TDR Targets

Basic information

Technical information

TDR Targets ID: 973096
Name: 4-[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]- N-phenylpiperazine-1-carboxamide
MW: 399.897 | Formula: C19H18ClN5OS
H donors: 1 H acceptors: 3 LogP: 4.16 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1nsc(n1)N1CCN(CC1)C(=O)Nc1ccccc1
InChi: 1S/C19H18ClN5OS/c20-15-8-6-14(7-9-15)17-22-19(27-23-17)25-12-10-24(11-13-25)18(26)21-16-4-2-1-3-5-16/h1-9H,10-13H2,(H,21,26)
InChiKey: ARAUGGCZUKMXPG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]-N-phenyl-piperazine-1-carboxamide
4-[3-(4-chlorophenyl)-1,2,4-thiadiazol-5-yl]-N-phenyl-1-piperazinecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid amide hydrolase	Starlite/ChEMBL	References
Rattus norvegicus	Anandamide amidohydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus granulosus	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Candida albicans	one of two amidase genes similar to S. pombe SPCC550.07 and to S. cerevisiae AMD2 (YDR242W)	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	fatty-acid amide hydrolase	Get druggable targets OG5_127783	All targets in OG5_127783
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127783	All targets in OG5_127783
Brugia malayi	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma mansoni	amidase	Get druggable targets OG5_127783	All targets in OG5_127783
Echinococcus multilocularis	fatty acid amide hydrolase 1	Get druggable targets OG5_127783	All targets in OG5_127783
Schistosoma japonicum	ko:K01175 fatty acid amide hydrolase [EC:3.1.-.-], putative	Get druggable targets OG5_127783	All targets in OG5_127783

