Detailed information for compound 1683066

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 356.459 | Formula: C21H28N2O3
  • H donors: 1 H acceptors: 1 LogP: 3.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1O[C@H]1CC2CC1C1C2CCC1)C1CNC(=O)N1C
  • InChi: 1S/C21H28N2O3/c1-23-17(11-22-21(23)24)12-6-7-18(25-2)20(9-12)26-19-10-13-8-16(19)15-5-3-4-14(13)15/h6-7,9,13-17,19H,3-5,8,10-11H2,1-2H3,(H,22,24)/t13?,14?,15?,16?,17?,19-/m0/s1
  • InChiKey: FHWOSRUUSHMKKA-PWKXAEOISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Phosphodiesterase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus SH3 domain-binding glutamic acid-rich protein homolog Phosphodiesterase 4   536 aa 527 aa 52.6 %
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Phosphodiesterase 4   536 aa 456 aa 27.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Echinococcus granulosus metabotropic glutamate receptor 2 0.062 0.6739 0.6734
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0137 0.1333 0.2029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni glutamate receptor NMDA 0.007 0.0575 0.0606
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0022 0.0036 0.0019
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0022 0.0036 0.0021
Trypanosoma brucei C-8 sterol isomerase, putative 0.0368 0.3912 0.6005
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0036 0.0036
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0532 0.0516
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0022 0.0036 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.0022 0.0036 0.0021
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0017 0.0149
Brugia malayi Guanylyl cyclase protein 23 0.007 0.0575 0.0691
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0081
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni lipoxygenase 0.05 0.5396 0.5844
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0112 0.1045 1
Mycobacterium tuberculosis Methoxy mycolic acid synthase 4 MmaA4 (methyl mycolic acid synthase 4) (MMA4) (hydroxy mycolic acid synthase) 0.0039 0.0231 0.1516
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0532 0.0638
Leishmania major C-8 sterol isomerase-like protein 0.0368 0.3912 0.6005
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0376 0.0376
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.007 0.0575 0.4153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 4 MMAA4 (METHYL MYCOLIC ACID SYNTHASE 4) (MMA4) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0039 0.0231 1
Echinococcus multilocularis neuropeptide s receptor 0.0022 0.0036 0.0019
Schistosoma mansoni rab6-interacting 0.012 0.1135 0.1214
Brugia malayi metabotropic GABA-B receptor subtype 2 0.012 0.1141 0.1393
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0203 0.0203
Echinococcus multilocularis g-protein coupled receptor 0.0022 0.0036 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0017
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0087 0.0763
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0939
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0069 0.0939
Brugia malayi sulfakinin receptor protein 0.0022 0.0036 0.0024
Echinococcus granulosus tachykinin peptides receptor 99D 0.0022 0.0036 0.0019
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.012 0.1141 0.8516
Schistosoma mansoni hypothetical protein 0.0176 0.1766 0.19
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0036 0.0019
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.007 0.0575 0.0575
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0532 0.056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0543 0.5877 0.587
Echinococcus granulosus neuropeptide receptor A26 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0069
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.1348 0.2052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0189 0.0189
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0203 0.0187
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Mycobacterium ulcerans methoxy mycolic acid synthase 5 MmaA5 0.0039 0.0231 0.1516
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni neuropeptide receptor 0.0022 0.0036 0.0021
Schistosoma mansoni biogenic amine receptor 0.0022 0.0036 0.0021
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1045 0.103
Echinococcus granulosus glutamate receptor 2 0.007 0.0575 0.0559
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0017 0.0149
Echinococcus granulosus atrial natriuretic peptide receptor 0.007 0.0575 0.0559
Brugia malayi putative neuropeptide receptor NPR1 0.0022 0.0036 0.0024
Schistosoma mansoni hypothetical protein 0.0176 0.1766 0.19
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.1333 0.2029
