Detailed information for compound 986358

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 358.825 | Formula: C17H19ClN6O
  • H donors: 3 H acceptors: 4 LogP: 2.02 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1O)c1nn(c2c1c(N)ncn2)CC1CCCNC1
  • InChi: 1S/C17H19ClN6O/c18-12-4-3-11(6-13(12)25)15-14-16(19)21-9-22-17(14)24(23-15)8-10-2-1-5-20-7-10/h3-4,6,9-10,20,25H,1-2,5,7-8H2,(H2,19,21,22)
  • InChiKey: MVFQHVQABARLKS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Homo sapiens protein kinase, DNA-activated, catalytic polypeptide Starlite/ChEMBL References
Homo sapiens epidermal growth factor receptor Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens HCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Furin-like cysteine rich region family protein Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus melanoma receptor tyrosine protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) TK/EGFR protein kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-4 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Receptor tyrosine-protein kinase erbB-2 precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05085 receptor tyrosine-protein kinase erbB-4, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus DNA dependent protein kinase catalytic subunit Get druggable targets OG5_132688 All targets in OG5_132688
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum Epidermal growth factor receptor precursor, putative Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Tyrosine-protein kinase transforming protein erbB, putative Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum hypothetical protein Get druggable targets OG5_128597 All targets in OG5_128597
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma japonicum IPR000494,EGF receptor, L domain,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_128597 All targets in OG5_128597
Echinococcus granulosus epidermal growth factor receptor Get druggable targets OG5_128597 All targets in OG5_128597
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing Get druggable targets OG5_128597 All targets in OG5_128597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tyrosine kinase 0.0031 0.0162 0.0162
Schistosoma mansoni tyrosine kinase 0.0031 0.0162 0.0162
Schistosoma mansoni tyrosine kinase 0.0062 0.1067 0.1067
Loa Loa (eye worm) SRC-1 0.0066 0.1177 0.139
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0223 0.5
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0334 0.0425
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0062 0.1067 0.1067
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.1562 0.1845
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Echinococcus multilocularis tyrosine protein kinase Blk 0.0054 0.0819 0.0819
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0031 0.0162 0.0162
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0652 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0176 0.4355 0.4355
Echinococcus multilocularis tyrosine protein kinase HCK 0.0041 0.0452 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.1371 0.1915
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0334 0.0271
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.2006 0.2713
Trypanosoma cruzi target of rapamycin kinase 3 0.0073 0.1372 0.1787
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0084 0.1691 0.2253
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0042 0.0474 0.0474
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0042 0.0474 0.0627
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0066 0.1177 0.1177
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0042 0.0474 0.0474
Schistosoma mansoni tyrosine kinase 0.0101 0.2197 0.2197
Loa Loa (eye worm) TK/EGFR protein kinase 0.0185 0.4599 0.5431
Echinococcus multilocularis c src tyrosine kinase 0.0031 0.0162 0.0162
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0042 0.0474 0.0627
Schistosoma mansoni tyrosine kinase 0.0101 0.2197 0.2197
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0268 0.6997 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0652 0.0735
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0787 0.1076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.1691 0.2375
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0084 0.1691 0.1691
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0148 0.0158
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0474 0.0551
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Schistosoma mansoni tyrosine kinase 0.0096 0.2035 0.2035
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0372 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0652 0.0931
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0048 0.0652 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0972 0.1341
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0268 0.6997 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0084 0.1691 0.2253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0942 0.1299
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0048 0.0652 0.0652
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0148 0.0148
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0474 0.1755
Echinococcus granulosus serine:threonine protein kinase SMG1 0.003 0.0148 0.0148
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0042 0.0474 0.0476
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0176 0.4355 0.4355
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0048 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0176 0.4355 0.5143
Echinococcus multilocularis tyrosine protein kinase Abl 0.0126 0.2907 0.2907
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0334 0.1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0101 0.2197 0.2197
Echinococcus multilocularis 0.0056 0.0882 0.0882
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0042 0.0474 0.0678
Echinococcus granulosus tyrosine protein kinase ABL1 0.0267 0.6984 0.6984
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0972 0.1341
Schistosoma mansoni tyrosine kinase 0.0096 0.2035 0.2035
Echinococcus granulosus epidermal growth factor receptor 0.0185 0.4599 0.4599
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0652 0.2709