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.7 %
Leishmania major	hypothetical protein, conserved	fatty acid amide hydrolase	579 aa	471 aa	26.5 %
Echinococcus multilocularis	fatty acid amide hydrolase 1	Anandamide amidohydrolase	579 aa	470 aa	28.3 %
Schistosoma japonicum	Fatty-acid amide hydrolase 1, putative	Anandamide amidohydrolase	579 aa	499 aa	24.6 %
Onchocerca volvulus		Anandamide amidohydrolase	579 aa	539 aa	34.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0078	0.1094	0.1086
Toxoplasma gondii	EGF family domain-containing protein	0.0254	0.3758	0.3417
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0078	0.1094	0.1065
Brugia malayi	Cadherin domain containing protein	0.0254	0.3758	0.3737
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.003	0.0356	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Schistosoma mansoni	hypothetical protein	0.0151	0.2186	0.2179
Onchocerca volvulus		0.0254	0.3758	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	Kringle domain containing protein	0.02	0.2938	0.2915
Loa Loa (eye worm)	hypothetical protein	0.0666	1	1
Onchocerca volvulus		0.0151	0.2186	0.1929
Echinococcus multilocularis	slit 2 protein	0.0254	0.3758	0.3752
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Onchocerca volvulus		0.0151	0.2186	0.1929
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.004	0.0518	0.0625
Schistosoma mansoni	hypothetical protein	0.0078	0.1094	0.1086
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0666	1	1
Onchocerca volvulus		0.0151	0.2186	0.1929
Echinococcus granulosus	dnaJ subfamily B	0.0387	0.5772	0.5768
Echinococcus multilocularis	tissue type plasminogen activator	0.02	0.2938	0.2932
Echinococcus granulosus	neurogenic locus protein delta	0.0254	0.3758	0.3752
Schistosoma mansoni	slit	0.0254	0.3758	0.3752
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Echinococcus granulosus	fibropellin Ia	0.0254	0.3758	0.3752
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0034	0.0025
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0151	0.2186	0.2179
Brugia malayi	Delta serrate ligand family protein	0.0254	0.3758	0.3737
Echinococcus granulosus	laminin	0.0666	1	1
Echinococcus multilocularis	cpg binding protein	0.0029	0.0342	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus multilocularis	fibropellin Ia	0.0254	0.3758	0.3752
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0246	0.3635	0.3629
Brugia malayi	Calcium binding EGF domain containing protein	0.0254	0.3758	0.3737
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0254	0.3758	0.3752
Loa Loa (eye worm)	TK/ROR protein kinase	0.02	0.2938	0.2914
Brugia malayi	Amidase family protein	0.003	0.0356	0.0325
Loa Loa (eye worm)	Notch2	0.0254	0.3758	0.3736
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0078	0.1094	0.1086
Echinococcus multilocularis	notch	0.0254	0.3758	0.3752
Onchocerca volvulus		0.02	0.2938	0.2706
Trypanosoma cruzi	hypothetical protein, conserved	0.02	0.2938	1
Loa Loa (eye worm)	hypothetical protein	0.0666	1	1
Brugia malayi	Trypsin family protein	0.0151	0.2186	0.2161
Mycobacterium leprae	PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A)	0.003	0.0356	0.5
Echinococcus granulosus	fatty acid amide hydrolase 1	0.003	0.0356	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	putative amidase	0.003	0.0356	0.0325
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0151	0.2186	0.2161
Echinococcus multilocularis	protein jagged 1	0.0254	0.3758	0.3752
Echinococcus multilocularis	dnaJ subfamily B	0.0387	0.5772	0.5768
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Schistosoma mansoni	hypothetical protein	0.0078	0.1094	0.1086
Echinococcus granulosus	transmembrane protease serine 3	0.0151	0.2186	0.2179
Brugia malayi	acetyltransferase, GNAT family protein	0.0137	0.1985	0.1959
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	egf-like domain protein	0.0666	1	1
Brugia malayi	notch-like transmembrane receptor	0.0254	0.3758	0.3737
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	septate junction protein	0.0254	0.3758	0.3752
Onchocerca volvulus		0.0151	0.2186	0.1929
Brugia malayi	Trypsin family protein	0.0151	0.2186	0.2161
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Brugia malayi	Fibulin-1 precursor	0.0666	1	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0319	0.0285
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Onchocerca volvulus	Putative cubilin	0.0254	0.3758	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Loa Loa (eye worm)	apoptosis regulator protein	0.0078	0.1094	0.1064
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.078	0.0772
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Echinococcus multilocularis	enteropeptidase	0.0151	0.2186	0.2179
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0137	0.1985	0.1978
Echinococcus granulosus	neurogenic locus notch protein 4	0.0254	0.3758	0.3752
Onchocerca volvulus		0.0254	0.3758	0.3552
Schistosoma mansoni	cpg binding protein	0.0029	0.0342	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus granulosus	notch	0.0254	0.3758	0.3752
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0666	1	1
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0078	0.1094	0.1086
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.003	0.0356	0.5
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.02	0.2938	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Echinococcus multilocularis	neural cadherin	0.0254	0.3758	0.3752
Echinococcus multilocularis	glycoprotein Antigen 5	0.0151	0.2186	0.2179
Schistosoma mansoni	fatty-acid amide hydrolase	0.003	0.0356	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0137	0.1985	0.1978
Echinococcus granulosus	protein jagged 2	0.0254	0.3758	0.3752
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0666	1	1
Brugia malayi	Trypsin-like protease protein 5	0.0151	0.2186	0.2161
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.003	0.0356	0.5
Onchocerca volvulus	Neurogenic locus notch homolog	0.0254	0.3758	0.3552
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.003	0.0356	0.5
Echinococcus granulosus	glycoprotein Antigen 5	0.0151	0.2186	0.2179
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Loa Loa (eye worm)	trypsin family protein	0.0151	0.2186	0.216
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.003	0.0356	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	Trypsin family protein	0.0151	0.2186	0.2161
Echinococcus granulosus	Tolloid protein 1	0.0666	1	1
Echinococcus multilocularis	Tolloid protein 1	0.0666	1	1
Leishmania major	hypothetical protein, conserved	0.02	0.2938	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0254	0.3758	0.3737
Echinococcus multilocularis	laminin	0.0666	1	1
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.003	0.0356	0.5
Brugia malayi	Trypsin family protein	0.0151	0.2186	0.2161
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Schistosoma mansoni	hypothetical protein	0.02	0.2938	0.2932
Mycobacterium ulcerans	hypothetical protein	0.0151	0.2186	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Echinococcus granulosus	cpg binding protein	0.0029	0.0342	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0034	0.0025
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Schistosoma mansoni	hypothetical protein	0.0387	0.5772	0.5768
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.003	0.0356	0.5
