TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.2 | Formula: C14H15BrN4
H donors: 1 H acceptors: 2 LogP: 2.82 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: N#CCCC[n+]1nc(ccc1N)c1ccccc1.[Br-]
InChi: 1S/C14H14N4.BrH/c15-10-4-5-11-18-14(16)9-8-13(17-18)12-6-2-1-3-7-12;/h1-3,6-9,16H,4-5,11H2;1H
InChiKey: ZKPPQBGECDFXAD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0088	0.0639	0.0925
Onchocerca volvulus		0.0048	0.0042	0.0006
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Onchocerca volvulus		0.0421	0.5559	1
Brugia malayi	carbohydrate phosphorylase	0.0107	0.0917	0.1329
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0382	0.4983	0.4983
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0089	0.065	0.0707
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Plasmodium vivax	serine-repeat antigen (SERA)	0.0088	0.0639	0.1149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Loa Loa (eye worm)	trypsin family protein	0.0048	0.0042	0.006
Trypanosoma cruzi	cysteine proteinase, putative	0.0223	0.2634	0.3814
Onchocerca volvulus		0.0048	0.0042	0.0006
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0219	0.2577	0.2803
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0219	0.2577	0.3732
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	Trypsin family protein	0.0048	0.0042	0.006
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0089	0.065	0.0941
Leishmania major	cysteine peptidase A (CPA)	0.0421	0.5559	0.7988
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.0639	0.0695
Entamoeba histolytica	glycogenphosphorylase, putative	0.0046	0.0017	0.0031
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Echinococcus multilocularis	prolyl endopeptidase	0.0315	0.3993	0.3993
Schistosoma mansoni	cathepsin C	0.0088	0.0639	0.0695
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0088	0.0639	0.1149
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.2634	0.3815
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0088	0.0639	0.1149
Schistosoma mansoni	calpain C (C02 family)	0.006	0.0221	0.024
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0512	0.6904	0.751
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0042
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Brugia malayi	cathepsin L-like precursor	0.0286	0.3564	0.5163
Schistosoma mansoni	microtubule-associated protein tau	0.0667	0.9193	1
Giardia lamblia	Glycogen phosphorylase	0.0107	0.0917	0.356
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Plasmodium falciparum	serine repeat antigen 7	0.0088	0.0639	0.1149
Leishmania major	cathepsin L-like protease	0.0512	0.6904	1
Toxoplasma gondii	cathepsin CPC1	0.0088	0.0639	0.1149
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0421	0.5559	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0512	0.6904	0.9999
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0089	0.065	0.065
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0219	0.2577	0.3732
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0315	0.3993	0.7163
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0088	0.0639	0.1149
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1491	0.216
Loa Loa (eye worm)	hypothetical protein	0.0315	0.3993	0.5784
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0512	0.6904	0.751
Trypanosoma cruzi	cysteine peptidase, putative	0.0512	0.6904	0.9999
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0167	0.1796	0.1796
Onchocerca volvulus		0.0048	0.0042	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1326	0.1921
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0203	0.2329	0.2533
Giardia lamblia	Encystation-specific protease	0.0088	0.0639	0.2479
Echinococcus granulosus	cysteine protease	0.0223	0.2634	0.2634
Mycobacterium ulcerans	hypothetical protein	0.0048	0.0042	0.0188
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0512	0.6904	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.0639	0.0695
Brugia malayi	Cytochrome P450 family protein	0.0051	0.0079	0.0115
Echinococcus multilocularis	glycogen phosphorylase	0.0107	0.0917	0.0917
Entamoeba histolytica	cysteine proteinase, putative	0.0421	0.5559	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Schistosoma mansoni	calpain-7 (C02 family)	0.006	0.0221	0.024
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0088	0.0639	0.1149
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0133	0.1306	0.1892
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0421	0.5559	0.5559
Trypanosoma cruzi	cruzipain precursor, putative	0.0135	0.1326	0.1921
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0639	0.1149
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0315	0.3993	0.4343
