Detailed information for compound 1776593

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 627.169 | Formula: C30H47ClN4O8
  • H donors: 6 H acceptors: 8 LogP: -2.65 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 3
  • SMILES: OC(=O)/C=C/C(=O)O.OCC(CNC(=O)[C@H](C(C)C)C[C@@H]([C@H](CN1CC(=O)N(CC1(C)C)c1ccccc1Cl)N)O)(C)C
  • InChi: 1S/C26H43ClN4O4.C4H4O4/c1-17(2)18(24(35)29-14-25(3,4)16-32)11-22(33)20(28)12-30-13-23(34)31(15-26(30,5)6)21-10-8-7-9-19(21)27;5-3(6)1-2-4(7)8/h7-10,17-18,20,22,32-33H,11-16,28H2,1-6H3,(H,29,35);1-2H,(H,5,6)(H,7,8)/b;2-1+/t18-,20-,22-;/m0./s1
  • InChiKey: VBASBCIQPQJXLW-ZOEOTTPFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens renin Starlite/ChEMBL References
Macaca fascicularis Renin Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin I Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium hominis aspartyl protease precursor Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva cathepsin E, putative Get druggable targets OG5_126885 All targets in OG5_126885
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl protease ASP1 Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Pepsinogen A1, related Get druggable targets OG5_126885 All targets in OG5_126885
Theileria parva pepsinogen, putative Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum ko:K01379 cathepsin D [EC3.4.23.5], putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi aspartyl protease, putative Get druggable targets OG5_126885 All targets in OG5_126885
Toxoplasma gondii aspartyl proteinase (eimepsin), putative Get druggable targets OG5_126885 All targets in OG5_126885
Loa Loa (eye worm) aspartic protease BmAsp-2 Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin IV Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium knowlesi plasmepsin IV, putative Get druggable targets OG5_126885 All targets in OG5_126885
Echinococcus granulosus cathepsin d lysosomal aspartyl protease Get druggable targets OG5_126885 All targets in OG5_126885
Babesia bovis eukaryotic aspartyl protease family protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium berghei plasmepsin VI Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma mansoni cathepsin D (A01 family) Get druggable targets OG5_126885 All targets in OG5_126885
Schistosoma japonicum Cathepsin D precursor, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium vivax aspartyl proteinase, putative Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium falciparum plasmepsin II Get druggable targets OG5_126885 All targets in OG5_126885
Cryptosporidium parvum membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain Get druggable targets OG5_126885 All targets in OG5_126885
Candida albicans vacuolar aspartic proteinase precursor similar to S. cerevisiae PEP4 (YPL154C) Get druggable targets OG5_126885 All targets in OG5_126885
Neospora caninum Renin, related Get druggable targets OG5_126885 All targets in OG5_126885
Plasmodium yoelii plasmepsin Get druggable targets OG5_126885 All targets in OG5_126885
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum plasmepsin III Renin   406 aa 346 aa 29.8 %
Candida albicans secretory aspartyl proteinase SAP7p Renin   406 aa 373 aa 24.4 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   406 aa 352 aa 20.7 %
Cryptosporidium parvum AT hook motif protein, putative Renin   406 aa 399 aa 21.3 %
Plasmodium vivax aspartyl protease, putative Renin   406 aa 348 aa 27.0 %
Toxoplasma gondii aspartyl protease Renin   406 aa 423 aa 29.1 %
Schistosoma japonicum Lysosomal aspartic protease precursor, putative Renin   406 aa 326 aa 33.1 %
Candida albicans secretory aspartyl proteinase SAP5p Renin   406 aa 347 aa 24.5 %
Plasmodium berghei plasmepsin X Renin   406 aa 355 aa 25.6 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   406 aa 344 aa 25.6 %
Candida albicans secretory aspartyl proteinase SAP7p Renin   406 aa 373 aa 24.4 %
Plasmodium falciparum plasmepsin VII Renin   406 aa 374 aa 25.7 %
Babesia bovis aspartyl protease, putative Renin   406 aa 327 aa 26.6 %
Dictyostelium discoideum hypothetical protein Renin   406 aa 396 aa 21.7 %
Neospora caninum hypothetical protein Renin   406 aa 359 aa 31.8 %
Plasmodium berghei plasmepsin VII Renin   406 aa 367 aa 26.2 %
Plasmodium falciparum plasmepsin X renin 406 aa 352 aa 26.4 %
Loa Loa (eye worm) aspartic protease BmAsp-1 Renin   406 aa 406 aa 27.3 %
Neospora caninum Cathepsin D enzyme (EC 3.4.23.5), related Renin   406 aa 415 aa 29.4 %
Onchocerca volvulus Sphingomyelin phosphodiesterase 1 homolog Renin   406 aa 398 aa 36.2 %
Plasmodium vivax aspartyl protease, putative Renin   406 aa 370 aa 25.1 %
Candida albicans secretory aspartyl proteinase SAP10p, related to SAP9p Renin   406 aa 352 aa 20.7 %
Onchocerca volvulus Renin   406 aa 391 aa 27.1 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   406 aa 355 aa 26.2 %
Babesia bovis aspartyl protease, putative Renin   406 aa 338 aa 25.4 %
Plasmodium yoelii Eukaryotic aspartyl protease, putative Renin   406 aa 355 aa 25.9 %
Candida albicans secretory aspartyl proteinase SAP6p Renin   406 aa 355 aa 26.2 %
Plasmodium falciparum plasmepsin X Renin   406 aa 352 aa 26.7 %
Drosophila melanogaster CG31926 gene product from transcript CG31926-RB Renin   406 aa 338 aa 32.8 %
Toxoplasma gondii aspartyl protease ASP3 Renin   406 aa 354 aa 32.2 %
Candida albicans secretory aspartyl proteinase SAP4p Renin   406 aa 344 aa 25.6 %
Plasmodium knowlesi aspartyl protease, putative Renin   406 aa 371 aa 26.1 %
