Detailed information for compound 986332

Basic information

Technical information
  • TDR Targets ID: 986332
  • Name: 2-[(8-methoxy-4-methylquinazolin-2-yl)amino]- 1H-quinazolin-4-one
  • MW: 333.344 | Formula: C18H15N5O2
  • H donors: 2 H acceptors: 5 LogP: 3.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc2c1nc(Nc1nc(O)c3c(n1)cccc3)nc2C
  • InChi: 1S/C18H15N5O2/c1-10-11-7-5-9-14(25-2)15(11)21-17(19-10)23-18-20-13-8-4-3-6-12(13)16(24)22-18/h3-9H,1-2H3,(H2,19,20,21,22,23,24)
  • InChiKey: XCQJPNOYQIHRNF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(8-methoxy-4-methyl-quinazolin-2-yl)amino]-1H-quinazolin-4-one
  • 2-[(8-methoxy-4-methyl-2-quinazolinyl)amino]-1H-quinazolin-4-one
  • STK000061
  • Oprea1_332512
  • ChemDiv1_007075
  • STK285117
  • ZINC00329301
  • Oprea1_607922

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni carbonic anhydrase-related 0.0162 0.1909 0.4468
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0078 0.0818 0.1053
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0162 0.1909 0.2458
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0161 0.189 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0161 0.189 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0165 0.1941 0.2976
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0165 0.1941 0.2499
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0087 0.0938 0.0938
Echinococcus multilocularis carbonic anhydrase 0.0162 0.1909 0.1909
Loa Loa (eye worm) hypothetical protein 0.0615 0.7768 1
Brugia malayi conserved hypotetical protein 0.0078 0.0818 0.1053
Loa Loa (eye worm) hypothetical protein 0.0087 0.0938 0.1208
Schistosoma mansoni retinoic acid receptor RXR 0.0165 0.1941 0.4543
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0823 0.1926
Loa Loa (eye worm) runx1 0.0065 0.0656 0.0845
Schistosoma mansoni hypothetical protein 0.0162 0.1909 0.4468
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0333 0.0645
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0333 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0165 0.1941 0.2499
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0333 0.5
Echinococcus granulosus histone acetyltransferase KAT2B 0.0144 0.1675 0.392
Brugia malayi nuclear hormone receptor 0.0165 0.1941 0.2499
Brugia malayi orphan nuclear receptor NR2E1 0.0078 0.0818 0.1053
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0427 0.0427
Echinococcus granulosus carbonic anhydrase 0.0162 0.1909 0.4468
Schistosoma mansoni thyroid hormone receptor 0.0295 0.3625 0.8484
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0427 0.0549
Echinococcus granulosus GPCR family 2 0.005 0.0466 0.109
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0614
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0174 0.0614
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0246 0.299 0.6997
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0165 0.1941 0.2499
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.1698 0.3885
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.0616
Echinococcus multilocularis carbonic anhydrase II 0.0345 0.4273 0.4273
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0165 0.1941 0.2499
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0614
Onchocerca volvulus 0.0204 0.2454 0.3762
Onchocerca volvulus 0.0078 0.0818 0.1254
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.9879
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0174 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0165 0.1941 0.2499
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.0616
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1729 0.2225
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0763 0.1786
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0189
Loa Loa (eye worm) nuclear receptor NHR-67 0.0078 0.0818 0.1053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0165 0.1941 0.4543
Schistosoma mansoni carbonic anhydrase 0.0162 0.1909 0.4468
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0162 0.1909 0.2458
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0165 0.1941 0.4543
Echinococcus granulosus lamin 0.0055 0.0529 0.1238
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0087 0.0938 0.2196
Brugia malayi small heat shock protein 0.0615 0.7768 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0345 0.4273 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0078 0.0818 0.1914
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.000000010732 0.000000025115
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0345 0.4273 0.5501
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0127 0.146 0.3416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0818 0.0818
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1499 0.3508
Echinococcus granulosus transcription factor Dp 1 0.0084 0.0905 0.2117
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0466 0.0466
Brugia malayi steroid hormone receptor 0.0165 0.1941 0.2499
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0378 0.0994
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0002 0.0004
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0165 0.1941 0.4543
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.1698 0.3885
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0146 0.1698 0.3885
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0165 0.1941 0.2976
