Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A3 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 307 aa | 26.4 % |
Schistosoma japonicum | ko:K04209 neuropeptide Y receptor, invertebrate, putative | Adenosine A2a receptor | 410 aa | 352 aa | 23.6 % |
Echinococcus granulosus | allatostatin A receptor | Adenosine A2a receptor | 410 aa | 368 aa | 22.6 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A1 receptor | 326 aa | 300 aa | 24.3 % |
Schistosoma japonicum | Rhodopsin, putative | Adenosine A3 receptor | 320 aa | 320 aa | 23.8 % |
Echinococcus granulosus | thyrotropin releasing hormone receptor | Adenosine A2a receptor | 410 aa | 342 aa | 23.1 % |
Schistosoma japonicum | ko:K04136 adrenergic receptor, alpha 1b, putative | Adenosine A2a receptor | 410 aa | 366 aa | 25.4 % |
Echinococcus multilocularis | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Schistosoma mansoni | adenoreceptor | Adenosine A3 receptor | 320 aa | 319 aa | 27.9 % |
Echinococcus multilocularis | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 282 aa | 24.1 % |
Echinococcus granulosus | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 290 aa | 23.4 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 350 aa | 24.9 % | |
Schistosoma japonicum | ko:K04255 opsin 4 (melanopsin), putative | Adenosine A3 receptor | 320 aa | 370 aa | 21.4 % |
Echinococcus granulosus | tachykinin peptides receptor 99D | Adenosine A3 receptor | 320 aa | 297 aa | 26.6 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 295 aa | 23.4 % | |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 306 aa | 23.5 % |
Onchocerca volvulus | Adenosine A2a receptor | 410 aa | 356 aa | 23.9 % | |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 320 aa | 24.4 % | |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 311 aa | 23.5 % | |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 308 aa | 20.5 % | |
Schistosoma mansoni | opsin-like receptor | Adenosine A3 receptor | 320 aa | 300 aa | 22.0 % |
Schistosoma japonicum | Alpha-1A adrenergic receptor, putative | Adenosine A3 receptor | 320 aa | 325 aa | 24.9 % |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | Adenosine A2a receptor | 410 aa | 342 aa | 23.1 % |
Brugia malayi | hypothetical protein | Adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Schistosoma mansoni | dro/myosuppressin receptor | Adenosine A1 receptor | 326 aa | 326 aa | 22.1 % |
Echinococcus multilocularis | allatostatin A receptor | Adenosine A2a receptor | 410 aa | 372 aa | 22.8 % |
Loa Loa (eye worm) | hypothetical protein | Adenosine A3 receptor | 320 aa | 309 aa | 24.9 % |
Schistosoma japonicum | 5-hydroxytryptamine receptor 4, putative | Adenosine A3 receptor | 320 aa | 311 aa | 27.3 % |
Schistosoma mansoni | neuropeptide receptor | Adenosine A3 receptor | 320 aa | 286 aa | 21.3 % |
Schistosoma mansoni | biogenic amine (5HT) receptor | Adenosine A2a receptor | 410 aa | 399 aa | 28.1 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 288 aa | 20.8 % | |
Schistosoma japonicum | ko:K04135 adrenergic receptor, alpha 1a, putative | Adenosine A2a receptor | 410 aa | 346 aa | 28.3 % |
Onchocerca volvulus | Mitochondrial inner membrane protein homolog | Adenosine A2a receptor | 410 aa | 340 aa | 27.9 % |
Onchocerca volvulus | Adenosine A2a receptor | 410 aa | 337 aa | 23.1 % | |
Schistosoma japonicum | ko:K04134 cholinergic receptor, invertebrate, putative | Adenosine A3 receptor | 320 aa | 332 aa | 24.4 % |
Onchocerca volvulus | Adenosine A3 receptor | 320 aa | 282 aa | 20.6 % | |
Onchocerca volvulus | Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog | Adenosine A1 receptor | 326 aa | 286 aa | 22.7 % |
Loa Loa (eye worm) | neuropeptide F receptor | Adenosine A3 receptor | 320 aa | 321 aa | 24.0 % |
Schistosoma mansoni | peptide (allatostatin)-like receptor | Adenosine A3 receptor | 320 aa | 296 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2229 | 1 | 1 |
Schistosoma mansoni | solute carrier family 33 (acetyl-CoA transporter | 0.2229 | 1 | 1 |
Echinococcus granulosus | solute carrier family 33 | 0.2229 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2229 | 1 | 0.5 |
Plasmodium falciparum | acetyl-CoA transporter, putative | 0.2229 | 1 | 0.5 |
Echinococcus multilocularis | solute carrier family 33 | 0.2229 | 1 | 0.5 |
Toxoplasma gondii | Acetyl-coenzyme A transporter, putative | 0.2229 | 1 | 0.5 |
Brugia malayi | Protein C21B10.09 in chromosome II | 0.2229 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 16.8 nM | Binding affinity against adenosine A2A receptor in rat striatal membranes using [3H]-CGS- 21680. | ChEMBL. | 9703463 |
Ki (binding) | = 405 nM | Binding affinity against rat adenosine A3 receptor expressed in CHO cells using [125I]-. | ChEMBL. | 9703463 |
Ki (binding) | = 725 nM | Binding affinity against adenosine A1 receptor in rat brain membranes using [3H]-R-PIA. | ChEMBL. | 9703463 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.