Detailed information for compound 993795

Basic information

Technical information
  • TDR Targets ID: 993795
  • Name: (4aS,8aR,9aS)-3,5,8a-trimethyl-4,4a,9,9a-tetr ahydrobenzo[f][1]benzoxol-2-one
  • MW: 230.302 | Formula: C15H18O2
  • H donors: 0 H acceptors: 1 LogP: 2.56 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1=C2C[C@H]3C(=CC=C[C@]3(C[C@@H]2OC1=O)C)C
  • InChi: 1S/C15H18O2/c1-9-5-4-6-15(3)8-13-11(7-12(9)15)10(2)14(16)17-13/h4-6,12-13H,7-8H2,1-3H3/t12-,13-,15-/m0/s1
  • InChiKey: MUUFCNJBWLIDFJ-YDHLFZDLSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4aS,8aR,9aS)-3,5,8a-trimethyl-4,4a,9,9a-tetrahydrobenzo[f]benzofuran-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.0412 0.0591 0.0591
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.05 0.0735 0.0549
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0222 0.0284 0.0284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0544 0.0806 0.0806
Schistosoma mansoni immunophilin 0.0145 0.0159 0.0159
Loa Loa (eye worm) hypothetical protein 0.0069 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6211 1 1
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0345 0.0345
Loa Loa (eye worm) hypothetical protein 0.133 0.2082 0.2082
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0159 0.0159
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2168 0.3441 0.3441
Trichomonas vaginalis PIKK family atypical protein kinase 0.3712 0.5947 0.5947
Trichomonas vaginalis PIKK family atypical protein kinase 0.2113 0.3352 0.3352
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2168 0.3441 0.3441
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0222 0.0284 0.0284
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0168 0.0196 0.0196
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0477 0.0697 0.0511
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6211 1 1
Echinococcus granulosus serine protein kinase ATM 0.1195 0.1862 0.1862
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0069 0.0035 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0477 0.0697 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.4949 0.7953 0.7953
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1195 0.1862 0.1862
Onchocerca volvulus 0.0412 0.0591 0.5
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0168 0.0196 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2113 0.3352 0.3352
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6211 1 1
Toxoplasma gondii FATC domain-containing protein 0.1195 0.1862 0.1856
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.0403
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2168 0.3441 0.3441
Leishmania major hypothetical protein, conserved 0.0511 0.0752 0.0567
Plasmodium vivax hypothetical protein 0.0412 0.0591 0.9189
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2168 0.3441 0.3422
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0196 0.0196
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0626 0.0439
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2168 0.3441 0.3422
Schistosoma mansoni hypothetical protein 0.0919 0.1414 0.1414
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0412 0.0591 0.0591
Schistosoma mansoni hypothetical protein 0.0412 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1195 0.1862 0.1862
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0412 0.0591 0.0591
Entamoeba histolytica hypothetical protein 0.0412 0.0591 0.0403
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0196 0.0196
Trichomonas vaginalis PIKK family atypical protein kinase 0.4949 0.7953 0.7953
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0619 0.0928 0.0928
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0477 0.0697 0.067
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1195 0.1862 0.1838
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0412 0.0591 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.3375 0.5399 0.5399
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0691 0.1045 0.1045
Echinococcus multilocularis serine protein kinase ATM 0.1195 0.1862 0.1862
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6211 1 1
Entamoeba histolytica hypothetical protein 0.0575 0.0857 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Giardia lamblia Phosphatidylinositol 4-kinase 0.0412 0.0591 0.0403
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0168 0.0196 0.0196
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0145 0.0159 0.0159
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0626 0.0439
Plasmodium vivax hypothetical protein, conserved 0.0412 0.0591 0.9189
Trichomonas vaginalis PIKK family atypical protein kinase 0.3693 0.5915 0.5915
Echinococcus multilocularis fk506 binding protein 0.0168 0.0196 0.0196
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0412 0.0591 0.0564
Loa Loa (eye worm) hypothetical protein 0.0207 0.0259 0.0259
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0477 0.0697 0.0511
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0168 0.0196 0.0196
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0575 0.0857 0.0674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0783 0.1194 0.1194
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0238 0.031 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.3369 0.539 0.539
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0807 0.1233 0.1233
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0433 0.0626 0.0626
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0919 0.1414 0.1414
Trichomonas vaginalis PIKK family atypical protein kinase 0.3712 0.5947 0.5947
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0433 0.0626 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4954 0.7962 0.7921
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0619 0.0928 0.0928
Echinococcus multilocularis Zinc finger, PHD finger 0.0433 0.0626 0.0626
