Detailed information for compound 669150

Basic information

Technical information
  • TDR Targets ID: 669150
  • Name: 2-[[5-(3-acetamidophenyl)-4-methyl-1,2,4-tria zol-3-yl]sulfanyl]-N-phenylacetamide
  • MW: 381.451 | Formula: C19H19N5O2S
  • H donors: 2 H acceptors: 4 LogP: 2.01 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1)CSc1nnc(n1C)c1cccc(c1)NC(=O)C
  • InChi: 1S/C19H19N5O2S/c1-13(25)20-16-10-6-7-14(11-16)18-22-23-19(24(18)2)27-12-17(26)21-15-8-4-3-5-9-15/h3-11H,12H2,1-2H3,(H,20,25)(H,21,26)
  • InChiKey: JUAVJLPMOMURDT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(3-acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-phenyl-acetamide
  • 2-[[5-(3-acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]thio]-N-phenylacetamide
  • 2-[[5-(3-acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]thio]-N-phenyl-acetamide
  • 2-[[5-(3-acetamidophenyl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-N-phenyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica histone deacetylase, putative 0.0198 0.2067 0.583
Giardia lamblia Histone deacetylase 0.0198 0.2067 0.5682
Plasmodium vivax histone deacetylase 2, putative 0.0056 0.0426 0.1416
Echinococcus multilocularis pyruvate kinase 0.0034 0.0163 0.0139
Leishmania major hypothetical protein, conserved 0.0055 0.0405 0.127
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0038 0.0109
Loa Loa (eye worm) hypothetical protein 0.0061 0.0475 0.1341
Loa Loa (eye worm) hypothetical protein 0.0079 0.0688 0.1942
Brugia malayi exodeoxyribonuclease III family protein 0.0081 0.0708 0.1781
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0081 0.0714 0.2894
Entamoeba histolytica hypothetical protein 0.0081 0.0714 0.193
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0426 0.1379
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0163 0.0089
Plasmodium vivax histone deacetylase, putative 0.0056 0.0426 0.1416
Brugia malayi Bromodomain containing protein 0.0084 0.0744 0.1884
Schistosoma mansoni alpha-glucosidase 0.0155 0.1567 0.1546
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0426 0.1379
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.3123 0.3106
Onchocerca volvulus 0.0263 0.2821 0.7882
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0237 0.051
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0055 0.0031
Echinococcus granulosus intermediate filament protein 0.0031 0.0133 0.0109
Echinococcus granulosus SAM and MBT domain containing protein 0.0053 0.039 0.0366
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0229 0.0074
Onchocerca volvulus Histone deacetylase 10 homolog 0.0056 0.0426 0.0859
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0426 0.0402
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.018 0.1857 0.5242
Schistosoma mansoni hypothetical protein 0.0082 0.0724 0.0701
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0545 0.0522
Schistosoma mansoni lamin 0.0031 0.0133 0.0109
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0229 0.0074
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0234 0.0079
Trypanosoma brucei histone deacetylase 2 0.0056 0.0426 0.0295
Trypanosoma brucei inositol phosphorylceramide synthase 0.0799 0.905 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0289 0.3123 0.8781
Loa Loa (eye worm) hypothetical protein 0.0043 0.0269 0.0758
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0081 0.0708 0.0685
Echinococcus granulosus sphingomyelin synthase protein 1 0.0081 0.0714 0.0691
Schistosoma mansoni myelin transcription factor 1 myt1 0.0061 0.0475 0.0452
Plasmodium vivax histone deacetylase, putative 0.0056 0.0426 0.1416
Brugia malayi hypothetical protein 0.004 0.0233 0.0403
Loa Loa (eye worm) hypothetical protein 0.0048 0.0324 0.0915
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0237 0.0212
Echinococcus multilocularis histone deacetylase 0.0056 0.0426 0.0402
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0233 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Schistosoma mansoni spingomyelin synthetase-related 0.0081 0.0714 0.0691
Trypanosoma brucei glucosidase, putative 0.004 0.0234 0.0079
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0081 0.0714 0.2894
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0229 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0177 0.183 0.5033
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1857 0.1837
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0234 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0237 0.0082
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0237 0.051
Brugia malayi mbt repeat family protein 0.0053 0.039 0.0857
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0053 0.039 0.0752
Entamoeba histolytica hypothetical protein 0.0081 0.0714 0.193
Loa Loa (eye worm) hypothetical protein 0.0045 0.0299 0.0845
Schistosoma mansoni hypothetical protein 0.0023 0.0038 0.0014
Loa Loa (eye worm) histone deacetylase 3 0.0198 0.2067 0.5834
Loa Loa (eye worm) histone deacetylase 7A 0.0056 0.0426 0.1202
Schistosoma mansoni pyruvate kinase 0.0034 0.0163 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.3123 0.3106
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0724 0.1827
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0843 0.9566 0.9564
Echinococcus granulosus histone deacetylase 3 0.0198 0.2067 0.2047
Loa Loa (eye worm) histone deacetylase 1 0.0198 0.2067 0.5834
