Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0275 | 0.5828 | 0.683 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0115 | 0 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0292 | 0.6438 | 0.6438 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 0.6438 | 0.6438 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.6438 | 0.7544 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0316 | 0.7295 | 0.8549 |
Onchocerca volvulus | 0.0292 | 0.6438 | 0.6438 | |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0115 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0115 | 0 | 0.5 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0115 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.039 | 1 | 1 |
Onchocerca volvulus | 0.039 | 1 | 1 | |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 0.6438 | 1 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0115 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.035 | 0.8533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.6438 | 0.7544 |
Echinococcus granulosus | aminopeptidase N | 0.039 | 1 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 0.6438 | 0.7544 |
Entamoeba histolytica | aminopeptidase, putative | 0.0115 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 0.6438 | 0.7544 |
Echinococcus multilocularis | serotonin transporter | 0.0292 | 0.6438 | 0.6438 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 0.6438 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 0.6438 | 0.7544 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 0.6438 | 0.7544 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 0.6438 | 1 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0115 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 53 nM | Inhibition of norepinephrine uptake at NET in rat brain synaptosome | ChEMBL. | 18539031 |
IC50 (binding) | = 71 nM | Inhibition of serotonin uptake at SERT in rat brain synaptosome | ChEMBL. | 18539031 |
IC50 (binding) | = 180 nM | Inhibition of dopamine uptake at cloned DAT in rat brain synaptosome | ChEMBL. | 18539031 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.