TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 514.036 | Formula: C26H28ClN3O4S
H donors: 3 H acceptors: 4 LogP: 3.85 Rotable bonds: 13
Rule of 5 violations (Lipinski): 2
SMILES: O=C(CCC(C(=O)NCc1ccccc1)NS(=O)(=O)c1cc(C)ccc1Cl)NCc1ccccc1
InChi: 1S/C26H28ClN3O4S/c1-19-12-13-22(27)24(16-19)35(33,34)30-23(26(32)29-18-21-10-6-3-7-11-21)14-15-25(31)28-17-20-8-4-2-5-9-20/h2-13,16,23,30H,14-15,17-18H2,1H3,(H,28,31)(H,29,32)
InChiKey: HBLFEHMPEVPDOW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	0.1318	0.131
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0139	0.0203	0.0194
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0134	0.0186	0.152
Trypanosoma cruzi	endonuclease G, putative	0.0319	0.0831	0.6553
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0134	0.0186	0.0183
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0134	0.0186	0.0183
Onchocerca volvulus		0.0134	0.0186	0.0421
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.0083	0.001	0.0006
Echinococcus granulosus	geminin	0.0168	0.0305	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0319	0.0831	0.6553
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0134	0.0186	0.0183
Schistosoma mansoni	hypothetical protein	0.0083	0.001	0.0006
Leishmania major	hypothetical protein, conserved	0.0416	0.1171	1
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0134	0.0186	0.0183
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.053	0.1571	0.1567
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0134	0.0186	0.152
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	ectonucleotide	0.0447	0.1279	0.1271
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1349	0.4428	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0139	0.0203	0.0194
Loa Loa (eye worm)	hypothetical protein	0.053	0.1571	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Plasmodium falciparum	GPI ethanolamine phosphate transferase 3, putative	0.0083	0.001	0.5
Leishmania major	endonuclease G, putative	0.0319	0.0831	0.7077
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.1349	0.4428	0.4423
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Schistosoma mansoni	pcd6 interacting protein-related	0.0134	0.0186	0.0183
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0416	0.1171	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0134	0.0186	0.0177
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0134	0.0186	0.0183
Onchocerca volvulus	GPI ethanolamine phosphate transferase 2 homolog	0.0083	0.001	0.0023
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1349	0.4428	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0134	0.0186	0.0177
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.053	0.1571	0.1562
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Schistosoma mansoni	protein tyrosine phosphatase	0.0134	0.0186	0.0183
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1349	0.4428	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0139	0.0203	0.02
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Leishmania major	tyrosine specific protein phosphatase, putative	0.0134	0.0186	0.152
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.0447	0.1279	0.1271
Brugia malayi	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	hypothetical protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Echinococcus granulosus	ectonucleotide	0.0447	0.1279	0.1271
Loa Loa (eye worm)	thrombospondin type 1 domain-containing protein	0.1145	0.3717	0.371
Brugia malayi	Thrombospondin type 1 domain containing protein	0.1145	0.3717	0.371
Onchocerca volvulus		0.1349	0.4428	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Trypanosoma brucei	endonuclease G, putative	0.0319	0.0831	0.7077
Onchocerca volvulus		0.0134	0.0186	0.0421
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Schistosoma mansoni	hypothetical protein	0.0083	0.001	0.0006
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0139	0.0203	0.0194
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0139	0.0203	0.0194
Brugia malayi	hypothetical protein	0.0134	0.0186	0.0177
Trypanosoma cruzi	hypothetical protein, conserved	0.0416	0.1171	1
Onchocerca volvulus		0.0134	0.0186	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0134	0.0186	0.0177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0134	0.0186	0.0177
Brugia malayi	endonuclease G, mitochondrial precursor	0.0319	0.0831	0.0822
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0134	0.0186	0.0177
Schistosoma mansoni	hypothetical protein	0.0168	0.0305	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Schistosoma mansoni	protein tyrosine phosphatase	0.0139	0.0203	0.02
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0134	0.0186	0.0399
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.021	0.0451	0.0441
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.053	0.1571	0.1567
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0803	0.2524	0.2516
Echinococcus multilocularis	neuropeptide s receptor	0.0458	0.1318	0.131
Echinococcus multilocularis	Endonuclease G	0.0319	0.0831	0.0822
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0134	0.0186	0.0399
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0933	0.2977	0.5
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.2944	1	1
Onchocerca volvulus		0.0134	0.0186	0.0421
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 7 homolog	0.0083	0.001	0.0023
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0134	0.0186	0.0183
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0134	0.0186	0.0177
Trypanosoma cruzi	endonuclease G, putative	0.0319	0.0831	0.6553
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0134	0.0186	0.0177
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0134	0.0186	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0447	0.1279	0.1271
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1349	0.4428	1
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0134	0.0186	0.0177
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1349	0.4428	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Schistosoma mansoni	endonuclease related	0.0319	0.0831	0.0828