Schistosoma mansoni hypothetical protein 0.0211 0.2546 0.5958
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0165 0.1941 0.2499
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0466 0.109
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0333 0.0645
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0266
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0818 0.1914
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1729 0.1729
Schistosoma mansoni nuclear receptor nhr-48 0.0078 0.0818 0.1914
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0197 0.0254
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Echinococcus granulosus Ankyrin 0.0014 0.0002 0.0004
Mycobacterium tuberculosis Hypothetical protein 0.0076 0.0802 0.4027
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0529 0.0681
Loa Loa (eye worm) hypothetical protein 0.0054 0.0516 0.0664
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0083 0.0888 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0078 0.0818 0.1053
Entamoeba histolytica hypothetical protein 0.0078 0.0823 0.4259
Echinococcus multilocularis musashi 0.0055 0.0529 0.0529
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0127 0.146 0.7638
Schistosoma mansoni hypothetical protein 0.005 0.0466 0.109
Brugia malayi follicle stimulating hormone receptor 0.0257 0.3134 0.4034
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0331 0.1356
Schistosoma mansoni steroid hormone receptor ad4bp 0.0165 0.1941 0.4543
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0162 0.1909 0.2458
Brugia malayi NAD-dependent deacetylase SIRT1 0.0083 0.0888 0.1143
Echinococcus granulosus nuclear receptor nhr 48 0.0078 0.0818 0.1914
Brugia malayi hypothetical protein 0.0204 0.2454 0.3159
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0197 0.0254
Echinococcus multilocularis FTZ F1 alpha 0.0165 0.1941 0.1941
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0165 0.1941 0.2499
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0165 0.1941 0.2499
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0345 0.4273 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0146 0.1698 0.2185
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0146 0.1698 0.2185
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0333 0.1453
Brugia malayi Nuclear hormone receptor E75 0.0078 0.0818 0.1053
Brugia malayi nuclear hormone receptor 0.0078 0.0818 0.1053
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.4341
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0174 0.0579
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0165 0.1941 0.2499
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0331 0.1029
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0146 0.1698 0.1698
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0146 0.1698 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0224
Echinococcus granulosus hormone sensitive lipase 0.0246 0.299 0.6997
Brugia malayi hypothetical protein 0.0087 0.0938 0.1208
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0529 0.0681
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0083 0.0888 0.2077
Echinococcus multilocularis carbonic anhydrase 0.0162 0.1909 0.1909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0427 0.0999
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0246 0.299 0.6997
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0146 0.1698 0.3973
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0818 0.1914
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0083 0.0888 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0127 0.146 0.332
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0165 0.1941 0.2499
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0165 0.1941 0.1941
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0062 0.008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0333 0.1384
Brugia malayi Protein kinase domain containing protein 0.0014 0.000000010732 0.000000013815
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0107
Brugia malayi hypothetical protein 0.0078 0.0823 0.1059
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0529 0.0681
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0268 0.055
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0127 0.146 0.146
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.4423
Echinococcus multilocularis Ankyrin 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0224
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0174 0.0614
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0763 0.0763
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0062 0.008
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0078 0.0818 0.0818
Mycobacterium ulcerans hypothetical protein 0.0028 0.0174 0.0614
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0146 0.1698 0.3885
Echinococcus granulosus carbonic anhydrase II 0.0345 0.4273 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0087 0.0938 0.2196
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.146 0.7647
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.026 0.3176 0.7432
Loa Loa (eye worm) hypothetical protein 0.0519 0.6524 0.8398
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0938 0.1208
Entamoeba histolytica hypothetical protein 0.0078 0.0823 0.4259
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1729 0.4046
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.146 0.3416
