Detailed information for compound 941129

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 369.845 | Formula: C20H20ClN3O2
  • H donors: 0 H acceptors: 2 LogP: 4.33 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1ccc(cc1)OCCN(C)C)/c1noc2c1cccc2.Cl
  • InChi: 1S/C20H19N3O2.ClH/c1-23(2)11-12-24-17-9-7-15(8-10-17)13-16(14-21)20-18-5-3-4-6-19(18)25-22-20;/h3-10,13H,11-12H2,1-2H3;1H/b16-13+;
  • InChiKey: DHDFRSCYPNJQHC-ZUQRMPMESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii diacylglycerol kinase, putative 0.0036 0.0658 0.1986
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0592 0.0728
Echinococcus multilocularis valyl tRNA synthetase 0.0042 0.086 0.086
Echinococcus granulosus raf serine:threonine protein kinase 0.0036 0.0658 0.0658
Echinococcus granulosus unc 13 munc13 0.0043 0.0897 0.0897
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0042 0.086 0.2594
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Echinococcus multilocularis leucyl tRNA synthetase 0.0042 0.086 0.086
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1134 0.1134
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0051 0.1134 0.1393
Loa Loa (eye worm) hypothetical protein 0.0234 0.6993 0.8591
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0017 0.005 0.0152
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0062
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0037 0.0693 0.0693
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0025 0.0321 0.0969
Loa Loa (eye worm) RNA binding protein 0.0061 0.147 0.1805
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0592 0.1787
Echinococcus granulosus protein kinase c epsilon type 0.0094 0.2519 0.2519
Schistosoma mansoni rac gtpase activating protein 0.0036 0.0658 0.0658
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0037 0.0693 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0592 0.166
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0119 0.3315 0.4072
Schistosoma mansoni serine/threonine protein kinase 0.0329 1 1
Echinococcus granulosus tar DNA binding protein 0.0061 0.147 0.147
Toxoplasma gondii Isoleucine-tRNA ligase 0.0017 0.005 0.0152
Loa Loa (eye worm) TAR-binding protein 0.0061 0.147 0.1805
Echinococcus granulosus N chimaerin 0.0036 0.0658 0.0658
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0094 0.2505 0.2505
Entamoeba histolytica protein kinase, putative 0.0051 0.1134 0.1988
Schistosoma mansoni serine/threonine protein kinase 0.0329 1 1
Schistosoma mansoni valine-tRNA ligase 0.0042 0.086 0.086
Echinococcus multilocularis serine threonine protein kinase 0.0293 0.8853 0.8853
Loa Loa (eye worm) hypothetical protein 0.0025 0.0321 0.0395
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0036 0.0658 0.0658
Brugia malayi hypothetical protein 0.0064 0.1549 0.1842
Mycobacterium ulcerans valyl-tRNA synthetase 0.0042 0.086 0.1092
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Schistosoma mansoni valine-tRNA ligase 0.0042 0.086 0.086
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0036 0.0658 0.0809
Leishmania major valyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Onchocerca volvulus 0.0042 0.086 0.2466
Echinococcus multilocularis unc 13 (munc13) 0.0043 0.0897 0.0897
Brugia malayi C1-like domain containing protein 0.0037 0.0693 0.0824
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0119 0.3315 0.6069
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0119 0.3315 1
Entamoeba histolytica hypothetical protein 0.0036 0.0658 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.147 0.1805
Onchocerca volvulus 0.0036 0.0658 0.1544
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0658 0.0243
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0042 0.086 0.0983
Giardia lamblia Valine-tRNA ligase 0.0042 0.086 0.248
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Treponema pallidum isoleucyl-tRNA synthetase 0.0119 0.3315 1
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0025 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.0025 0.0321 0.0395
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0119 0.3315 0.5021
Schistosoma mansoni transcription factor btf3 0.0034 0.0592 0.0592
Plasmodium falciparum valine--tRNA ligase, putative 0.0042 0.086 0.1302
Schistosoma mansoni vav2 0.0036 0.0658 0.0658
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0081 0.2107 0.2107
Loa Loa (eye worm) hypothetical protein 0.0042 0.086 0.1056
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0051 0.1134 0.1393