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus multilocularis nmda type glutamate receptor 0.007 0.0575 0.0559
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1045 0.103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus lipoxygenase domain containing protein 0.012 0.1135 0.112
Schistosoma mansoni neuropeptide receptor 0.0022 0.0036 0.0021
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0132 0.0116
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.0455
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0022 0.0036 0.0024
Schistosoma mansoni hypothetical protein 0.0139 0.135 0.1449
Loa Loa (eye worm) hypothetical protein 0.019 0.192 0.192
Echinococcus granulosus tyrosine kinase 0.007 0.0575 0.0559
Mycobacterium leprae POSSIBLE FATTY ACID SYNTHASE 0.0039 0.0231 1
Brugia malayi larval opioid receptor 0.0022 0.0036 0.0024
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0036 0.0019
Schistosoma mansoni loxhd1 0.012 0.1135 0.1214
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0036 0.0019
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.3075 0.4715
Schistosoma mansoni neuropeptide receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0368 0.3912 0.4828
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0069 0.0455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0324 0.0308
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Plasmodium vivax hypothetical protein, conserved 0.003 0.0132 0.1165
Schistosoma mansoni hypothetical protein 0.012 0.1141 0.1221
Mycobacterium ulcerans methoxy mycolic acid synthase 4, MmaA4 0.0039 0.0231 0.1516
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0036 0.0019
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0672 0.0712
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.1333 0.2029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Mycobacterium tuberculosis Possible fatty acid synthase 0.0039 0.0231 0.1516
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0132 0.0125
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0022 0.0036 0.0019
Echinococcus multilocularis G-protein coupled receptor, putative 0.0022 0.0036 0.0019
Schistosoma mansoni amine GPCR 0.0022 0.0036 0.0021
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0099 0.0899 0.0883
Schistosoma mansoni tyrosine kinase 0.007 0.0575 0.0606
Leishmania major sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 0.0039 0.0231 0.1516
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0022 0.0036 0.0021
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0455 0.4259
Loa Loa (eye worm) hypothetical protein 0.003 0.0132 0.0132
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0324 0.0381
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0036 0.0019
Echinococcus granulosus glutamate receptor 2 0.007 0.0575 0.0559
Echinococcus granulosus biogenic amine 5HT receptor 0.0022 0.0036 0.0019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0022 0.0036 0.0021
Echinococcus multilocularis peregrin 0.003 0.0132 0.0116
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Loa Loa (eye worm) RecQ helicase 0.002 0.0017 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0324 0.0308
Loa Loa (eye worm) hypothetical protein 0.0911 1 1
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0036 0.0019
Schistosoma mansoni hypothetical protein 0.003 0.0132 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0087 0.0107
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0455 0.2986
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0036 0.0019
Brugia malayi hypothetical protein 0.007 0.0575 0.0691
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0098 0.0893 0.1086
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0203 0.0187
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0039 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Leishmania major sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Trypanosoma cruzi extracellular receptor, putative 0.007 0.0575 0.086
Echinococcus multilocularis neuropeptide receptor 0.0022 0.0036 0.0019
Echinococcus multilocularis G protein coupled receptor 139 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0231 0.0231
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0324 0.0334
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0575 0.0559
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0324 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0532 0.056
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0132 0.0132
Onchocerca volvulus 0.0024 0.0069 0.0255
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0021
