Detailed information for compound 1777971

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 365.386 | Formula: C19H19N5O3
  • H donors: 3 H acceptors: 2 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)Nc1nc(N)nc2c1c1ccccc1[nH]2
  • InChi: 1S/C19H19N5O3/c1-25-13-8-10(9-14(26-2)16(13)27-3)21-17-15-11-6-4-5-7-12(11)22-18(15)24-19(20)23-17/h4-9H,1-3H3,(H4,20,21,22,23,24)
  • InChiKey: LEMZUALSHMQLSS-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Heat shock protein HSP 90-alpha 0.0012 0.0119 0.2279
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0207 0.3273 0.4467
Schistosoma mansoni pyruvate dehydrogenase 0.0207 0.3273 0.4467
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0012 0.0119 0.0163
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0027 0.0364 0.0496
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0027 0.0364 0.0496
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0012 0.0119 0.0446
Mycobacterium ulcerans two component sensor kinase MprB 0.0012 0.0119 0.0163
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0027 0.0364 0.0366
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0027 0.0364 0.0364
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0027 0.0364 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.028 0.0381
Echinococcus granulosus bloom syndrome protein 0.0015 0.0181 0.0247
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0012 0.0119 0.0163
Trypanosoma brucei oxidoreductase-like protein 0.0031 0.043 0.0433
Brugia malayi MAP kinase sur-1 0.0037 0.0524 0.0715
Schistosoma mansoni heat shock protein 0.0012 0.0119 0.0163
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.043 0.0587
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0031 0.043 0.0587
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0229 0.3625 0.4947
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0006 0.0036 0.0049
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0027 0.0364 0.0496
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Plasmodium falciparum DNA topoisomerase 2 0.0012 0.0119 0.0162
Trichomonas vaginalis receptor histidine kinase, putative 0.0012 0.0119 0.0446
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0012 0.0119 0.012
Echinococcus granulosus heat shock protein 0.0012 0.0119 0.0163
Mycobacterium tuberculosis Probable two component sensor kinase 0.0012 0.0119 0.0163
Trichomonas vaginalis heat shock protein, putative 0.0012 0.0119 0.0446
Trichomonas vaginalis receptor histidine kinase, putative 0.0012 0.0119 0.0446
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0027 0.0364 0.0493
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0012 0.0119 0.0163
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0207 0.3273 0.4434
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0462 0.7381 1
Loa Loa (eye worm) heat shock protein 90 0.0012 0.0119 0.0163
Plasmodium vivax DNA gyrase subunit B, putative 0.0012 0.0119 0.0162
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0066 0.0089
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0027 0.0364 0.0493
Brugia malayi Pre-SET motif family protein 0.0021 0.028 0.0381
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0031 0.043 0.0582
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0012 0.0119 0.0163
Mycobacterium ulcerans putative regultory protein 0.0012 0.0119 0.0163
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0012 0.0119 0.0163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0036 0.0049
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0037 0.0524 0.071
Toxoplasma gondii heat shock protein HSP90 0.0012 0.0119 0.0162
Trypanosoma cruzi heat shock protein 85, putative 0.0012 0.0119 0.0162
Mycobacterium ulcerans oxidoreductase 0.0027 0.0364 0.0496
Leishmania major hypothetical protein, conserved 0.0012 0.0119 0.0119
Loa Loa (eye worm) endoplasmin 0.0012 0.0119 0.0163
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0012 0.0119 0.0446
Trypanosoma cruzi heat shock protein 90, putative 0.0012 0.0119 0.0162
Plasmodium falciparum 1-cys peroxiredoxin 0.009 0.1391 0.1885
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0072 0.1101 0.1108
Giardia lamblia Kinase, CMGC MAPK 0.0037 0.0524 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0462 0.7381 1
Brugia malayi dihydrofolate reductase family protein 0.0459 0.7327 1
Chlamydia trachomatis oxoacy-ACP reductase 0.0027 0.0364 0.0339
Trypanosoma brucei developmentally regulated phosphoprotein 0.0207 0.3273 0.3295
Trichomonas vaginalis CMGC family protein kinase 0.0037 0.0524 0.1957
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0012 0.0119 0.0163
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0012 0.0119 0.0163