Leishmania major	cathepsin L-like protease	0.0512	0.6904	1
Loa Loa (eye worm)	prolyl oligopeptidase	0.0203	0.2329	0.3373
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0088	0.0639	0.1149
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0219	0.2577	0.3525
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0048	0.0042	0.0042
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0203	0.2329	0.2329
Schistosoma mansoni	glycogen phosphorylase	0.0107	0.0917	0.0998
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0088	0.0639	0.0925
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0088	0.0639	0.1149
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0167	0.1796	0.1953
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0286	0.3564	0.6412
Plasmodium falciparum	serine repeat antigen 4	0.0088	0.0639	0.1149
Brugia malayi	cathepsin F-like cysteine proteinase	0.0088	0.0639	0.0925
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.0221	0.032
Echinococcus multilocularis	transmembrane protease serine 3	0.0048	0.0042	0.0042
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0048	0.0042	0.006
Onchocerca volvulus		0.0088	0.0639	0.1088
Schistosoma mansoni	glycogen phosphorylase	0.0046	0.0017	0.0019
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Echinococcus multilocularis	cathepsin b	0.0512	0.6904	0.6904
Toxoplasma gondii	prolyl endopeptidase	0.0315	0.3993	0.7183
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Echinococcus multilocularis	calpain A	0.0167	0.1796	0.1796
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0088	0.0639	0.1149
Onchocerca volvulus	Cathepsin L homolog	0.0088	0.0639	0.1088
Echinococcus multilocularis	calpain 5	0.006	0.0221	0.0221
Trypanosoma brucei	calpain-like protein, putative	0.006	0.0221	0.032
Trypanosoma cruzi	oligopeptidase b	0.0133	0.1306	0.1892
Plasmodium falciparum	serine repeat antigen 1	0.0088	0.0639	0.1149
Trypanosoma cruzi	cysteine peptidase, putative	0.0512	0.6904	0.9999
Plasmodium falciparum	serine repeat antigen 6	0.0088	0.0639	0.1149
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1133	0.164
Onchocerca volvulus		0.0099	0.08	0.1379
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0088	0.0639	0.1149
Schistosoma mansoni	glycogen phosphorylase	0.0107	0.0917	0.0998
Brugia malayi	prolyl oligopeptidase family protein	0.0203	0.2329	0.3373
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0107	0.0917	0.1592
Schistosoma mansoni	calpain-7 (C02 family)	0.006	0.0221	0.024
Trypanosoma cruzi	major cysteine proteinase, putative	0.0179	0.1984	0.2873
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0088	0.0639	0.1149
Brugia malayi	Cathepsin L-like precursor	0.0286	0.3564	0.5163
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0382	0.4983	0.542
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Loa Loa (eye worm)	calpain	0.006	0.0221	0.032
Schistosoma mansoni	hypothetical protein	0.0183	0.2038	0.2217
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0088	0.0639	0.1149
Onchocerca volvulus		0.0421	0.5559	1
Giardia lamblia	Cysteine protease	0.0088	0.0639	0.2479
Schistosoma mansoni	hypothetical protein	0.0048	0.0042	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0038	0.0056
Schistosoma mansoni	hypothetical protein	0.0183	0.2038	0.2217
Chlamydia trachomatis	glycogen phosphorylase	0.0107	0.0917	0.5
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0089	0.065	0.065
Echinococcus multilocularis	cathepsin L cysteine protease	0.0421	0.5559	0.5559
Trypanosoma brucei	calpain-like protein, putative	0.006	0.0221	0.032
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0088	0.0639	0.1149
Echinococcus multilocularis	calpain 7 (C02 family)	0.006	0.0221	0.0221
Toxoplasma gondii	cathepsin CPC2	0.0088	0.0639	0.1149
Plasmodium falciparum	serine repeat antigen 9	0.0088	0.0639	0.1149
Echinococcus multilocularis	microtubule associated protein 2	0.0667	0.9193	0.9193
Giardia lamblia	Hypothetical protein	0.0088	0.0639	0.2479
Trypanosoma cruzi	major cysteine proteinase, putative	0.0088	0.0639	0.0925
Leishmania major	cathepsin L-like protease	0.0421	0.5559	0.7988
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Schistosoma mansoni	calpain (C02 family)	0.006	0.0221	0.024
Trypanosoma cruzi	cysteine peptidase, putative	0.0223	0.2634	0.3814
Schistosoma mansoni	cathepsin B (C01 family)	0.0088	0.0639	0.0695
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0107	0.0917	0.0917
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0421	0.5559	0.5559
Onchocerca volvulus		0.0048	0.0042	0.0006
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0088	0.0639	0.1149
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Plasmodium vivax	unspecified product	0.0223	0.2634	0.4737