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Entamoeba histolytica protein kinase, putative 0.0041 0.0452 0.0444
Echinococcus granulosus tyrosine protein kinase Blk 0.0054 0.0819 0.0819
Leishmania major phosphatidylinositol 3-kinase, putative 0.0048 0.0652 0.1247
Echinococcus granulosus tyrosine protein kinase Src64B 0.0066 0.1177 0.1177
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0334 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0066 0.1188 0.1652
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0334 0.0425
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0084 0.1691 0.2417
Leishmania major phosphatidylinositol 3-kinase, putative 0.0042 0.0474 0.0551
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Entamoeba histolytica hypothetical protein 0.0215 0.5466 0.7763
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0268 0.6997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.1691 0.2375
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0148 0.0158
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0042 0.0474 0.0474
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0474 0.2855
Echinococcus granulosus tyrosine protein kinase Lyn 0.0066 0.1177 0.1177
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0084 0.1691 0.2253
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0268 0.6997 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0031 0.0162 0.0162
Giardia lamblia GTOR 0.0084 0.1691 0.2359
Toxoplasma gondii target of rapamycin (TOR), putative 0.007 0.129 1
Loa Loa (eye worm) TK protein kinase 0.0041 0.0452 0.0534
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0268 0.6997 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0267 0.6984 0.8247
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0474 0.0476
Brugia malayi Protein kinase domain containing protein 0.0062 0.1067 0.1524
Echinococcus multilocularis insulin receptor 0.0062 0.1067 0.1067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0652 0.0881
Echinococcus granulosus serine protein kinase ATM 0.003 0.0148 0.0148
Schistosoma mansoni inositol monophosphatase 0.0037 0.0334 0.0334
Schistosoma mansoni inositol monophosphatase 0.0037 0.0334 0.0334
Brugia malayi Furin-like cysteine rich region family protein 0.0185 0.4599 0.6573
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.371 0.5302
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0334 0.0271
Onchocerca volvulus Tyrosine kinase homolog 0.0175 0.4324 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.1371 0.1915
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0031 0.0162 0.0162
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0215 0.5466 0.7763
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Schistosoma mansoni fkbp-rapamycin associated protein 0.003 0.0148 0.0148
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0042 0.0474 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.1371 0.1915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.1052 0.1457
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0042 0.0474 0.0627
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0334 0.0334
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0186 0.4649 0.6625
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0042 0.0474 0.056
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0073 0.1372 0.6589
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0042 0.0474 0.2855
Echinococcus granulosus tyrosine kinase 0.0054 0.0819 0.0819
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0267 0.6984 0.6984
Echinococcus granulosus tyrosine protein kinase Src42A 0.0066 0.1177 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0148 0.0158
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0176 0.4355 0.6224
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0334 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.1371 0.1915
Echinococcus multilocularis epidermal growth factor receptor 0.0101 0.2197 0.2197
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0334 0.0425
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0066 0.1177 0.1177
Loa Loa (eye worm) inositol-1 0.0037 0.0334 0.0395
Loa Loa (eye worm) hypothetical protein 0.0101 0.2183 0.2577
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.003 0.0148 0.0148
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0066 0.1177 0.1177
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0066 0.1177 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.097 0.1339
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0148 0.0212
Echinococcus granulosus tyrosine protein kinase HCK 0.0041 0.0452 0.0452
Echinococcus multilocularis Zinc finger, PHD finger 0.0042 0.0474 0.0474
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.2436 0.334
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0223 0.0265
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187 0.4671 0.5516
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0066 0.1177 0.1177
Leishmania major hypothetical protein, conserved 0.0125 0.288 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Brugia malayi protein-tyrosine kinase 0.0054 0.0819 0.1171
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0048 0.0652 0.2709
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0066 0.1177 0.1177
Brugia malayi Inositol-1 0.0037 0.0334 0.0478
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0372 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0084 0.1691 0.5331
Schistosoma mansoni tyrosine kinase 0.0066 0.1177 0.1177
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0657 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.1052 0.1457
Loa Loa (eye worm) hypothetical protein 0.0033 0.0223 0.0263
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0079 0.1562 0.2064
Schistosoma mansoni tyrosine kinase 0.0062 0.1067 0.1067
Schistosoma mansoni tyrosine kinase 0.0255 0.6617 0.6617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0972 0.1341
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0095 0.2006 0.2828
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0148 0.0148
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0223 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0095 0.2006 0.2828
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.2907 0.4155
