Detailed information for compound 1513487

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 265.292 | Formula: C10H11N5O2S
  • H donors: 1 H acceptors: 3 LogP: 1.43 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)/N=[N+](/c1c(C)n(nc1c1cccs1)C)\[O-]
  • InChi: 1S/C10H11N5O2S/c1-6-9(15(17)13-10(11)16)8(12-14(6)2)7-4-3-5-18-7/h3-5H,1-2H3,(H2,11,16)/b15-13-
  • InChiKey: IOPDUMRQJDYZNU-SQFISAMPSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0028 0.0218 0.0425
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0029 0.0047
Toxoplasma gondii thioredoxin reductase 0.0037 0.0326 0.1426
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0303 0.0339
Loa Loa (eye worm) hypothetical protein 0.0196 0.2382 0.4635
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0094 0.0111
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0179 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.03 0.0506
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0415 0.0471
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0029 0.0056
Brugia malayi Flap endonuclease-1 0.0025 0.0179 0.0349
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0295 0.0556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0568
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0094 0.031
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0024 0.0165 0.0509
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0301 0.1039
Schistosoma mansoni DNA polymerase eta 0.0019 0.0094 0.0111
Brugia malayi beta-lactamase 0.0037 0.0323 0.063
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0094 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0415 0.0703
Schistosoma mansoni hypothetical protein 0.0169 0.2027 0.2388
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0415 0.1372
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0181 0.2187 0.2174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0062 0.0653 0.0638
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0029 0.0055
Treponema pallidum NADH oxidase 0.0013 0.0017 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0323 0.1117
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0323 0.038
Loa Loa (eye worm) hypothetical protein 0.0134 0.1582 0.3071
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0029 0.0036
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1009 0.1188
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0029 0.0086
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0042 0.0098
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0159 0.0144
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0323 0.0362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.023 0.0387
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0323 0.1225
Echinococcus granulosus tumor protein p63 0.0329 0.4081 0.4798
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0017 0.002
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0452 0.1336
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0933 0.3256
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0165 0.0275
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0165 0.4782
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0326 0.1129
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Giardia lamblia GTOR 0.0044 0.0415 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0303 0.0357
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0156 0.026
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0452 0.1336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0042 0.0064
Brugia malayi intermediate filament protein 0.0026 0.0191 0.0373
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0165 0.0322
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0024 0.0165 0.0275
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0218 0.0238
Plasmodium falciparum glutathione reductase 0.0037 0.0326 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0094 0.0267
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0062 0.0653 0.0752
Echinococcus granulosus muscleblind protein 0.0145 0.1722 0.2014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0323 0.0612
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0179 0.033
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0029 0.0056
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.6482
Mycobacterium ulcerans hypothetical protein 0.0037 0.0323 0.094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0452 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0452 0.1336
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0933 0.3256
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0301 0.0871
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0933 0.3256
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0094 0.0267
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0415 0.0792
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Schistosoma mansoni flap endonuclease-1 0.0023 0.0147 0.0174
Echinococcus multilocularis tumor protein p63 0.0329 0.4081 0.4072
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Mycobacterium tuberculosis Probable reductase 0.0084 0.0933 0.3256
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0094 0.0092
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0029 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0415 0.0703
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0159 0.0571
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.0953
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0179 0.3544
Loa Loa (eye worm) beta-lactamase 0.0037 0.0323 0.0612
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0218 0.0925
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.8488 0.8486
Schistosoma mansoni hypothetical protein 0.0035 0.0303 0.0357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0323 0.038
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0323 0.1054
Toxoplasma gondii hypothetical protein 0.0024 0.0165 0.0682
Mycobacterium tuberculosis Conserved protein 0.0037 0.0323 0.1117
Echinococcus multilocularis lamin dm0 0.0026 0.0191 0.0175
Schistosoma mansoni hypothetical protein 0.0062 0.0653 0.0769
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0273 0.2387
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0323 0.0307
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0094 0.031
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0029 0.0383
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0029 0.0036
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0024 0.0165 0.0322
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0323 0.094
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0323 0.0545
Loa Loa (eye worm) hypothetical protein 0.0145 0.1722 0.3346
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0165 0.0592
Brugia malayi jmjC domain containing protein 0.0034 0.0295 0.0574
