TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 463.321 | Formula: C21H23Cl2F3N2O2
H donors: 1 H acceptors: 1 LogP: 4.76 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O[C@H](CN1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)COc1ccc(cc1)C(F)(F)F
InChi: 1S/C21H23Cl2F3N2O2/c22-19-6-1-15(11-20(19)23)12-27-7-9-28(10-8-27)13-17(29)14-30-18-4-2-16(3-5-18)21(24,25)26/h1-6,11,17,29H,7-10,12-14H2/t17-/m1/s1
InChiKey: ZBFPUQHQISPHIK-QGZVFWFLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium channel, voltage-dependent, T type, alpha 1G subunit	Starlite/ChEMBL	References
Homo sapiens	potassium voltage-gated channel, subfamily H (eag-related), member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	Get druggable targets OG5_128858	All targets in OG5_128858
Loa Loa (eye worm)	voltage and ligand gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_129328	All targets in OG5_129328
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma japonicum	ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	Get druggable targets OG5_129328	All targets in OG5_129328
Schistosoma japonicum	Potassium voltage-gated channel subfamily H member 2, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	Get druggable targets OG5_128858	All targets in OG5_128858
Schistosoma mansoni	voltage-gated potassium channel	Get druggable targets OG5_128858	All targets in OG5_128858
Echinococcus granulosus	potassium voltage gated channel subfamily H	Get druggable targets OG5_128858	All targets in OG5_128858

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus granulosus	histone lysine n methyltransferase suv420h1	0.0014	0.012	0.012
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.012	0.012
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0015	0.0149	0.0149
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0019	0.0253	0.0253
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0015	0.0149	0.0149
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Echinococcus multilocularis	SET (trithorax:polycomb) domain containing protein	0.0014	0.012	0.012
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0019	0.0253	0.0253
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Giardia lamblia	Aurora kinase	0.0132	0.3117	1
Echinococcus multilocularis	SET and MYND domain containing protein 5	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	predicted SET domain protein	0.0014	0.012	0.0384
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.012	0.012
Loa Loa (eye worm)	histone methyltransferase	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Schistosoma mansoni	huntingtin interacting protein-related	0.0014	0.012	0.012
Loa Loa (eye worm)	SET domain-containing protein	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0832	0.1442
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0015	0.0149	0.0149
Echinococcus granulosus	histone lysine N methyltransferase MLL5	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Chlamydia trachomatis	hypothetical protein	0.0014	0.012	0.5
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	histone lysine N methyltransferase NSD3	0.0014	0.012	0.012
Loa Loa (eye worm)	AUR protein kinase	0.0132	0.3117	0.3117
Echinococcus multilocularis	histone lysine n methyltransferase suv420h1	0.0014	0.012	0.012
Trypanosoma brucei	aurora B kinase	0.0132	0.3117	1
Echinococcus multilocularis	SET and MYND domain containing protein 4	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase, H3 lysine 36	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase NSD3	0.0014	0.012	0.012
Brugia malayi	serine/threonine-protein kinase 6	0.0132	0.3117	0.3117
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.1159	0.1159
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.3117	0.607
Echinococcus multilocularis	SET and MYND domain containing protein 4	0.0014	0.012	0.012
Schistosoma mansoni	ran binding protein 9-related	0.0014	0.012	0.012
Entamoeba histolytica	protein kinase, putative	0.0132	0.3117	1
Schistosoma mansoni	SET domain protein	0.0014	0.012	0.012
Schistosoma mansoni	voltage-gated potassium channel	0.0013	0.0104	0.0104
Brugia malayi	serine/threonine kinase 12	0.0132	0.3117	0.3117
Leishmania major	protein kinase, putative	0.0132	0.3117	1
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0015	0.0149	0.0149
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase MLL5	0.0014	0.012	0.012
Schistosoma mansoni	60S ribosomal protein L21	0.0013	0.0104	0.0104
Schistosoma mansoni	mixed-lineage leukemia 5 mll5	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	voltage gated potassium channel	0.0019	0.0253	0.0253
Echinococcus multilocularis	calcium activated potassium channel	0.001	0.0027	0.0027
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	ATP-grasp domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0015	0.0149	0.0149
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	SET domain protein	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0015	0.0149	0.006