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0088	0.0639	0.2479
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.2634	0.4737
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0088	0.0639	0.2479
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.006	0.0221	0.032
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0167	0.1796	0.1796
Echinococcus multilocularis	cysteine protease	0.0421	0.5559	0.5559
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.0221	0.032
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0088	0.0639	0.1149
Trypanosoma cruzi	cysteine peptidase, putative	0.0421	0.5559	0.8052
Loa Loa (eye worm)	hypothetical protein	0.0421	0.5559	0.8052
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0377	0.4909	0.711
Echinococcus multilocularis	glycoprotein Antigen 5	0.0048	0.0042	0.0042
Plasmodium vivax	calpain, putative	0.006	0.0221	0.0397
Giardia lamblia	Hypothetical protein	0.0088	0.0639	0.2479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Onchocerca volvulus		0.0421	0.5559	1
Echinococcus multilocularis	calpain family protein 1, d	0.0117	0.1067	0.1067
Echinococcus multilocularis	cathepsin b	0.0512	0.6904	0.6904
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0286	0.3564	0.6412
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0089	0.065	0.0941
Echinococcus multilocularis	cathepsin L	0.0223	0.2634	0.2634
Entamoeba histolytica	glycogen phosphorylase, putative	0.0107	0.0917	0.165
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0088	0.0639	0.1149
Onchocerca volvulus		0.0146	0.1491	0.2631
Brugia malayi	Trypsin family protein	0.0048	0.0042	0.006
Brugia malayi	Papain family cysteine protease containing protein	0.0088	0.0639	0.0925
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Echinococcus granulosus	cathepsin b	0.0512	0.6904	0.6904
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0088	0.0639	0.0695
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Plasmodium falciparum	serine repeat antigen 3	0.0088	0.0639	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Brugia malayi	Papain family cysteine protease containing protein	0.0223	0.2634	0.3814
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0088	0.0639	0.0925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.006	0.0221	0.032
Entamoeba histolytica	glycogen phosphorylase, putative	0.0046	0.0017	0.0031
Brugia malayi	Trypsin family protein	0.0048	0.0042	0.006
Giardia lamblia	Cathepsin B precursor	0.0088	0.0639	0.2479
Schistosoma mansoni	hypothetical protein	0.0048	0.0042	0.0045
Echinococcus granulosus	prolyl endopeptidase	0.0315	0.3993	0.3993
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	Cathepsin L-like precursor	0.0135	0.1326	0.1921
Echinococcus granulosus	cathepsin l1	0.0286	0.3564	0.3564
Echinococcus granulosus	glycoprotein Antigen 5	0.0048	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3564	0.5163
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0088	0.0639	0.1149
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.2634	0.4737
Trypanosoma cruzi	prolyl endopeptidase	0.0315	0.3993	0.5784
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0088	0.0639	0.1149
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0223	0.2634	0.2865
Entamoeba histolytica	cysteine proteinase 2	0.0223	0.2634	0.4737
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0088	0.0639	0.0695
Loa Loa (eye worm)	cytochrome P450 family protein	0.0051	0.0079	0.0115
Toxoplasma gondii	cathepsin B	0.0219	0.2577	0.4635
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0203	0.2329	0.4149
Loa Loa (eye worm)	hypothetical protein	0.0099	0.08	0.1158
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0088	0.0639	0.2479
Echinococcus granulosus	calpain 7 C02 family	0.006	0.0221	0.0221
Loa Loa (eye worm)	cathepsin B	0.0219	0.2577	0.3732
Echinococcus granulosus	cathepsin L	0.0088	0.0639	0.0639
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	0.1326	0.1921
Onchocerca volvulus	Cathepsin L homolog	0.0421	0.5559	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.0221	0.032
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0167	0.1796	0.1953
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Brugia malayi	cathepsin L precursor	0.0088	0.0639	0.0925
Brugia malayi	cathepsin B-like cysteine proteinase	0.0512	0.6904	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0088	0.0639	0.1149
Echinococcus multilocularis	calpain	0.006	0.0221	0.0221
Entamoeba histolytica	cysteine proteinase, putative	0.0286	0.3564	0.6412
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Leishmania major	cathepsin L-like protease	0.0512	0.6904	1
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.2634	0.4737