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0084 0.1691 0.8305
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0095 0.2006 0.2006
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0042 0.0474 0.0474
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.1371 0.1915
Trichomonas vaginalis PIKK family atypical protein kinase 0.0084 0.1691 0.2375
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0325 0.8634 0.8634
Echinococcus multilocularis epidermal growth factor receptor 0.0185 0.4599 0.4599
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0084 0.1691 0.2253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0652 0.0881
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0095 0.2006 1
Echinococcus granulosus insulin receptor 0.0062 0.1067 0.1067
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0095 0.2006 0.2713
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0042 0.0474 0.0476
Loa Loa (eye worm) TK protein kinase 0.0054 0.0819 0.0967
Echinococcus granulosus c src tyrosine kinase 0.0031 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0787 0.1076
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0084 0.1691 0.8305
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0334 0.0334
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0123 0.2823 0.3905
Loa Loa (eye worm) hypothetical protein 0.0092 0.1918 0.2265
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0334 0.0271
Brugia malayi SRC-1 0.0066 0.1177 0.1682
Loa Loa (eye worm) phosphatidylinositol 3 0.0084 0.1691 0.1997
Echinococcus granulosus tyrosine protein kinase Fyn 0.0066 0.1177 0.1177
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0133 0.3117 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0652 0.0881
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0044 0.0543 0.2123
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0033 0.0223 0.0651
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0066 0.1177 0.1177
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0084 0.1691 0.5331
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0268 0.6997 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0062 0.1067 0.126
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0095 0.2006 0.2713
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0325 0.8634 0.8634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.097 0.1339
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0252 0.6553 0.9352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0787 0.1076
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0657 0.0657
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0042 0.0474 0.0476
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0148 0.0212
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0819 0.0819
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0268 0.6997 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0868 0.1192
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0095 0.2006 0.2828
Schistosoma mansoni tyrosine kinase 0.0066 0.1177 0.1177
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0062 0.1067 0.1067
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0042 0.0474 0.5
Schistosoma mansoni tyrosine kinase 0.0096 0.2035 0.2035
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0054 0.0819 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0652 0.0881
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0186 0.4649 0.6625
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.2278 0.3256
Schistosoma mansoni tyrosine kinase 0.0185 0.4599 0.4599
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0066 0.1177 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0972 0.1341
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0048 0.0652 0.0735
Loa Loa (eye worm) phosphatidylinositol 3 0.0319 0.8468 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.0054 0.0819 0.0819
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0042 0.0474 0.0474
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0084 0.1691 0.1691
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0084 0.1691 0.1691
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0048 0.0652 0.1247
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0334 0.1627
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187 0.4671 0.6675
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.097 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.007 0.129 0.1799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0652 0.0881
Echinococcus granulosus epidermal growth factor receptor 0.0101 0.2197 0.2197
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0095 0.2006 0.2867
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0038 0.0358 0.113
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0073 0.1372 0.4079

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.132 uM Inhibition of recombinant c-Src by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 1.13 uM Inhibition of recombinant HCK by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 1.93 uM Inhibition of DNA-PK by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 2.72 uM Inhibition of recombinant EGFR by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 3.2 uM Inhibition of recombinant mTOR by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 6.05 uM Inhibition of recombinant PI3Kdelta by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 7.16 uM Inhibition of recombinant VEGFR2 by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 7.93 uM Inhibition of recombinant c-Abl by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 12.5 uM Inhibition of recombinant PI3Kgamma by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 100 uM Inhibition of recombinant PI3Kalpha by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 100 uM Inhibition of recombinant PI3Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 100 uM Inhibition of recombinant PI4Kbeta by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971
IC50 (binding) = 100 uM Inhibition of recombinant EphB4R by radioactive phosphotransfer assay in presence of 10 uM ATP ChEMBL. 18849971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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