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0165 0.1941 0.4543
Schistosoma mansoni RAR-like nuclear receptor 0.0165 0.1941 0.4543
Echinococcus multilocularis lamin 0.0055 0.0529 0.0529
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0165 0.1941 0.1941
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0466 0.0599
Trypanosoma brucei carbonic anhydrase-like protein 0.0345 0.4273 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0938 0.1208
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0174 0.0614
Toxoplasma gondii aldehyde dehydrogenase 0.0127 0.146 0.717
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0159 0.1872 0.2409
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1499 0.1499
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0165 0.1941 0.4543
Brugia malayi Cytochrome P450 family protein 0.0019 0.0062 0.008
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0345 0.4273 0.5501
Loa Loa (eye worm) acetyltransferase 0.0148 0.1729 0.2225
Loa Loa (eye worm) hypothetical protein 0.0072 0.0747 0.0961
Brugia malayi Inositol-1 0.0039 0.0321 0.0414
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0333 0.0429
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0078 0.0818 0.0818
Schistosoma mansoni hypothetical protein 0.0109 0.1221 0.2857
Schistosoma mansoni ap endonuclease 0.004 0.0333 0.078
Loa Loa (eye worm) hypothetical protein 0.0109 0.1221 0.1572
Echinococcus multilocularis lamin dm0 0.0055 0.0529 0.0529
Leishmania major 4-coumarate:coa ligase-like protein 0.0028 0.0174 0.0266
Schistosoma mansoni hypothetical protein 0.0165 0.1943 0.4548
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0345 0.4273 1
Schistosoma mansoni hypothetical protein 0.005 0.0466 0.109
Brugia malayi bZIP transcription factor family protein 0.026 0.3176 0.4088
Brugia malayi Calcitonin receptor-like protein seb-1 0.0159 0.1872 0.2409
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0802 0.8487
Echinococcus multilocularis muscleblind protein 0.0157 0.1839 0.1839
Schistosoma mansoni zinc finger protein 0.0078 0.0818 0.1914
Loa Loa (eye worm) thymidylate synthase 0.0161 0.189 0.2433
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0321 0.142
Loa Loa (eye worm) hypothetical protein 0.0087 0.0938 0.1208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0165 0.1941 0.2499
Loa Loa (eye worm) hypothetical protein 0.0157 0.1839 0.2368
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0162 0.1909 0.2458
Onchocerca volvulus 0.0055 0.0529 0.0811
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0165 0.1941 0.1941
Brugia malayi nuclear receptor NHR-88 0.0165 0.1941 0.2499
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0159 0.1872 0.2409
Echinococcus granulosus intermediate filament protein 0.0055 0.0529 0.1238
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0333 0.0645
Echinococcus multilocularis thyroid hormone receptor alpha 0.0295 0.3625 0.3625
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0162 0.1909 0.2458
Entamoeba histolytica hypothetical protein 0.0078 0.0823 0.4259
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0087 0.0938 0.1208
Entamoeba histolytica hypothetical protein 0.0078 0.0823 0.4259
Schistosoma mansoni lamin 0.0055 0.0529 0.1238
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0078 0.0818 0.1914
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.1221 0.1572
Brugia malayi hypothetical protein 0.0078 0.0818 0.1053
Echinococcus multilocularis hormone sensitive lipase 0.0246 0.299 0.299
Schistosoma mansoni carbonic anhydrase-related 0.0162 0.1909 0.4468
Loa Loa (eye worm) hypothetical protein 0.0159 0.1872 0.2409
Brugia malayi hypothetical protein 0.0519 0.6524 0.8398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0427 0.0999
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0083 0.0888 1
Brugia malayi Uncoordinated protein 44 0.0014 0.000000010732 0.000000013815
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0333 0.0429
Loa Loa (eye worm) hypothetical protein 0.0027 0.016 0.0205
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.146 0.7647
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0165 0.1941 0.2499
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0165 0.1941 0.4543
Brugia malayi Nuclear hormone receptor-like 1 0.0087 0.0938 0.1208
Brugia malayi hypothetical protein 0.0087 0.0938 0.1208
Schistosoma mansoni inositol monophosphatase 0.0039 0.0321 0.0752
Brugia malayi ecdysone receptor 0.0078 0.0818 0.1053
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0224
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0062 0.008
Echinococcus granulosus lamin dm0 0.0055 0.0529 0.1238
Schistosoma mansoni jun-related protein 0.0211 0.2546 0.5958
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.3134 0.4034
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0083 0.0888 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0165 0.1941 0.2499
Echinococcus multilocularis geminin 0.0165 0.1943 0.1943
Schistosoma mansoni inositol monophosphatase 0.0039 0.0321 0.0752
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Echinococcus multilocularis nuclear receptor nhr 48 0.0078 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0157 0.1839 0.2368
Echinococcus multilocularis carbonic anhydrase 0.0162 0.1909 0.1909
Echinococcus granulosus thymidylate synthase 0.0161 0.189 0.4423
