Detailed information for compound 518116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 435.484 | Formula: C24H21N9
  • H donors: 3 H acceptors: 6 LogP: 4.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](c1ccccc1)Nc1nccc(c1)Nc1nccc(n1)c1ccc(cc1)c1nnn[nH]1
  • InChi: 1S/C24H21N9/c1-16(17-5-3-2-4-6-17)27-22-15-20(11-13-25-22)28-24-26-14-12-21(29-24)18-7-9-19(10-8-18)23-30-32-33-31-23/h2-16H,1H3,(H,30,31,32,33)(H2,25,26,27,28,29)/t16-/m0/s1
  • InChiKey: UEUYEHKEXODDCI-INIZCTEOSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens calcium/calmodulin-dependent protein kinase II delta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis CDPK2 Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K08794 calcium/calmodulin-dependent protein kinase I, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calmodulin-domain protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calmodulin-domain protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania infantum protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calmodulin-like domain protein kinase isoenzyme gamma, related Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum Calcium-dependent protein kinase 2, related Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II alpha chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dependent protein kinase-3 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Brugia malayi Cam kinase protein 1 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2B Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 5, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania donovani protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis calcium-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium knowlesi calcium-dependent protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) CAMK/CAMK2 protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Theileria parva calcium-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Candida albicans Serine-threonine protein kinase similar to S. cerevisiae CMK2 (YOL016C) calcium/calmodulin-dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II beta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum Calcium/calmodulin-dependent protein kinase type II delta chain, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calmodulin-domain protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 1 Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma japonicum ko:K04515 calcium/calmodulin-dependent protein kinase (CaM kinase) II, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 2 Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium dependent protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium falciparum calcium-dependent protein kinase 5 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii Plasmodium falciparum CDPK2 protein Get druggable targets OG5_126600 All targets in OG5_126600
Babesia bovis calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Neospora caninum hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 3, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 4 Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Leishmania major protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium berghei calcium-dependent protein kinase 3 Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK2A Get druggable targets OG5_126600 All targets in OG5_126600
Toxoplasma gondii calcium-dependent protein kinase CDPK3 Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium vivax calcium-dependent protein kinase 4, putative Get druggable targets OG5_126600 All targets in OG5_126600
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands Get druggable targets OG5_126600 All targets in OG5_126600
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126600 All targets in OG5_126600
Cryptosporidium parvum calmodulin-domain protein kinase 1, putative Get druggable targets OG5_126600 All targets in OG5_126600
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126600 All targets in OG5_126600
Plasmodium yoelii calcium-dept. protein kinase Get druggable targets OG5_126600 All targets in OG5_126600
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.022
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0828 0.3041
Mycobacterium tuberculosis Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) 0.0041 0.0366 1
Brugia malayi cytochrome P450 0.0033 0.023 0.0366
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0052 0.0052
Echinococcus granulosus tar DNA binding protein 0.0069 0.0828 0.2659
Mycobacterium tuberculosis Mycolic acid synthase PcaA (cyclopropane synthase) 0.0041 0.0366 1
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0041 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0402 0.6287 1
Mycobacterium ulcerans methoxy mycolic acid synthase 5 MmaA5 0.0041 0.0366 0.0692
Mycobacterium ulcerans methoxy mycolic acid synthase 2, MmaA2 0.0041 0.0366 0.0692
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0306 0.4718 0.7504
Schistosoma mansoni protein kinase 0.0152 0.2186 0.8028
Loa Loa (eye worm) RecQ helicase 0.0022 0.0052 0.0082
Leishmania major cytochrome p450-like protein 0.0033 0.023 0.023
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0033 0.023 0.0183
Mycobacterium ulcerans hypothetical protein 0.0152 0.2196 1
