TDR Targets

Basic information

Technical information

TDR Targets ID: 797434
Name: N'-(1,1-dioxo-1,2-benzothiazol-3-yl)-N-(4-met hylphenyl)sulfonylpropanehydrazide
MW: 407.464 | Formula: C17H17N3O5S2
H donors: 1 H acceptors: 5 LogP: 2.14 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCC(=O)N(S(=O)(=O)c1ccc(cc1)C)NC1=NS(=O)(=O)c2c1cccc2
InChi: 1S/C17H17N3O5S2/c1-3-16(21)20(27(24,25)13-10-8-12(2)9-11-13)18-17-14-6-4-5-7-15(14)26(22,23)19-17/h4-11H,3H2,1-2H3,(H,18,19)
InChiKey: SJMPTEWAYQXFIM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N'-(1,1-dioxo-1,2-benzothiazol-3-yl)-N-(4-methylphenyl)sulfonyl-propanehydrazide
N'-(1,1-diketo-1,2-benzothiazol-3-yl)-N-(4-methylphenyl)sulfonyl-propionohydrazide
MLS000714164
SMR000274144
ZINC00849992
A2155/0090496
BAS 01101769

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	l(3)mbt-like 1 (Drosophila)	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130415	All targets in OG5_130415
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 3 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	endonuclease exonuclease phosphatase	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Lethal(3)malignant brain tumor-like 4 protein, putative	Get druggable targets OG5_130415	All targets in OG5_130415
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0029	0.049	0.067
Onchocerca volvulus		0.0135	0.2653	0.5218
Echinococcus granulosus	thymidylate synthase	0.0251	0.5026	0.6868
Onchocerca volvulus		0.0033	0.0563	0.1005
Echinococcus granulosus	dihydrofolate reductase	0.0363	0.7317	1
Giardia lamblia	Kinase, CMGC MAPK	0.0029	0.049	1
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.0329	0.0082
Schistosoma mansoni	dihydropteridine reductase	0.0021	0.0329	0.045
Echinococcus multilocularis	dihydrofolate reductase	0.0363	0.7317	1
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0058	0.1075	0.2037
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0008	0.0065	0.0088
Trichomonas vaginalis	CMGC family protein kinase	0.0029	0.049	0.1754
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Brugia malayi	Uncoordinated protein 44	0.0008	0.0065	0.0088
Mycobacterium tuberculosis	Probable dehydrogenase/reductase	0.0021	0.0329	0.0082
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0287	0.0392
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0021	0.0329	0.0341
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.1075	0.1469
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0029	0.049	0.067
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0021	0.0329	0.0082
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0008	0.0063	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0329	0.045
Brugia malayi	Dihydrofolate reductase	0.0363	0.7317	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0011	0.0116	0.0131
Trichomonas vaginalis	CMGC family protein kinase	0.0029	0.049	0.1754
Brugia malayi	Pre-SET motif family protein	0.0118	0.2317	0.3167
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0024	0.0396	0.0176
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0021	0.0329	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Trichomonas vaginalis	CMGC family protein kinase	0.0029	0.049	0.1754
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0021	0.0329	0.0374
Trypanosoma cruzi	beta-ketoacyl-ACP reductase	0.0021	0.0329	0.0341
Brugia malayi	dihydrofolate reductase family protein	0.0363	0.7317	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0024	0.0396	0.0176
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0021	0.0329	0.0082
Plasmodium falciparum	1-cys peroxiredoxin	0.0072	0.136	0.1546
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0016	0.0219	0.0299
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0029	0.049	0.0525
Trypanosoma brucei	protein kinase, putative	0.0029	0.049	0.0464
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Echinococcus granulosus	lamin dm0	0.0033	0.0563	0.077
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0245	0.0334
Plasmodium vivax	SET domain protein, putative	0.0017	0.0245	0.0205
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0066	0.1238	0.1692
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0287	0.0392
Echinococcus granulosus	GPCR family 2	0.0019	0.0287	0.0392
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0021	0.0329	0.03
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1027	0.1403
Loa Loa (eye worm)	retinol dehydrogenase 12	0.0021	0.0329	0.045
Wolbachia endosymbiont of Brugia malayi	Short-chain alcohol dehydrogenase family enzyme	0.0021	0.0329	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0021	0.0329	0.0302