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0452 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0094 0.031
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0191 0.0354
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2187 0.2576
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0333 0.0374
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0646 0.0761
Echinococcus granulosus dna polymerase kappa 0.0019 0.0094 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Brugia malayi glutaminase DH11.1 0.0266 0.3274 0.6384
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0415 0.081
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0361 0.0345
Brugia malayi MH2 domain containing protein 0.0116 0.1347 0.2627
Leishmania major DNA polymerase eta, putative 0.0019 0.0094 0.031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0415 0.0703
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0323 0.1225
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0301 0.0977
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0017 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0646 0.0761
Trypanosoma brucei unspecified product 0.0019 0.0094 0.0267
Echinococcus granulosus geminin 0.0169 0.2027 0.2374
Loa Loa (eye worm) RNA binding protein 0.0062 0.0646 0.1242
Loa Loa (eye worm) oxidoreductase 0.0014 0.0029 0.0037
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0042 0.0085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1009 0.1172
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0024 0.0165 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0333 0.0563
Brugia malayi Pre-SET motif family protein 0.0059 0.0609 0.1189
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0029 0.0055
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0181 0.2187 0.2562
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.0953
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0094 0.0267
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.03 0.0506
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0472 0.0556
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0452 0.1336
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0323 0.1117
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1053 0.3678
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Plasmodium falciparum thioredoxin reductase 0.0037 0.0326 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0042 0.0049
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1347 0.2612
Trypanosoma brucei inositol phosphorylceramide synthase 0.0238 0.2921 1
Onchocerca volvulus 0.0466 0.5856 1
Plasmodium vivax glutathione reductase, putative 0.0037 0.0326 0.522
Echinococcus granulosus sphingomyelin synthase protein 1 0.0024 0.0165 0.0176
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0029 0.0034
Plasmodium falciparum flap endonuclease 1 0.0025 0.0179 0.5232
Onchocerca volvulus 0.0037 0.0323 0.0505
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0029 0.0013
Echinococcus multilocularis muscleblind protein 0.0145 0.1722 0.1709
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0024 0.0165 0.4782
Loa Loa (eye worm) hypothetical protein 0.0028 0.0218 0.0406
Mycobacterium ulcerans hypothetical protein 0.0024 0.0159 0.0438
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0323 0.1117
Mycobacterium ulcerans beta-lactamase 0.0037 0.0323 0.094
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0029 0.0086
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0646 0.1259
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.5127 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0165 0.0322
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0094 0.0316
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0165 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0157 0.0261
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0017 0.0022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Brugia malayi beta-lactamase family protein 0.0037 0.0323 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0024 0.0165 0.4782
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0323 0.2871
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0323 0.0362
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0034 0.0066
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0323 0.6942
Loa Loa (eye worm) hypothetical protein 0.0019 0.0094 0.0165
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0271 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0042 0.0064
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0029 0.0037
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0159 0.0571
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0062 0.0653 0.0638
Trichomonas vaginalis set domain proteins, putative 0.0466 0.5856 1
Echinococcus granulosus intermediate filament protein 0.0026 0.0191 0.0207
Entamoeba histolytica hypothetical protein 0.0024 0.0165 0.3216
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0323 0.1223
Echinococcus granulosus tar DNA binding protein 0.0062 0.0646 0.0743
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0042 0.0098
Loa Loa (eye worm) hypothetical protein 0.0062 0.0653 0.1257
Brugia malayi beta-lactamase family protein 0.0037 0.0323 0.063
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0159 0.0544
Loa Loa (eye worm) hypothetical protein 0.0047 0.0452 0.0864
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0029 0.0036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0017 0.0033
Mycobacterium ulcerans lipase LipD 0.0037 0.0323 0.094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.03 0.0506
Schistosoma mansoni aldehyde dehydrogenase 0.0181 0.2187 0.2576
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0326 0.1238
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0218 0.0406
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0218 0.0202
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0452 0.157
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0323 0.1052
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0009
Trichomonas vaginalis glutaminase, putative 0.0266 0.3274 0.5587
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0415 0.1595
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0159 0.0438
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0301 0.4786
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1009 0.0994
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0452 0.1741
Brugia malayi Pre-SET motif family protein 0.041 0.5127 1
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0029 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0191 0.0354
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0218 0.0257
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0452 0.0881