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0027 0.0364 0.0493
Trypanosoma cruzi heat shock protein 85, putative 0.0012 0.0119 0.0162
Mycobacterium leprae Probable two component sensor kinase MprB 0.0012 0.0119 0.0163
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0119 0.0162
Trypanosoma brucei heat shock protein 90, putative 0.0012 0.0119 0.012
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0006 0.0036 0.0049
Brugia malayi Dihydrofolate reductase 0.0459 0.7327 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0462 0.7381 1
Plasmodium falciparum DNA gyrase subunit B 0.0012 0.0119 0.0162
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0084 0.1287 0.1743
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0129 0.0176
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0012 0.0119 0.0446
Trichomonas vaginalis DNA helicase recq, putative 0.0008 0.0066 0.0245
Mycobacterium leprae Probable two-component sensor kinase 0.0012 0.0119 0.0163
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0037 0.0524 0.071
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0099 0.0134
Trichomonas vaginalis CMGC family protein kinase 0.0037 0.0524 0.1957
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0364 0.0496
Brugia malayi heat shock protein 90 0.0012 0.0119 0.0163
Plasmodium vivax SET domain protein, putative 0.0021 0.028 0.0379
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0229 0.3625 0.4947
Trichomonas vaginalis DNA topoisomerase II, putative 0.0012 0.0119 0.0446
Echinococcus multilocularis netrin receptor unc 5 0.001 0.01 0.0137
Giardia lamblia Sgs1 DNA helicase, putative 0.0006 0.0036 0.0681
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0012 0.0119 0.0163
Trichomonas vaginalis CMGC family protein kinase 0.0037 0.0524 0.1957
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0072 0.1101 0.1492
Leishmania major oxidoreductase-like protein 0.0031 0.043 0.043
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0027 0.0364 0.0496
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0066 0.0066
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Brugia malayi Death domain containing protein 0.001 0.01 0.0137
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0031 0.043 0.0582
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Mycobacterium ulcerans two component regulator - sensor kinase 0.0012 0.0119 0.0163
Entamoeba histolytica heat shock protein 90, putative 0.0012 0.0119 0.3285
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0364 0.0496
Mycobacterium ulcerans short chain dehydrogenase 0.0031 0.043 0.0587
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0072 0.1101 0.1101
Trichomonas vaginalis CMGC family protein kinase 0.0037 0.0524 0.1957
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Plasmodium vivax DNA topoisomerase II, putative 0.0012 0.0119 0.0162
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0207 0.3273 0.4467
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0012 0.0119 0.012
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0027 0.0364 0.0493
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0027 0.0364 0.0364
Mycobacterium tuberculosis Hypothetical protein 0.0109 0.169 0.2306
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0012 0.0119 0.0163
Brugia malayi Uncoordinated protein 44 0.001 0.01 0.0137
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0027 0.0364 0.0364
Brugia malayi Protein kinase domain containing protein 0.0011 0.0106 0.0144
Schistosoma mansoni endoplasmin 0.0012 0.0119 0.0163
Entamoeba histolytica heat shock protein 90, putative 0.0012 0.0119 0.3285
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0364 0.0496
Mycobacterium ulcerans thymidylate synthase 0.0229 0.3625 0.4947
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0006 0.0036 0.0049
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0364 0.0496
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0012 0.0119 0.0162
Echinococcus multilocularis thymidylate synthase 0.0229 0.3625 0.4947
Echinococcus granulosus death domain containing protein 0.001 0.01 0.0137
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0037 0.0524 0.0524
Schistosoma mansoni DNA helicase recq1 0.0006 0.0036 0.0049
Onchocerca volvulus Netrin receptor homolog 0.001 0.01 0.0276
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0027 0.0364 0.0496
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0027 0.0364 0.0496
Echinococcus granulosus Ankyrin 0.001 0.0102 0.0139
Onchocerca volvulus 0.0229 0.3625 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0012 0.0119 0.012
Trichomonas vaginalis peroxiredoxin, putative 0.0023 0.0306 0.1143
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0006 0.0036 0.0049