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0146 0.1698 0.3973
Mycobacterium ulcerans aldehyde dehydrogenase 0.0127 0.146 0.7647
Brugia malayi Death domain containing protein 0.0014 0.000000010732 0.000000013815
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0823 0.0823
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0268 0.1097
Loa Loa (eye worm) hypothetical protein 0.0083 0.0888 0.1143
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0165 0.1941 0.2499
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0165 0.1941 0.2499
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.0616
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0333 0.1369
Onchocerca volvulus 0.0519 0.6524 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0345 0.4273 0.5501
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0028 0.0174 0.0224
Brugia malayi nuclear receptor NHR-88 0.0078 0.0818 0.1053
Brugia malayi Latrophilin receptor protein 2 0.005 0.0466 0.0599
Loa Loa (eye worm) hypothetical protein 0.0026 0.0146 0.0189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0165 0.1941 0.2499
Onchocerca volvulus 0.0028 0.0174 0.0267
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0321 0.0616
Schistosoma mansoni hypothetical protein 0.005 0.0466 0.109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0078 0.0818 0.0818
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0174 0.0614
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0333 0.0333
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0078 0.0818 0.1254
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0165 0.1941 0.2499
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0333 0.078
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0165 0.1941 0.1941
Loa Loa (eye worm) steroid hormone receptor 0.0165 0.1941 0.2499
Brugia malayi nuclear receptor NHR-67 0.0078 0.0818 0.1053
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0083 0.0117
Schistosoma mansoni hypothetical protein 0.013 0.1499 0.3508
Loa Loa (eye worm) nuclear hormone receptor 0.0078 0.0818 0.1053
Echinococcus granulosus jun protein 0.026 0.3176 0.7432
Echinococcus granulosus ecdysone induced protein 78C 0.0165 0.1941 0.4543
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0466 0.0599
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0321 0.0321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0078 0.0818 0.0818
Brugia malayi thymidylate synthase 0.0161 0.189 0.2433
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0083 0.0888 0.0888
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0107
Schistosoma mansoni nuclear hormone receptor 0.0165 0.1941 0.4543
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0165 0.1941 0.4543
Loa Loa (eye worm) hypothetical protein 0.0519 0.6524 0.8398
Loa Loa (eye worm) carbonic anhydrase 3 0.0345 0.4273 0.5501
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0165 0.1941 0.1941
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0246 0.299 0.6997
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0087 0.0938 0.2196
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0224
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.000000010732 0.000000010732
Schistosoma mansoni hypothetical protein 0.0078 0.0823 0.1926
Toxoplasma gondii hypothetical protein 0.0162 0.1909 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0078 0.0818 0.1914
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0823 0.1926
Echinococcus multilocularis Protein lozenge 0.0065 0.0656 0.0656
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0466 0.109
Loa Loa (eye worm) hypothetical protein 0.0162 0.1909 0.2458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0427 0.0999
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0427 0.0427
Schistosoma mansoni lamin 0.0055 0.0529 0.1238
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0107
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0466 0.0466
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0078 0.0818 0.1254
Echinococcus granulosus carbonic anhydrase 0.0162 0.1909 0.4468
Schistosoma mansoni thyroid hormone receptor 0.0295 0.3625 0.8484
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0321 0.0752
Brugia malayi photoreceptor-specific nuclear receptor 0.0165 0.1941 0.2499
Brugia malayi nuclear hormone receptor family member nhr-6 0.0078 0.0818 0.1053
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0321 0.0968
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.026 0.3176 0.3176
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0378 0.163
Brugia malayi tailless protein 0.0078 0.0818 0.1053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0165 0.1941 0.4543
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0333 0.0645
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0378 0.0994
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.016 0.0373
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0174 0.0579
Brugia malayi Muscleblind-like protein 0.0157 0.1839 0.2368
Plasmodium falciparum carbonic anhydrase 0.0162 0.1909 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0378 0.0355
Echinococcus multilocularis jun protein 0.026 0.3176 0.3176
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0333 0.0209
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0333 0.1045
Schistosoma mansoni nuclear receptor 0.0078 0.0818 0.1914
Echinococcus granulosus FTZ F1 alpha 0.0165 0.1941 0.4543
