Detailed information for compound 936671

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 631.785 | Formula: C34H41N5O5S
  • H donors: 3 H acceptors: 6 LogP: 3.4 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: O[C@@H]1C[C@H](N(C1)C(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)C)C(=O)NCc1ccc(cc1)c1scnc1C
  • InChi: 1S/C34H41N5O5S/c1-20-29(45-19-36-20)23-12-10-22(11-13-23)16-35-31(42)28-15-26(41)18-39(28)33(44)30(34(3,4)5)37-32(43)27-14-24-8-6-7-9-25(24)17-38(27)21(2)40/h6-13,19,26-28,30,41H,14-18H2,1-5H3,(H,35,42)(H,37,43)/t26-,27+,28+,30-/m1/s1
  • InChiKey: WKPWNIOEWRMFEX-GPRIDDLASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_134630 All targets in OG5_134630
Brugia malayi hypothetical protein Get druggable targets OG5_134630 All targets in OG5_134630
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_134630 All targets in OG5_134630
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0882 0.1814 0.1757
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.0463
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.053 0.053
Schistosoma mansoni fkbp-rapamycin associated protein 0.0882 0.1814 0.1814
Leishmania major hypothetical protein, conserved 0.0403 0.0748 0.0653
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0098 0.0068 0.0068
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0577 0.1135 0.1073
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.7944 0.7943
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0113 0.0103 0.0095
Leishmania major phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.0431
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0305 0.053 0.8999
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0882 0.1814 0.1757
Loa Loa (eye worm) hypothetical protein 0.0577 0.1135 0.1135
Giardia lamblia Hypothetical protein 0.0305 0.053 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.5377 0.5374
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0577 0.0479
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0511 0.0988 0.0981
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0103 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0305 0.053 0.0523
Trichomonas vaginalis fk506-binding protein, putative 0.0113 0.0103 0.0095
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4561 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.037 0.0673 0.0667
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0232 0.0367 0.0367
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.0103 0.0103
Plasmodium vivax hypothetical protein, conserved 0.0305 0.053 0.8999
Trichomonas vaginalis PIKK family atypical protein kinase 0.2717 0.5896 0.5893
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0305 0.053 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5369 0.5366
Leishmania major phosphatidylinositol kinase related protein, putative 0.0305 0.053 0.0431
Loa Loa (eye worm) phosphatidylinositol 3 0.0654 0.1307 0.1307
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0511 0.0988 0.0981
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0113 0.0103 0.0095
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0326 0.0577 0.057
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0698 0.1403 0.1403
Trichomonas vaginalis PIKK family atypical protein kinase 0.2726 0.5918 0.5915
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0677 0.1358 0.1358
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0326 0.0577 0.057
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.0988 0.0988
Trypanosoma brucei target of rapamycin kinase 3, putative 0.364 0.7952 0.7951
Schistosoma mansoni immunophilin 0.0113 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0098 0.0068 0.0068
Entamoeba histolytica hypothetical protein 0.0468 0.0891 0.0885
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0232 0.0367 0.0367
Loa Loa (eye worm) hypothetical protein 0.0436 0.0821 0.0821
Mycobacterium tuberculosis Conserved hypothetical protein 0.0305 0.053 0.5
Brugia malayi Protein kinase domain containing protein 0.1004 0.2084 0.2084
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0103 0.0095
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4561 1 1
Entamoeba histolytica hypothetical protein 0.0305 0.053 0.0523
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0113 0.0103 0.0095
Schistosoma mansoni voltage-gated potassium channel 0.0253 0.0414 0.0414
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1614 0.3443 0.3443
Trichomonas vaginalis PIKK family atypical protein kinase 0.156 0.3321 0.3317
Trichomonas vaginalis PIKK family atypical protein kinase 0.2726 0.5918 0.5915
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1614 0.3443 0.3443
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0401 0.0743 0.0647
Loa Loa (eye worm) hypothetical protein 0.0075 0.0017 0.0017
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0882 0.1814 0.1814
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4561 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.037 0.0673 0.0667
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4561 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.156 0.3321 0.3317
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0326 0.0577 0.0577
Schistosoma mansoni immunophilin 0.0113 0.0103 0.0103
Echinococcus granulosus serine protein kinase ATM 0.0882 0.1814 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.7944 0.7943
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1614 0.3443 0.3397
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0305 0.053 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 0.1814 0.1808
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0326 0.0577 0.057
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.8999
Trichomonas vaginalis immunophilin, putative 0.0113 0.0103 0.0095
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1614 0.3443 0.3397
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0821 0.0821
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0698 0.1403 0.1403