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0119 0.3315 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.1134 0.1347
Brugia malayi protein kinase C II. 0.0094 0.2519 0.2994
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0693 0.0693
Schistosoma mansoni leucyl-tRNA synthetase 0.0042 0.086 0.086
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Schistosoma mansoni leucyl-tRNA synthetase 0.0017 0.005 0.005
Leishmania major basic transcription factor 3a, putative 0.0034 0.0592 0.1787
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0042 0.086 0.0983
Schistosoma mansoni unc-13 (munc13) 0.0043 0.0897 0.0897
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0051 0.1134 0.1134
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0592 0.1787
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0036 0.0658 0.0658
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0051 0.1134 0.1134
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0051 0.1134 0.1134
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1134 0.1134
Echinococcus multilocularis leucyl tRNA synthetase 0.0042 0.086 0.086
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Echinococcus granulosus serine:threonine protein kinase N2 0.0051 0.1134 0.1134
Mycobacterium tuberculosis Possible DNA glycosylase 0.018 0.5254 1
Schistosoma mansoni methionine-tRNA synthetase 0.0025 0.0321 0.0321
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0592 0.1787
Brugia malayi isoleucyl-tRNA synthetase 0.0119 0.3315 0.394
Schistosoma mansoni isoleucine--tRNA ligase 0.0119 0.3315 0.3315
Schistosoma mansoni tar DNA-binding protein 0.0061 0.147 0.147
Schistosoma mansoni protein kinase C mu 0.0036 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Echinococcus multilocularis protein kinase c epsilon type 0.0094 0.2519 0.2519
Onchocerca volvulus 0.0094 0.2505 1
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0025 0.0321 0.0321
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0043 0.0897 0.0897
Plasmodium vivax valine--tRNA ligase, putative 0.0017 0.005 0.0152
Echinococcus multilocularis Diacylglycerol kinase theta 0.0036 0.0658 0.0658
Schistosoma mansoni protein kinase C 0.0043 0.0897 0.0897
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0042 0.086 0.248
Brugia malayi p70 ribosomal S6 kinase beta 0.0051 0.1134 0.1347
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0119 0.3315 1
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.018 0.5254 1
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0077 0.1967 0.3743
Schistosoma mansoni unc-13 (munc13) 0.0045 0.0956 0.0956
Brugia malayi Protein kinase domain containing protein 0.0051 0.1134 0.1347
Echinococcus multilocularis myotubularin protein 13 0.0036 0.0658 0.0658
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0119 0.3315 1
Echinococcus multilocularis jun protein 0.0081 0.2107 0.2107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Echinococcus granulosus transcription factor btf3 0.0034 0.0592 0.0592
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0042 0.086 0.248
Brugia malayi Hr1 repeat family protein 0.0051 0.1134 0.1347
Echinococcus multilocularis protein kinase c iota type 0.0087 0.228 0.228
Brugia malayi Protein kinase domain containing protein 0.0037 0.0693 0.0824
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Entamoeba histolytica diacylglycerol kinase, putative 0.0036 0.0658 0.0243
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0037 0.0693 0.0824
Toxoplasma gondii valyl-tRNA synthetase 0.0042 0.086 0.2594
Loa Loa (eye worm) hypothetical protein 0.0043 0.0897 0.1102
Schistosoma mansoni leucyl-tRNA synthetase 0.0017 0.005 0.005
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0592 0.1787
Loa Loa (eye worm) VRS-2 protein 0.0017 0.005 0.0062
Treponema pallidum valyl-tRNA synthetase 0.0042 0.086 0.18
Plasmodium vivax hypothetical protein, conserved 0.0042 0.086 0.2594
Schistosoma mansoni tar DNA-binding protein 0.0061 0.147 0.147
Brugia malayi Pleckstrin Homology Domain 0.0036 0.0658 0.0783
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0025 0.0321 0.083
Schistosoma mansoni protein kinase C mu 0.0037 0.0693 0.0693
Leishmania major isoleucyl-tRNA synthetase, putative 0.0119 0.3315 1
Echinococcus multilocularis valyl tRNA synthetase 0.0042 0.086 0.086
Echinococcus multilocularis raf serine:threonine protein kinase 0.0036 0.0658 0.0658
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Schistosoma mansoni hypothetical protein 0.0164 0.4749 0.4749
