Detailed information for compound 940699

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 368.34 | Formula: C20H27Cl2NO
  • H donors: 0 H acceptors: 0 LogP: 6.52 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCCCOc1ccc(cc1)/C=C/c1ccccc1)C.Cl.Cl
  • InChi: 1S/C20H25NO.2ClH/c1-21(2)16-6-7-17-22-20-14-12-19(13-15-20)11-10-18-8-4-3-5-9-18;;/h3-5,8-15H,6-7,16-17H2,1-2H3;2*1H/b11-10+;;
  • InChiKey: KVFBKULTDWIXQK-BGNBUWATSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus serine protein kinase ATM 0.0409 0.1779 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0176 0.061 0.0343
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0458 0.0458
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0186 0.0663 0.0663
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0376 0.1611 0.1373
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0437 0.1919 0.1763
Leishmania major phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0264 0.1051 0.0796
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0146 0.0458 0.0275
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0343 0.1447 0.1204
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0265 0.1055 0.1055
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0109 0.0276 0.0276
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0276 0.0089
Loa Loa (eye worm) hypothetical protein 0.0162 0.054 0.054
Trichomonas vaginalis PIKK family atypical protein kinase 0.2052 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.1128 0.5374 0.5243
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0276 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.1642 0.7946 0.7888
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.5456
Trichomonas vaginalis PIKK family atypical protein kinase 0.1129 0.5383 0.5252
Toxoplasma gondii FATC domain-containing protein 0.0409 0.1779 0.1895
Plasmodium vivax hypothetical protein, conserved 0.0146 0.0458 0.5456
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0458 0.0458
Leishmania major phosphatidylinositol 3-kinase, putative 0.0719 0.3329 0.314
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0413 0.1796 0.1796
Trichomonas vaginalis PIKK family atypical protein kinase 0.073 0.3385 0.3197
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0437 0.1919 0.1689
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.0187
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0146 0.0458 0.0458
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0176 0.061 0.0217
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0237 0.0917 0.0917
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0176 0.061 0.0429
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2052 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0866 0.4062 0.3893
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.031 0.128 0.128
Echinococcus multilocularis 0.0146 0.0458 0.0458
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0109 0.0276 0.0276
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0719 0.3329 0.314
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0455 0.2008 0.2224
Echinococcus multilocularis serine protein kinase ATM 0.0409 0.1779 0.1779
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0176 0.061 0.061
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0276 0.0276
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.0458 0.5
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0276 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.1779 0.1779
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0174 0.0601 0.0334
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0207 0.0766 0.0503
Trichomonas vaginalis PIKK family atypical protein kinase 0.0719 0.3329 0.314
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2052 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0176 0.061 0.061
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0176 0.061 1
Plasmodium vivax hypothetical protein 0.0146 0.0458 0.5456
Loa Loa (eye worm) hypothetical protein 0.0409 0.1775 0.1775
Toxoplasma gondii target of rapamycin (TOR), putative 0.1538 0.7428 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0176 0.061 0.061
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0237 0.0917 0.0659
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0772 0.3592 0.3592
Onchocerca volvulus 0.0146 0.0458 0.5
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0748 0.0748
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2052 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1128 0.5374 0.5243
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0146 0.0458 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.1233 0.5901 0.5785
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0176 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.0458 0.0187
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0109 0.0276 0.0276
Schistosoma mansoni immunophilin 0.0109 0.0276 0.0276
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0702 0.3244 0.3244
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2052 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.1643 0.7955 0.7915
Loa Loa (eye worm) hypothetical protein 0.0409 0.1779 0.1779
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0331 0.1388 0.1388
Leishmania major phosphatidylinositol kinase, putative 0.0146 0.0458 0.0187
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0437 0.1919 0.1689
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0146 0.0458 0.0187
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0201 0.0201
Brugia malayi FAT domain containing protein 0.031 0.128 0.128
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0109 0.0276 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0264 0.1051 0.0796
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0176 0.061 0.061
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1081 0.0828
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0458 0.0458
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2052 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2052 1 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0146 0.0458 0.5456
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0409 0.1779 0.1621
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0109 0.0276 0.0089
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0702 0.3244 0.3244
Trichomonas vaginalis PIKK family atypical protein kinase 0.2052 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0455 0.2008 0.1781
Loa Loa (eye worm) phosphatidylinositol kinase 0.0146 0.0458 0.0458
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0331 0.1388 0.1388
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0146 0.0458 0.5456
Leishmania major phosphatidylinositol kinase related protein, putative 0.0146 0.0458 0.0187
Schistosoma mansoni immunophilin 0.0109 0.0276 0.0276
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1643 0.7955 0.7897
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0409 0.1779 0.1779
Entamoeba histolytica protein kinase rad3, putative 0.0409 0.1779 0.1546
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0458 0.0458
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.0275
Trichomonas vaginalis PIKK family atypical protein kinase 0.1378 0.6625 0.653
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Schistosoma mansoni hypothetical protein 0.0146 0.0458 0.0458
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0146 0.0458 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0343 0.1447 0.1204
Leishmania major hypothetical protein, unknown function 0.0146 0.0458 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.1129 0.5383 0.5252
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0409 0.1779 0.1779
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0109 0.0276 0.0276
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Loa Loa (eye worm) phosphatidylinositol 3 0.0092 0.0189 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.031 0.128 0.1032
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0146 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.2052 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0186 0.0663 0.0663
Loa Loa (eye worm) hypothetical protein 0.0146 0.0458 0.0458
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0413 0.1796 0.1796