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0323 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0159 0.0438
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0415 0.1372
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0029 0.0047
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0029 0.0041
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0029 0.0056
Brugia malayi hypothetical protein 0.0147 0.1744 0.3401
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0609 0.0718
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0323 0.1117
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0029 0.0047
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0062 0.0653 0.0752
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0452 0.0881
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0301 1
Entamoeba histolytica hypothetical protein 0.0024 0.0165 0.3216
Echinococcus granulosus dna polymerase eta 0.0019 0.0094 0.0092
Echinococcus granulosus GPCR family 2 0.0062 0.0653 0.0752
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0568
Plasmodium vivax sphingomyelin synthase 1, putative 0.0024 0.0165 0.2497
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.6482
Schistosoma mansoni hypothetical protein 0.0062 0.0653 0.0769
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0094 0.031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1009 0.1188
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.6482
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0029 0.0043
Schistosoma mansoni hypothetical protein 0.0062 0.0653 0.0769
Schistosoma mansoni hypothetical protein 0.0134 0.1582 0.1863
Brugia malayi Muscleblind-like protein 0.0145 0.1722 0.3359
Onchocerca volvulus Alhambra homolog 0.0028 0.0218 0.0324
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0087 0.0239
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0333 0.0317
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1009 0.1952
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0029 0.0086
Brugia malayi RNA binding protein 0.0062 0.0646 0.1259
Brugia malayi latrophilin 2 splice variant baaae 0.0134 0.1582 0.3084
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0295 0.0279
Schistosoma mansoni intermediate filament proteins 0.0026 0.0191 0.0225
Leishmania major trypanothione reductase 0.0037 0.0326 0.1238
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0452 0.157
Brugia malayi Calcitonin receptor-like protein seb-1 0.0196 0.2382 0.4645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0156 0.026
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0323 0.1223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0189 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2515 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0165 0.0322
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0017 0.0001
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0452 0.1741
Brugia malayi Cytochrome P450 family protein 0.0048 0.0465 0.0906
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0029 0.0086
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0301 0.9168
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Leishmania major DNA polymerase kappa, putative 0.0019 0.0094 0.031
Echinococcus granulosus peregrin 0.0028 0.0218 0.0238
Plasmodium vivax SET domain protein, putative 0.0059 0.0609 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.1722 0.3346
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0323 0.0545
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0029 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0646 0.0761
Brugia malayi PHD-finger family protein 0.0028 0.0218 0.0425
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0157 0.0261
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0933 0.3256
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0094 0.0238
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0042 0.0081
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0042 0.0098
Loa Loa (eye worm) glutaminase 0.0266 0.3274 0.6377
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0034 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0009
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0029 0.0036
Mycobacterium leprae Probable lipase LipE 0.0037 0.0323 0.2871
Echinococcus granulosus lamin 0.0026 0.0191 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0189 0.0316
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.0953
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1053 1
Echinococcus granulosus microtubule associated protein 2 0.0671 0.8488 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0094 0.0155
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0582 0.0668
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0019 0.0009
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0013 0.0017 0.0044
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0165 0.0592
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0029 0.0041
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0094 0.031
Echinococcus multilocularis geminin 0.0169 0.2027 0.2014
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0609 0.0594
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0029 0.0086
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0181 0.2187 0.7654
Loa Loa (eye worm) hypothetical protein 0.0147 0.1744 0.3388
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0415 0.1595
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1009 0.1967
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0094 0.155
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0042 0.0062
Entamoeba histolytica hypothetical protein 0.0024 0.0165 0.3216
Loa Loa (eye worm) glutaminase 2 0.0266 0.3274 0.6377
Toxoplasma gondii ABC1 family protein 0.0037 0.0323 0.141
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0179 0.0648
Onchocerca volvulus 0.0048 0.0472 0.076
Onchocerca volvulus 0.0026 0.0191 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.2515 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0609 0.07
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0029 0.0055
Echinococcus multilocularis GPCR, family 2 0.0062 0.0653 0.0638
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.8488 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0609 0.0718
Brugia malayi glutathione reductase 0.0037 0.0326 0.0636
Loa Loa (eye worm) inositol-1 0.0036 0.0323 0.0611
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0094 0.0184
Loa Loa (eye worm) hypothetical protein 0.0049 0.0478 0.0915
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0465 0.0888
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0273 0.0943
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0609 0.0718
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0179 0.2731
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0029 0.0086