Cryptosporidium parvum secreted pepsinogen like aspartyl protease having a signal peptide Renin   406 aa 382 aa 22.0 %
Plasmodium knowlesi eukaryotic aspartyl protease, putative Renin   406 aa 353 aa 27.5 %
Candida albicans secretory aspartyl proteinase SAP5p Renin   406 aa 347 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0096 0.1553 0.2123
Brugia malayi Dihydrofolate reductase 0.0429 0.7317 1
Onchocerca volvulus 0.0214 0.3602 1
Plasmodium vivax aspartyl protease, putative 0.0028 0.038 0.043
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0011 0.0084 0.0115
Trichomonas vaginalis peroxiredoxin, putative 0.0022 0.0271 0.092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.014 0.2317 0.3167
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.1553 0.2123
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0096 0.1553 0.2123
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0096 0.1553 0.2123
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus neuropeptide receptor 0.0096 0.1553 0.2123
Brugia malayi hypothetical protein 0.0028 0.038 0.0519
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Plasmodium vivax SET domain protein, putative 0.002 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.001 0.0065 0.0088
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0025 0.0329 0.0446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Probable oxidoreductase 0.0029 0.0396 0.0431
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Onchocerca volvulus 0.0096 0.1553 0.4208
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus neuropeptide receptor A26 0.0096 0.1553 0.2123
Plasmodium falciparum plasmepsin II 0.0118 0.1937 0.2628
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Brugia malayi heat shock protein 90 0.0011 0.0084 0.0115
Leishmania major mitochondrial DNA topoisomerase II 0.0011 0.0084 0.0054
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0011 0.0084 0.0054
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0429 0.7317 1
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Plasmodium falciparum plasmepsin IX 0.0028 0.038 0.0515
Echinococcus multilocularis somatostatin receptor 0.0096 0.1553 0.2123
Onchocerca volvulus 0.0028 0.038 0.0891
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0214 0.3602 0.4864
Brugia malayi dihydrofolate reductase family protein 0.0429 0.7317 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) retinol dehydrogenase 12 0.0025 0.0329 0.045
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0096 0.1553 0.2123
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.002 0.0245 0.0332
Schistosoma mansoni endoplasmin 0.0011 0.0084 0.0115
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0063 0.0086
Plasmodium falciparum plasmepsin III 0.0028 0.038 0.0515
Onchocerca volvulus 0.0096 0.1553 0.4208
Echinococcus granulosus tachykinin peptides receptor 99D 0.0096 0.1553 0.2123
Onchocerca volvulus Neuropeptide F receptor homolog 0.0096 0.1553 0.4208
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0194 0.3249 0.4384
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0329 0.045
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.1553 0.2123
Trypanosoma brucei oxidoreductase-like protein 0.0029 0.0396 0.0369
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) endoplasmin 0.0011 0.0084 0.0115
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0029 0.0396 0.0453
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus multilocularis fmrfamide receptor 0.0096 0.1553 0.2123
Plasmodium vivax aspartyl protease, putative 0.0028 0.038 0.043
Mycobacterium ulcerans putative regultory protein 0.0011 0.0084 0.0023
Onchocerca volvulus 0.0159 0.2653 0.7318
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0025 0.0329 0.0446
Onchocerca volvulus 0.0029 0.0396 0.0935
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0011 0.0084 0.0206
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.001 0.0065 0.0088
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0022 0.0271 0.0259
Schistosoma mansoni hypothetical protein 0.0096 0.1553 0.2123
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0011 0.0084 0.0206
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.1553 0.2123
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Brugia malayi Serotonin receptor 0.0096 0.1553 0.2123
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0329 0.0407
Trichomonas vaginalis hypothetical protein 0.0025 0.0329 0.114
Brugia malayi Dopamine receptor 0.0096 0.1553 0.2123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0096 0.1553 0.2123
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Plasmodium vivax aspartyl proteinase, putative 0.0118 0.1937 0.2562
Brugia malayi G protein-coupled receptor 0.0096 0.1553 0.2123
Onchocerca volvulus 0.0096 0.1553 0.4208
Plasmodium falciparum heat shock protein 90 0.0011 0.0084 0.0114
Schistosoma mansoni amine GPCR 0.0096 0.1553 0.2123
Echinococcus multilocularis neuropeptide receptor 0.0096 0.1553 0.2123
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Echinococcus granulosus orexin receptor type 2 0.0096 0.1553 0.2123
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0025 0.0329 0.0339
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0022 0.0271 0.0259
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0011 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0245 0.0334
Echinococcus granulosus dihydrofolate reductase 0.0429 0.7317 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0096 0.1553 0.4208