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.012	0.012
Onchocerca volvulus		0.0014	0.012	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Entamoeba histolytica	protein kinase domain containing protein	0.0132	0.3117	1
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0253	0.0253
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Schistosoma mansoni	set and mynd domain containing	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	aurora B kinase, putative	0.0132	0.3117	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	SET trithorax:polycomb domain containing protein	0.0014	0.012	0.012
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0042	0.0832	0.1442
Trichomonas vaginalis	conserved hypothetical protein	0.0208	0.5058	1
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	SET and MYND domain containing protein 5	0.0014	0.012	0.012
Echinococcus granulosus	aurora kinase A	0.0132	0.3117	0.3117
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0015	0.0149	0.0149
Entamoeba histolytica	protein kinase , putative	0.0132	0.3117	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0906	0.0906
Plasmodium falciparum	SET domain protein, putative	0.0403	1	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0014	0.012	0.012
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0132	0.3117	0.3117
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0014	0.012	0.012
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.012	0.012
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	histone lysine N methyltransferase Ez	0.0014	0.012	0.012
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0015	0.0149	0.0149
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0014	0.012	0.012
Brugia malayi	Pre-SET motif family protein	0.0014	0.012	0.012
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0015	0.0149	0.006
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0015	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Schistosoma mansoni	enhancer of zeste ezh	0.0014	0.012	0.012
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0014	0.012	0.012
Schistosoma mansoni	hypothetical protein	0.0014	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.005	0.1055	0.1055
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	conserved protein, unknown function	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0149	0.0149
Echinococcus granulosus	calcium activated potassium channel	0.001	0.0027	0.0027
Schistosoma mansoni	set and mynd domain containing	0.0014	0.012	0.012
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0132	0.3117	0.3117
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0014	0.012	0.012
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0149	0.0149
Echinococcus granulosus	SET and MYND domain containing protein 4	0.0014	0.012	0.012
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase SET2	0.0014	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0132	0.3117	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Plasmodium vivax	SET domain protein, putative	0.0403	1	1
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.3117	0.607
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0253	0.0253
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0014	0.012	0.012
Trypanosoma cruzi	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	histone lysine N methyltransferase SETD2	0.0014	0.012	0.012
Loa Loa (eye worm)	AUR protein kinase	0.0132	0.3117	0.3117
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0015	0.0149	0.0149
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0019	0.0253	0.0253
Echinococcus multilocularis	aurora kinase A	0.0132	0.3117	0.3117
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0014	0.012	0.012
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0015	0.0149	0.0149
Onchocerca volvulus		0.0014	0.012	1
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	histone lysine N methyltransferase E(z)	0.0014	0.012	0.012
Loa Loa (eye worm)	histone methyltransferase	0.0014	0.012	0.012
Loa Loa (eye worm)	SET domain-containing protein	0.0014	0.012	0.012
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0132	0.3117	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0015	0.0149	0.0149
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus granulosus	voltage gated potassium channel	0.0019	0.0253	0.0253
Schistosoma mansoni	set and mynd domain containing	0.0014	0.012	0.012
Schistosoma mansoni	suppressor of variegation 4-20-related	0.0014	0.012	0.012
Brugia malayi	Pre-SET motif family protein	0.0014	0.012	0.012
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	myeloid:lymphoid or mixed lineage leukemia 5	0.0014	0.012	0.012
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0014	0.012	0.012
Echinococcus granulosus	histone lysine methyltransferase setb	0.0014	0.012	0.012
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0014	0.012	0.012