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0326 0.0618
Schistosoma mansoni hypothetical protein 0.0028 0.0218 0.0257
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0029 0.0086
Mycobacterium ulcerans glutaminase 0.0266 0.3274 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0196 0.2382 0.4635
Schistosoma mansoni spingomyelin synthetase-related 0.0024 0.0165 0.0194
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0042 0.003
Onchocerca volvulus 0.0147 0.1744 0.2943
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0415 0.0489
Onchocerca volvulus 0.0059 0.0609 0.0996
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0295 0.0347
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0452 0.1336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0157 0.0261
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0452 0.4131
Brugia malayi hypothetical protein 0.0035 0.0303 0.0591
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0029 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Mycobacterium ulcerans hypothetical protein 0.0047 0.0452 0.1336
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0218 0.0925
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Onchocerca volvulus 0.0037 0.0323 0.0505
Trypanosoma brucei trypanothione reductase 0.0037 0.0326 0.1065
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0415 0.1595
Brugia malayi Thioredoxin reductase 0.0037 0.0326 0.0636
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0802 0.0945
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1347 0.2612
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0037
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0029 0.0047
Schistosoma mansoni glutaminase 0.0266 0.3274 0.3857
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0165 0.0275
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0415 0.9133
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0159 0.0266
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.2515 0.8601
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0238 0.2921 0.4985
Leishmania major hypothetical protein, conserved 0.0037 0.0323 0.1225
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0094 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0029 0.0056
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0024 0.0165 0.0322
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0323 0.0545
Loa Loa (eye worm) hypothetical protein 0.0048 0.0472 0.0903
Loa Loa (eye worm) glutathione reductase 0.0037 0.0326 0.0618
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0181 0.2187 0.8686
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0323 0.1117
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0323 0.0545
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0646 0.0761
Echinococcus multilocularis dna polymerase eta 0.0019 0.0094 0.0078
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0179 0.0299
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0323 0.1223
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0323 0.0307
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0361 0.0407
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.03 0.0506
Schistosoma mansoni inositol monophosphatase 0.0036 0.0323 0.038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0452 0.0881
Schistosoma mansoni hypothetical protein 0.0169 0.2027 0.2388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0156 0.026
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0179 0.4063
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0042 0.0098
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0609 0.0594
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1053 0.3678
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0159 0.0169
Trypanosoma brucei unspecified product 0.0013 0.0019 0.0009
Entamoeba histolytica hypothetical protein 0.0035 0.0303 0.6482
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0323 0.0938
Echinococcus granulosus lamin dm0 0.0026 0.0191 0.0207
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0094 0.0111
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0029 0.0015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0323 0.0545
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0042 0.0064
Plasmodium falciparum phd finger protein, putative 0.0028 0.0218 0.6491
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1722 0.1709
Mycobacterium tuberculosis Conserved protein 0.0037 0.0323 0.1117
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1009 0.1172
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0029 0.0047
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0029 0.0056
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0323 0.5164
Trichomonas vaginalis hypothetical protein 0.0024 0.0165 0.0275
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1053 0.3678
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0024 0.0165 0.0509
Schistosoma mansoni inositol monophosphatase 0.0036 0.0323 0.038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0196 0.2382 0.4645
Echinococcus multilocularis lamin 0.0026 0.0191 0.0175
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1048 0.1033
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0238 0.2921 0.4985
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0017 0.0001
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0029 0.0047
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0094 0.0238
Entamoeba histolytica hypothetical membrane-spanning protein 0.0024 0.0165 0.3216
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0303 0.0287
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0218 0.3389
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0415 0.1595
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0452 0.4131
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0452 0.1336
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0415 0.9133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1009 0.1188
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0062 0.0653 0.1274
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0094 0.0316
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0029 0.0036
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2187 0.6663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0157 0.0261
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Schistosoma mansoni hypothetical protein 0.0062 0.0653 0.0769
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0323 0.094
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2187 0.6663
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0323 0.1117
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0029 0.0036
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0094 0.0078
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0179 0.0557