Plasmodium falciparum endoplasmin, putative 0.0011 0.0084 0.0114
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Brugia malayi Death domain containing protein 0.001 0.0065 0.0088
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Loa Loa (eye worm) melatonin receptor type 1A 0.0096 0.1553 0.2123
Plasmodium vivax peroxiredoxin, putative 0.0085 0.136 0.1772
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0034 0.049 0.0626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Echinococcus multilocularis Mastin 0.001 0.0067 0.0092
Brugia malayi hypothetical protein 0.0102 0.166 0.2268
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0441 0.7522 0.7515
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0339
Schistosoma mansoni opsin-like receptor 0.0096 0.1553 0.2123
Leishmania major hypothetical protein, conserved 0.0011 0.0084 0.0054
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Toxoplasma gondii aspartyl protease ASP3 0.0028 0.038 0.0515
Trypanosoma cruzi heat shock protein 85, putative 0.0011 0.0084 0.0073
Echinococcus granulosus netrin receptor unc 5 0.001 0.0065 0.0088
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0025 0.0329 0.0361
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0011 0.0084 0.0073
Schistosoma mansoni pyruvate dehydrogenase 0.0194 0.3249 0.444
Schistosoma mansoni biogenic amine receptor 0.0096 0.1553 0.2123
Trypanosoma cruzi Heat shock protein 83, putative 0.0011 0.0084 0.0073
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0194 0.3249 0.444
Brugia malayi Pre-SET motif family protein 0.014 0.2317 0.3167
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.1553 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0025 0.0329 0.0339
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0011 0.0084 0.0206
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0022 0.0271 0.0259
Brugia malayi Pepsin A precursor 0.0028 0.038 0.0519
Loa Loa (eye worm) dihydrofolate reductase 0.0429 0.7317 1
Echinococcus granulosus glycoprotein Antigen 5 0.001 0.0067 0.0092
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.1553 0.2123
Giardia lamblia Kinase, CMGC MAPK 0.0034 0.049 1
Echinococcus multilocularis glycoprotein Antigen 5 0.001 0.0067 0.0092
Echinococcus granulosus heat shock protein 0.0011 0.0084 0.0115
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0068 0.1069 0.1042
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0096 0.1553 0.2123
Brugia malayi Trypsin family protein 0.001 0.0067 0.0092
Echinococcus multilocularis Ankyrin 0.001 0.0066 0.009
Schistosoma mansoni cathepsin D (A01 family) 0.0348 0.5912 0.8079
Echinococcus granulosus neuropeptide FF receptor 2 0.0096 0.1553 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Mycobacterium ulcerans DNA gyrase subunit B 0.0011 0.0084 0.0023
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni biogenic amine receptor 0.0096 0.1553 0.2123
Trypanosoma brucei pteridine reductase 1 0.058 0.9933 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0025 0.0329 0.045
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.1553 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Entamoeba histolytica heat shock protein 90, putative 0.0011 0.0084 0.1803
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Schistosoma mansoni neuropeptide receptor 0.0096 0.1553 0.2123
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.049 0.1754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Mycobacterium ulcerans two component sensor kinase MprB 0.0011 0.0084 0.0023
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0011 0.0084 0.0023
Loa Loa (eye worm) RecQ helicase 0.0014 0.0146 0.0199
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0329 0.0361
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0096 0.1553 0.2123
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0029 0.0396 0.0537
Echinococcus multilocularis fmrfamide receptor 0.0096 0.1553 0.2123
Echinococcus granulosus hypothetical protein 0.0096 0.1553 0.2123
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0118 0.1937 0.7275
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Loa Loa (eye worm) heat shock protein 90 0.0011 0.0084 0.0115
Schistosoma mansoni amine GPCR 0.0096 0.1553 0.2123
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0034 0.049 0.0461
Brugia malayi putative neuropeptide receptor NPR1 0.0096 0.1553 0.2123
Entamoeba histolytica DNA topoisomerase II, putative 0.0011 0.0084 0.1803
Onchocerca volvulus 0.002 0.0245 0.0509
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Brugia malayi Serotonin receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis allatostatin A receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Echinococcus granulosus Mastin 0.001 0.0067 0.0092
Brugia malayi Dopamine receptor protein 2 0.0096 0.1553 0.2123
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0096 0.1553 0.2123
Schistosoma mansoni neuropeptide receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis mitogen activated protein kinase 3 0.0034 0.049 0.067
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0102 0.166 0.222
Onchocerca volvulus 0.0096 0.1553 0.4208
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.049 0.0626
Echinococcus multilocularis neuropeptide receptor A26 0.0096 0.1553 0.2123
Trichomonas vaginalis endoplasmin, putative 0.0011 0.0084 0.0206
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0011 0.0084 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0214 0.3602 0.4923