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0234 0.6993 0.6993
Giardia lamblia Isoleucyl-tRNA synthetase 0.0119 0.3315 1
Echinococcus granulosus myotubularin protein 13 0.0036 0.0658 0.0658
Brugia malayi protein ZK524.3 0.0017 0.005 0.006
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Chlamydia trachomatis isoleucine--tRNA ligase 0.0119 0.3315 1
Echinococcus granulosus Diacylglycerol kinase theta 0.0036 0.0658 0.0658
Echinococcus multilocularis tar DNA binding protein 0.0061 0.147 0.147
Brugia malayi protein kinase C3,putative 0.0037 0.0693 0.0824
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0094 0.2505 0.2505
Echinococcus granulosus jun protein 0.0081 0.2107 0.2107
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1134 0.1134
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0119 0.3315 0.5587
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0592 0.166
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0062
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0592 0.0897
Entamoeba histolytica protein kinase, putative 0.0051 0.1134 0.1988
Echinococcus multilocularis N chimaerin 0.0036 0.0658 0.0658
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0094 0.2519 0.3094
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0119 0.3315 1
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0043 0.0897 0.0897
Brugia malayi diacylglycerol kinase 0.0036 0.0658 0.0783
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0025 0.0321 0.083
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.0658 0.0658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Loa Loa (eye worm) hypothetical protein 0.027 0.814 1
Brugia malayi bZIP transcription factor family protein 0.0081 0.2107 0.2504
Entamoeba histolytica valyl tRNA synthetase, putative 0.0042 0.086 0.0983
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.2519 0.2519
Brugia malayi RhoGAP domain containing protein 0.0036 0.0658 0.0783
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.147 0.1747
Brugia malayi Protein kinase domain containing protein 0.0051 0.1134 0.1347
Loa Loa (eye worm) hypothetical protein 0.0094 0.2505 0.3078
Onchocerca volvulus 0.0036 0.0658 0.1544
Brugia malayi valyl-tRNA synthetase family protein 0.0042 0.086 0.1022
Schistosoma mansoni jun-related protein 0.0066 0.162 0.162
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0592 0.166
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0243 0.7266 0.8927
Echinococcus multilocularis transcription factor btf3 0.0034 0.0592 0.0592
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Plasmodium falciparum valine--tRNA ligase, putative 0.0042 0.086 0.1302
Echinococcus granulosus NDR protein kinase 0.0051 0.1134 0.1134
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0037 0.0693 0.0693
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.005 0.1099 0.3211
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.018 0.5254 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0051 0.1134 0.1134
Chlamydia trachomatis valine--tRNA ligase 0.0042 0.086 0.18
Echinococcus granulosus valyl tRNA synthetase 0.0042 0.086 0.086
Entamoeba histolytica protein kinase, putative 0.0051 0.1134 0.1988
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0025 0.0321 0.083
Brugia malayi TAR-binding protein 0.0061 0.147 0.1747
Schistosoma mansoni tar DNA-binding protein 0.0061 0.147 0.147
Echinococcus multilocularis serine:threonine protein kinase N2 0.0051 0.1134 0.1134
Echinococcus multilocularis serine:threonine protein kinase N2 0.0051 0.1134 0.1134
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0329 1 1
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0222 0.6602 1
Schistosoma mansoni tar DNA-binding protein 0.0061 0.147 0.147
Schistosoma mansoni isoleucine--tRNA ligase 0.0119 0.3315 0.3315
Echinococcus granulosus protein kinase c iota type 0.0087 0.228 0.228
Echinococcus multilocularis geminin 0.0164 0.4749 0.4749
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0051 0.1134 0.1134
Plasmodium falciparum leucine--tRNA ligase, putative 0.0042 0.086 0.1302
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0119 0.3315 0.394
Loa Loa (eye worm) raf kinase 0.0036 0.0658 0.0809
Plasmodium vivax valine--tRNA ligase, putative 0.0042 0.086 0.2594
Echinococcus granulosus protein kinase C gamma type 0.0293 0.8853 0.8853
Echinococcus granulosus Rac GTPase activating protein 1 0.0036 0.0658 0.0658
Brugia malayi beta-NAC-like protein 0.0034 0.0592 0.0704
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0119 0.3315 0.3315