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2125 0.3371 0.3238
Loa Loa (eye worm) phosphatidylinositol 3 0.6211 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0433 0.0626 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0433 0.0626 0.0626
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0433 0.0626 0.0626
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0168 0.0196 0.0196
Leishmania major phosphatidylinositol kinase, putative 0.0412 0.0591 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.5292 0.851 0.851
Trichomonas vaginalis PIKK family atypical protein kinase 0.4949 0.7953 0.7953
Echinococcus multilocularis 0.0412 0.0591 0.0591
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0433 0.0626 0.0626
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2929 0.4676 0.457
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0544 0.0806 0.0806
Loa Loa (eye worm) phosphatidylinositol kinase 0.0412 0.0591 0.0591
Schistosoma mansoni voltage-gated potassium channel 0.0069 0.0035 0.0035
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0619 0.0928 0.0901
Entamoeba histolytica hypothetical protein 0.1195 0.1862 0.1699
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.1862 0.1862
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0412 0.0591 0.9189
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6211 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0477 0.0697 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0412 0.0591 0.0591
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0433 0.0626 0.0626
Trichomonas vaginalis conserved hypothetical protein 0.0783 0.1194 0.1194
Trichomonas vaginalis PIKK family atypical protein kinase 0.3375 0.5399 0.5399
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.0564
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1195 0.1862 0.1862
Loa Loa (eye worm) phosphatidylinositol 3 0.2125 0.3371 0.3371
Entamoeba histolytica hypothetical protein 0.0412 0.0591 0.0403
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0433 0.0626 0.0626
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0477 0.0697 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.4949 0.7953 0.7953
Trichomonas vaginalis PIKK family atypical protein kinase 0.3375 0.5399 0.5399
Brugia malayi FAT domain containing protein 0.0919 0.1414 0.1414
Onchocerca volvulus 0.0412 0.0591 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3693 0.5915 0.5915
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0433 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1668 0.263 0.263
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0196 0.0168
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0807 0.1233 0.1233
Loa Loa (eye worm) phosphatidylinositol 3 0.0764 0.1162 0.1162
Loa Loa (eye worm) hypothetical protein 0.1256 0.1962 0.1962
Trichomonas vaginalis PIKK family atypical protein kinase 0.4031 0.6463 0.6463
Loa Loa (eye worm) hypothetical protein 0.0145 0.0159 0.0159
Echinococcus multilocularis voltage gated potassium channel 0.0069 0.0035 0.0035
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0433 0.0626 0.0051
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0238 0.031 0.031
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0412 0.0591 0.0591
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0552 0.0819 0.0819
Trichomonas vaginalis PIKK family atypical protein kinase 0.2113 0.3352 0.3352
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0238 0.031 0.031
Echinococcus granulosus voltage gated potassium channel 0.0069 0.0035 0.0035
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0477 0.0697 0.0697
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2125 0.3371 0.3238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1195 0.1862 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.6211 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0455 0.0662 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.6211 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0412 0.0591 0.0591
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0552 0.0819 0.0819
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2592 0.4128 0.4011
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0168 0.0196 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0919 0.1414 0.1414
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0433 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1206 0.1881 0.1881
Trichomonas vaginalis PIKK family atypical protein kinase 0.2113 0.3352 0.3352
Mycobacterium leprae conserved hypothetical protein 0.0412 0.0591 0.5
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0477 0.0697 0.0697
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0626 0.0599
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6211 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0783 0.1194 0.1168
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0433 0.0626 0.0439
Loa Loa (eye worm) phosphatidylinositol 3 0.0412 0.0591 0.0591
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0069 0.0035 0.0035
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6211 1 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2113 0.3352 0.3219
Trypanosoma cruzi hypothetical protein, conserved 0.0099 0.0084 0.0055
Loa Loa (eye worm) FKBP5 protein 0.0168 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0412 0.0591 0.0591
Schistosoma mansoni immunophilin 0.0168 0.0196 0.0196
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1195 0.1862 0.1862
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0619 0.0928 0.0928
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0238 0.031 0.031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0069 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0412 0.0591 0.0403
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0508 0.0749 0.0563
