TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 806.911 | Formula: C40H57F3N6O8
H donors: 5 H acceptors: 7 LogP: 4.23 Rotable bonds: 22
Rule of 5 violations (Lipinski): 2
SMILES: [O-]C(=O)C(F)(F)F.COC1=CC(=O)N([C@H]1Cc1c[nH]c2c1cccc2)C(=O)/C=C/[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]([NH+](C)C)C(C)C)CC(C)C)CC(C)C)C
InChi: 1S/C38H56N6O6.C2HF3O2/c1-22(2)17-29(41-37(48)30(18-23(3)4)42-38(49)35(24(5)6)43(8)9)36(47)40-25(7)15-16-33(45)44-31(32(50-10)20-34(44)46)19-26-21-39-28-14-12-11-13-27(26)28;3-2(4,5)1(6)7/h11-16,20-25,29-31,35,39H,17-19H2,1-10H3,(H,40,47)(H,41,48)(H,42,49);(H,6,7)/b16-15+;/t25-,29-,30-,31-,35-;/m0./s1
InChiKey: FOJRDKJOMKTMMK-JIQKKVDDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	cysteine proteinase falcipain 2a	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium vivax	vivapain-3	cysteine proteinase falcipain 2a	484 aa	497 aa	45.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0009	0.0009
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.4137	0.8627	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0009	0.3182
Echinococcus multilocularis	cysteine protease	0.0027	0.0027	0.0027
Plasmodium falciparum	transporter, putative	0.0026	0.0026	0.945
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Loa Loa (eye worm)	fibroinase	0.0027	0.0027	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Schistosoma mansoni	cathepsin F (C01 family)	0.0018	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0027	0.0027	0.0027
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0027	0.0027
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0026	0.0026
Onchocerca volvulus		0.0027	0.0027	0.0019
Trypanosoma cruzi	cruzipain precursor, putative	0.0027	0.0027	0.0032
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0026	0.0026	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Plasmodium falciparum	amino acid transporter, putative	0.0026	0.0026	0.945
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Onchocerca volvulus		0.0027	0.0027	0.0019
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0027	0.0032
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Loa Loa (eye worm)	serotonin transporter b	0.0155	0.0294	0.0286
Brugia malayi	cathepsin L-like precursor	0.0018	0.0009	0.0009
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0027	0.0032
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Plasmodium vivax	hypothetical protein, conserved	0.0026	0.0026	0.945
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0026	0.0026	0.0026
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Plasmodium vivax	vivapain-2	0.0027	0.0027	1
Onchocerca volvulus		0.0026	0.0026	0.0017
Onchocerca volvulus		0.0026	0.0026	0.0017
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Brugia malayi	Papain family cysteine protease containing protein	0.0027	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0294	0.0286
Schistosoma mansoni	vesicular acetylcholine transporter	0.4794	1	1
Echinococcus granulosus	vesicular acetylcholine transporter	0.4794	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0027	0.0032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0027	0.0027	0.0027
Onchocerca volvulus		0.0027	0.0027	0.0019
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0027	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0294	0.0286
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Echinococcus granulosus	cathepsin l1	0.0018	0.0009	0.0009
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0026	0.0026
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0027	0.0027	1
Entamoeba histolytica	cysteine proteinase, putative	0.0027	0.0027	1
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0155	0.0294	0.0294
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0027	0.0027	0.0027
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0026	0.0017
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0027	0.0019
Entamoeba histolytica	cysteine protease, putative	0.0027	0.0027	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0026	0.0026
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0155	0.0294	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0026	0.0026
Leishmania major	C-8 sterol isomerase-like protein	0.4137	0.8627	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0026	0.0026	0.0017
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Echinococcus granulosus	sodium and chloride dependent glycine	0.0026	0.0026	0.0026
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Onchocerca volvulus	Cathepsin L homolog	0.0027	0.0027	0.0019
Echinococcus multilocularis	vesicular acetylcholine transporter	0.4794	1	1
Brugia malayi	Cathepsin L-like precursor	0.0018	0.0009	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0027	0.0027	1