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0051 0.1134 0.1393
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0037 0.0693 0.0852
Loa Loa (eye worm) AGC/AKT protein kinase 0.0051 0.1134 0.1393
Schistosoma mansoni diacylglycerol kinase theta 0.0036 0.0658 0.0658
Schistosoma mansoni serine/threonine kinase 0.0051 0.1134 0.1134
Loa Loa (eye worm) hypothetical protein 0.0051 0.1134 0.1393
Entamoeba histolytica protein kinase, putative 0.0051 0.1134 0.1988
Loa Loa (eye worm) AGC/NDR protein kinase 0.0051 0.1134 0.1393
Toxoplasma gondii leucyl-tRNA synthetase 0.0042 0.086 0.2594
Leishmania major leucyl-tRNA synthetase, putative 0.0042 0.086 0.2594
Loa Loa (eye worm) RasGEF domain-containing protein 0.0036 0.0658 0.0809
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0693 0.0693
Trichomonas vaginalis AGC family protein kinase 0.0051 0.1134 0.3318
Echinococcus granulosus RNA directed DNA polymerase 0.0234 0.6993 0.6993
Brugia malayi Ras association domain family 1 isoform A 0.0036 0.0658 0.0783
Loa Loa (eye worm) AGC/PKN protein kinase 0.0051 0.1134 0.1393
Schistosoma mansoni tar DNA-binding protein 0.0061 0.147 0.147
Schistosoma mansoni hypothetical protein 0.0164 0.4749 0.4749
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0017 0.005 0.0152
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0119 0.3315 0.3315
Echinococcus multilocularis protein kinase c eta type 0.0036 0.0658 0.0658
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.018 0.5254 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0036 0.0658 0.0658
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0051 0.1134 0.1393
Loa Loa (eye worm) hypothetical protein 0.0079 0.2035 0.2501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Onchocerca volvulus 0.0043 0.0897 0.2635
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.018 0.5254 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0592 0.1787
Echinococcus multilocularis Rac GTPase activating protein 1 0.0036 0.0658 0.0658
Brugia malayi Valyl-tRNA synthetase 0.0042 0.086 0.1022
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0658 0.0783
Loa Loa (eye worm) hypothetical protein 0.0119 0.3315 0.4072
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0051 0.1134 0.1134
Brugia malayi RhoGEF domain containing protein 0.0036 0.0658 0.0783
Brugia malayi diacylglycerol kinase 0.0036 0.0658 0.0783
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0658 0.0658
Brugia malayi RhoGAP domain containing protein 0.0036 0.0658 0.0783
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0036 0.0658 0.0809
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0119 0.3315 0.5587
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0081 0.2107 0.2107
Echinococcus granulosus leucyl tRNA synthetase 0.0042 0.086 0.086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0658 0.0809
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0042 0.086 0.1637
Brugia malayi leucyl-tRNA synthetase 0.0042 0.086 0.1022
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0036 0.0658 0.0658
Echinococcus granulosus valyl tRNA synthetase 0.0042 0.086 0.086
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0036 0.0658 0.0809
Onchocerca volvulus 0.0064 0.1549 0.5623
Echinococcus granulosus protein kinase c eta type 0.0036 0.0658 0.0658
Brugia malayi RNA binding protein 0.0061 0.147 0.1747
Toxoplasma gondii tRNA synthetase, putative 0.0042 0.086 0.2594
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0051 0.1134 0.1134
Echinococcus multilocularis RNA directed DNA polymerase 0.0234 0.6993 0.6993
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.018 0.5254 1
Schistosoma mansoni atypical protein kinase C 0.0087 0.228 0.228
Plasmodium falciparum leucine--tRNA ligase, putative 0.0017 0.005 0.0076
Brugia malayi Protein kinase c protein 2 0.0279 0.8413 1
Schistosoma mansoni hypothetical protein 0.0036 0.0658 0.0658
Trypanosoma brucei rac serine-threonine kinase, putative 0.0051 0.1134 0.342
Toxoplasma gondii AGC kinase 0.0051 0.1134 0.342
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0119 0.3315 1
Schistosoma mansoni hypothetical protein 0.0066 0.162 0.162
Echinococcus granulosus geminin 0.0164 0.4749 0.4749
Loa Loa (eye worm) hypothetical protein 0.0017 0.005 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.1134 0.1134
Echinococcus granulosus leucyl tRNA synthetase 0.0042 0.086 0.086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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