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0226 0.2399 0.238
Echinococcus granulosus histone deacetylase 6 0.0056 0.0426 0.0402
Echinococcus multilocularis pyruvate kinase 0.0027 0.0081 0.0056
Brugia malayi Cytochrome P450 family protein 0.0056 0.0426 0.0962
Schistosoma mansoni histone deacetylase 4 5 0.0056 0.0426 0.0402
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0405 0.0272
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0081 0.0714 0.2894
Brugia malayi Histone deacetylase family protein 0.0056 0.0426 0.0962
Echinococcus multilocularis pyruvate kinase 0.0034 0.0163 0.0139
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0233 0.0209
Plasmodium vivax histone deacetylase 1, putative 0.0198 0.2067 1
Echinococcus granulosus histone deacetylase 8 0.0056 0.0426 0.0402
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.3514 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0067 0.0548 0.0525
Echinococcus granulosus lamin dm0 0.0031 0.0133 0.0109
Echinococcus multilocularis SAM and MBT domain containing protein 0.0053 0.039 0.0366
Trypanosoma cruzi histone deacetylase 1, putative 0.0198 0.2067 1
Schistosoma mansoni alpha-glucosidase 0.0155 0.1567 0.1546
Brugia malayi beta-lactamase family protein 0.004 0.0237 0.0413
Brugia malayi histone deacetylase 3 (HD3) 0.0198 0.2067 0.572
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Schistosoma mansoni histone deacetylase 1 2 3 0.0056 0.0426 0.0402
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0133 0.0375
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0426 0.1379
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0234 0.0079
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0163 0.0089
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0163 0.0201
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Echinococcus multilocularis lamin dm0 0.0031 0.0133 0.0109
Mycobacterium tuberculosis Conserved protein 0.004 0.0237 0.0283
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0234 0.0545
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0133 0.0375
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0799 0.905 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Loa Loa (eye worm) inositol-1 0.0039 0.0229 0.0647
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0163 0.0089
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0237 0.0668
Brugia malayi Pre-SET motif family protein 0.0231 0.2451 0.6832
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0081 0.0708 0.211
Toxoplasma gondii histone deacetylase HDAC5 0.0056 0.0426 0.1416
Toxoplasma gondii hypothetical protein 0.0081 0.0714 0.2924
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3123 0.3106
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0237 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0376 0.0353
Schistosoma mansoni histone deacetylase 0.0198 0.2067 0.2047
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0198 0.2067 0.2142
Brugia malayi Glycosyl hydrolases family 31 protein 0.018 0.1857 0.5112
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0081 0.0714 0.2894
Onchocerca volvulus 0.004 0.0237 0.0304
Plasmodium falciparum histone deacetylase, putative 0.0056 0.0426 0.1379
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0237 0.0212
Echinococcus granulosus lysosomal alpha glucosidase 0.018 0.1857 0.1837
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0234 0.0545
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0237 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0405 0.127
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0063 0.0039
Loa Loa (eye worm) hypothetical protein 0.0082 0.0724 0.2043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0234 0.066
Toxoplasma gondii histone deacetylase HDAC3 0.0198 0.2067 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.018 0.1857 0.1837
Echinococcus multilocularis histone deacetylase 3 0.0198 0.2067 0.2047
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0376 0.0353
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0229 0.0345
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0234 0.0079
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0233 0.0209
Giardia lamblia Fructose-bisphosphate aldolase 0.0322 0.3514 1
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0081 0.0714 0.2894
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0708 0.0613
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0163 0.0201
Schistosoma mansoni lamin 0.0031 0.0133 0.0109
Mycobacterium leprae conserved hypothetical protein 0.004 0.0237 0.051
Brugia malayi Inositol-1 0.0039 0.0229 0.0392
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0237 0.0213
Onchocerca volvulus 0.004 0.0237 0.0304
Echinococcus multilocularis histone deacetylase 1 0.0198 0.2067 0.2047
Treponema pallidum fructose-bisphosphate aldolase 0.0322 0.3514 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0181 0.0069
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.039 0.0366
Schistosoma mansoni hypothetical protein 0.0082 0.0724 0.0701
Schistosoma mansoni inositol monophosphatase 0.0039 0.0229 0.0205
Brugia malayi histone deacetylase 11 0.0056 0.0426 0.0962
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0081 0.0714 0.062
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0405 0.1307
Entamoeba histolytica hypothetical protein 0.004 0.0233 0.0543
Echinococcus multilocularis lamin 0.0031 0.0133 0.0109