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0034 0.049 0.0626
Brugia malayi Bloom's syndrome protein homolog 0.0014 0.0146 0.0199
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0011 0.0084 0.0023
Brugia malayi hypothetical protein 0.0028 0.038 0.0519
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Echinococcus granulosus allatostatin A receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans thiol peroxidase 0.0022 0.0271 0.0282
Brugia malayi neuropeptide F receptor 0.0096 0.1553 0.2123
Echinococcus granulosus serotonin receptor 0.0096 0.1553 0.2123
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0093 0.0128
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0079 0.1256 0.1703
Leishmania major developmentally regulated phosphoprotein-like protein 0.0194 0.3249 0.3229
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0096 0.1553 0.2123
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0096 0.1553 0.2123
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0025 0.0329 1
Onchocerca volvulus 0.001 0.0067 0.0007
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0329 0.0361
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0029 0.0396 0.0453
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0096 0.1553 0.2123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0245 0.0334
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0034 0.049 0.0665
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0096 0.1553 0.2123
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.001 0.0067 0.0092
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0025 0.0329 0.045
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Echinococcus granulosus transmembrane protease serine 3 0.001 0.0067 0.0092
Schistosoma mansoni opsin-like receptor 0.0096 0.1553 0.2123
Echinococcus granulosus mitogen activated protein kinase 0.0034 0.049 0.067
Brugia malayi Eukaryotic aspartyl protease family protein 0.0028 0.038 0.0519
Schistosoma mansoni ankyrin 23/unc44 0.001 0.0065 0.0088
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0096 0.1553 0.2123
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.049 0.1754
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.1553 0.2123
Brugia malayi Probable DNA topoisomerase II 0.0011 0.0084 0.0115
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0329 0.0339
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.1553 0.2123
Echinococcus multilocularis g protein coupled receptor 0.0096 0.1553 0.2123
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0025 0.0329 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0034 0.049 0.0626
Mycobacterium ulcerans oxidoreductase 0.0025 0.0329 0.0361
Brugia malayi aspartic protease BmAsp-2, identical 0.0028 0.038 0.0519
Toxoplasma gondii redoxin domain-containing protein 0.0085 0.136 0.1845
Chlamydia trachomatis oxoacy-ACP reductase 0.0025 0.0329 0.0339
Echinococcus granulosus mitogen activated protein kinase 3 0.0034 0.049 0.067
Echinococcus multilocularis nuclear factor of activated T cells 5 0.005 0.0754 0.103
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0011 0.0084 0.0115
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0214 0.3602 0.4864
Loa Loa (eye worm) aspartyl protease 6 0.0028 0.038 0.0519
Schistosoma mansoni netrin receptor unc5 0.001 0.0065 0.0088
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Onchocerca volvulus 0.001 0.0067 0.0007
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0068 0.1069 0.145
Schistosoma mansoni dihydropteridine reductase 0.0025 0.0329 0.045
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0011 0.0084 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0096 0.1553 0.2123
Toxoplasma gondii heat shock protein 90, putative 0.0011 0.0084 0.0114
Schistosoma mansoni neuropeptide f receptor 76f 0.0096 0.1553 0.2123
Toxoplasma gondii aspartyl protease ASP1 0.0118 0.1937 0.2628
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.0065 0.0088
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus dro:myosuppressin receptor 0.0096 0.1553 0.2123
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0011 0.0084 0.0073
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0019 0.0232 0.0317
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Plasmodium falciparum plasmepsin X 0.0028 0.038 0.0515
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0118 0.1937 0.2648
Plasmodium falciparum plasmepsin VIII, putative 0.0028 0.038 0.0515
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0011 0.0084 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0096 0.1553 0.2123
Mycobacterium ulcerans thymidylate synthase 0.0214 0.3602 0.4876
Schistosoma mansoni hypothetical protein 0.001 0.0065 0.0088
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.049 0.1754
Mycobacterium tuberculosis Hypothetical protein 0.0102 0.166 0.2179
Schistosoma mansoni dihydrofolate reductase 0.0429 0.7317 1
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0025 0.0329 0.045
Trypanosoma brucei DNA topoisomerase ii 0.0011 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0519
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Plasmodium vivax DNA gyrase subunit B, putative 0.0011 0.0084 0.0026
Trypanosoma cruzi heat shock protein 85, putative 0.0011 0.0084 0.0073
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.001 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0011 0.0084 0.0115
Schistosoma mansoni neuropeptide receptor 0.0096 0.1553 0.2123
Brugia malayi GnHR receptor homolog 0.0096 0.1553 0.2123
