Detailed information for compound 950010

Basic information

Technical information
  • TDR Targets ID: 950010
  • Name: (2R)-2-hydroxy-2-[8-(hydroxymethyl)-9-oxo-11H -indolizino[1,2-b]quinolin-7-yl]butanoic acid
  • MW: 366.367 | Formula: C20H18N2O5
  • H donors: 3 H acceptors: 6 LogP: 0.75 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC[C@@](c1cc2c3nc4ccccc4cc3Cn2c(=O)c1CO)(C(=O)O)O
  • InChi: 1S/C20H18N2O5/c1-2-20(27,19(25)26)14-8-16-17-12(9-22(16)18(24)13(14)10-23)7-11-5-3-4-6-15(11)21-17/h3-8,23,27H,2,9-10H2,1H3,(H,25,26)/t20-/m1/s1
  • InChiKey: SARNOWGPKQIWFT-HXUWFJFHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2R)-2-hydroxy-2-(9-keto-8-methylol-11H-indolizino[1,2-b]quinolin-7-yl)butyric acid
  • NCI60_000025

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0044 0.0109
Schistosoma mansoni hypothetical protein 0.0359 0.3792 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1864 0.4906
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0097
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0097
Echinococcus multilocularis geminin 0.0359 0.3792 0.3787
Loa Loa (eye worm) transcription factor SMAD2 0.038 0.4028 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0097
Brugia malayi MH2 domain containing protein 0.0026 0.0095 0.0235
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0185 0.1864 0.4618
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0461
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0182 0.0687
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0044 0.0133
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.308 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0182 0.0176
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0182 0.0451
Entamoeba histolytica hypothetical protein 0.0114 0.1071 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0182 0.0434
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0182 0.0464
Mycobacterium ulcerans hypothetical protein 0.0155 0.1531 0.5
Loa Loa (eye worm) hypothetical protein 0.0027 0.0106 0.0246
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0044 0.0092
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0037
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0095 0.0218
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0267 0.0847
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2052 0.6712
Plasmodium vivax SET domain protein, putative 0.0034 0.0182 0.0687
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0248 0.2562 1
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0568 0.1827
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0044 0.0097
Brugia malayi ecdysteroid receptor 0.0021 0.0044 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0368 0.1175
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0063 0.0502 0.1612
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0044 0.0109
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0248 0.2562 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1356 0.4204
Leishmania major cathepsin L-like protease 0.0069 0.0568 0.1827
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0248 0.2562 0.6752
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0095 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0182 0.0175
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0097
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0182 0.0451
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.1531 0.5
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0292 0.3053 0.7581
Schistosoma mansoni coup transcription factor 0.0021 0.0044 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Toxoplasma gondii preprocathepsin c precursor, putative 0.0248 0.2562 1
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0461
Schistosoma mansoni hypothetical protein 0.0073 0.0616 0.1609
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0044 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.0109
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.308 1
Brugia malayi MH1 domain containing protein 0.0026 0.0095 0.0235
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.0109
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0267 0.0847
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0044 0.0097
Brugia malayi steroid hormone receptor 0.0021 0.0044 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Echinococcus multilocularis smad 0.0026 0.0095 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0044 0.0109
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0095 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.0092
Entamoeba histolytica hypothetical protein 0.0114 0.1071 1
Echinococcus multilocularis Smad4 0.0026 0.0095 0.0088
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0568 0.1827
Brugia malayi hypothetical protein 0.0139 0.1347 0.3345
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0044 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0044 0.0097
Onchocerca volvulus 0.0021 0.0044 0.0133
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0007 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0182 0.0464
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2785 0.9118
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0106 0.0387
Brugia malayi Smad1 0.0026 0.0095 0.0235
Onchocerca volvulus Huntingtin homolog 0.0139 0.1347 0.4825
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0169 0.0427
Loa Loa (eye worm) hypothetical protein 0.0139 0.1347 0.3333
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0248 0.2562 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1172 0.3079
Schistosoma mansoni hypothetical protein 0.0123 0.1172 0.3079
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0248 0.2562 1
Entamoeba histolytica hypothetical protein 0.0114 0.1071 1
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0095 0.0232
Brugia malayi hypothetical protein 0.0027 0.0106 0.0263
Toxoplasma gondii cathepsin CPC1 0.0248 0.2562 1
Brugia malayi nuclear receptor NHR-88 0.0021 0.0044 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.0109
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1864 0.4906
Loa Loa (eye worm) hypothetical protein 0.0169 0.1685 0.4173
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.099 0.2459
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0292 0.3053 0.7577
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.308 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1864 0.1858
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0106 0.0322
Trypanosoma cruzi cysteine peptidase, putative 0.0069 0.0568 0.1827
Loa Loa (eye worm) hypothetical protein 0.0073 0.0616 0.1515
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0461
Onchocerca volvulus Glucosylceramidase homolog 0.0192 0.1937 0.6949
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Leishmania major hypothetical protein, conserved 0.0027 0.0106 0.0322
Onchocerca volvulus 0.0268 0.2785 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0095 0.0088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0044 0.0097
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0044 0.0133
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0182 0.0461
Onchocerca volvulus Huntingtin homolog 0.0139 0.1347 0.4825