Brugia malayi Synaptic glycoprotein SC2 0.0021 0.0048 0.0077
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.015 0.2159 0.2121
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 0.0041 0.0366 0.0692
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0052 0.0082
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0328 0.507 0.507
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.023 0.0183
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0041 0.0366 1
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0828 0.3041
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 0.0041 0.0366 0.0692
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0048 0.022
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0152 0.2196 0.2158
Mycobacterium tuberculosis Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) 0.0041 0.0366 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0022 0.0052 0.0235
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0048 0.022
Loa Loa (eye worm) hypothetical protein 0.0022 0.0052 0.0082
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0022 0.0052 0.0166
Schistosoma mansoni cytochrome P450 0.0033 0.023 0.0844
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0152 0.2196 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0402 0.6287 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0052 0.0003
Loa Loa (eye worm) CYP4Cod1 0.0033 0.023 0.0366
Echinococcus multilocularis synaptic glycoprotein sc2 0.0021 0.0048 0.0155
Brugia malayi Cytochrome P450 family protein 0.0033 0.023 0.0366
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.023 0.0183
Loa Loa (eye worm) cytochrome P450 0.0033 0.023 0.0366
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0041 0.0366 0.0319
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0021 0.0048 0.0178
Mycobacterium ulcerans methoxy mycolic acid synthase 4, MmaA4 0.0041 0.0366 0.0692
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0021 0.0048 0.022
Echinococcus granulosus bloom syndrome protein 0.0022 0.0052 0.0166
Loa Loa (eye worm) hypothetical protein 0.0041 0.0366 0.0582
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0152 0.2196 0.2196
Mycobacterium tuberculosis Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) 0.0041 0.0366 1
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0828 0.1317
Trypanosoma cruzi Emopamil binding protein, putative 0.015 0.2159 0.2121
Entamoeba histolytica hypothetical protein 0.0021 0.0048 0.022
Loa Loa (eye worm) hypothetical protein 0.0152 0.2196 0.3493
Mycobacterium ulcerans mycolic acid synthase PcaA 0.0041 0.0366 0.0692
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0052 0.0235
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.023 0.0366
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0828 0.2659
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0052 0.0052
Echinococcus granulosus Desert hedgehog protein 0.0208 0.3115 1
Leishmania major cytochrome p450-like protein 0.0033 0.023 0.023
Brugia malayi Cytochrome P450 family protein 0.0033 0.023 0.0366
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0628 1 1
Echinococcus granulosus cytochrome P450 2K1 0.0033 0.023 0.0738
Schistosoma mansoni protein kinase 0.0152 0.2186 0.8028
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0021 0.0048 0.022
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0133 0.1883 0.2995
Schistosoma mansoni hypothetical protein 0.0033 0.023 0.0844
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0022 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0306 0.4718 0.7504
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.0041 0.0366 1
Schistosoma mansoni DNA helicase recq5 0.0022 0.0052 0.0189
Loa Loa (eye worm) RNA binding protein 0.0069 0.0828 0.1317
Loa Loa (eye worm) hypothetical protein 0.0041 0.0366 0.0582
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.023 0.0366
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0052 0.0235
Mycobacterium tuberculosis Possible fatty acid synthase 0.0041 0.0366 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0052 0.0082
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0022 0.0052 0.0166
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0048 0.9374
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0152 0.2196 1
Mycobacterium ulcerans mycolic acid synthase UmaA 0.0041 0.0366 0.0692
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0041 0.0366 1
Mycobacterium tuberculosis Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) 0.0041 0.0366 1
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.015 0.2159 0.2121
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0152 0.2196 0.3493
Leishmania major cytochrome p450-like protein 0.0033 0.023 0.023
Onchocerca volvulus 0.0041 0.0366 0.1505
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0033 0.023 0.0183
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0152 0.2186 0.7019
Echinococcus multilocularis 0.0033 0.023 0.0738
Brugia malayi Cytochrome P450 family protein 0.0033 0.023 0.0366
Echinococcus multilocularis bloom syndrome protein 0.0022 0.0052 0.0166
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0586 0.0932
Loa Loa (eye worm) hypothetical protein 0.0041 0.0366 0.0582
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0022 0.0052 0.0166