Echinococcus multilocularis	neurogenic locus protein delta	0.0254	0.3758	0.3752
Schistosoma mansoni	hypothetical protein	0.0151	0.2186	0.2179
Trichomonas vaginalis	bromodomain-containing protein, putative	0.004	0.0518	1
Schistosoma mansoni	amidase	0.0246	0.3635	0.3629
Plasmodium falciparum	cysteine repeat modular protein 1	0.02	0.2938	1
Loa Loa (eye worm)	acetyltransferase	0.0137	0.1985	0.1958
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.003	0.0356	0.5
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0254	0.3758	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus multilocularis	neurogenic locus notch protein	0.0254	0.3758	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus granulosus	slit 2 protein	0.0254	0.3758	0.3752
Loa Loa (eye worm)	notch protein	0.0254	0.3758	0.3736
Echinococcus granulosus	neural cadherin	0.0254	0.3758	0.3752
Brugia malayi	Cadherin domain containing protein	0.0254	0.3758	0.3737
Loa Loa (eye worm)	hypothetical protein	0.0666	1	1
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Onchocerca volvulus	Slit protein homolog	0.0254	0.3758	0.3552
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Echinococcus granulosus	enteropeptidase	0.0151	0.2186	0.2179
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0151	0.2186	0.2179
Schistosoma mansoni	cpg binding protein	0.0027	0.0319	0.031
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Echinococcus multilocularis	protein jagged 2	0.0254	0.3758	0.3752
Entamoeba histolytica	acetyltransferase, GNAT family	0.0037	0.0467	0.5
Echinococcus multilocularis	Mastin	0.0151	0.2186	0.2179
Loa Loa (eye worm)	hypothetical protein	0.0666	1	1
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	Amidase family protein	0.003	0.0356	0.0325
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.003	0.0356	0.5
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0133	0.1927	0.1919
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0254	0.3758	0.3552
Schistosoma mansoni	notch	0.0254	0.3758	0.3752
Schistosoma mansoni	laminin gamma-3 chain	0.0254	0.3758	0.3752
Echinococcus granulosus	Mastin	0.0151	0.2186	0.2179
Echinococcus granulosus	protein jagged 2	0.0254	0.3758	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Brugia malayi	Muscle positioning protein 4	0.0254	0.3758	0.3737
Brugia malayi	GCC2 and GCC3 family protein	0.0254	0.3758	0.3737
Echinococcus granulosus	neurogenic locus notch protein	0.0254	0.3758	0.3752
Echinococcus multilocularis	protein jagged 1	0.0254	0.3758	0.3752
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0078	0.1094	0.1086
Schistosoma mansoni	apoptosis regulator bax	0.0078	0.1094	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus granulosus	delta-like protein 1	0.0254	0.3758	0.3752
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Brugia malayi	Protein kinase domain containing protein	0.02	0.2938	0.2915
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0246	0.3635	0.3629
Loa Loa (eye worm)	hypothetical protein	0.0246	0.3635	0.3613
Echinococcus granulosus	histone acetyltransferase KAT2B	0.004	0.0518	0.0509
Loa Loa (eye worm)	amidase	0.003	0.0356	0.0323
Onchocerca volvulus		0.0254	0.3758	0.3552
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.003	0.0356	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Loa Loa (eye worm)	amidase	0.003	0.0356	0.0323
Mycobacterium leprae	PROBABLE AMIDASE AMIC (AMINOHYDROLASE)	0.003	0.0356	0.5
Echinococcus granulosus	neurogenic locus notch protein	0.0254	0.3758	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus granulosus	protein jagged 1	0.0254	0.3758	0.3752
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0319	0.0287
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0246	0.3635	0.3629
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.004	0.0518	1
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0078	0.1094	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1094	0.1064
Schistosoma mansoni	cell polarity protein	0.0254	0.3758	0.3752
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Brugia malayi	Calcium binding EGF domain containing protein	0.0254	0.3758	0.3737
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.003	0.0356	0.5
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Giardia lamblia	High cysteine protein	0.0254	0.3758	1
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0254	0.3758	0.3752
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0246	0.3635	0.3629
Echinococcus multilocularis	fibrillin 1	0.0666	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0254	0.3758	0.3737
Echinococcus multilocularis	transmembrane protease serine 3	0.0151	0.2186	0.2179
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0151	0.2186	0.2179
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Echinococcus granulosus	protein jagged 1	0.0254	0.3758	0.3752
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Schistosoma mansoni	fatty-acid amide hydrolase	0.0246	0.3635	0.3629
Onchocerca volvulus		0.0254	0.3758	0.3552
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Echinococcus multilocularis	neurogenic locus protein delta	0.0254	0.3758	0.3752
Schistosoma mansoni	cpg binding protein	0.0029	0.0342	0.0333
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0666	1	1
Onchocerca volvulus		0.0151	0.2186	0.1929
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.2186	0.2179
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Loa Loa (eye worm)	hypothetical protein	0.02	0.2938	0.2914
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Onchocerca volvulus		0.0254	0.3758	0.3552
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Echinococcus multilocularis	neurogenic locus notch protein	0.0254	0.3758	0.3752
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Echinococcus granulosus	tissue type plasminogen activator	0.02	0.2938	0.2932
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0666	1	1
Toxoplasma gondii	kringle domain-containing protein	0.02	0.2938	0.2552
Onchocerca volvulus	Arrow homolog	0.0666	1	1
Schistosoma mansoni	hypothetical protein	0.0254	0.3758	0.3752
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0078	0.1094	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0666	1	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.0037	0.0467	0.0428
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.003	0.0356	0.5
Onchocerca volvulus		0.0151	0.2186	0.1929
Brugia malayi	EGF-like domain containing protein	0.0254	0.3758	0.3737
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2186	0.216
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0666	1	1
Loa Loa (eye worm)	hypothetical protein	0.0254	0.3758	0.3736
Brugia malayi	amidase	0.0246	0.3635	0.3614
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0738	0.0232
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.2186	0.2179
Brugia malayi	hypothetical protein	0.0151	0.2186	0.2161
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.003	0.0356	0.0348
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0666	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 248 nM	Inhibition of rat FAAH preincubated for 20 mins	ChEMBL.	18693015
IC50 (binding)	> 10000 nM	Inhibition of human FAAH preincubated for 20 mins	ChEMBL.	18693015

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL472530

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 973096