Detailed information for compound 981871

Basic information

Technical information
  • TDR Targets ID: 981871
  • Name: 4-(2-ethoxy-2-oxoethoxy)-1-hydroxynaphthalene -2-carboxylic acid
  • MW: 290.268 | Formula: C15H14O6
  • H donors: 2 H acceptors: 4 LogP: 3.15 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)COc1cc(C(=O)O)c(c2c1cccc2)O
  • InChi: 1S/C15H14O6/c1-2-20-13(16)8-21-12-7-11(15(18)19)14(17)10-6-4-3-5-9(10)12/h3-7,17H,2,8H2,1H3,(H,18,19)
  • InChiKey: JWAJPJVUIOBOOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-ethoxy-2-oxo-ethoxy)-1-hydroxy-naphthalene-2-carboxylic acid
  • 4-(2-ethoxy-2-oxoethoxy)-1-hydroxy-2-naphthalenecarboxylic acid
  • 4-(2-ethoxy-2-keto-ethoxy)-1-hydroxy-2-naphthoic acid
  • ST5447459

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0165 0.0407
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0165 0.0165
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.2092 0.2092
Loa Loa (eye worm) endoprotease bli-4 0.0009 0.0192 0.0192
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0009 0.0192 0.0192
Brugia malayi Animal haem peroxidase family protein 0.0063 0.2092 0.2092
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0009 0.0192 0.5
Leishmania major metacaspase, putative 0.0032 0.0996 1
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0009 0.0192 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Giardia lamblia High cysteine protein 0.0008 0.0165 0.5
Schistosoma mansoni septate junction protein 0.0008 0.0165 0.0165
Onchocerca volvulus Peroxidase homolog 0.0063 0.2092 1
Echinococcus multilocularis neural cadherin 0.0008 0.0165 0.0407
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0165 0.0407
Echinococcus multilocularis protein jagged 1 0.0008 0.0165 0.0407
Schistosoma mansoni slit 0.0008 0.0165 0.0165
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0009 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0032 0.0996 0.0996
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0165 0.0407
Brugia malayi notch-like transmembrane receptor 0.0008 0.0165 0.0165
Trypanosoma brucei Metacaspase-4 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0996 0.0996
Brugia malayi celfurPC protein 0.0009 0.0192 0.0192
Onchocerca volvulus 0.0063 0.2092 1
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 0.4057 1
Echinococcus multilocularis peroxidasin 0.0063 0.2092 0.5156
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0996 1
Onchocerca volvulus Dual oxidase homolog 0.0063 0.2092 1
Onchocerca volvulus Peroxidasin homolog 0.0063 0.2092 1
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0165 0.0165
Brugia malayi Muscle positioning protein 4 0.0008 0.0165 0.0165
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0996 1
Echinococcus granulosus membrane bound transcription factor site 1 0.0009 0.0192 0.0472
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Echinococcus granulosus neuroendocrine convertase 2 0.0009 0.0192 0.0472
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.2092 0.2092
Brugia malayi Delta serrate ligand family protein 0.0008 0.0165 0.0165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Toxoplasma gondii subtilisin SUB1 0.0009 0.0192 0.032
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0165 0.0407
Echinococcus granulosus delta-like protein 1 0.0008 0.0165 0.0407
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0165 0.0407
Schistosoma mansoni notch 0.0008 0.0165 0.0165
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Plasmodium falciparum metacaspase-like protein 0.0032 0.0996 1
Toxoplasma gondii subtilisin SUB10 0.0009 0.0192 0.032
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Echinococcus multilocularis transient receptor potential cation channel 0.0003 0.000000057967 0.00000014288
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1
Echinococcus multilocularis transient receptor potential cation channel 0.0003 0.000000057967 0.00000014288
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Schistosoma mansoni peroxidasin 0.0063 0.2092 0.2092
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0009 0.0192 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Brugia malayi POT family protein 0.0085 0.2855 0.2855
Schistosoma mansoni notch 0.0008 0.0165 0.0165
Echinococcus granulosus neural cadherin 0.0008 0.0165 0.0407
Loa Loa (eye worm) hypothetical protein 0.0009 0.0192 0.0192
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0165 0.0407
Trypanosoma cruzi metacaspase, putative 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus multilocularis protein jagged 2 0.0008 0.0165 0.0407