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0011 0.0084 0.0023
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0096 0.1553 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0096 0.1553 0.2123
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.1553 0.2123
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0096 0.1553 0.2123
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.1553 0.2123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0025 0.0329 0.045
Trypanosoma cruzi DNA topoisomerase II, putative 0.0011 0.0084 0.0073
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0194 0.3249 0.444
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0329 0.0361
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Giardia lamblia Heat shock protein HSP 90-alpha 0.0011 0.0084 0.1714
Toxoplasma gondii DNA topoisomerase 2, putative 0.0011 0.0084 0.0114
Brugia malayi thymidylate synthase 0.0214 0.3602 0.4923
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.002 0.0245 0.0334
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0025 0.0329 0.0361
Mycobacterium ulcerans short chain dehydrogenase 0.0029 0.0396 0.0453
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0329 0.0361
Trichomonas vaginalis peroxiredoxin, putative 0.0022 0.0271 0.092
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Loa Loa (eye worm) G-protein coupled receptor 0.0096 0.1553 0.2123
Trypanosoma cruzi heat shock protein 85, putative 0.0011 0.0084 0.0073
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Plasmodium vivax endoplasmin, putative 0.0011 0.0084 0.0026
Echinococcus multilocularis heat shock protein 90 0.0011 0.0084 0.0115
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.1553 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Echinococcus multilocularis neuropeptide s receptor 0.0096 0.1553 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Schistosoma mansoni cathepsin D (A01 family) 0.0348 0.5912 0.8079
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Trypanosoma brucei Heat shock protein 83, putative 0.0011 0.0084 0.0054
Brugia malayi larval opioid receptor 0.0096 0.1553 0.2123
Brugia malayi Endoplasmin precursor 0.0011 0.0084 0.0115
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis G-protein coupled receptor, putative 0.0096 0.1553 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0096 0.1553 0.2123
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Echinococcus granulosus neuropeptide Y receptor 0.0096 0.1553 0.2123
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0025 0.0329 0.0361
Echinococcus multilocularis neuropeptides capa receptor 0.0096 0.1553 0.2123
Trypanosoma brucei heat shock protein, putative 0.0011 0.0084 0.0054
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0096 0.1553 0.2123
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0432 0.7372 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.001 0.0067 0.0092
Onchocerca volvulus 0.0096 0.1553 0.4208
Echinococcus granulosus g protein coupled receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0146 0.0441
Brugia malayi G-protein coupled receptor 0.0096 0.1553 0.2123
Schistosoma mansoni endoplasmin 0.0011 0.0084 0.0115
Onchocerca volvulus 0.0028 0.038 0.0891
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0066 0.009
Leishmania major oxidoreductase-like protein 0.0029 0.0396 0.0367
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni amine GPCR 0.0096 0.1553 0.2123
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0432 0.7372 0.7413
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis neuropeptide receptor 0.0096 0.1553 0.2123
Plasmodium falciparum plasmepsin VII 0.0028 0.038 0.0515
Onchocerca volvulus 0.0096 0.1553 0.4208
Brugia malayi Trypsin family protein 0.001 0.0067 0.0092
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0068 0.1069 0.1415
Schistosoma mansoni hypothetical protein 0.0096 0.1553 0.2123
Brugia malayi AKH receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Echinococcus multilocularis serotonin receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.002 0.0245 0.0334
Trypanosoma cruzi heat shock protein 90, putative 0.0011 0.0084 0.0073
Plasmodium falciparum plasmepsin V 0.0028 0.038 0.0515
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0025 0.0329 0.0446
Onchocerca volvulus 0.0096 0.1553 0.4208
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.000000000046643 0.000000000063273
Echinococcus multilocularis orexin receptor type 2 0.0096 0.1553 0.2123
Plasmodium vivax DNA topoisomerase II, putative 0.0011 0.0084 0.0026
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0118 0.1937 0.2648
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0011 0.0084 0.0023
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0011 0.0084 0.0023
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0025 0.0329 0.0339
Brugia malayi ORL1-like opioid receptor 0.0096 0.1553 0.2123
Echinococcus granulosus 7tm_1 domain containing protein 0.0096 0.1553 0.2123
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0025 0.0329 0.0339
Trypanosoma brucei protein kinase, putative 0.0034 0.049 0.0464
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0194 0.3249 0.444
Echinococcus multilocularis neuropeptide FF receptor 2 0.0096 0.1553 0.2123
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0096 0.1553 0.2123
Schistosoma mansoni amine GPCR 0.0096 0.1553 0.2123
Trichomonas vaginalis receptor histidine kinase, putative 0.0011 0.0084 0.0206