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 0.0048 0.022
Brugia malayi Hint module family protein 0.0057 0.0625 0.0994
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0828 0.3041
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0828 0.3041
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0052 1
Brugia malayi Hint module family protein 0.0057 0.0625 0.0994
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0021 0.0048 0.0155
Giardia lamblia Sgs1 DNA helicase, putative 0.0022 0.0052 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0052 0.0235
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0022 0.0052 0.0166
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0628 1 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0152 0.2196 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0994
Schistosoma mansoni hypothetical protein 0.0185 0.2723 1
Schistosoma mansoni hypothetical protein 0.0185 0.2723 1
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.015 0.2159 0.2159
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0052 0.0235
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0828 0.1317
Echinococcus granulosus synaptic glycoprotein sc2 0.0021 0.0048 0.0155
Leishmania major sterol 24-c-methyltransferase, putative 0.0628 1 1
Trypanosoma cruzi Emopamil binding protein, putative 0.015 0.2159 0.2121
Brugia malayi Cytochrome P450 family protein 0.0054 0.0586 0.0932
Schistosoma mansoni hypothetical protein 0.0152 0.2186 0.8028
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0048 1
Onchocerca volvulus 0.015 0.2159 1
Echinococcus multilocularis geminin 0.0185 0.2723 0.8743
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0021 0.0048 0.022
Loa Loa (eye worm) hypothetical protein 0.0057 0.0625 0.0994
Loa Loa (eye worm) hypothetical protein 0.0205 0.3065 0.4875
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0048 0.0048
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0022 0.0052 0.0235
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0152 0.2196 1
Trypanosoma brucei C-8 sterol isomerase, putative 0.0402 0.6287 0.6287
Mycobacterium tuberculosis Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) 0.0041 0.0366 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0133 0.1883 0.2995
Schistosoma mansoni DNA helicase recq1 0.0022 0.0052 0.0189
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0041 0.0366 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0077
Echinococcus granulosus geminin 0.0185 0.2723 0.8743
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0021 0.0048 0.022
Toxoplasma gondii cytochrome p450 superfamily protein 0.0033 0.023 0.1047
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0022 0.0052 1
Mycobacterium ulcerans methoxy mycolic acid synthase 3, MmaA3 0.0041 0.0366 0.0692
Brugia malayi TAR-binding protein 0.0069 0.0828 0.1317
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0021 0.0048 0.022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0077
Schistosoma mansoni protein kinase 0.0152 0.2186 0.8028
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0021 0.0048 0.0178
Echinococcus multilocularis hedgehog 0.0208 0.3115 1
Brugia malayi Bloom's syndrome protein homolog 0.0022 0.0052 0.0082
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0033 0.023 0.023
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0033 0.023 0.023
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0402 0.6287 0.6269
Trypanosoma cruzi cytochrome P450, putative 0.0033 0.023 0.0183
Plasmodium falciparum polyprenol reductase, putative 0.0021 0.0048 0.9374
Leishmania major C-8 sterol isomerase-like protein 0.0402 0.6287 0.6287
Trypanosoma brucei Sterol methyltransferase, putative 0.0628 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0828 0.1317
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0628 1 1
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0021 0.0048 0.0155
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0628 1 1
Mycobacterium leprae CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC AC 0.0041 0.0366 1
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0152 0.2196 0.2158
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0152 0.2196 0.2196
Leishmania major hypothetical protein, conserved 0.015 0.2159 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0048 0.022
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0828 0.3041
Plasmodium vivax polyprenol reductase, putative 0.0021 0.0048 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0152 0.2186 0.7019
Mycobacterium leprae MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) 0.0041 0.0366 1
Trypanosoma brucei cytochrome P450, putative 0.0033 0.023 0.023
Brugia malayi RNA binding protein 0.0069 0.0828 0.1317
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0628 1 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0152 0.2196 1
Trypanosoma brucei Emopamil binding protein, putative 0.015 0.2159 0.2159
Mycobacterium leprae POSSIBLE FATTY ACID SYNTHASE 0.0041 0.0366 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.26 uM Inhibition of cloned CaMK2delta (unknown origin) ChEMBL. 18334293
IC50 (binding) = 2.26 uM Inhibition of cloned CaMK2delta (unknown origin) ChEMBL. 18334293

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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