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Brugia malayi Dopamine receptor 0.0022 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0292 0.3064 0.3064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus neuropeptide receptor 0.0022 0.0036 0.0019
Echinococcus granulosus Desert hedgehog protein 0.0191 0.193 0.1917
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0264 0.0248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0112 0.1045 0.103
Echinococcus multilocularis neuropeptide Y receptor 0.0022 0.0036 0.0019
Brugia malayi Doublecortin family protein 0.012 0.1135 0.1385
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0069 0.0939
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.046 0.0444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0324 0.0308
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0532 0.0532
Leishmania major hypothetical protein, conserved 0.0026 0.0087 0.0107
Echinococcus granulosus serotonin receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0368 0.3912 0.6005
Mycobacterium ulcerans methoxy mycolic acid synthase 2, MmaA2 0.0039 0.0231 0.1516
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0716 0.7806 0.7803
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0022 0.0036 0.0021
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0036 0.0019
Echinococcus multilocularis serotonin receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1348 0.2052
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0052 0.0375 0.0375
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.0455
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0455 0.0675
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0051 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus g protein coupled receptor 0.0022 0.0036 0.0019
Echinococcus granulosus tm gpcr rhodopsin 0.0543 0.5877 0.587
Onchocerca volvulus 0.007 0.0575 0.4153
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0036 0.0021
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0575 0.0559
Mycobacterium leprae METHOXY MYCOLIC ACID SYNTHASE 1 MMAA1 (METHYL MYCOLIC ACID SYNTHASE 1) (MMA1) (HYDROXY MYCOLIC ACID SYNTHASE) 0.0039 0.0231 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0087 0.0107
Plasmodium falciparum LCCL domain-containing protein 0.012 0.1135 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0022 0.0036 0.0036
Echinococcus multilocularis lipoxygenase domain containing protein 0.012 0.1135 0.112
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0036 0.0036
Plasmodium falciparum phd finger protein, putative 0.003 0.0132 0.1165
Onchocerca volvulus Alhambra homolog 0.003 0.0132 0.0741
Loa Loa (eye worm) melatonin receptor type 1A 0.0022 0.0036 0.0036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0455 0.2986
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0842 0.9221 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0532 0.056
Brugia malayi G-protein coupled receptor 0.0022 0.0036 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0036 0.0021
Echinococcus granulosus receptor type guanylyl cyclase 0.007 0.0575 0.0559
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0036 0.0019
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0022 0.0036 0.0019
Toxoplasma gondii hypothetical protein 0.0047 0.0324 0.299
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0371 0.0439
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0137 0.1333 0.2029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0324 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus Polycystic kidney disease protein 0.012 0.1135 0.112
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus g-protein coupled receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0324 0.0324
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0532 0.056
Schistosoma mansoni hypothetical protein 0.012 0.1135 0.1214
Trypanosoma brucei Emopamil binding protein, putative 0.0137 0.1333 0.2029
Brugia malayi Receptor family ligand binding region containing protein 0.019 0.192 0.2359
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0132 0.1122
Loa Loa (eye worm) hypothetical protein 0.0052 0.0375 0.0375
Trypanosoma brucei Sterol methyltransferase, putative 0.0599 0.6503 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3075 0.4715
Schistosoma mansoni hypothetical protein 0.0035 0.0189 0.0187
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0189 0.0213
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0065
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0017 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0491 0.0491
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 1 CmaA1 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0039 0.0231 0.1516