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Toxoplasma gondii heat shock protein HSP90 0.0011 0.0084 0.0114
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0429 0.7317 1
Echinococcus multilocularis g protein coupled receptor 0.0096 0.1553 0.2123
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0011 0.0084 0.0206
Trypanosoma brucei heat shock protein 90, putative 0.0011 0.0084 0.0054
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0096 0.1553 0.2123
Schistosoma mansoni DNA topoisomerase II 0.0011 0.0084 0.0115
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0118 0.1937 0.2648
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0329 0.0339
Echinococcus granulosus Ankyrin 0.001 0.0066 0.009
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.001 0.0066 0.009
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0011 0.0084 0.0023
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0096 0.1553 0.2123
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0025 0.0329 0.0302
Schistosoma mansoni pyruvate dehydrogenase 0.0183 0.3063 0.4186
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0011 0.0084 0.0023
Brugia malayi Dopamine receptor protein 1 0.0096 0.1553 0.2123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0245 0.0334
Loa Loa (eye worm) hypothetical protein 0.0011 0.0095 0.013
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Brugia malayi putative neuropeptide receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis thymidylate synthase 0.0214 0.3602 0.4923
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.0065 0.0088
Brugia malayi Uncoordinated protein 44 0.001 0.0065 0.0088
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0025 0.0329 0.045
Echinococcus multilocularis mitogen activated protein kinase 0.0034 0.049 0.067
Schistosoma mansoni heat shock protein 0.0011 0.0084 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis g protein coupled receptor 0.0096 0.1553 0.2123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0245 0.0334
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0034 0.049 0.067
Schistosoma mansoni amine GPCR 0.0096 0.1553 0.2123
Schistosoma mansoni myosin xvIII 0.0096 0.1553 0.2123
Brugia malayi G-protein coupled receptor 0.0096 0.1553 0.2123
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0329 0.03
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus multilocularis netrin receptor unc 5 0.001 0.0065 0.0088
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0025 0.0329 0.0339
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0025 0.0329 0.0407
Schistosoma mansoni pyruvate dehydrogenase 0.0183 0.3063 0.4186
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis dro:myosuppressin receptor 0.0096 0.1553 0.2123
Brugia malayi kinase, mitochondrial precursor 0.0194 0.3249 0.444
Echinococcus granulosus somatostatin receptor 0.0096 0.1553 0.2123
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Echinococcus multilocularis g-protein coupled receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Plasmodium falciparum plasmepsin VI 0.0118 0.1937 0.2628
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0025 0.0329 0.0339
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Brugia malayi Cytochrome P450 family protein 0.0015 0.0161 0.0219
Trichomonas vaginalis peroxiredoxin, putative 0.0022 0.0271 0.092
Plasmodium falciparum enoyl-acyl carrier reductase 0.0025 0.0329 0.0446
Loa Loa (eye worm) neuropeptide F receptor 0.0096 0.1553 0.2123
Onchocerca volvulus 0.001 0.0067 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Brugia malayi sulfakinin receptor protein 0.0096 0.1553 0.2123
Chlamydia trachomatis dihydrofolate reductase 0.0429 0.7317 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0011 0.0084 0.0073
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Brugia malayi Trypsin family protein 0.001 0.0067 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0025 0.0329 0.0339
Trypanosoma cruzi heat shock protein 90, putative 0.0011 0.0084 0.0073
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.001 0.0065 0.0088
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus peptide allatostatin:somatostatin 0.0096 0.1553 0.2123
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0028 0.038 0.0519
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0011 0.0084 0.0114
Echinococcus granulosus heat shock protein 90 0.0011 0.0084 0.0115
Echinococcus granulosus nuclear factor of activated T cells 5 0.005 0.0754 0.103
Schistosoma mansoni hypothetical protein 0.0096 0.1553 0.2123
Plasmodium vivax aspartyl proteinase, putative 0.0028 0.038 0.043
Plasmodium vivax aspartyl protease, putative 0.0028 0.038 0.043
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Trichomonas vaginalis heat shock protein, putative 0.0011 0.0084 0.0206
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0025 0.0329 0.0361
Schistosoma mansoni neuropeptide receptor 0.0096 0.1553 0.2123
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0118 0.1937 0.2648
Trichomonas vaginalis CMGC family protein kinase 0.0034 0.049 0.1754
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Onchocerca volvulus 0.001 0.0067 0.0007
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0245 0.0334
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.001 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus g protein coupled receptor 0.0096 0.1553 0.2123
Echinococcus granulosus neuropeptide s receptor 0.0096 0.1553 0.2123