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0416	0.1171	0.232
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.053	0.1571	0.1562
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0139	0.0203	0.0194
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0139	0.0203	0.02
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0139	0.0203	0.0194
Brugia malayi	Protein-tyrosine phosphatase 1	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Schistosoma mansoni	hypothetical protein	0.0083	0.001	0.0006
Echinococcus multilocularis		0.0134	0.0186	0.0177
Toxoplasma gondii	DNA/RNA non-specific endonuclease	0.0319	0.0831	0.5
Onchocerca volvulus		0.0134	0.0186	0.0421
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1349	0.4428	1
Onchocerca volvulus		0.0134	0.0186	0.0421
Onchocerca volvulus	4.1 G protein, putative homolog	0.0134	0.0186	0.0421
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0139	0.0203	0.0194
Schistosoma mansoni	lipoxygenase	0.0117	0.0127	0.0123
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0139	0.0203	0.02
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0139	0.0203	0.0194
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase	0.0214	0.0468	0.0458
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	hypothetical protein	0.0134	0.0186	0.0177
Schistosoma mansoni	hypothetical protein	0.0168	0.0305	0.0301
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.053	0.1571	0.1567
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.0447	0.1279	0.1271
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0139	0.0203	0.02
Giardia lamblia	Protein tyrosine phosphatase	0.0134	0.0186	0.0399
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0139	0.0203	0.0194
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0139	0.0203	0.0194
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Brugia malayi	hypothetical protein	0.0134	0.0186	0.0177
Onchocerca volvulus	GPI ethanolamine phosphate transferase 3 homolog	0.0083	0.001	0.0023
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0117	0.0127	0.0117
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0134	0.0186	0.0183
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	geminin	0.0168	0.0305	0.0295
Mycobacterium leprae	hypothetical protein	0.0083	0.001	0.5
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0139	0.0203	0.0194
Onchocerca volvulus		0.0134	0.0186	0.0421
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0134	0.0186	0.0177
Schistosoma mansoni	protein tyrosine phosphatase	0.0134	0.0186	0.0183
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0134	0.0186	0.0177
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0139	0.0203	0.02
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.1349	0.4428	1
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Echinococcus granulosus	neuropeptide s receptor	0.0458	0.1318	0.131
Onchocerca volvulus		0.053	0.1571	0.3547
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Onchocerca volvulus		0.053	0.1571	0.3547
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.2944	1	1
Schistosoma mansoni	ectonucleotide pyrophosphatase/phosphodiesterase	0.053	0.1571	0.1567
Onchocerca volvulus		0.0134	0.0186	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.2944	1	1
Leishmania major	DNA/RNA non-specific endonuclease-like protein	0.0319	0.0831	0.7077
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.2944	1	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.1349	0.4428	1
Onchocerca volvulus	Ectonucleotide pyrophosphatase\/phosphodiesterase family member 6 homolog	0.0083	0.001	0.0023
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.1349	0.4428	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0117	0.0127	0.0117
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.1349	0.4428	0.4423
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0134	0.0186	0.0177
Onchocerca volvulus		0.0134	0.0186	0.0421
Schistosoma mansoni	hypothetical protein	0.0083	0.001	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Onchocerca volvulus	GPI ethanolamine phosphate transferase 1 homolog	0.0083	0.001	0.0023
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Echinococcus multilocularis	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0134	0.0186	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0134	0.0186	0.0177
Schistosoma mansoni	hypothetical protein	0.1145	0.3717	0.3714
Loa Loa (eye worm)	hypothetical protein	0.0134	0.0186	0.0177
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0134	0.0186	0.0177
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Echinococcus granulosus	neuropeptide receptor A26	0.0458	0.1318	0.131
Trypanosoma brucei	endonuclease G, putative	0.0319	0.0831	0.7077
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0134	0.0186	0.0399
Brugia malayi	Type I phosphodiesterase / nucleotide pyrophosphatase family protein	0.053	0.1571	0.1562
Onchocerca volvulus		0.0134	0.0186	0.0421
Onchocerca volvulus		0.1145	0.3717	0.8393
Trypanosoma cruzi	DNA/RNA non-specific endonuclease protein-like, putative	0.0319	0.0831	0.6553
Echinococcus granulosus	ectonucleotide pyrophosphatase:phosphodiesterase	0.053	0.1571	0.1562
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0416	0.1171	0.232
Onchocerca volvulus		0.0134	0.0186	0.0421
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0134	0.0186	0.0177
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.1349	0.4428	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0134	0.0186	0.0177
Trypanosoma cruzi	hypothetical protein, conserved	0.0416	0.1171	1
Trypanosoma brucei	endonuclease G, putative	0.0319	0.0831	0.7077
Echinococcus granulosus	Endonuclease G	0.0319	0.0831	0.0822
Onchocerca volvulus		0.0134	0.0186	0.0421

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL474181

Bibliographic References

No literature references available for this target.

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Detailed information for compound 975879