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0146 0.0458 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.1642 0.7946 0.7888
Trypanosoma cruzi hypothetical protein, conserved 0.0095 0.0204 0.0016
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.0275
Onchocerca volvulus 0.0146 0.0458 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0237 0.0917 0.0659
Entamoeba histolytica hypothetical protein 0.0409 0.1779 0.1546
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0331 0.1388 0.1388
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0176 0.061 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.1779 0.1546
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0176 0.061 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.1228 0.5878 0.5761
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0409 0.1779 0.1621
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0331 0.1388 0.1388
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1643 0.7955 0.7897
Giardia lamblia Hypothetical protein 0.0146 0.0458 0.0187
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0458 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.1228 0.5878 0.5761
Loa Loa (eye worm) FKBP5 protein 0.0109 0.0276 0.0276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0458 0.0458
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0237 0.0917 0.0659
Schistosoma mansoni hypothetical protein 0.031 0.128 0.128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0409 0.1779 0.1546
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0276 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1128 0.5374 0.5243
Entamoeba histolytica hypothetical protein 0.0146 0.0458 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.1233 0.5901 0.5785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0719 0.3329 0.314
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0772 0.3592 0.3469
Entamoeba histolytica hypothetical protein 0.0146 0.0458 0.0187
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0109 0.0276 0.0276
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0772 0.3592 0.3592
Loa Loa (eye worm) phosphatidylinositol 3 0.2052 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0237 0.0917 0.0742
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0237 0.0917 0.0659
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0437 0.1919 0.1919
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0264 0.1051 0.0879
Giardia lamblia Phosphatidylinositol 4-kinase 0.0146 0.0458 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0176 0.061 0.0343
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0094 0.0201 0.0201
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0292 0.119 0.094
Schistosoma mansoni immunophilin 0.0094 0.0201 0.0201
Loa Loa (eye worm) phosphatidylinositol 3 0.0641 0.2937 0.2937
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0146 0.0458 0.0458
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2052 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0176 0.061 0.0429
Loa Loa (eye worm) hypothetical protein 0.0094 0.0201 0.0201
Loa Loa (eye worm) phosphatidylinositol 3 0.0146 0.0458 0.0458
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0772 0.3592 0.3592
Loa Loa (eye worm) hypothetical protein 0.0264 0.1051 0.1051
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0772 0.3592 0.3592
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0409 0.1779 0.1546
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0176 0.061 0.0217
Loa Loa (eye worm) hypothetical protein 0.0106 0.026 0.026
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0437 0.1919 0.1689
Trichomonas vaginalis PIKK family atypical protein kinase 0.1642 0.7946 0.7888
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2052 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0719 0.3329 0.314
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0421 0.1835 0.1603
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0772 0.3592 0.3469
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0146 0.0458 0.5456
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0409 0.1779 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0146 0.0458 0.0187
Entamoeba histolytica hypothetical protein 0.0146 0.0458 0.0187
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0176 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.1332 0.6396 0.6294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0554 0.2504 0.2291
Entamoeba histolytica hypothetical protein 0.0376 0.1611 0.1373
Loa Loa (eye worm) hypothetical protein 0.031 0.128 0.128
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0146 0.0458 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0719 0.3329 0.314
Trichomonas vaginalis PIKK family atypical protein kinase 0.1228 0.5878 0.5761
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0146 0.0458 0.0275
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0702 0.3244 0.3244
Echinococcus multilocularis Zinc finger, PHD finger 0.0176 0.061 0.061
Echinococcus multilocularis fk506 binding protein 0.0109 0.0276 0.0276
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0237 0.0917 0.0659
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2052 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.073 0.3385 0.3197
Leishmania major hypothetical protein, conserved 0.024 0.0932 0.0675
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2052 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0437 0.1919 0.1689
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0176 0.061 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.1642 0.7946 0.7888
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0964 0.4557 0.4403
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0176 0.061 1
Mycobacterium leprae conserved hypothetical protein 0.0146 0.0458 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0282 0.114 0.0888
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.031 0.128 0.128
Leishmania major phosphatidylinositol 3-related kinase, putative 0.073 0.3385 0.3197
Schistosoma mansoni voltage-gated potassium channel 0.0204 0.0748 0.0748
Giardia lamblia GTOR 0.2052 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0186 0.0663 0.0663
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0109 0.0276 0.0276
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0146 0.0458 0.5456
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0176 0.061 0.0343
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0176 0.061 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.1742 0.845 0.8406
Trichomonas vaginalis PIKK family atypical protein kinase 0.0421 0.1835 0.1603
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0146 0.0458 0.0458
Loa Loa (eye worm) phosphatidylinositol 3 0.073 0.3385 0.3385
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0409 0.1779 0.1779
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0237 0.0917 0.0917
Leishmania major phosphatidylinositol 3-kinase, putative 0.0176 0.061 0.0343
Trichomonas vaginalis PIKK family atypical protein kinase 0.1129 0.5383 0.5252
Trichomonas vaginalis PIKK family atypical protein kinase 0.1642 0.7946 0.7888
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0146 0.0458 0.0458
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0176 0.061 0.0343
Loa Loa (eye worm) hypothetical protein 0.0455 0.2008 0.2008
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0437 0.1919 0.1763
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0146 0.0458 0.0458
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0186 0.0663 0.0663
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0237 0.0917 0.0659
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0174 0.0601 0.0334
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2052 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1538 0.7428 0.7355
Schistosoma mansoni fkbp-rapamycin associated protein 0.0409 0.1779 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.1129 0.5383 0.5252

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 12.5 % Ability to supress maximal electroshock induced tonic extensor convulsion in mice after oral administration at 50 mg/kg ChEMBL. 6716402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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