Trichomonas vaginalis sensor histidine kinase, putative 0.0011 0.0084 0.0206
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0096 0.1553 0.2123
Schistosoma mansoni growth hormone secretagogue receptor 0.0096 0.1553 0.2123
Plasmodium falciparum 1-cys peroxiredoxin 0.0085 0.136 0.1845
Echinococcus multilocularis G protein coupled receptor 139 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0092
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0011 0.0084 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0084 0.0115
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0329 0.0361
Echinococcus multilocularis serotonin receptor 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0429 0.7317 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.001 0.0067 0.0092
Schistosoma mansoni opsin-like receptor 0.0096 0.1553 0.2123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.1553 0.2123
Trichomonas vaginalis receptor histidine kinase, putative 0.0011 0.0084 0.0206
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0432 0.7372 1
Plasmodium falciparum DNA gyrase subunit B 0.0011 0.0084 0.0114
Brugia malayi MAP kinase sur-1 0.0034 0.049 0.067
Schistosoma mansoni alpha-1 adrenergic receptor 0.0096 0.1553 0.2123
Schistosoma mansoni histamine h1 receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0028 0.038 0.0515
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Echinococcus multilocularis heat shock protein 0.0011 0.0084 0.0115
Brugia malayi hypothetical protein 0.001 0.0067 0.0092
Trypanosoma brucei heat shock protein 90, putative 0.0011 0.0084 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0161 0.0219
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Trichomonas vaginalis set domain proteins, putative 0.0159 0.2652 1
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Plasmodium vivax heat shock protein 86, putative 0.0011 0.0084 0.0026
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0096 0.1553 0.2123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Mycobacterium ulcerans two component regulator - sensor kinase 0.0011 0.0084 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0096 0.1553 0.2123
Echinococcus granulosus death domain containing protein 0.001 0.0065 0.0088
Echinococcus granulosus g-protein coupled receptor 0.0096 0.1553 0.2123
Brugia malayi RE15519p 0.0096 0.1553 0.2123
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Trichomonas vaginalis heat shock protein, putative 0.0011 0.0084 0.0206
Brugia malayi Trypsin family protein 0.001 0.0067 0.0092
Brugia malayi aspartic protease BmAsp-1, identical 0.0028 0.038 0.0519
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0096 0.1553 0.2123
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0025 0.0329 0.03
Brugia malayi follicle stimulating hormone receptor 0.0096 0.1553 0.2123
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Echinococcus granulosus neuropeptide receptor 0.0096 0.1553 0.2123
Brugia malayi neuropeptide F receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) oxidoreductase 0.0025 0.0329 0.045
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0096 0.1553 0.2123
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.1553 0.2123
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0013 0.0116 0.0157
Plasmodium vivax plasmepsin IV, putative 0.0118 0.1937 0.2562
Echinococcus granulosus G protein coupled receptor 139 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0118 0.1937 0.2648
Brugia malayi Tachykinin-like peptides receptor 99D 0.0096 0.1553 0.2123
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) TOPoisomerase family member 0.0011 0.0084 0.0115
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus enteropeptidase 0.001 0.0067 0.0092
Plasmodium falciparum plasmepsin I 0.0118 0.1937 0.2628
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0011 0.0084 0.0115
Echinococcus multilocularis bloom syndrome protein 0.0014 0.0146 0.0199
Brugia malayi Melatonin receptor type 1A 0.0096 0.1553 0.2123
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.1553 0.2123
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0011 0.0084 0.0114
Brugia malayi Trypsin-like protease protein 5 0.001 0.0067 0.0092
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0034 0.049 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0084 0.0026
Trichomonas vaginalis DNA topoisomerase II, putative 0.0011 0.0084 0.0206
Onchocerca volvulus 0.001 0.0067 0.0007
Echinococcus multilocularis sex peptide receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) trypsin family protein 0.001 0.0067 0.0092
Schistosoma mansoni hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus thymidylate synthase 0.0214 0.3602 0.4923
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.001 0.0067 0.0092
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0029 0.0396 0.0498
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Schistosoma mansoni hypothetical protein 0.001 0.0067 0.0092
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0034 0.049 0.0464
Loa Loa (eye worm) thymidylate synthase 0.0214 0.3602 0.4923
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0025 0.0329 0.045
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Echinococcus granulosus neuropeptides capa receptor 0.0096 0.1553 0.2123
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Echinococcus granulosus fmrfamide receptor 0.0096 0.1553 0.2123
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.002 0.0245 0.0334
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0025 0.0329 1