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0237 0.0082
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0234 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0234 0.0079
Entamoeba histolytica hypothetical protein 0.0081 0.0714 0.193
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0198 0.2067 0.2142
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0376 0.0353
Toxoplasma gondii histone deacetylase HDAC2 0.0198 0.2067 1
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0045 0.0126
Trichomonas vaginalis ap endonuclease, putative 0.0081 0.0708 0.0613
Echinococcus multilocularis musashi 0.0031 0.0133 0.0109
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.7566 0.756
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0799 0.905 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0234 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0081 0.0708 0.2863
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0229 0.0345
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0237 0.0283
Onchocerca volvulus 0.0053 0.039 0.0752
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0063 0.0039
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0081 0.0714 0.1798
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0234 0.0079
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0405 0.127
Loa Loa (eye worm) hypothetical protein 0.0031 0.0133 0.0375
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0405 0.127
Leishmania major hypothetical protein, conserved 0.004 0.0237 0.0385
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0234 0.037
Plasmodium falciparum histone deacetylase 2 0.0056 0.0426 0.1379
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0237 0.0082
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0237 0.0283
Loa Loa (eye worm) beta-lactamase 0.004 0.0237 0.0668
Brugia malayi Sphingomyelin synthase-related 1 0.0081 0.0714 0.1798
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0229 0.0205
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0405 0.127
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0237 0.0283
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0081 0.0708 0.1913
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0545 0.0522
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0724 0.1827
Leishmania major histone deacetylase, putative 0.0198 0.2067 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0289 0.3123 0.3106
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0714 0.062
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0237 0.0283
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0234 0.037
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0081 0.0708 0.1999
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0426 0.0402
Leishmania major histone deacetylase, putative 0.0056 0.0426 0.1379
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0081 0.0714 0.062
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Echinococcus granulosus histone deacetylase 6 0.0056 0.0426 0.0402
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0063 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0256 0.2746 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0234 0.0079
Schistosoma mansoni ap endonuclease 0.0081 0.0708 0.0685
Schistosoma mansoni hypothetical protein 0.0177 0.183 0.181
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0181 0.0123
Brugia malayi beta-lactamase family protein 0.004 0.0237 0.0413
Loa Loa (eye worm) hypothetical protein 0.0177 0.183 0.5165
Mycobacterium ulcerans hypothetical protein 0.004 0.0237 0.051
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0157 0.1599 0.5559
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0155 0.0131
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0234 0.021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0724 0.0701
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0229 0.0386
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0081 0.0714 0.1798
Echinococcus granulosus histone deacetylase 7 0.0056 0.0426 0.0402
Echinococcus granulosus pyruvate kinase 0.0034 0.0163 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0724 0.0701
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0081 0.0714 0.1798
Brugia malayi Pre-SET motif family protein 0.0033 0.0155 0.0178
Schistosoma mansoni sex comb on midleg homolog 0.0053 0.039 0.0366
Brugia malayi Calcitonin receptor-like protein seb-1 0.0259 0.2783 0.7797
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0357
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Loa Loa (eye worm) hypothetical protein 0.0034 0.0163 0.0461
Onchocerca volvulus 0.0325 0.3543 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0229 0.0532
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0426 0.1379
Toxoplasma gondii histone deacetylase HDAC1 0.0056 0.0426 0.1416
Echinococcus granulosus histone deacetylase 1 0.0198 0.2067 0.2047
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0081 0.0714 0.062
Brugia malayi MH2 domain containing protein 0.0249 0.2665 0.7453
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0289 0.3123 0.3106
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0155 0.0131
Entamoeba histolytica hypothetical protein 0.004 0.0233 0.0543
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0141 0.0117
Schistosoma mansoni hypothetical protein 0.004 0.0233 0.0209