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Schistosoma mansoni site-1 peptidase (S08 family) 0.0009 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Onchocerca volvulus Chorion peroxidase homolog 0.0063 0.2092 1
Echinococcus multilocularis caspase 0.012 0.4057 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus multilocularis notch 0.0008 0.0165 0.0407
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma cruzi metacaspase, putative 0.0032 0.0996 1
Echinococcus granulosus protein jagged 1 0.0008 0.0165 0.0407
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0165 0.0165
Toxoplasma gondii subtilisin SUB6 0.0009 0.0192 0.032
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0009 0.0192 0.5
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1
Echinococcus granulosus furin 0.0009 0.0192 0.0472
Echinococcus granulosus Furin 1 0.0009 0.0192 0.0472
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Schistosoma mansoni peroxidasin 0.0063 0.2092 0.2092
Echinococcus granulosus fibropellin Ia 0.0008 0.0165 0.0407
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma brucei metacaspase 0.0032 0.0996 1
Brugia malayi Animal haem peroxidase family protein 0.0063 0.2092 0.2092
Toxoplasma gondii subtilisin SUB7 0.0009 0.0192 0.032
Echinococcus granulosus caspase 2 0.0032 0.0996 0.2455
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0165 0.0165
Schistosoma mansoni cell polarity protein 0.0008 0.0165 0.0165
Schistosoma mansoni notch 0.0008 0.0165 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1
Brugia malayi endoprotease bli-4 precursor 0.0009 0.0192 0.0192
Toxoplasma gondii subtilisin SUB2 0.0009 0.0192 0.032
Echinococcus multilocularis membrane bound transcription factor site 1 0.0009 0.0192 0.0472
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Leishmania major hypothetical protein, conserved 0.001 0.0221 0.0361
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.2092 0.2092
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0009 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0009 0.0192 0.5
Brugia malayi follicle stimulating hormone receptor 0.0236 0.8111 0.8111
Loa Loa (eye worm) notch protein 0.0008 0.0165 0.0165
Echinococcus granulosus notch 0.0008 0.0165 0.0407
Onchocerca volvulus 0.0063 0.2092 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.012 0.4057 1
Schistosoma mansoni site-1 peptidase (S08 family) 0.0009 0.0192 0.0192
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Schistosoma mansoni caspase-7 (C14 family) 0.012 0.4057 0.4057
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0009 0.0192 0.0192
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0165 0.0407
Schistosoma mansoni furin-1 (S08 family) 0.0009 0.0192 0.0192
Toxoplasma gondii subtilisin SUB9 0.0009 0.0192 0.032
Onchocerca volvulus Peroxidase homolog 0.0063 0.2092 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.029 1 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Brugia malayi Cadherin domain containing protein 0.0008 0.0165 0.0165
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0009 0.0192 0.0192
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Echinococcus granulosus protein jagged 2 0.0008 0.0165 0.0407
Plasmodium falciparum metacaspase 1 0.0032 0.0996 1
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0996 1
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Schistosoma mansoni notch 0.0008 0.0173 0.0173
Echinococcus granulosus caspase 8 0.0032 0.0996 0.2455
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0109 0.3668 0.9042
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0009 0.0192 0.5
Brugia malayi Blistered cuticle protein 3 0.0063 0.2092 0.2092
Echinococcus granulosus peroxidasin 0.0063 0.2092 0.5156
Trypanosoma brucei metacaspase MCA3 0.0032 0.0996 1
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0009 0.0192 0.0472
Loa Loa (eye worm) proprotein convertase 2 0.0009 0.0192 0.0192
Plasmodium vivax metacaspase 1, putative 0.0032 0.0996 1
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0165 0.0407
Brugia malayi neuroendocrine convertase 1 precursor 0.0009 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.8111 0.8111
Echinococcus granulosus slit 2 protein 0.0008 0.0165 0.0407
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0009 0.0192 0.5
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Echinococcus multilocularis caspase 3 0.0088 0.294 0.7246
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Brugia malayi hypothetical protein 0.0063 0.2092 0.2092
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus granulosus protein jagged 2 0.0008 0.0165 0.0407
Echinococcus multilocularis caspase 8 0.0032 0.0996 0.2455
Schistosoma mansoni caspase-3 (C14 family) 0.012 0.4057 0.4057