Schistosoma mansoni biogenic amine (5HT) receptor 0.0022 0.0036 0.0021
Brugia malayi Dopamine receptor protein 1 0.0022 0.0036 0.0024
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.1333 0.2029
Echinococcus granulosus neuropeptide FF receptor 2 0.0022 0.0036 0.0019
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0112 0.1045 0.103
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0069 0.0455
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0022 0.0036 0.0021
Brugia malayi Bromodomain containing protein 0.003 0.0132 0.0143
Brugia malayi hypothetical protein 0.012 0.1135 0.1385
Brugia malayi Serotonin receptor 0.0022 0.0036 0.0024
Onchocerca volvulus 0.0039 0.0231 0.1502
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0455 0.0439
Echinococcus granulosus tm gpcr rhodopsin 0.0022 0.0036 0.0019
Brugia malayi RNA binding protein 0.0066 0.0532 0.0638
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Brugia malayi Hint module family protein 0.0052 0.0375 0.0444
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0575 0.0575
Schistosoma mansoni metabotropic glutamate receptor 0.0361 0.3836 0.4149
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0575 0.0559
Schistosoma mansoni neuropeptide receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0455 0.2986
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi PHD-finger family protein 0.003 0.0132 0.0143
Mycobacterium tuberculosis Methoxy mycolic acid synthase 2 MmaA2 (methyl mycolic acid synthase 2) (MMA2) (hydroxy mycolic acid synthase) 0.0039 0.0231 0.1516
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0087
Echinococcus multilocularis tyrosine kinase 0.007 0.0575 0.0559
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.046 0.0444
Echinococcus multilocularis RUN 0.012 0.1135 0.112
Brugia malayi ORL1-like opioid receptor 0.0022 0.0036 0.0024
Schistosoma mansoni polycystin 1-related 0.012 0.1135 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus neuropeptide s receptor 0.0022 0.0036 0.0019
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0455 0.2986
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0021
Brugia malayi G protein-coupled receptor 0.0022 0.0036 0.0024
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0099 0.0899 0.0883
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Onchocerca volvulus 0.012 0.1135 0.8469
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi neuropeptide F receptor 0.0022 0.0036 0.0024
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.007 0.0575 0.0559
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi S-adenosyl-methionine cycloartenol-C24-methyltransferase 0.0292 0.3064 0.3777
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0022 0.0036 0.0019
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0017 0.5
Schistosoma mansoni protein kinase 0.007 0.0575 0.0606
Echinococcus multilocularis GPCR, family 3, C terminal 0.012 0.1141 0.1126
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0036 0.0021
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0203 0.0202
Mycobacterium leprae CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE 2 CMAA2 (CYCLOPROPANE FATTY ACID SYNTHASE) (CFA SYNTHASE) (CYCLOPROPANE MYCOLIC AC 0.0039 0.0231 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0455 0.0476
Loa Loa (eye worm) hypothetical protein 0.0368 0.3912 0.3912
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0575 0.0559
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus multilocularis atrial natriuretic peptide receptor 0.007 0.0575 0.0559
Schistosoma mansoni tyrosine kinase 0.007 0.0575 0.0606
Echinococcus multilocularis neuropeptide receptor A26 0.0022 0.0036 0.0019
Echinococcus granulosus G protein coupled receptor 139 0.0022 0.0036 0.0019
Echinococcus granulosus allatostatin A receptor 0.0022 0.0036 0.0019
Schistosoma mansoni alpha-1 adrenergic receptor 0.0022 0.0036 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.046 0.0482
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0036 0.0019
Echinococcus granulosus dro:myosuppressin receptor 0.0022 0.0036 0.0019
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0036 0.0019
Schistosoma mansoni growth hormone secretagogue receptor 0.0022 0.0036 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0575 0.0575
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0036 0.0021
Echinococcus multilocularis somatostatin receptor 0.0022 0.0036 0.0019
Schistosoma mansoni opsin-like receptor 0.0022 0.0036 0.0021
Echinococcus granulosus geminin 0.0176 0.1766 0.1752
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0112 0.1045 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0069 0.0455
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0455 0.0439
