 0.1266 0.1237
Trichomonas vaginalis PIKK family atypical protein kinase 0.049 0.1818 0.1791
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0229 0.0753 0.0722
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0171 0.0518 0.8616
Leishmania major hypothetical protein, unknown function 0.0171 0.0518 0.0485
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.049 0.1818 0.1791
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0914 0.3543 0.3543
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0419 0.1527 0.1527
Leishmania major hypothetical protein, conserved 0.0259 0.0875 0.0844
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.8616
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0005 0.0005
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0914 0.3543 0.3543
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.019 0.0595 0.0563
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.049 0.1818 0.1791
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0914 0.3543 0.3543
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0171 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.049 0.1818 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.1996 0.7951 0.7944
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0005 0.0005
Echinococcus multilocularis 0.0171 0.0518 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.0865 0.3345 0.3322
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.25 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0229 0.0753 0.0753
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.25 1 1
Entamoeba histolytica hypothetical protein 0.049 0.1818 0.1791
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0229 0.0753 0.0722
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0914 0.3543 0.3521
Trichomonas vaginalis PIKK family atypical protein kinase 0.1495 0.5908 0.5894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0865 0.3345 0.3322
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0914 0.3543 0.3543
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0034 0.0034
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0152 0.0438 0.0438
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0171 0.0518 0.0518
Giardia lamblia GTOR 0.25 1 1
Loa Loa (eye worm) hypothetical protein 0.0546 0.2044 0.2044
Loa Loa (eye worm) phosphatidylinositol 3 0.0171 0.0518 0.0518
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0249 0.0837 0.0806
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0152 0.0438 0.0438
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0288 0.0995 0.0995
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0546 0.2044 0.2207
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1998 0.7959 0.7952
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.25 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0052 0.0034 0.5
Loa Loa (eye worm) FKBP5 protein 0.0052 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0045 0.0005 0.0005
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0167 0.0501 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0319 0.1122 0.1092
Loa Loa (eye worm) hypothetical protein 0.0501 0.1862 0.1862
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0355 0.1266 0.1237
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0171 0.0518 0.0518
Trichomonas vaginalis conserved hypothetical protein 0.0375 0.1348 0.1318
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.8616
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.019 0.0595 0.0112
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0914 0.3543 0.3521
Schistosoma mansoni fkbp-rapamycin associated protein 0.049 0.1818 0.1818
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0171 0.0518 0.0518
Loa Loa (eye worm) phosphatidylinositol 3 0.0171 0.0518 0.0518
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.25 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.019 0.0595 0.0563
Leishmania major phosphatidylinositol kinase related protein, putative 0.0171 0.0518 0.0485
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.019 0.0595 0.0563
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.019 0.0595 0.0563
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Schistosoma mansoni hypothetical protein 0.0171 0.0518 0.0518
Entamoeba histolytica hypothetical protein 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.1366 0.5385 0.537
Loa Loa (eye worm) phosphatidylinositol 3 0.0171 0.0518 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.1495 0.5911 0.5897
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Entamoeba histolytica protein kinase rad3, putative 0.049 0.1818 0.1791
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0142 0.0398 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.1677 0.665 0.6639
Entamoeba histolytica hypothetical protein 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Leishmania major phosphatidylinositol kinase, putative 0.0171 0.0518 0.0485
Trypanosoma cruzi target of rapamycin kinase 3 0.1998 0.7959 0.7952
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.049 0.1818 0.1818
Schistosoma mansoni immunophilin 0.0052 0.0034 0.0034
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0171 0.0518 0.0518
Giardia lamblia Phosphatidylinositol 4-kinase 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.1869 0.7434 0.7425
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.25 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.25 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0288 0.0995 0.0995
Echinococcus multilocularis fk506 binding protein 0.0052 0.0034 0.0034
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0229 0.0753 0.0722
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0184 0.057 0.0538
Plasmodium vivax hypothetical protein, conserved 0.0171 0.0518 0.8616
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0522 0.1946 0.1946
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0171 0.0518 0.0518
Loa Loa (eye worm) hypothetical protein 0.0319 0.1122 0.1122
Loa Loa (eye worm) phosphatidylinositol 3 0.0171 0.0518 0.0518
Echinococcus granulosus serine:threonine protein kinase SMG1 0.049 0.1818 0.1818
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0171 0.0518 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.25 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0546 0.2044 0.2017
Loa Loa (eye worm) hypothetical protein 0.0067 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.1996 0.7951 0.7944
Trichomonas vaginalis PIKK family atypical protein kinase 0.1368 0.5393 0.5378
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0171 0.0518 0.0485
Trypanosoma cruzi hypothetical protein, conserved 0.0088 0.0179 0.0146
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.0485
Schistosoma mansoni hypothetical protein 0.0375 0.1348 0.1348
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0171 0.0518 0.0518
Plasmodium vivax hypothetical protein 0.0171 0.0518 0.8616
Trichomonas vaginalis PIKK family atypical protein kinase 0.1366 0.5385 0.537
Trichomonas vaginalis PIKK family atypical protein kinase 0.25 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0876 0.3387 0.3387
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.049 0.1818 0.1791
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0171 0.0518 0.0485
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0171 0.0518 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.049 0.1818 0.1791
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0865 0.3345 0.3322
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0171 0.0518 0.0518
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.019 0.0595 0.0595
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0355 0.1266 0.1237
Echinococcus granulosus serine protein kinase ATM 0.049 0.1818 0.1818
Toxoplasma gondii target of rapamycin (TOR), putative 0.1869 0.7434 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0357 0.0357
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.019 0.0595 0.0563
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0152 0.0438 0.0438
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0355 0.1266 0.1237
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0171 0.0518 0.0518
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0257 0.0867 0.0836
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0057 0.0057
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.0057 0.0023
Loa Loa (eye worm) hypothetical protein 0.0288 0.0995 0.0995
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.049 0.1818 0.1818
Loa Loa (eye worm) hypothetical protein 0.0171 0.0518 0.0518
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0052 0.0034 0.0034
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0052 0.0034 0.0034
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.019 0.0595 0.0595
Onchocerca volvulus 0.0171 0.0518 0.5
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.25 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0865 0.3345 0.3322
Loa Loa (eye worm) hypothetical protein 0.0375 0.1348 0.1348
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.019 0.0595 0.0563
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.25 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0229 0.0753 0.0722
Onchocerca volvulus 0.0171 0.0518 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.019 0.0595 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0419 0.1527 0.1527
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0522 0.1946 0.1946
Leishmania major phosphatidylinositol 3-kinase, putative 0.0865 0.3345 0.3322
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1049 0.4093 0.4073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0296 0.1025 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0171 0.0518 0.0485
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0052 0.0034 0.0034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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