Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acyl-CoA desaturase 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Candida albicans | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase | Acyl-CoA desaturase 1 | 358 aa | 317 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0018 | 0.0422 | 0.5412 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0558 | 0.0558 |
Echinococcus granulosus | roundabout 2 | 0.0017 | 0.0379 | 0.4859 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0068 | 0.3413 | 0.3413 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0422 | 0.0422 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0166 | 0.2135 |
Echinococcus multilocularis | plexin a4 | 0.0024 | 0.078 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0.0422 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.0086 | 0.4487 | 1 |
Echinococcus granulosus | plexin a4 | 0.0024 | 0.078 | 1 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0018 | 0.0422 | 0.5412 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0379 | 0.0379 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0213 | 0.2725 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.3413 | 0.7358 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0018 | 0.0422 | 0.5 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0068 | 0.3413 | 0.5 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0213 | 0.0213 |
Echinococcus multilocularis | roundabout 2 | 0.0017 | 0.0379 | 0.4859 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0053 | 0.0053 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0018 | 0.0422 | 0.5 |
Leishmania major | stearic acid desaturase, putative | 0.0086 | 0.4487 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0086 | 0.4487 | 1 |
Onchocerca volvulus | 0.0086 | 0.4487 | 0.4577 | |
Schistosoma mansoni | nephrin | 0.0014 | 0.0166 | 0.2982 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0167 | 0.9302 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0379 | 0.0379 |
Brugia malayi | acyl-CoA desaturase | 0.0068 | 0.3413 | 0.3413 |
Onchocerca volvulus | 0.0086 | 0.4487 | 0.4577 | |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0068 | 0.3413 | 0.7358 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0166 | 0.2135 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0018 | 0.0422 | 0.0422 |
Brugia malayi | plexin A | 0.0024 | 0.078 | 0.078 |
Schistosoma mansoni | plexin | 0.0012 | 0.0053 | 0.0943 |
Leishmania major | fatty-acid desaturase, putative | 0.0086 | 0.4487 | 1 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0018 | 0.0422 | 0.5412 |
Brugia malayi | Fatty acid desaturase family protein | 0.0018 | 0.0422 | 0.0422 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | plexin A | 0.0024 | 0.078 | 0.078 |
Schistosoma mansoni | fatty acid desaturase | 0.0018 | 0.0422 | 0.7559 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0018 | 0.0422 | 0.5412 |
Onchocerca volvulus | 0.002 | 0.0558 | 0.0153 | |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0068 | 0.3413 | 0.5 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0018 | 0.0422 | 0.5412 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0018 | 0.0422 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0179 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0053 | 0.0943 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0166 | 0.2135 |
Brugia malayi | Fatty acid desaturase family protein | 0.0018 | 0.0422 | 0.0422 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0018 | 0.0422 | 0.0422 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0018 | 0.0422 | 0.5 |
Schistosoma mansoni | plexin | 0.002 | 0.0558 | 1 |
Brugia malayi | Plexin repeat family protein | 0.002 | 0.0558 | 0.0558 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0018 | 0.0422 | 0.0422 |
Onchocerca volvulus | 0.0162 | 0.9017 | 0.9679 | |
Loa Loa (eye worm) | FAT-3 protein | 0.0018 | 0.0422 | 0.0422 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0213 | 0.3806 |
Mycobacterium ulcerans | hypothetical protein | 0.0018 | 0.0422 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11600 nM | Inhibition of rat microsomal delta-(9)-desaturase | ChEMBL. | 19394219 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.