Onchocerca volvulus 0.012 0.1135 0.8469
Echinococcus multilocularis serotonin receptor 0.0022 0.0036 0.0019
Mycobacterium ulcerans cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 0.0039 0.0231 0.1516
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Onchocerca volvulus Poor gastrulation protein homolog 0.012 0.1141 0.8516
Brugia malayi hypothetical protein 0.012 0.1135 0.1385
Echinococcus multilocularis glutamate receptor 2 0.007 0.0575 0.0559
Echinococcus granulosus peptide allatostatin:somatostatin 0.0022 0.0036 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0532 0.056
Echinococcus granulosus neuropeptides capa receptor 0.0022 0.0036 0.0019
Schistosoma mansoni neuropeptide F-like receptor 0.0022 0.0036 0.0021
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0132 0.1122
Loa Loa (eye worm) hypothetical protein 0.012 0.1135 0.1135
Brugia malayi G protein-coupled receptor F59B2.13 0.0022 0.0036 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0069 0.0455
Brugia malayi metabotropic GABA-B receptor subtype 2 0.007 0.0575 0.0691
Echinococcus granulosus RUN 0.012 0.1135 0.112
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus multilocularis receptor type guanylyl cyclase 0.007 0.0575 0.0559
Echinococcus granulosus somatostatin receptor 0.0022 0.0036 0.0019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Mycobacterium tuberculosis Methoxy mycolic acid synthase 3 MmaA3 (methyl mycolic acid synthase 3) (MMA3) (hydroxy mycolic acid synthase) 0.0039 0.0231 0.1516
Echinococcus granulosus 7tm_1 domain containing protein 0.0022 0.0036 0.0019
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.1523 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0203 0.0202
Echinococcus multilocularis hedgehog 0.0191 0.193 0.1917
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0036 0.0019
Brugia malayi TAR-binding protein 0.0066 0.0532 0.0638
Loa Loa (eye worm) hypothetical protein 0.0039 0.0231 0.0231
Echinococcus multilocularis geminin 0.0176 0.1766 0.1752
Schistosoma mansoni amine GPCR 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0112 0.1045 0.1117
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0022 0.0036 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0357 0.0525
Loa Loa (eye worm) RGC/RGC protein kinase 0.007 0.0575 0.0575
Brugia malayi Melatonin receptor type 1A 0.0022 0.0036 0.0024
Onchocerca volvulus 0.007 0.0575 0.4153
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus GPCR family 3 C terminal 0.012 0.1141 0.1126
Echinococcus multilocularis sex peptide receptor 0.0022 0.0036 0.0019
Schistosoma mansoni rab6-interacting 0.012 0.1135 0.1214
Brugia malayi metabotropic glutamate receptor type 2 0.0361 0.3836 0.4733
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.3075 0.4715
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0371 0.0371
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0671 0.7305 0.9034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.007 0.0575 0.0559
Plasmodium vivax multidomain scavenger receptor, putative 0.012 0.1135 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0022 0.0036 0.0024
Brugia malayi hypothetical protein 0.0026 0.0087 0.0086
Loa Loa (eye worm) hypothetical protein 0.0052 0.0373 0.0373
Mycobacterium ulcerans mycolic acid synthase UmaA 0.0039 0.0231 0.1516
Brugia malayi Dopamine receptor protein 2 0.0022 0.0036 0.0024
Brugia malayi GnHR receptor homolog 0.0022 0.0036 0.0024
Brugia malayi follicle stimulating hormone receptor 0.0022 0.0036 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0837 0.9166 0.9164
Echinococcus multilocularis g protein coupled receptor 0.0022 0.0036 0.0019
Schistosoma mansoni biogenic amine receptor 0.0022 0.0036 0.0021
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0036 0.0019
Mycobacterium tuberculosis Probable cyclopropane-fatty-acyl-phospholipid synthase UfaA1 (cyclopropane fatty acid synthase) (CFA synthase) 0.0039 0.0231 0.1516
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.019 0.192 0.192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0324 0.0308
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.046 0.3022
Mycobacterium tuberculosis Methoxy mycolic acid synthase 1 MmaA1 (methyl mycolic acid synthase 1) (MMA1) (hydroxy mycolic acid synthase) 0.0039 0.0231 0.1516
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0069 0.0065
Echinococcus multilocularis fmrfamide receptor 0.0022 0.0036 0.0019
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0022 0.0036 0.0024
Echinococcus granulosus orexin receptor type 2 0.0022 0.0036 0.0019
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0599 0.6503 1