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0044 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0044 0.0109
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0044 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0044 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0044 0.0092
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0106 0.0387
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Echinococcus granulosus GPCR family 2 0.0034 0.0182 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0248 0.2562 0.8388
Brugia malayi hypothetical protein 0.0114 0.1071 0.2659
Brugia malayi MH2 domain containing protein 0.038 0.4028 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0185 0.1864 0.1858
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0044 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0044 0.0109
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0182 0.0176
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0044 0.0109
Schistosoma mansoni hypothetical protein 0.0114 0.1071 0.2811
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1172 0.1166
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Entamoeba histolytica hypothetical protein 0.0114 0.1071 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.1071 0.2811
Loa Loa (eye worm) hypothetical protein 0.0139 0.1347 0.3333
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0182 0.0461
Echinococcus granulosus muscleblind protein 0.0169 0.1685 0.4433
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.0092
Brugia malayi nuclear hormone receptor 0.0021 0.0044 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0044 0.0097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.099 0.2459
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0106 0.0387
Schistosoma mansoni smad1 5 8 and 0.0026 0.0095 0.0232
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Loa Loa (eye worm) hypothetical protein 0.0169 0.1685 0.4173
Echinococcus multilocularis GPCR, family 2 0.0034 0.0182 0.0175
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0044 0.0037
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0182 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0044 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1864 0.4906
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.099 0.2446
Loa Loa (eye worm) hypothetical protein 0.0107 0.099 0.2446
Echinococcus granulosus geminin 0.0359 0.3792 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0185 0.1864 0.4627
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0044 0.0092
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Brugia malayi Pre-SET motif family protein 0.0034 0.0182 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Echinococcus multilocularis muscleblind protein 1 0.0169 0.1685 0.1679
Echinococcus multilocularis muscleblind protein 0.0169 0.1685 0.1679
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0044 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0044 0.0109
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0405 0.1297
Brugia malayi MH1 domain containing protein 0.0026 0.0095 0.0235
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0267 0.0543
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0044 0.0109
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0044 0.0037
Echinococcus granulosus Smad4 0.0026 0.0095 0.0232
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.0092
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0044 0.0037
Leishmania major cathepsin L-like protease 0.0069 0.0568 0.1827
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.1409 0.1403
Echinococcus granulosus smad 0.0026 0.0095 0.0232
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.1071 0.2811
Schistosoma mansoni smad1 5 8 and 0.0026 0.0095 0.0232
Brugia malayi Cathepsin L-like precursor 0.0018 0.0007 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Schistosoma mansoni hypothetical protein 0.0034 0.0182 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0267 0.0847
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0182 0.0175
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0182 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0044 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0037
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Onchocerca volvulus 0.0034 0.0182 0.0632
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0044 0.0133
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0044 0.0097
Schistosoma mansoni hypothetical protein 0.0359 0.3792 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.1071 0.1065
Brugia malayi Pre-SET motif family protein 0.0236 0.2423 0.6016
Loa Loa (eye worm) Smad1 0.0026 0.0095 0.0218
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0095 0.0232
Trypanosoma cruzi cruzipain precursor, putative 0.0069 0.0568 0.1827
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0044 0.0109
Trichomonas vaginalis glucosylceramidase, putative 0.0292 0.3053 1
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1409 0.3705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0182 0.0464
Loa Loa (eye worm) MH2 domain-containing protein 0.038 0.4028 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0044 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.2052 0.6712
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0044 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0044 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1937 0.6336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0185 0.1864 0.4906
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.0092
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0185 0.1864 0.4906
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0106 0.0387
Brugia malayi Muscleblind-like protein 0.0169 0.1685 0.4183
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.308 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.2423 0.6009
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1409 0.3705
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1356 0.439
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0044 0.0097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0182 0.0436
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0095 0.0232
Toxoplasma gondii hypothetical protein 0.0048 0.0335 0.1284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0106 0.0322
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0616 0.153
Schistosoma mansoni Smad4 0.0026 0.0095 0.0232
Schistosoma mansoni smad 0.0026 0.0095 0.0232
Brugia malayi MH2 domain containing protein 0.0026 0.0095 0.0235
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1356 0.439
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0248 0.2562 1
Leishmania major cathepsin L-like protease 0.0069 0.0568 0.1827
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0069 0.0568 0.1555
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0044 0.0037
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0044 0.0097
Schistosoma mansoni smad1 5 8 and 0.0026 0.0095 0.0232
Loa Loa (eye worm) hypothetical protein 0.0034 0.0182 0.0434

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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