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0237 0.0082
Entamoeba histolytica hypothetical membrane-spanning protein 0.0081 0.0714 0.193
Brugia malayi Bromodomain containing protein 0.0043 0.0268 0.0504
Schistosoma mansoni hypothetical protein 0.0082 0.0724 0.0701
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0548 0.2682
Loa Loa (eye worm) transcription factor SMAD2 0.0249 0.2665 0.752
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0234 0.0079
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0081 0.0708 0.2863
Mycobacterium ulcerans beta-lactamase 0.004 0.0237 0.051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0376 0.1062
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Loa Loa (eye worm) histone deacetylase 0.0056 0.0426 0.1202
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0053 0.039 0.0366
Echinococcus multilocularis geminin 0.088 1 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0081 0.0714 0.062
Echinococcus multilocularis histone deacetylase 6 0.0056 0.0426 0.0402
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0157 0.1599 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0724 0.0701
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0081 0.0714 0.1798
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0081 0.0714 0.0691
Echinococcus granulosus histone deacetylase 6 0.0056 0.0426 0.0402
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0081 0.0714 0.2894
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0237 0.0212
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0081 0.0708 0.0685
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0226 0.2399 0.238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3123 0.3106
Entamoeba histolytica hypothetical protein 0.004 0.0233 0.0543
Loa Loa (eye worm) MBCTL1 0.0061 0.0475 0.1341
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0237 0.0385
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0237 0.0213
Schistosoma mansoni histone deacetylase hda2 0.0056 0.0426 0.0402
Schistosoma mansoni alpha glucosidase 0.004 0.0234 0.021
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0234 0.0405
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Schistosoma mansoni histone deacetylase 0.0198 0.2067 0.2047
Schistosoma mansoni pyruvate kinase 0.0034 0.0163 0.0139
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0376 0.0353
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0708 0.2893
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0237 0.0283
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0163 0.0461
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0724 0.0701
Mycobacterium leprae Probable lipase LipE 0.004 0.0237 0.051
Toxoplasma gondii ABC1 family protein 0.004 0.0237 0.0425
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0157 0.1599 1
Trichomonas vaginalis set domain proteins, putative 0.0263 0.2821 0.2991
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0081 0.0708 0.2863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0259 0.2783 0.7855
Toxoplasma gondii exonuclease III APE 0.0081 0.0708 0.2893
Plasmodium vivax hypothetical protein, conserved 0.004 0.0237 0.0425
Brugia malayi Histone deacetylase 1 0.0198 0.2067 0.572
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0067 0.0548 0.1491
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0237 0.0212
Schistosoma mansoni histone deacetylase hda2 0.0056 0.0426 0.0402
Trypanosoma cruzi histone deacetylase, putative 0.0056 0.0426 0.1379
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0067 0.0548 0.0525
Schistosoma mansoni hypothetical protein 0.034 0.3722 0.3706
Echinococcus granulosus histone deacetylase 0.0056 0.0426 0.0402
Brugia malayi mbt repeat family protein 0.0053 0.039 0.0857
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.7566 0.756
Echinococcus multilocularis histone deacetylase 7 0.0056 0.0426 0.0402
Schistosoma mansoni hypothetical protein 0.088 1 1
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0234 0.037
Plasmodium falciparum histone deacetylase 1 0.0198 0.2067 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0081 0.0708 0.2863
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0081 0.0708 0.1627
Trypanosoma brucei histone deacetylase 1 0.0198 0.2067 0.2142
Brugia malayi hypothetical protein 0.0055 0.0405 0.0902
Echinococcus granulosus lamin 0.0031 0.0133 0.0109
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0237 0.0283
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Echinococcus granulosus histone acetyltransferase MYST2 0.0061 0.0475 0.0452
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0163 0.0043
Trypanosoma brucei histone deacetylase 3 0.0056 0.0426 0.0295
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0231 0.2451 0.6916
Mycobacterium ulcerans lipase LipD 0.004 0.0237 0.051
Loa Loa (eye worm) hypothetical protein 0.004 0.0237 0.0668
Schistosoma mansoni intermediate filament proteins 0.0031 0.0133 0.0109
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0229 0.0345
Loa Loa (eye worm) hypothetical protein 0.0024 0.0045 0.0126
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0724 0.2043
Echinococcus multilocularis GPCR, family 2 0.0082 0.0724 0.0701
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0061 0.0475 0.0452
Trypanosoma brucei histone deacetylase 4 0.0056 0.0426 0.0295
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0405 0.1307