Echinococcus granulosus g protein coupled receptor 0.0022 0.0036 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Mycobacterium leprae MYCOLIC ACID SYNTHASE PCAA (CYCLOPROPANE SYNTHASE) 0.0039 0.0231 1
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0264 0.0248
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0098 0.0893 0.0878
Mycobacterium ulcerans methoxy mycolic acid synthase 3, MmaA3 0.0039 0.0231 0.1516
Mycobacterium tuberculosis Possible mycolic acid synthase UmaA 0.0039 0.0231 0.1516
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0112 0.1045 0.1045
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0087 0.0763
Loa Loa (eye worm) doublecortin family protein 0.012 0.1135 0.1135
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0022 0.0036 0.0019
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.1348 0.2052
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0022 0.0036 0.0036
Echinococcus granulosus nmda type glutamate receptor 0.007 0.0575 0.0559
Schistosoma mansoni biogenic amine receptor 0.0022 0.0036 0.0021
Giardia lamblia PHD finger protein 15 0.003 0.0132 0.1122
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0087 0.0107
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0256 0.0369
Loa Loa (eye worm) G-protein coupled receptor 0.0022 0.0036 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.0022 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0024 0.0069 0.0069
Echinococcus granulosus g protein coupled receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus granulosus neuropeptide receptor 0.0022 0.0036 0.0019
Brugia malayi neuropeptide F receptor 0.0022 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni adenoreceptor 0.0022 0.0036 0.0021
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0455 0.0476
Echinococcus granulosus alpha 1A adrenergic receptor 0.0022 0.0036 0.0019
Echinococcus multilocularis orexin receptor type 2 0.0022 0.0036 0.0019
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0098 0.0893 0.0893
Echinococcus granulosus peregrin 0.003 0.0132 0.0116
Schistosoma mansoni metabotropic glutamate receptor 0.062 0.6739 0.7304
Echinococcus granulosus tar DNA binding protein 0.0066 0.0532 0.0516
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0069 0.0455
Echinococcus granulosus 7TM GPCR rhodopsin 0.0022 0.0036 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0256 0.0369
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0022 0.0036 0.0019
Brugia malayi jmjC domain containing protein 0.0099 0.0899 0.1093
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni lipoxygenase 0.0716 0.7806 0.8464
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.3075 0.4715
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Echinococcus multilocularis neuropeptide FF receptor 2 0.0022 0.0036 0.0019
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0098 0.0893 0.0878
Schistosoma mansoni opsin-like receptor 0.0022 0.0036 0.0021
Trypanosoma brucei sterol 24-c-methyltransferase, putative 0.0312 0.3293 0.5052
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Schistosoma mansoni myosin xvIII 0.0022 0.0036 0.0021
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) RNA binding protein 0.0066 0.0532 0.0532
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0022 0.0036 0.0021
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.019 0.192 0.192
Brugia malayi Serotonin receptor 0.0022 0.0036 0.0024
Echinococcus multilocularis Polycystic kidney disease protein 0.012 0.1135 0.112
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0716 0.7806 0.7803
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Echinococcus granulosus neuropeptide Y receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) glutamate receptor 0.074 0.8085 0.8085
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0022 0.0036 0.0021
Leishmania major extracellular receptor, putative 0.007 0.0575 0.086
Schistosoma mansoni amine GPCR 0.0022 0.0036 0.0021
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0256 0.0369
Mycobacterium ulcerans hypothetical protein 0.0154 0.1523 1
Brugia malayi RE15519p 0.0022 0.0036 0.0024
Mycobacterium ulcerans hypothetical protein 0.0024 0.0069 0.0455
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0022 0.0036 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.046 0.3022
Echinococcus multilocularis allatostatin A receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi Metabotropic glutamate receptor precursor. 0.074 0.8085 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0022 0.0036 0.0036
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0911 1 1
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.046 0.055
Loa Loa (eye worm) hypothetical protein 0.012 0.1135 0.1135