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0165 0.1941 0.2499
Brugia malayi Nuclear hormone receptor-like 1 0.0165 0.1941 0.2499
Brugia malayi hypothetical protein 0.0076 0.0802 0.1032
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0818 0.1914
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0165 0.1941 0.2976
Mycobacterium ulcerans thymidylate synthase 0.0161 0.189 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0333 0.0044
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0427 0.0999
Loa Loa (eye worm) hypothetical protein 0.005 0.0466 0.0599
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0165 0.1941 0.4543
Brugia malayi nuclear receptor RXR 0.0087 0.0938 0.1208
Schistosoma mansoni intermediate filament proteins 0.0055 0.0529 0.1238
Loa Loa (eye worm) hypothetical protein 0.0162 0.1909 0.2458
Loa Loa (eye worm) hypothetical protein 0.0165 0.1941 0.2499
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0165 0.1941 0.4543
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.000000010732 0.000000025115
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0165 0.1941 0.2499
Brugia malayi hypothetical protein 0.0078 0.0818 0.1053
Schistosoma mansoni hypothetical protein 0.005 0.0466 0.109
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.4341
Schistosoma mansoni chromatin regulatory protein sir2 0.0083 0.0888 0.2077
Loa Loa (eye worm) hypothetical protein 0.0246 0.299 0.3849
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0162 0.1909 0.2458
Brugia malayi Steroid receptor seven-up type 2 0.0165 0.1941 0.2499
Brugia malayi intermediate filament protein 0.0055 0.0529 0.0681
Schistosoma mansoni ap endonuclease 0.004 0.0333 0.078
Echinococcus multilocularis ecdysone induced protein 78C 0.0165 0.1941 0.1941
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0378 0.0355
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0174 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0165 0.1941 0.2499
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0078 0.0818 0.1053
Schistosoma mansoni coup transcription factor 0.0165 0.1941 0.4543
Brugia malayi Nuclear hormone receptor E75 0.0078 0.0818 0.1053
Loa Loa (eye worm) inositol-1 0.0039 0.0321 0.0414
Brugia malayi ecdysteroid receptor 0.0165 0.1941 0.2499
Echinococcus granulosus carbonic anhydrase 0.0162 0.1909 0.4468
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0427 0.0999
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0165 0.1941 0.1941
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0107
Loa Loa (eye worm) hypothetical protein 0.0087 0.0938 0.1208
Schistosoma mansoni hypothetical protein 0.0165 0.1943 0.4548
Loa Loa (eye worm) hypothetical protein 0.0162 0.1909 0.2458
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0083 0.0888 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0938 0.1208
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0161 0.189 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0378 0.0884
Echinococcus granulosus Nuclear hormone receptor HR96 0.0078 0.0818 0.1914
Loa Loa (eye worm) hypothetical protein 0.0253 0.3083 0.3969
Schistosoma mansoni carbonic anhydrase-related 0.0162 0.1909 0.4468
Onchocerca volvulus 0.0165 0.1941 0.2976
Echinococcus granulosus geminin 0.0165 0.1943 0.4548
Schistosoma mansoni aldehyde dehydrogenase 0.0127 0.146 0.3416
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.9895
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0078 0.0818 0.1914
Toxoplasma gondii exonuclease III APE 0.004 0.0333 0.0075
Echinococcus multilocularis muscleblind protein 1 0.0157 0.1839 0.1839
Loa Loa (eye worm) DR-78 0.0078 0.0818 0.1053
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0076 0.0802 0.1758
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0427 0.0549
Loa Loa (eye worm) hypothetical protein 0.0055 0.0529 0.0681
Echinococcus multilocularis transcription factor Dp 1 0.0084 0.0905 0.0905
Onchocerca volvulus 0.0055 0.0529 0.0811
Schistosoma mansoni lozenge 0.0065 0.0656 0.1536
Onchocerca volvulus 0.0078 0.0818 0.1254
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0078 0.0818 0.1053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0165 0.1941 0.4543
Echinococcus multilocularis GPCR, family 2 0.005 0.0466 0.0466
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0161 0.189 0.4341
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0083 0.5
Brugia malayi nuclear receptor RXR 0.0078 0.0818 0.1053
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0333 0.1485
Echinococcus granulosus thyroid hormone receptor alpha 0.0078 0.0818 0.1914
Onchocerca volvulus 0.0161 0.189 0.2897
Echinococcus multilocularis thymidylate synthase 0.0161 0.189 0.189
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0345 0.4273 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0333 0.0209
Echinococcus granulosus muscleblind protein 0.0157 0.1839 0.4304
Leishmania major carbonic anhydrase-like protein 0.0345 0.4273 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0083 0.008
Brugia malayi Cytochrome P450 family protein 0.0019 0.0062 0.008
Schistosoma mansoni nuclear receptor 0.0078 0.0818 0.1914
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0165 0.1941 0.4543
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0165 0.1941 0.4543

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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