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Mycobacterium leprae Possible secreted protease 0.0009 0.0192 0.5
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0165 0.0407
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma brucei metacaspase MCA2 0.0032 0.0996 1
Schistosoma mansoni hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0996 1
Echinococcus multilocularis slit 2 protein 0.0008 0.0165 0.0407
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) blistered cuticle protein 3 0.0063 0.2092 0.2092
Echinococcus multilocularis protein jagged 1 0.0008 0.0165 0.0407
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0996 0.0996
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0996 0.0996
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0009 0.0192 0.5
Echinococcus granulosus transient receptor potential cation channel 0.0003 0.000000057967 0.00000014288
Schistosoma mansoni notch 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Brugia malayi proprotein convertase 2 0.0009 0.0192 0.0192
Toxoplasma gondii subtilisin SUB8 0.0009 0.0192 0.032
Echinococcus multilocularis neuroendocrine convertase 2 0.0009 0.0192 0.0472
Toxoplasma gondii subtilisin SUB4 0.0009 0.0192 0.032
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0221 0.0361
Loa Loa (eye worm) POT family protein 0.0085 0.2855 0.2855
Toxoplasma gondii subtilisin SUB12 0.0009 0.0192 0.032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0221 0.0361
Onchocerca volvulus 0.0063 0.2092 1
Echinococcus multilocularis fibropellin Ia 0.0008 0.0165 0.0407
Echinococcus multilocularis 0.0009 0.0192 0.0472
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0009 0.0192 0.0192
Brugia malayi Cadherin domain containing protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0173 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Onchocerca volvulus 0.0009 0.0192 0.0138
Brugia malayi Animal haem peroxidase family protein 0.0063 0.2092 0.2092
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0165 0.00000030082
Brugia malayi Cell death protein 3 precursor 0.0032 0.0996 0.0996
Loa Loa (eye worm) Notch2 0.0008 0.0165 0.0165
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0165 0.0407
Toxoplasma gondii subtilisin SUB5 0.0009 0.0192 0.032
Echinococcus granulosus caspase 3 0.0088 0.294 0.7246
Brugia malayi EGF-like domain containing protein 0.0008 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Trypanosoma cruzi metacaspase, putative 0.0032 0.0996 1
Echinococcus granulosus caspase 0.012 0.4057 1
Echinococcus multilocularis caspase 2 0.0032 0.0996 0.2455
Onchocerca volvulus Peroxidasin homolog 0.0063 0.2092 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0165 0.0165
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0996 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus multilocularis Furin 1 0.0009 0.0192 0.0472
Schistosoma mansoni notch 0.0008 0.0165 0.0165
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0996 0.0996
Brugia malayi Peroxidasin 0.0063 0.2092 0.2092
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0996 1
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0996 0.4313
Loa Loa (eye worm) hypothetical protein 0.0008 0.0165 0.0165
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0009 0.0192 0.0472
Echinococcus granulosus protein jagged 1 0.0008 0.0165 0.0407
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0165 0.0165
Brugia malayi Animal haem peroxidase family protein 0.0063 0.2092 0.2092
Trypanosoma cruzi metacaspase, putative 0.0032 0.0996 1
Loa Loa (eye worm) subtilase 0.029 1 1
Toxoplasma gondii subtilisin SUB11 0.0009 0.0192 0.032
Loa Loa (eye worm) hypothetical protein 0.0063 0.2092 0.2092
Loa Loa (eye worm) animal heme peroxidase 0.0063 0.2092 0.2092
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0109 0.3668 0.9042
Brugia malayi Animal haem peroxidase family protein 0.0063 0.2092 0.2092
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0009 0.0192 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0996 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0996 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 13.6 uM Inhibition of human recombinant caspase 3 preincubated for 10 mins ChEMBL. 18387304
IC50 (binding) = 84.9 uM Inhibition of human recombinant caspase 7 preincubated for 10 mins ChEMBL. 18387304
IC50 (binding) = 93 uM Inhibition of human recombinant caspase 9 preincubated for 10 mins ChEMBL. 18387304
IC50 (binding) > 100 uM Inhibition of human recombinant caspase 8 preincubated for 10 mins ChEMBL. 18387304

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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