Echinococcus multilocularis lipoxygenase domain containing protein 0.012 0.1135 0.112
Entamoeba histolytica hypothetical protein 0.007 0.0575 1
Schistosoma mansoni amine GPCR 0.0022 0.0036 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0081
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) glutamate receptor 0.0291 0.3056 0.3056
Echinococcus multilocularis neuropeptides capa receptor 0.0022 0.0036 0.0019
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Brugia malayi Hint module family protein 0.0052 0.0375 0.0444
Mycobacterium ulcerans mycolic acid synthase PcaA 0.0039 0.0231 0.1516
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0132 0.0116
Schistosoma mansoni opsin-like receptor 0.0022 0.0036 0.0021
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Schistosoma mansoni amine GPCR 0.0022 0.0036 0.0021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.046 0.3022
Echinococcus multilocularis dro:myosuppressin receptor 0.0022 0.0036 0.0019
Mycobacterium tuberculosis Mycolic acid synthase PcaA (cyclopropane synthase) 0.0039 0.0231 0.1516
Schistosoma mansoni hypothetical protein 0.0022 0.0036 0.0021
Brugia malayi G-protein coupled receptor 0.0022 0.0036 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0087 0.0678
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0022 0.0036 0.0036
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0022 0.0036 0.0019
Echinococcus granulosus fmrfamide receptor 0.0022 0.0036 0.0019
Echinococcus granulosus rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0022 0.0036 0.0021
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Loa Loa (eye worm) hypothetical protein 0.012 0.1141 0.1141
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0069 0.0455
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0069 0.0081
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0256 0.0369
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0017 0.00000000098146
Loa Loa (eye worm) hypothetical protein 0.0188 0.1899 0.1899
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0087 0.0763
Echinococcus multilocularis rhodopsin orphan GPCR 0.0022 0.0036 0.0019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0371 0.0439
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.007 0.0575 0.0559
Loa Loa (eye worm) TYRA-2 protein 0.0022 0.0036 0.0036
Mycobacterium tuberculosis Cyclopropane-fatty-acyl-phospholipid synthase 2 CmaA2 (cyclopropane fatty acid synthase) (CFA synthase) (cyclopropane mycolic ac 0.0039 0.0231 0.1516
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.007 0.0575 0.0559
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0069 0.0455
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0017 0.5
Echinococcus multilocularis metabotropic glutamate receptor 2 0.062 0.6739 0.6734
Brugia malayi Receptor family ligand binding region containing protein 0.007 0.0575 0.0691
Echinococcus multilocularis glutamate receptor 2 0.007 0.0575 0.0559
Loa Loa (eye worm) hypothetical protein 0.007 0.0575 0.0575
Schistosoma mansoni histamine h1 receptor 0.0022 0.0036 0.0021
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0022 0.0036 0.0021
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.046 0.0684
Onchocerca volvulus 0.0137 0.1333 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0022 0.0036 0.0024
Brugia malayi jmjC domain containing protein 0.0036 0.0203 0.0231
Brugia malayi AKH receptor 0.0022 0.0036 0.0024
Trypanosoma cruzi Emopamil binding protein, putative 0.0137 0.1333 0.2029
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0022 0.0036 0.0024
Brugia malayi putative neuropeptide receptor 0.0022 0.0036 0.0024
Brugia malayi hypothetical protein 0.0022 0.0036 0.0024
Echinococcus granulosus hypothetical protein 0.0022 0.0036 0.0019
Echinococcus granulosus lipoxygenase domain containing protein 0.012 0.1135 0.112
Echinococcus granulosus sex peptide receptor 0.0022 0.0036 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0036
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0017 0.0017
Trypanosoma cruzi sterol 24-c-methyltransferase, putative 0.0039 0.0231 0.033

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 23 nM Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes. ChEMBL. 1992129
IC50 (binding) = 0.56 uM Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE). ChEMBL. 1992129
MED (functional) = 0.32 mg kg-1 Reversal of reserpine-induced hypothermia in mice by intraperitoneal dose ChEMBL. 1992129
MED (functional) = 32 mg kg-1 Minimum effective peroral dose (MED) in mouse forced-swim test ChEMBL. 1992129

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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