Trypanosoma cruzi DNA topoisomerase II, putative 0.0012 0.0119 0.0162
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.001 0.01 0.0137
Entamoeba histolytica DNA topoisomerase II, putative 0.0012 0.0119 0.3285
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0012 0.0119 0.0329
Schistosoma mansoni endoplasmin 0.0012 0.0119 0.0163
Plasmodium falciparum heat shock protein 90 0.0012 0.0119 0.0162
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Trypanosoma cruzi heat shock protein 90, putative 0.0012 0.0119 0.0162
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0037 0.0524 0.0524
Toxoplasma gondii heat shock protein 90, putative 0.0012 0.0119 0.0162
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Brugia malayi Probable DNA topoisomerase II 0.0012 0.0119 0.0163
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0036 0.0048
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis Possible oxidoreductase 0.0027 0.0364 0.0496
Loa Loa (eye worm) hypothetical protein 0.001 0.0102 0.0139
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0462 0.7381 0.743
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0027 0.0364 1
Loa Loa (eye worm) dihydrofolate reductase 0.0459 0.7327 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0037 0.0524 0.071
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Echinococcus multilocularis mitogen activated protein kinase 0.0037 0.0524 0.0715
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0036 0.0048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0101 0.0137
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0012 0.0119 0.0163
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0027 0.0364 0.0339
Trypanosoma brucei DNA topoisomerase ii 0.0012 0.0119 0.012
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0006 0.0036 0.0049
Onchocerca volvulus 0.0027 0.0364 0.1003
Loa Loa (eye worm) retinol dehydrogenase 12 0.0027 0.0364 0.0496
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.001 0.0102 0.0139
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.015 0.2345 0.32
Trichomonas vaginalis sensor histidine kinase, putative 0.0012 0.0119 0.0446
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0037 0.0524 0.0527
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Echinococcus multilocularis heat shock protein 0.0012 0.0119 0.0163
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0012 0.0119 0.0329
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Echinococcus granulosus netrin receptor unc 5 0.001 0.01 0.0137
Plasmodium falciparum endoplasmin, putative 0.0012 0.0119 0.0162
Loa Loa (eye worm) hypothetical protein 0.0207 0.3273 0.4467
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0027 0.0364 0.0496
Loa Loa (eye worm) oxidoreductase 0.0027 0.0364 0.0496
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0037 0.0524 0.071
Brugia malayi Bloom's syndrome protein homolog 0.0015 0.0181 0.0247
Brugia malayi Immunoglobulin I-set domain containing protein 0.001 0.01 0.0137
Toxoplasma gondii DNA topoisomerase 2, putative 0.0012 0.0119 0.0162
Leishmania major developmentally regulated phosphoprotein-like protein 0.0207 0.3273 0.3273
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.169 0.6309
Mycobacterium ulcerans thiol peroxidase 0.0023 0.0306 0.0418
Echinococcus multilocularis mitogen activated protein kinase 3 0.0037 0.0524 0.0715
Trichomonas vaginalis endoplasmin, putative 0.0012 0.0119 0.0446
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0036 0.0049
Echinococcus granulosus dihydrofolate reductase 0.0459 0.7327 1
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0524 0.0715
Schistosoma mansoni pyruvate dehydrogenase 0.0196 0.3087 0.4214
Brugia malayi Endoplasmin precursor 0.0012 0.0119 0.0163
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0027 0.0364 0.0493
Echinococcus multilocularis heat shock protein 90 0.0012 0.0119 0.0163
Mycobacterium leprae POSSIBLE MEMBRANE-ANCHORED THIOREDOXIN-LIKE PROTEIN (THIOL-DISULFIDE INTERCHANGE RELATED PROTEIN) 0.0023 0.0306 0.0418
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0012 0.0119 0.0162
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0027 0.0364 0.0496
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0027 0.0364 0.0496
Trichomonas vaginalis hypothetical protein 0.0027 0.0364 0.1358
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0012 0.0119 0.0446
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0027 0.0364 0.0496
Trypanosoma brucei pteridine reductase 1 0.0621 0.9934 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0012 0.0119 0.0163
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0012 0.0119 0.0163