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0289 0.3123 0.8814
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0548 0.0525
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0234 0.0411
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0081 0.0708 0.0613
Leishmania major histone deacetylase, putative 0.0056 0.0426 0.1379
Trypanosoma brucei histone deacetylase, putative 0.0056 0.0426 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0237 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0289 0.3123 0.3106
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0133 0.0113
Loa Loa (eye worm) hypothetical protein 0.0259 0.2783 0.7855
Plasmodium vivax sphingomyelin synthase 1, putative 0.0081 0.0714 0.2924
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0548 0.2682
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0229 0.0074
Loa Loa (eye worm) hypothetical protein 0.0198 0.2067 0.5834
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0163 0.0043
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0081 0.0714 0.1798
Loa Loa (eye worm) hypothetical protein 0.0053 0.039 0.11
Echinococcus granulosus polycomb protein SCMH1 0.0053 0.039 0.0366
Schistosoma mansoni inositol monophosphatase 0.0039 0.0229 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0067 0.0548 0.0525
Schistosoma mansoni bromodomain containing protein 0.0071 0.0592 0.0568
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Onchocerca volvulus 0.0104 0.0978 0.2477
Leishmania major histone deacetylase, putative 0.0198 0.2067 1
Entamoeba histolytica hypothetical protein 0.0081 0.0714 0.193
Echinococcus granulosus GPCR family 2 0.0082 0.0724 0.0701
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0259 0.2783 0.7797
Chlamydia trachomatis pyruvate kinase 0.0034 0.0163 0.5
Echinococcus multilocularis polycomb protein SCMH1 0.0053 0.039 0.0366
Toxoplasma gondii histone deacetylase HDAC4 0.0056 0.0426 0.1416
Entamoeba histolytica hypothetical protein 0.0081 0.0714 0.193
Schistosoma mansoni ap endonuclease 0.0081 0.0708 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0249 0.2665 0.752
Echinococcus multilocularis histone deacetylase 8 0.0056 0.0426 0.0402
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0081 0.0714 0.062
Loa Loa (eye worm) mbt repeat family protein 0.0053 0.039 0.11
Brugia malayi hypothetical protein 0.0035 0.018 0.025
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0081 0.0708 1
Onchocerca volvulus 0.004 0.0237 0.0304
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0322 0.3514 1
Trichomonas vaginalis esterase, putative 0.004 0.0237 0.0082
Brugia malayi hypothetical protein 0.0325 0.3543 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0198 0.2067 0.2142
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0163 0.0461
Mycobacterium tuberculosis Conserved protein 0.004 0.0237 0.0283
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0061 0.0475 0.0452
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0229 0.0074
Brugia malayi Histone deacetylase family protein 0.0056 0.0426 0.0962
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0061 0.0475 0.1105
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0229 0.0458
Trichomonas vaginalis hypothetical protein 0.0081 0.0714 0.062
Echinococcus granulosus pyruvate kinase 0.0034 0.0163 0.0139
Brugia malayi beta-lactamase 0.004 0.0237 0.0413
Echinococcus granulosus microtubule associated protein 2 0.0671 0.7566 0.756
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0055 0.0031
Trypanosoma cruzi histone deacetylase 1, putative 0.0198 0.2067 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0067 0.0548 0.2682
Loa Loa (eye worm) hypothetical protein 0.0081 0.0714 0.2016
Brugia malayi intermediate filament protein 0.0031 0.0133 0.0113
Toxoplasma gondii aldehyde dehydrogenase 0.0067 0.0548 0.2057
Loa Loa (eye worm) hypothetical protein 0.0056 0.0426 0.1202
Loa Loa (eye worm) hypothetical protein 0.0325 0.3543 1
Schistosoma mansoni hypothetical protein 0.0082 0.0724 0.0701
Entamoeba histolytica hypothetical protein 0.004 0.0233 0.0543
Brugia malayi histone deacetylase 1 (HD1) 0.0198 0.2067 0.572
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0237 0.0413
Trichomonas vaginalis histone deacetylase, putative 0.0198 0.2067 0.2142
Echinococcus multilocularis histone acetyltransferase MYST2 0.0061 0.0475 0.0452
Schistosoma mansoni histone deacetylase 4 5 0.0056 0.0426 0.0402
Plasmodium vivax sphingomyelin synthase 2, putative 0.0081 0.0714 0.2924
Mycobacterium tuberculosis Conserved protein 0.004 0.0237 0.0283
Loa Loa (eye worm) histone deacetylase 11 0.0056 0.0426 0.1202
Schistosoma mansoni hypothetical protein 0.088 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0067 0.0548 0.2023
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0426 0.1202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0322 0.3514 0.377
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0081 0.0708 0.3795
Onchocerca volvulus 0.0033 0.0155 0.0065
Schistosoma mansoni hypothetical protein 0.0024 0.0055 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0405 0.1143
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0237 0.0283
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0155 0.0131
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0163 0.0461

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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