Trypanosoma brucei	C-8 sterol isomerase, putative	0.4137	0.8627	1
Loa Loa (eye worm)	hypothetical protein	0.4137	0.8627	0.8626
Onchocerca volvulus		0.0027	0.0027	0.0019
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0027	0.0027	0.0027
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0026	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.2115	0.4395	0.439
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0027	0.0027	0.0019
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0018	0.0009	0.3182
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0018	0.0009	0.0009
Entamoeba histolytica	cysteine proteinase, putative	0.0018	0.0009	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0026	0.0026	0.0026
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Echinococcus granulosus	serotonin transporter	0.0155	0.0294	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Echinococcus multilocularis	cysteine protease	0.0027	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0026	0.0026	0.0026
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Loa Loa (eye worm)	cysteine protease	0.0027	0.0027	0.0019
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.4137	0.8627	0.8627
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Toxoplasma gondii	cathepsin CPL	0.0027	0.0027	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0026	0.0026	0.0026
Echinococcus granulosus	cathepsin l1	0.0027	0.0027	0.0027
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0155	0.0294	0.0294
Onchocerca volvulus		0.0155	0.0294	0.0286
Plasmodium vivax	vivapain-2	0.0027	0.0027	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0026	0.0017
Loa Loa (eye worm)	norepinephrine transporter	0.0155	0.0294	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Loa Loa (eye worm)	ctsf protein	0.0027	0.0027	0.0019
Brugia malayi	hypothetical protein	0.0026	0.0026	0.0026
Loa Loa (eye worm)	hypothetical protein	0.0155	0.0294	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0027	0.0027	1
Onchocerca volvulus		0.0027	0.0027	0.0019
Onchocerca volvulus	Cathepsin F homolog	0.0027	0.0027	0.0019
Onchocerca volvulus		0.0027	0.0027	0.0019
Onchocerca volvulus		0.0026	0.0026	0.0017
Echinococcus multilocularis	serotonin transporter	0.0155	0.0294	0.0294
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0026	0.0026	0.0026
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0026	0.0026	0.0026
Schistosoma mansoni	sodium/chloride dependent transporter	0.0026	0.0026	0.0026
Brugia malayi	Cathepsin L-like precursor	0.0027	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0027	0.0027	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0155	0.0294	0.0294
Treponema pallidum	sodium- and chloride- dependent transporter	0.0155	0.0294	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0027	0.0019
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.4794	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0027	0.0027	0.0032
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.4794	1	1
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0026	0.0026	0.0026
Plasmodium vivax	amine transporter, putative	0.0026	0.0026	0.945
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0027	0.0027	0.0019
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0026	0.0026	0.0026
Onchocerca volvulus		0.0027	0.0027	0.0019
Schistosoma mansoni	cathepsin F (C01 family)	0.0027	0.0027	0.0027
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0027	0.0027	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0027	0.0027	0.0032
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0026	0.0026	0.0026
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0018	0.0009	0.001

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Antiplasmodial activity against Plasmodium falciparum 3D7 trophozoite stage assessed as swollen food vacuole at <5 nM after 3 days by Giemsa staining-based assay	ChEMBL.	25412465
IC50 (binding)	= 12 nM	Inhibition of Plasmodium falciparum FP2 using Z-Phe-Arg-AMC as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by fluorescence assay	ChEMBL.	25412465
IC50 (functional)	= 29 nM	Antiplasmodial activity against multidrug-resistant Plasmodium falciparum Dd2 infected in human erythrocytes by [3H]-hypoxanthine incorporation assay	ChEMBL.	25412465
Inhibition (binding)		Inhibition of human cathepsin L expressed in Pichia pastoris using N-Cbz-Phe-Arg-7-amino-4-methylcoumarin as substrate incubated for 90 mins prior to substrate addition measured after 30 mins by fluorescence assay	ChEMBL.	25412465

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	25412465

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3358143

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 946625