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0037 0.0524 0.0715
Trypanosoma brucei heat shock protein 90, putative 0.0012 0.0119 0.012
Giardia lamblia Pms1-like protein 0.0012 0.0119 0.2279
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0364 0.0496
Loa Loa (eye worm) hypothetical protein 0.001 0.01 0.0137
Schistosoma mansoni netrin receptor unc5 0.001 0.01 0.0137
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0109 0.169 0.2289
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.001 0.01 0.0137
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0021 0.028 0.0379
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0027 0.0364 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0012 0.0119 0.0163
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0012 0.0119 0.0163
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0027 0.0364 0.0496
Loa Loa (eye worm) thymidylate synthase 0.0229 0.3625 0.4947
Schistosoma mansoni hypothetical protein 0.001 0.01 0.0137
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0012 0.0119 0.0162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0012 0.0119 0.0163
Trichomonas vaginalis peroxiredoxin, putative 0.0023 0.0306 0.1143
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0012 0.0119 0.0162
Trypanosoma brucei protein kinase, putative 0.0037 0.0524 0.0527
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Schistosoma mansoni heat shock protein 0.0012 0.0119 0.0163
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Mycobacterium tuberculosis Conserved protein 0.0012 0.0119 0.0163
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0012 0.0119 0.0163
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Loa Loa (eye worm) RecQ helicase 0.0015 0.0181 0.0247
Plasmodium vivax heat shock protein 86, putative 0.0012 0.0119 0.0162
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0229 0.3625 0.4947
Schistosoma mansoni ankyrin 23/unc44 0.001 0.01 0.0137
Plasmodium vivax peroxiredoxin, putative 0.009 0.1391 0.1885
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0027 0.0364 0.0493
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Trypanosoma cruzi Heat shock protein 83, putative 0.0012 0.0119 0.0162
Echinococcus granulosus mitogen activated protein kinase 3 0.0037 0.0524 0.0715
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0027 0.0364 0.0496
Echinococcus granulosus mitogen activated protein kinase 0.0037 0.0524 0.0715
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0012 0.0119 0.0329
Leishmania major biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120 0.0472 0.7531 0.7531
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Schistosoma mansoni dihydrofolate reductase 0.0459 0.7327 1
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0012 0.0119 0.3285
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0012 0.0119 0.0446
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0459 0.7327 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0196 0.0267
Mycobacterium tuberculosis Possible two component sensor kinase 0.0012 0.0119 0.0163
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.028 0.0381
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0012 0.0119 0.0162
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0012 0.0119 0.0163
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0072 0.1101 0.1492
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.001 0.01 0.0137
Trichomonas vaginalis set domain proteins, putative 0.017 0.2678 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0021 0.028 0.0381
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0021 0.0267 0.0364
Schistosoma mansoni pyruvate dehydrogenase 0.0196 0.3087 0.4214
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0027 0.0364 0.0496
Brugia malayi kinase, mitochondrial precursor 0.0207 0.3273 0.4467
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0012 0.0119 0.0163
Schistosoma mansoni DNA topoisomerase II 0.0012 0.0119 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.0119 0.0163
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0027 0.0364 0.0496
Echinococcus multilocularis Ankyrin 0.001 0.0102 0.0139
Onchocerca volvulus 0.0021 0.028 0.0771
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0207 0.3273 0.4467
Trypanosoma cruzi heat shock protein 85, putative 0.0012 0.0119 0.0162
Loa Loa (eye worm) TOPoisomerase family member 0.0012 0.0119 0.0163
Echinococcus multilocularis bloom syndrome protein 0.0015 0.0181 0.0247
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0027 0.0364 0.0493
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0027 0.0364 0.0496
Schistosoma mansoni DNA helicase recq5 0.0006 0.0036 0.0049