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0245	0.0334
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0029	0.049	0.0525
Schistosoma mansoni	hypothetical protein	0.0008	0.0065	0.0088
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0042	0.0754	0.103
Echinococcus granulosus	polycomb protein SCMH1	0.0058	0.1075	0.1469
Plasmodium vivax	3-oxoacyl-[acyl-carrier-protein] reductase, putative	0.0021	0.0329	0.0302
Echinococcus multilocularis	netrin receptor unc 5	0.0008	0.0065	0.0088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1027	0.1403
Loa Loa (eye worm)	hypothetical protein	0.006	0.1128	0.1542
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0029	0.049	0.0464
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0029	0.049	0.0461
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0021	0.0329	0.0374
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0227	0.4538	0.6202
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0287	0.0392
Echinococcus multilocularis	bloom syndrome protein	0.0012	0.0146	0.0199
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1027	0.1403
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0161	0.0219
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0042	0.0754	0.103
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.0329	0.0082
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0024	0.0396	0.0417
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.0329	0.0082
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0287	0.0392
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0245	0.0334
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0024	0.0396	0.0176
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0029	0.049	0.0557
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0016	0.0219	0.0299
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0029	0.049	0.0461
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0563	0.077
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0066	0.1238	0.1692
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1027	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0219	0.0299
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0066	0.1238	0.1692
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1027	0.1403
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0251	0.5026	0.6748
Echinococcus granulosus	death domain containing protein	0.0008	0.0065	0.0088
Trypanosoma brucei	pteridine reductase 1	0.0491	0.9933	1
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.0329	0.0082
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0245	0.0334
Mycobacterium ulcerans	thymidylate synthase	0.0251	0.5026	0.6748
Onchocerca volvulus		0.0024	0.0396	0.0667
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Echinococcus granulosus	3 oxoacyl acyl carrier protein reductase	0.0021	0.0329	0.045
Loa Loa (eye worm)	mbt repeat family protein	0.0058	0.1075	0.1469
Trichomonas vaginalis	peroxiredoxin, putative	0.0018	0.0271	0.092
Schistosoma mansoni	3-oxoacyl-[ACP] reductase	0.0021	0.0329	0.045
Trypanosoma brucei	beta-ketoacyl-ACP reductase	0.0021	0.0329	0.0302
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1128	0.1542
Brugia malayi	Pre-SET motif family protein	0.0017	0.0245	0.0334
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Loa Loa (eye worm)	thymidylate synthase	0.0251	0.5026	0.6868
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0563	0.077
Trichomonas vaginalis	peroxiredoxin, putative	0.0018	0.0271	0.092
Schistosoma mansoni	hypothetical protein	0.0019	0.0287	0.0392
Trichomonas vaginalis	hypothetical protein	0.0021	0.0329	0.114
Onchocerca volvulus		0.0251	0.5026	1
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0021	0.0329	0.045
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0066	0.1238	0.1692
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0287	0.0392
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0161	0.0219
Schistosoma mansoni	dihydrofolate reductase	0.0363	0.7317	1
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0363	0.7317	1
Plasmodium falciparum	3-oxoacyl-[acyl-carrier-protein] reductase	0.0021	0.0329	0.0374
Brugia malayi	mbt repeat family protein	0.0058	0.1075	0.1469
Brugia malayi	MAP kinase sur-1	0.0029	0.049	0.067
Onchocerca volvulus		0.0058	0.1075	0.2037
Echinococcus granulosus	lamin	0.0033	0.0563	0.077
Mycobacterium leprae	3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI	0.0021	0.0329	0.0082
Onchocerca volvulus		0.0033	0.0563	0.1005
Brugia malayi	Protein kinase domain containing protein	0.0008	0.007	0.0096
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0287	0.0392