Echinococcus multilocularis enteropeptidase 0.001 0.0067 0.0092
Schistosoma mansoni memapsin-2 (A01 family) 0.0028 0.038 0.0519
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus multilocularis neuropeptide Y receptor 0.0096 0.1553 0.2123
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0011 0.0084 0.0114
Schistosoma mansoni neuropeptide F-like receptor 0.0096 0.1553 0.2123
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0011 0.0084 0.0054
Trypanosoma brucei developmentally regulated phosphoprotein 0.0194 0.3249 0.325
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0339
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus g protein coupled receptor 0.0096 0.1553 0.2123
Echinococcus granulosus sex peptide receptor 0.0096 0.1553 0.2123
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.166 0.6216
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0096 0.1553 0.2123
Treponema pallidum thioredoxin 0.0022 0.0271 1
Plasmodium falciparum plasmepsin IV 0.0118 0.1937 0.2628
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0432 0.7372 1
Echinococcus multilocularis dihydrofolate reductase 0.0429 0.7317 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Onchocerca volvulus 0.0025 0.0329 0.0747
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0011 0.0084 0.0054
Echinococcus multilocularis transmembrane protease serine 3 0.001 0.0067 0.0092
Schistosoma mansoni serine/threonine protein kinase 0.0034 0.049 0.067
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus bloom syndrome protein 0.0014 0.0146 0.0199
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0118 0.1937 0.2628
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0011 0.0084 0.0206
Schistosoma mansoni biogenic amine receptor 0.0096 0.1553 0.2123
Plasmodium vivax plasmepsin V, putative 0.0028 0.038 0.043
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Echinococcus multilocularis rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Trichomonas vaginalis DNA helicase recq1, putative 0.0014 0.0146 0.0441
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus rhodopsin orphan GPCR 0.0096 0.1553 0.2123
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0432 0.7372 0.7364
Onchocerca volvulus 0.001 0.0067 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Schistosoma mansoni heat shock protein 0.0011 0.0084 0.0115
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0025 0.0329 0.0361
Mycobacterium ulcerans short chain dehydrogenase 0.0025 0.0329 0.0361
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0025 0.0329 0.0339
Giardia lamblia Pms1-like protein 0.0011 0.0084 0.1714
Schistosoma mansoni cercarial elastase (S01 family) 0.001 0.0067 0.0092
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0025 0.0329 0.0446
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0025 0.0329 0.03
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0011 0.0084 0.0073
Loa Loa (eye worm) hypothetical protein 0.001 0.0067 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.038 0.0519
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0096 0.1553 0.2123
Onchocerca volvulus 0.0096 0.1553 0.4208
Brugia malayi Pre-SET motif family protein 0.002 0.0245 0.0334
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0025 0.0329 0.0361
Brugia malayi hypothetical protein 0.0096 0.1553 0.2123
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0022 0.0271 0.0259
Plasmodium falciparum DNA topoisomerase 2 0.0011 0.0084 0.0114
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0339
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0028 0.038 0.0519
Echinococcus granulosus tm gpcr rhodopsin 0.0096 0.1553 0.2123
Entamoeba histolytica heat shock protein 90, putative 0.0011 0.0084 0.1803
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0432 0.7372 1
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0068 0.1069 0.1049
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Toxoplasma gondii aspartyl protease 0.0028 0.038 0.0515
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0025 0.0329 0.0361
Onchocerca volvulus 0.0096 0.1553 0.4208
Schistosoma mansoni adenoreceptor 0.0096 0.1553 0.2123
Echinococcus granulosus alpha 1A adrenergic receptor 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0096 0.1553 0.2123
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0029 0.0396 0.0453
Leishmania major heat shock protein 83-1 0.0011 0.0084 0.0054
Leishmania major DNA topoisomerase ii 0.0011 0.0084 0.0054
Brugia malayi Protein kinase domain containing protein 0.001 0.007 0.0096
Loa Loa (eye worm) hypothetical protein 0.0096 0.1553 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0096 0.1553 0.2123
Loa Loa (eye worm) hypothetical protein 0.0194 0.3249 0.444
Onchocerca volvulus 0.0096 0.1553 0.4208
Brugia malayi G protein-coupled receptor F59B2.13 0.0096 0.1553 0.2123

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.7 nM Inhibition of human recombinant renin using Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys (DABCYL)-Arg as substrate incubated for 10 mins prior to substrate addition measured after 90 mins by fluorescence assay ChEMBL. 23598247
IC50 (binding) = 9.6 nM Inhibition of renin in cynomolgus monkey plasma after 1 hr by RIA ChEMBL. 23598247
Ratio IC50 (binding) = 0.8 Ratio of fumaric acid IC50 to compound IC50 for renin in cynomolgus monkey plasma ChEMBL. 23598247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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