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0223	0.2634	0.3814
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0203	0.2329	0.2329
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.027	0.3325	1
Entamoeba histolytica	glycogen phosphorylase, putative	0.0107	0.0917	0.165
Brugia malayi	Papain family cysteine protease containing protein	0.0088	0.0639	0.0925
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Loa Loa (eye worm)	calpain family protein 1	0.0117	0.1067	0.1546
Entamoeba histolytica	cysteine protease, putative	0.0088	0.0639	0.1149
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0223	0.2634	0.2865
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3564	0.5163
Trypanosoma cruzi	cysteine proteinase, putative	0.0223	0.2634	0.3814
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Echinococcus granulosus	calpain 5	0.006	0.0221	0.0221
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0088	0.0639	0.1149
Schistosoma mansoni	Mername-AA248 (C02 family)	0.006	0.0221	0.024
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0133	0.1306	0.1892
Plasmodium falciparum	serine repeat antigen 5	0.0088	0.0639	0.1149
Echinococcus granulosus	microtubule associated protein 2	0.0667	0.9193	0.9193
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0088	0.0639	0.1149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1326	0.1921
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Echinococcus multilocularis	expressed protein	0.0721	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0421	0.5559	1
Echinococcus multilocularis	Mastin	0.0048	0.0042	0.0042
Leishmania major	cathepsin L-like protease	0.0421	0.5559	0.7988
Loa Loa (eye worm)	ctsf protein	0.0421	0.5559	0.8052
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0048	0.0042	0.0045
Brugia malayi	Trypsin-like protease protein 5	0.0048	0.0042	0.006
Loa Loa (eye worm)	fibroinase	0.0421	0.5559	0.8052
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0512	0.6904	0.751
Trypanosoma cruzi	cruzipain precursor, putative	0.0512	0.6904	0.9999
Trypanosoma brucei	calpain-like protein, putative	0.006	0.0221	0.032
Brugia malayi	cathepsin F-like cysteine proteinase	0.0135	0.1326	0.1921
Giardia lamblia	Cathepsin B precursor	0.0219	0.2577	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0286	0.3564	0.3877
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0315	0.3993	0.5645
Giardia lamblia	Cathepsin L-like protease	0.0088	0.0639	0.2479
Echinococcus granulosus	geminin	0.0183	0.2038	0.2038
Echinococcus granulosus	glycogen phosphorylase	0.0107	0.0917	0.0917
Echinococcus granulosus	calpain	0.006	0.0221	0.0221
Echinococcus multilocularis	tumor protein p63	0.0326	0.416	0.416
Echinococcus multilocularis	cathepsin L cysteine protease	0.0421	0.5559	0.5559
Entamoeba histolytica	hypothetical protein	0.0088	0.0639	0.1149
Echinococcus granulosus	Mastin	0.0048	0.0042	0.0042
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0089	0.065	0.0941
Plasmodium vivax	unspecified product	0.0135	0.1326	0.2386
Schistosoma mansoni	cathepsin s	0.0135	0.1326	0.1443
Plasmodium vivax	serine-repeat antigen (SERA)	0.0088	0.0639	0.1149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.2634	0.4737
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Giardia lamblia	Cysteine protease	0.0088	0.0639	0.2479
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0421	0.5559	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	Papain family cysteine protease containing protein	0.0421	0.5559	0.8052
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0159	0.1689	0.1837
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0089	0.065	0.0642
Brugia malayi	Cathepsin L-like precursor	0.0421	0.5559	0.8052
Leishmania major	cathepsin L-like protease	0.0421	0.5559	0.7988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Echinococcus multilocularis	geminin	0.0183	0.2038	0.2038
Onchocerca volvulus		0.0421	0.5559	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0421	0.5559	0.6047
Echinococcus granulosus	glycogen phosphorylase	0.0107	0.0917	0.0917
Giardia lamblia	Cathepsin B precursor	0.0219	0.2577	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Plasmodium vivax	vivapain-2	0.0421	0.5559	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0088	0.0639	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0421	0.5559	1
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0107	0.0917	0.165
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0048	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0141	0.1422	0.2059
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0089	0.065	0.0941
Brugia malayi	Papain family cysteine protease containing protein	0.0088	0.0639	0.0925