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Toxoplasma gondii redoxin domain-containing protein 0.009 0.1391 0.1885
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0012 0.0119 0.0163
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0181 0.0675
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0027 0.0364 0.0496
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0012 0.0119 0.0163
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0012 0.0119 0.3285
Onchocerca volvulus 0.0171 0.2679 0.7392
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0027 0.0364 0.0496
Loa Loa (eye worm) hypothetical protein 0.0027 0.0364 0.0496
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0037 0.0524 0.071
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0027 0.0364 0.0496
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0459 0.7327 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.028 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.028 0.0381
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0006 0.0036 0.0048
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0012 0.0119 0.0162
Trypanosoma cruzi DNA topoisomerase II, putative 0.0012 0.0119 0.0162
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Echinococcus granulosus nuclear factor of activated T cells 5 0.0053 0.0787 0.1074
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.028 0.0381
Entamoeba histolytica recQ family helicase, putative 0.0008 0.0066 0.1808
Mycobacterium tuberculosis Soluble secreted antigen Mpt53 precursor 0.0023 0.0306 0.0418
Brugia malayi Pre-SET motif family protein 0.015 0.2345 0.32
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0381
Plasmodium falciparum enoyl-acyl carrier reductase 0.0027 0.0364 0.0493
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0031 0.043 0.0587
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0462 0.7381 1
Leishmania major DNA topoisomerase ii 0.0012 0.0119 0.0119
Trichomonas vaginalis peroxiredoxin, putative 0.0023 0.0306 0.1143
Loa Loa (eye worm) hypothetical protein 0.0006 0.0036 0.0049
Mycobacterium ulcerans DNA gyrase subunit B 0.0012 0.0119 0.0163
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0012 0.0119 0.0163
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0008 0.0066 0.0066
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0013 0.0151 0.0204
Echinococcus granulosus heat shock protein 90 0.0012 0.0119 0.0163
Mycobacterium tuberculosis Probable oxidoreductase 0.0031 0.043 0.0587
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0012 0.0119 0.0163
Chlamydia trachomatis dihydrofolate reductase 0.0459 0.7327 1
Echinococcus granulosus thymidylate synthase 0.0229 0.3625 0.4947
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis Probable conserved lipoprotein DsbF 0.0023 0.0306 0.0418
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Mycobacterium ulcerans short chain dehydrogenase 0.0027 0.0364 0.0496
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0012 0.0119 0.3285
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0012 0.0119 0.0163
Brugia malayi hypothetical protein 0.0109 0.169 0.2306
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0027 0.0364 1
Schistosoma mansoni dihydropteridine reductase 0.0027 0.0364 0.0496
Leishmania major mitochondrial DNA topoisomerase II 0.0012 0.0119 0.0119
Leishmania major heat shock protein 83-1 0.0012 0.0119 0.0119
Treponema pallidum thioredoxin 0.0023 0.0306 1
Echinococcus multilocularis dihydrofolate reductase 0.0459 0.7327 1
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0012 0.0119 0.0163
Brugia malayi Cytochrome P450 family protein 0.0016 0.0196 0.0267
Brugia malayi thymidylate synthase 0.0229 0.3625 0.4947
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0462 0.7381 0.7381
Trypanosoma brucei Heat shock protein 83, putative 0.0012 0.0119 0.012
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0012 0.0119 0.0163
Loa Loa (eye worm) hypothetical protein 0.0012 0.0131 0.0179
Mycobacterium tuberculosis Probable thiol peroxidase Tpx 0.0023 0.0306 0.0418
Onchocerca volvulus 0.0031 0.043 0.1186
Trichomonas vaginalis DNA helicase recq1, putative 0.0015 0.0181 0.0675
Trypanosoma brucei heat shock protein, putative 0.0012 0.0119 0.012
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0053 0.0787 0.1074
Plasmodium vivax endoplasmin, putative 0.0012 0.0119 0.0162
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0027 0.0364 0.0496
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0459 0.7327 1
Trichomonas vaginalis heat shock protein, putative 0.0012 0.0119 0.0446
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0021 0.028 0.0381

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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