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1614 0.3443 0.3443
Trichomonas vaginalis PIKK family atypical protein kinase 0.1225 0.2577 0.2572
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0326 0.0577 0.0577
Trichomonas vaginalis PIKK family atypical protein kinase 0.2717 0.5896 0.5893
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0305 0.053 0.053
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0187 0.0266 0.0266
Schistosoma mansoni voltage-gated potassium channel 0.0253 0.0414 0.0414
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.053 0.053
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0113 0.0103 0.0103
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0326 0.0577 0.0069
Schistosoma mansoni immunophilin 0.0098 0.0068 0.0068
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0582 0.1147 0.1147
Trichomonas vaginalis PIKK family atypical protein kinase 0.2959 0.6437 0.6434
Trichomonas vaginalis conserved hypothetical protein 0.0982 0.2037 0.2031
Brugia malayi FAT domain containing protein 0.0677 0.1358 0.1358
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0305 0.053 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.156 0.3321 0.3317
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0511 0.0988 0.0925
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1571 0.3347 0.3342
Brugia malayi hypothetical protein 0.0416 0.0775 0.0775
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0113 0.0103 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4561 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0894 0.184 0.1834
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4561 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.037 0.0673 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.4561 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0348 0.0626 0.0529
Loa Loa (eye worm) phosphatidylinositol 3 0.1571 0.3347 0.3347
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.037 0.0673 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3883 0.8493 0.8492
Echinococcus multilocularis fk506 binding protein 0.0113 0.0103 0.0103
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.053 0.053
Leishmania major phosphatidylinositol 3-kinase, putative 0.0326 0.0577 0.0479
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0326 0.0577 0.057
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2149 0.4633 0.4629
Echinococcus multilocularis Zinc finger, PHD finger 0.0326 0.0577 0.0577
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0577 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.7944 0.7943
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0511 0.0988 0.0981
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0113 0.0103 0.0095
Loa Loa (eye worm) phosphatidylinositol kinase 0.0305 0.053 0.053
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0445 0.084 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.053 0.0523
Loa Loa (eye worm) hypothetical protein 0.092 0.1898 0.1898
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0326 0.0577 0.0577
Entamoeba histolytica hypothetical protein 0.0882 0.1814 0.1808
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.5377 0.5374
Loa Loa (eye worm) hypothetical protein 0.0677 0.1358 0.1358
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0326 0.0577 0.0577
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4561 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0725 0.0718
Onchocerca volvulus 0.0305 0.053 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1571 0.3347 0.3342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0882 0.1814 0.1808
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.8999
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.5377 0.5374
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.037 0.0673 0.0673
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.7944 0.7943
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0882 0.1814 0.1814
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0326 0.0577 0.057
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0305 0.053 0.8999
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0882 0.1814 0.1814
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0821 0.0821
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0206 0.0309 0.0302
Loa Loa (eye worm) hypothetical protein 0.0201 0.0298 0.0298
Entamoeba histolytica hypothetical protein 0.0305 0.053 0.0523
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0821 0.0821
Giardia lamblia Phosphatidylinositol 4-kinase 0.0305 0.053 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0577 0.1135 0.1129
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0103 0.0033
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0326 0.0577 0.0577
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0232 0.0367 0.0367
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0882 0.1814 0.1814
Toxoplasma gondii target of rapamycin (TOR), putative 0.3404 0.7425 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0582 0.1147 0.1147
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0326 0.0577 1
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0305 0.053 0.053
Leishmania major phosphatidylinositol 3-kinase, putative 0.156 0.3321 0.3252
Loa Loa (eye worm) hypothetical protein 0.0882 0.1814 0.1814
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0305 0.053 0.0463
Plasmodium vivax hypothetical protein 0.0305 0.053 0.8999
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0882 0.1814 0.1808
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1571 0.3347 0.3278
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4561 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0305 0.053 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5369 0.5366
Echinococcus multilocularis 0.0305 0.053 0.053
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0677 0.1358 0.1358
Schistosoma mansoni hypothetical protein 0.0305 0.053 0.053
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0333 0.0326