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Plasmodium vivax	vivapain-1	0.0223	0.2634	0.4737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Brugia malayi	prolyl oligopeptidase family protein	0.0089	0.065	0.0941
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.006	0.0221	0.032
Trypanosoma brucei	prolyl endopeptidase	0.0315	0.3993	0.5784
Brugia malayi	prolyl oligopeptidase family protein	0.0315	0.3993	0.5784
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.006	0.0221	0.032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0088	0.0639	0.1149
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0135	0.1326	0.1921
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0088	0.0639	0.2479
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0133	0.1306	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0088	0.0639	0.1149
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0421	0.5559	0.5559
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0133	0.1306	0.1624
Leishmania major	cathepsin L-like protease	0.0421	0.5559	0.7988
Brugia malayi	hypothetical protein	0.0146	0.1491	0.216
Onchocerca volvulus		0.0421	0.5559	1
Plasmodium vivax	unspecified product	0.0088	0.0639	0.1149
Onchocerca volvulus		0.0048	0.0042	0.0006
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0088	0.0639	0.0925
Brugia malayi	Papain family cysteine protease containing protein	0.0223	0.2634	0.3814
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Trypanosoma brucei	antigen, putative	0.006	0.0221	0.032
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0088	0.0639	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0512	0.6904	1
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0088	0.0639	0.0925
Echinococcus granulosus	transmembrane protease serine 3	0.0048	0.0042	0.0042
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0088	0.0639	0.1149
Leishmania major	cathepsin L-like protease	0.0421	0.5559	0.7988
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.0038	0.0042
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0088	0.0639	0.0695
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0048	0.0042	0.0042
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.0639	0.0695
Toxoplasma gondii	cathepsin CPL	0.0421	0.5559	1
Echinococcus granulosus	cathepsin b	0.0512	0.6904	0.6904
Echinococcus granulosus	calpain A	0.0167	0.1796	0.1796
Trypanosoma cruzi	oligopeptidase b	0.0133	0.1306	0.1892
Trypanosoma brucei	calpain-like protein, putative	0.006	0.0221	0.032
Giardia lamblia	Cathepsin B precursor	0.0219	0.2577	1
Trypanosoma cruzi	cysteine protease, putative	0.0223	0.2634	0.3814
Giardia lamblia	Cysteine protease	0.0088	0.0639	0.2479
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0133	0.1306	0.1892
Echinococcus multilocularis	glycogen phosphorylase	0.0107	0.0917	0.0917
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0088	0.0639	0.1149
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0421	0.5559	0.8052
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0042	0.006
Giardia lamblia	Cysteine protease	0.0088	0.0639	0.2479
Plasmodium vivax	vivapain-2	0.0421	0.5559	1
Echinococcus granulosus	calpain A	0.006	0.0221	0.0221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1133	0.164
Entamoeba histolytica	cysteine protease, putative	0.0421	0.5559	1
Giardia lamblia	Cathepsin L-like protease	0.0088	0.0639	0.2479
Entamoeba histolytica	cysteine proteinase 1, putative	0.0223	0.2634	0.4737
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0088	0.0639	0.1149
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.0639	0.0695
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0088	0.0639	0.1149
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Brugia malayi	Cathepsin L-like precursor	0.0286	0.3564	0.5163
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	calpain 7	0.006	0.0221	0.032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0223	0.2634	0.2865
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0135	0.1326	0.1921
Giardia lamblia	Cathepsin B precursor	0.0088	0.0639	0.2479
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0088	0.0639	0.0695
Entamoeba histolytica	cysteine proteinase, putative	0.0223	0.2634	0.4737
Brugia malayi	MH2 domain containing protein	0.0122	0.1133	0.164
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0219	0.2577	0.4635
Brugia malayi	fibroinase precursor	0.0088	0.0639	0.0925
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0133	0.1306	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0223	0.2634	0.3815
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1067	0.1546
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Giardia lamblia	Cathepsin B precursor	0.0088	0.0639	0.2479