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Trypanosoma cruzi	D-ala D-ala ligase C-terminus/SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0014	0.012	0.012
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0014	0.012	0.012
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.005	0.1055	0.1055
Schistosoma mansoni	protein kinase	0.0132	0.3117	0.3117
Echinococcus multilocularis	histone lysine n methyltransferase setd8	0.0403	1	1
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.3117	0.607
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.005	0.1055	0.1055
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0132	0.3117	1
Schistosoma mansoni	serine/threonine protein kinase	0.0132	0.3117	0.3117
Schistosoma mansoni	histone-lysine n-methyltransferase seto7	0.0403	1	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	hyperpolarization activated cyclic	0.0015	0.0149	0.0149
Toxoplasma gondii	histone lysine methyltransferase SET8	0.0403	1	1
Echinococcus granulosus	histone lysine n methyltransferase setd8	0.0403	1	1
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0217	0.5281	0.5281
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	hypothetical protein	0.0014	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0217	0.5281	0.5281
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Echinococcus granulosus	histone lysine N methyltransferase H3 lysine 36	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Loa Loa (eye worm)	AUR protein kinase	0.0132	0.3117	0.3117
Brugia malayi	F/Y-rich N-terminus family protein	0.0014	0.012	0.012
Trypanosoma brucei	ATP-grasp domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus multilocularis	SET domain containing protein 3	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Onchocerca volvulus		0.0014	0.012	1
Echinococcus granulosus	SET and MYND domain containing protein 4	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Schistosoma mansoni	voltage-gated potassium channel	0.0015	0.0149	0.0149
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Entamoeba histolytica	protein kinase, putative	0.0132	0.3117	1
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0015	0.0149	0.0149
Loa Loa (eye worm)	SET domain-containing protein	0.0014	0.012	0.012
Trichomonas vaginalis	AGC family protein kinase	0.0132	0.3117	0.607
Trypanosoma brucei	SET domain containing protein, putative	0.0014	0.012	0.0384
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.005	0.1055	0.1055
Trypanosoma cruzi	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Leishmania major	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	hypothetical protein, conserved	0.0014	0.012	0.0384
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0015	0.0149	0.0149
Leishmania major	SET domain protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	voltage-gated potassium channel	0.0054	0.1159	0.1159
Brugia malayi	serine/threonine protein kinase 6	0.0132	0.3117	0.3117
Echinococcus granulosus	SET domain containing protein 3	0.0014	0.012	0.012
Echinococcus granulosus	hyperpolarization activated cyclic	0.0015	0.0149	0.0149
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0132	0.3117	0.3034
Loa Loa (eye worm)	hypothetical protein	0.0403	1	1
Brugia malayi	SET domain containing protein	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0014	0.012	0.012
Toxoplasma gondii	apical complex lysine methyltransferase	0.0014	0.012	0.012
Echinococcus multilocularis	histone lysine N methyltransferase SETD2	0.0014	0.012	0.012
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0253	0.0253
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0015	0.0149	0.0149
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0015	0.0149	0.0149
Trypanosoma brucei	TPR repeat/SET domain containing protein, putative	0.0014	0.012	0.0384
Toxoplasma gondii	histone lysine methyltransferase, SET, putative	0.0014	0.012	0.012
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Echinococcus granulosus	myeloid:lymphoid or mixed lineage leukemia 5	0.0014	0.012	0.012
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0014	0.012	0.012
Toxoplasma gondii	aurora kinase	0.0132	0.3117	0.3117
Trypanosoma brucei	hypothetical protein, conserved	0.0014	0.012	0.0384
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0132	0.3117	0.3034
Trypanosoma cruzi	SET domain containing protein, putative	0.0014	0.012	0.0384
Schistosoma mansoni	set and mynd domain containing	0.0014	0.012	0.012

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.27 uM	Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp method	ChEMBL.	23395659
IC50 (binding)	= 9.2 uM	Inhibition of human ERG	ChEMBL.	23395659
Inhibition (binding)	= 38.81 %	Inhibition of alpha-1G calcium channel in human HEK293 cells at 10 uM by whole-cell patch-clamp method	ChEMBL.	23395659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2334610

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1735299