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0329	0.045
Loa Loa (eye worm)	oxidoreductase	0.0021	0.0329	0.045
Schistosoma mansoni	serine/threonine protein kinase	0.0029	0.049	0.067
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0024	0.0396	0.045
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0017	0.0245	0.0334
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0287	0.0392
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0024	0.0396	0.0176
Echinococcus granulosus	intermediate filament protein	0.0033	0.0563	0.077
Echinococcus multilocularis	lamin	0.0033	0.0563	0.077
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0563	0.077
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0066	0.009
Mycobacterium ulcerans	oxidoreductase	0.0021	0.0329	0.0082
Schistosoma mansoni	hypothetical protein	0.0019	0.0287	0.0392
Mycobacterium tuberculosis	Possible oxidoreductase	0.0021	0.0329	0.0082
Echinococcus multilocularis	Ankyrin	0.0008	0.0066	0.009
Trichomonas vaginalis	DNA helicase recq1, putative	0.0012	0.0146	0.0441
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1027	0.1403
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Schistosoma mansoni	hypothetical protein	0.0019	0.0287	0.0392
Echinococcus granulosus	mitogen activated protein kinase 3	0.0029	0.049	0.067
Trypanosoma brucei	oxidoreductase-like protein	0.0024	0.0396	0.0369
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.0329	0.0082
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1128	0.1542
Trichomonas vaginalis	peroxiredoxin, putative	0.0018	0.0271	0.092
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0563	0.077
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0251	0.5026	0.6748
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0739	0.101
Schistosoma mansoni	lamin	0.0033	0.0563	0.077
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0207	0.0282
Echinococcus multilocularis	musashi	0.0033	0.0563	0.077
Schistosoma mansoni	hypothetical protein	0.0019	0.0287	0.0392
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0363	0.7317	1
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0435	0.8795	0.8851
Treponema pallidum	thioredoxin	0.0018	0.0271	0.5
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0017	0.0245	0.0334
Onchocerca volvulus		0.0017	0.0245	0.0363
Entamoeba histolytica	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0021	0.0329	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1128	0.1542
Loa Loa (eye worm)	RecQ helicase	0.0012	0.0146	0.0199
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.0119	0.2337	0.2632
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0029	0.049	0.0525
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0005	0.000000000046643	0.000000000053031
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1027	0.1403
Echinococcus granulosus	SAM and MBT domain containing protein	0.0058	0.1075	0.1469
Trichomonas vaginalis	DNA helicase recq, putative	0.0012	0.0146	0.0441
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0008	0.0065	0.0088
Toxoplasma gondii	redoxin domain-containing protein	0.0072	0.136	0.1546
Echinococcus granulosus	mitogen activated protein kinase	0.0029	0.049	0.067
Schistosoma mansoni	hypothetical protein	0.0041	0.0739	0.101
Echinococcus multilocularis	3 oxoacyl acyl carrier protein reductase	0.0021	0.0329	0.045
Brugia malayi	intermediate filament protein	0.0033	0.0563	0.077
Echinococcus multilocularis	lamin dm0	0.0033	0.0563	0.077
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0118	0.2317	0.3167
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1027	0.1403
Mycobacterium ulcerans	20-beta-hydroxysteroid dehydrogenase FabG3	0.0021	0.0329	0.0082
Brugia malayi	Death domain containing protein	0.0008	0.0065	0.0088
Mycobacterium ulcerans	3-ketoacyl-ACP reductase	0.0021	0.0329	0.0082
Mycobacterium tuberculosis	Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase)	0.0021	0.0329	0.0082
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0021	0.0329	0.0082
Loa Loa (eye worm)	dihydrofolate reductase	0.0363	0.7317	1
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Leishmania major	dehydrogenase/oxidoreductase-like protein	0.0021	0.0329	0.03
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0254	0.0347
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0008	0.0065	0.0088
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0029	0.049	0.0525
Brugia malayi	hypothetical protein	0.0119	0.2337	0.3194
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0008	0.0065	0.0088
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0017	0.0245	0.0278