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0133	0.1306	0.3897
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0088	0.0639	0.0925
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0315	0.3993	0.4343
Schistosoma mansoni	cathepsin S (C01 family)	0.0088	0.0639	0.0695
Echinococcus granulosus	cathepsin L cysteine protease	0.0223	0.2634	0.2634
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Leishmania major	oligopeptidase b	0.0133	0.1306	0.1624
Echinococcus multilocularis	cysteine protease	0.0421	0.5559	0.5559
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0286	0.3564	0.5163
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0223	0.2634	0.4737
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Onchocerca volvulus		0.0048	0.0042	0.0006
Echinococcus multilocularis	hypothetical protein	0.006	0.0221	0.0221
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0089	0.065	0.1169
Echinococcus granulosus	cathepsin l1	0.0421	0.5559	0.5559
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	calpain family protein 1	0.0159	0.1689	0.2446
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Brugia malayi	hypothetical protein	0.0048	0.0042	0.006
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Echinococcus granulosus	Glycosyl transferase family 35	0.0107	0.0917	0.0917
Brugia malayi	cathepsin L-like cysteine proteinase	0.0088	0.0639	0.0925
Onchocerca volvulus		0.0421	0.5559	1
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0133	0.1306	0.1892
Schistosoma mansoni	cathepsin F (C01 family)	0.0421	0.5559	0.6047
Brugia malayi	Trypsin family protein	0.0048	0.0042	0.006
Loa Loa (eye worm)	cysteine protease	0.0421	0.5559	0.8052
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0088	0.0639	0.1149
Echinococcus granulosus	cathepsin L	0.0223	0.2634	0.2634
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0107	0.0917	0.165
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0048	0.0042	0.0045
Echinococcus granulosus	tumor protein p63	0.0326	0.416	0.416
Entamoeba histolytica	glycogen phosphorylase, putative	0.0046	0.0017	0.0031
Loa Loa (eye worm)	calpain family protein 1	0.0159	0.1689	0.2446
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0512	0.6904	0.751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0223	0.2634	0.4737
Giardia lamblia	Cathepsin B precursor	0.0088	0.0639	0.2479
Loa Loa (eye worm)	hypothetical protein	0.0286	0.3564	0.5163
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0421	0.5559	1
Echinococcus multilocularis	cathepsin L	0.0088	0.0639	0.0639
Trypanosoma brucei	oligopeptidase b	0.0133	0.1306	0.1892
Onchocerca volvulus		0.0421	0.5559	1
Mycobacterium tuberculosis	Probable peptidase	0.0133	0.1306	0.3897
Loa Loa (eye worm)	hypothetical protein	0.0135	0.1326	0.1921
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0088	0.0639	0.0695
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0382	0.4983	0.4983
Giardia lamblia	Cathepsin L precursor	0.0088	0.0639	0.2479
Giardia lamblia	Cathepsin B precursor	0.0088	0.0639	0.2479
Echinococcus multilocularis	enteropeptidase	0.0048	0.0042	0.0042
Onchocerca volvulus	Cathepsin F homolog	0.0421	0.5559	1
Brugia malayi	calpain family protein 1	0.0159	0.1689	0.2446
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0639	0.0925
Schistosoma mansoni	cercarial elastase (S01 family)	0.0048	0.0042	0.0045
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0421	0.5559	0.5559
Plasmodium falciparum	serine repeat antigen 2	0.0088	0.0639	0.1149
Plasmodium falciparum	serine repeat antigen 8	0.0088	0.0639	0.1149
Onchocerca volvulus		0.0286	0.3564	0.6387
Plasmodium vivax	vivapain-3	0.0223	0.2634	0.4737
Loa Loa (eye worm)	glycogen phosphorylase	0.0107	0.0917	0.1329
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0421	0.5559	0.8052
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0421	0.5559	1
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1689	0.2446
Echinococcus granulosus	enteropeptidase	0.0048	0.0042	0.0042
Trichomonas vaginalis	conserved hypothetical protein	0.0088	0.0639	0.1149
Entamoeba histolytica	cysteine protease, putative	0.0223	0.2634	0.4737
Onchocerca volvulus	Cathepsin L homolog	0.0421	0.5559	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0512	0.6904	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 91 uM	Binding affinity, determined by its ability to displace the [3H]-GABA from Gamma-aminobutyric-acid A (GABA-A) receptor site of rat brain membranes	ChEMBL.	3027337

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1202185

Bibliographic References

No literature references available for this target.

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Detailed information for compound 939533