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0305 0.053 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.2483 0.5377 0.5374
Trichomonas vaginalis PIKK family atypical protein kinase 0.3637 0.7944 0.7943
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0113 0.0103 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1906 0.4093 0.4089
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.053 0.053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0468 0.0891 0.0885
Trichomonas vaginalis PIKK family atypical protein kinase 0.156 0.3321 0.3317
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0982 0.2037 0.2186
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0698 0.1403 0.1403
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0326 0.0577 0.0577
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0326 0.0577 0.0577
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.037 0.0673 0.0667
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4561 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.007 0.0007 0.0007
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0326 0.0577 1
Schistosoma mansoni hypothetical protein 0.0677 0.1358 0.1358
Trichomonas vaginalis PIKK family atypical protein kinase 0.156 0.3321 0.3317
Loa Loa (eye worm) FKBP5 protein 0.0113 0.0103 0.0103
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0098 0.0068 0.0068
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4561 1 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.053 0.053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.037 0.0673 0.0667
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0103 0.0033
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0113 0.0103 0.0103
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.053 0.053
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Onchocerca volvulus 0.0305 0.053 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2726 0.5918 0.5915
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5369 0.5366
Entamoeba histolytica hypothetical protein 0.0305 0.053 0.0523
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0305 0.053 0.0463
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0577 0.057
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0326 0.0577 0.0069
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.053 0.053
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.053 0.053
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.037 0.0673 0.0667
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4561 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0882 0.1814 0.1814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.053 0.0523
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.037 0.0673 0.0673
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1614 0.3443 0.3443
Trichomonas vaginalis conserved hypothetical protein 0.0677 0.1358 0.1352
Mycobacterium leprae conserved hypothetical protein 0.0305 0.053 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0577 0.1135 0.1129
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0305 0.053 0.0523
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0894 0.184 0.1834
Brugia malayi Protein kinase domain containing protein 0.007 0.0007 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0511 0.0988 0.0925
Leishmania major hypothetical protein, unknown function 0.0305 0.053 0.0431
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0113 0.0103 0.0103
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0113 0.0103 0.0103
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0113 0.0103 0.0103
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0113 0.0103 0.0033
Giardia lamblia GTOR 0.4561 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.364 0.7952 0.7938
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.1004 0.2084 0.2084
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0217 0.0333 0.0326
Schistosoma mansoni serine/threonine protein kinase 0.1004 0.2084 0.2084
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4561 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0305 0.053 0.8999
Echinococcus multilocularis serine protein kinase ATM 0.0882 0.1814 0.1814
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0511 0.0988 0.0981
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.053 0.053
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.0463
Loa Loa (eye worm) hypothetical protein 0.0982 0.2037 0.2037
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.053 0.053
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0577 0.0511
Loa Loa (eye worm) hypothetical protein 0.0416 0.0775 0.0775
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0113 0.0103 0.0103
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0445 0.084 0.0833
Trichomonas vaginalis PIKK family atypical protein kinase 0.4561 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.4561 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0305 0.053 0.0523
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.053 0.053
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0113 0.0103 0.0033
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.364 0.7952 0.7931
Toxoplasma gondii FATC domain-containing protein 0.0882 0.1814 0.1863
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.053 0.053
Leishmania major phosphatidylinositol kinase, putative 0.0305 0.053 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.3404 0.7425 0.7423
Trichomonas vaginalis PIKK family atypical protein kinase 0.306 0.6659 0.6657
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0232 0.0367 0.0367
Entamoeba histolytica protein kinase rad3, putative 0.0882 0.1814 0.1808

Activities

Activity type Activity value Assay description Source Reference
Kd (binding) = 2.32 uM Binding affinity to N-terminal His6-tagged pVHL (54 to 213 amino acids) (unknown origin) expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry ChEMBL. 25166285

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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