Toxoplasma gondii	short chain dehydrogenase family protein, putative	0.0021	0.0329	0.0374
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0227	0.4538	0.6202
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0551	0.0753
Mycobacterium tuberculosis	Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase)	0.0021	0.0329	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1075	0.1469
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0245	0.0334
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0021	0.0329	0.0082
Schistosoma mansoni	hypothetical protein	0.035	0.7056	0.9643
Loa Loa (eye worm)	MBCTL1	0.0066	0.1238	0.1692
Mycobacterium leprae	POSSIBLE OXIDOREDUCTASE	0.0021	0.0329	0.0082
Echinococcus multilocularis	polycomb protein SCMH1	0.0058	0.1075	0.1469
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1027	0.1403
Plasmodium vivax	peroxiredoxin, putative	0.0072	0.136	0.1483
Brugia malayi	thymidylate synthase	0.0251	0.5026	0.6868
Brugia malayi	cytoplasmic intermediate filament protein	0.0017	0.0254	0.0347
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0066	0.1238	0.1692
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0021	0.0329	0.0082
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0435	0.8795	1
Brugia malayi	Bloom's syndrome protein homolog	0.0012	0.0146	0.0199
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0093	0.0128
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Mycobacterium tuberculosis	Probable oxidoreductase	0.0024	0.0396	0.0176
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0058	0.1075	0.1469
Schistosoma mansoni	sex comb on midleg homolog	0.0058	0.1075	0.1469
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0058	0.1075	0.1469
Schistosoma mansoni	netrin receptor unc5	0.0008	0.0065	0.0088
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0207	0.0282
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0065	0.0088
Leishmania major	3-oxoacyl-ACP reductase, putative	0.0021	0.0329	0.03
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0287	0.0392
Leishmania major	oxidoreductase-like protein	0.0024	0.0396	0.0367
Trichomonas vaginalis	CMGC family protein kinase	0.0029	0.049	0.1754
Toxoplasma gondii	3-ketoacyl-(acyl-carrier-protein) reductase	0.0021	0.0329	0.0374
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0245	0.0334
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0563	0.077
Mycobacterium ulcerans	3-oxoacyl-ACP reductase	0.0021	0.0329	0.0082
Echinococcus granulosus	Ankyrin	0.0008	0.0066	0.009
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0739	0.101
Echinococcus granulosus	netrin receptor unc 5	0.0008	0.0065	0.0088
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0251	0.5026	0.6868
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0021	0.0329	0.045
Echinococcus granulosus	bloom syndrome protein	0.0012	0.0146	0.0199
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0435	0.8795	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0066	0.1238	0.1692
Mycobacterium tuberculosis	Hypothetical protein	0.0119	0.2337	0.2932
Schistosoma mansoni	lamin	0.0033	0.0563	0.077
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0016	0.0232	0.0317
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Trichomonas vaginalis	set domain proteins, putative	0.0135	0.2652	1
Trichomonas vaginalis	conserved hypothetical protein	0.0119	0.2337	0.88
Echinococcus multilocularis	thymidylate synthase	0.0251	0.5026	0.6868
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0435	0.8795	1
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1238	0.1692
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0435	0.8795	0.8792
Schistosoma mansoni	ankyrin 23/unc44	0.0008	0.0065	0.0088
Leishmania major	biopterin transporter, putative;with=GeneDB:LinJ35_V3.5120	0.0373	0.7522	0.7515
Brugia malayi	mbt repeat family protein	0.0058	0.1075	0.1469
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0435	0.8795	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0287	0.0392
Mycobacterium ulcerans	short chain dehydrogenase	0.0021	0.0329	0.0082
Echinococcus multilocularis	mitogen activated protein kinase	0.0029	0.049	0.067
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0363	0.7317	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0008	0.0066	0.009
Loa Loa (eye worm)	hypothetical protein	0.001	0.0095	0.013
Onchocerca volvulus		0.0021	0.0329	0.0533
Chlamydia trachomatis	dihydrofolate reductase	0.0363	0.7317	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.0251 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1407666
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 797434