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0196 0.0168
Trichomonas vaginalis fk506-binding protein, putative 0.0168 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0544 0.0806 0.0806
Entamoeba histolytica protein kinase rad3, putative 0.1195 0.1862 0.1699
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0188 0.0229 0.0229
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0433 0.0626 0.0439
Leishmania major phosphatidylinositol 3-kinase, putative 0.0433 0.0626 0.0439
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0691 0.1045 0.1045
Leishmania major phosphatidylinositol 3-kinase, putative 0.2113 0.3352 0.3219
Leishmania major phosphatidylinositol kinase related protein, putative 0.0412 0.0591 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.3371 0.3371
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1195 0.1862 0.1838
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.0564
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1195 0.1862 0.1862
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0412 0.0591 0.0591
Loa Loa (eye worm) phosphatidylinositol 3 0.0412 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.3369 0.539 0.539
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0412 0.0591 0.9189
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6211 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3375 0.5399 0.5399
Leishmania major phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.4949 0.7953 0.7953
Schistosoma mansoni immunophilin 0.0168 0.0196 0.0196
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0412 0.0591 0.0403
Loa Loa (eye worm) hypothetical protein 0.0783 0.1194 0.1194
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0919 0.1414 0.1414
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0412 0.0591 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.6211 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0168 0.0196 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.133 0.2082 0.2177
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1206 0.1881 0.1718
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0412 0.0591 0.0591
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0619 0.0928 0.0746
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0412 0.0591 0.9189
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0544 0.0806 0.0806
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0477 0.0697 0.0697
Mycobacterium tuberculosis Conserved hypothetical protein 0.0412 0.0591 0.5
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0168 0.0196 0.0196
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.9189
Giardia lamblia GTOR 0.6211 1 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6211 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0412 0.0591 0.0591
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0412 0.0591 0.0591
Leishmania major hypothetical protein, unknown function 0.0412 0.0591 0.0403
Loa Loa (eye worm) hypothetical protein 0.0919 0.1414 0.1414
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4954 0.7962 0.7921
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0168 0.0196 0.0168
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1195 0.1862 0.1699
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0207 0.026 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.4166 0.6683 0.6683
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0412 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.3369 0.539 0.539
Giardia lamblia Hypothetical protein 0.0412 0.0591 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0412 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.3712 0.5947 0.5947
Toxoplasma gondii target of rapamycin (TOR), putative 0.4631 0.7437 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0412 0.0591 0.0591
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0412 0.0591 0.0564
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0433 0.0626 0.0626
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0433 0.0626 0.0599
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0433 0.0626 0.0626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2168 0.3441 0.3441
Loa Loa (eye worm) hypothetical protein 0.1195 0.1862 0.1862
Loa Loa (eye worm) phosphatidylinositol 3 0.0412 0.0591 0.0591
Trichomonas vaginalis PIKK family atypical protein kinase 0.4631 0.7437 0.7437
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0412 0.0591 0.0591
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0433 0.0626 0.0051
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6211 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0065 0.0029 0.0029
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0619 0.0928 0.0928
Schistosoma mansoni fkbp-rapamycin associated protein 0.1195 0.1862 0.1862
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0412 0.0591 0.0591
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0807 0.1233 0.1233
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0412 0.0591 0.9189
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0168 0.0196 0.0196
Schistosoma mansoni voltage-gated potassium channel 0.026 0.0345 0.0345
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0619 0.0928 0.0901
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0168 0.0196 0.0168
Trichomonas vaginalis immunophilin, putative 0.0168 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.0075 0.0046 0.0046
Trichomonas vaginalis conserved hypothetical protein 0.133 0.2082 0.2082
Trypanosoma cruzi target of rapamycin kinase 3 0.4954 0.7962 0.7956
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6211 1 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 3.69 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 11720526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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