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0159 0.0438
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0042 0.0064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0323 0.1117
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0029 0.0036
Mycobacterium tuberculosis Conserved protein 0.0037 0.0323 0.1117
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0094 0.0184
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0646 0.0761
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0029 0.02
Brugia malayi Latrophilin receptor protein 2 0.0062 0.0653 0.1274
Echinococcus multilocularis peregrin 0.0028 0.0218 0.0202
Loa Loa (eye worm) hypothetical protein 0.0047 0.0452 0.0864
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2856 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0568
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0029 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Loa Loa (eye worm) hypothetical protein 0.0037 0.0323 0.0612
Onchocerca volvulus 0.0047 0.0452 0.0726
Loa Loa (eye worm) hypothetical protein 0.0059 0.0609 0.1172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.03 0.0506
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0301 0.1136
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0029 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0094 0.0267
Plasmodium vivax sphingomyelin synthase 2, putative 0.0024 0.0165 0.2497
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0301 0.1136
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0179 0.0746
Brugia malayi Inositol-1 0.0036 0.0323 0.0629
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0933 0.8824
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0119 0.0351
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1048 0.1218
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0452 0.1741
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0179 0.0648
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.0295 0.0329
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0029 0.0086
Onchocerca volvulus 0.0037 0.0323 0.0505
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.0295 0.0347
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0323 0.0545
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0159 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0276 0.0953
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0323 0.063
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0933 0.3256
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0606 0.1165
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0646 0.063
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0191 0.0354
Brugia malayi jmjC domain containing protein 0.0093 0.1048 0.2043
Trichomonas vaginalis esterase, putative 0.0037 0.0323 0.0545
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0323 0.0545
Loa Loa (eye worm) hypothetical protein 0.0026 0.0185 0.0342
Loa Loa (eye worm) hypothetical protein 0.0014 0.0029 0.0037
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0029 0.0036
Toxoplasma gondii aldehyde dehydrogenase 0.0181 0.2187 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0609 0.0718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0189 0.0316
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0029 0.0086
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0029 0.0047
Loa Loa (eye worm) hypothetical protein 0.0024 0.0165 0.0303
Brugia malayi TAR-binding protein 0.0062 0.0646 0.1259
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0042 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0218 0.0366
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0452 0.1336
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0186 0.0311
Mycobacterium ulcerans aldehyde dehydrogenase 0.0181 0.2187 0.6663
Loa Loa (eye worm) hypothetical protein 0.0047 0.0452 0.0864
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0609 0.2731
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0094 0.0267
Mycobacterium tuberculosis Conserved protein 0.0024 0.0159 0.0544
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0094 0.0155
Loa Loa (eye worm) hypothetical protein 0.0035 0.0301 0.0568
Schistosoma mansoni lamin 0.0026 0.0191 0.0225
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0042 0.0085
Giardia lamblia PHD finger protein 15 0.0028 0.0218 0.5041
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0646 0.1242
Entamoeba histolytica hypothetical protein 0.0024 0.0165 0.3216
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0646 0.1242
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0323 0.0545
Echinococcus granulosus flap endonuclease 1 0.0025 0.0179 0.0192
Brugia malayi Sphingomyelin synthase-related 1 0.0024 0.0165 0.0322
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1009 0.0994
Echinococcus multilocularis musashi 0.0026 0.0191 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0029 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0062 0.0653 0.1257
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0094 0.0165
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0415 0.04
Giardia lamblia DINP protein human, muc B family 0.0019 0.0094 0.1945
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0452 1
Schistosoma mansoni lamin 0.0026 0.0191 0.0225
Entamoeba histolytica hypothetical protein 0.0024 0.0165 0.3216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0042 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0186 0.0311
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0159 0.0438
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0191 0.0373
Onchocerca volvulus 0.0026 0.0191 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0271 0.0457
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0323 0.1408
Leishmania major hypothetical protein, conserved 0.0207 0.2515 1
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0024 0.0165 0.0592
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0326 0.522

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antimicrobial activity against Escherichia coli isolate after 48 hrs by microdilution broth method ChEMBL. 21530247
MIC (functional) > 128 ug ml-1 Antimicrobial activity against Candida albicans isolate 31 after 48 hrs by microdilution broth method ChEMBL. 21530247
MIC (functional) > 128 ug ml-1 Antimicrobial activity against Candida albicans isolate 47 after 48 hrs by microdilution broth method ChEMBL. 21530247
MIC (functional) > 128 ug ml-1 Antimicrobial activity against Candida albicans isolate 48 after 48 hrs by microdilution broth method ChEMBL. 21530247
MIC (functional) > 128 ug ml-1 Antimicrobial activity against Candida albicans ATCC 90028 after 48 hrs by microdilution broth method ChEMBL. 21530247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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