Detailed information for compound 1262428

Basic information

Technical information
  • TDR Targets ID: 1262428
  • Name: 7-[(3R)-3-(2-aminopropan-2-yl)pyrrolidin-1-yl ]-9-cyclopropyl-6-fluoro-8-methoxy-[1,2]thiaz olo[5,4-b]quinoline-3,4-dione
  • MW: 432.512 | Formula: C21H25FN4O3S
  • H donors: 2 H acceptors: 2 LogP: 2.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(N2CC[C@H](C2)C(N)(C)C)c(F)cc2c1n(C1CC1)c1c(c2=O)c(=O)[nH]s1
  • InChi: 1S/C21H25FN4O3S/c1-21(2,23)10-6-7-25(9-10)16-13(22)8-12-15(18(16)29-3)26(11-4-5-11)20-14(17(12)27)19(28)24-30-20/h8,10-11H,4-7,9,23H2,1-3H3,(H,24,28)/t10-/m1/s1
  • InChiKey: CECJUHKZSOSOJJ-SNVBAGLBSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-[(3R)-3-(1-amino-1-methyl-ethyl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-isothiazolo[5,4-b]quinoline-3,4-dione
  • 7-[(3R)-3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-9-cyclopropyl-6-fluoro-8-methoxyisothiazolo[5,4-b]quinoline-3,4-dione
  • 7-[(3R)-3-(1-amino-1-methyl-ethyl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-isothiazolo[5,4-b]quinoline-3,4-quinone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus DNA gyrase Starlite/ChEMBL References
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Theileria parva DNA topoisomerase II, putative DNA gyrase   644 aa 683 aa 23.9 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 676 aa 23.4 %
Plasmodium falciparum DNA topoisomerase 2 DNA gyrase   644 aa 647 aa 23.2 %
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein DNA gyrase   644 aa 548 aa 25.7 %
Babesia bovis DNA topoisomerase II, putative DNA gyrase   644 aa 587 aa 22.7 %
Brugia malayi DNA topoisomerase II, alpha isozyme DNA gyrase   644 aa 659 aa 24.3 %
Theileria parva DNA gyrase subunit B, putative DNA gyrase   644 aa 638 aa 37.1 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 666 aa 23.4 %
Leishmania braziliensis DNA topoisomerase ii DNA gyrase   644 aa 675 aa 23.0 %
Trypanosoma brucei DNA topoisomerase ii DNA gyrase   644 aa 619 aa 25.7 %
Onchocerca volvulus DNA gyrase   644 aa 618 aa 26.5 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Leishmania infantum DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.6 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.9 %
Schistosoma mansoni DNA topoisomerase II DNA gyrase   644 aa 633 aa 24.3 %
Brugia malayi Probable DNA topoisomerase II DNA gyrase   644 aa 672 aa 25.9 %
Plasmodium knowlesi DNA gyrase subunit B, putative DNA gyrase   644 aa 517 aa 36.0 %
Leishmania donovani DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.4 %
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Trypanosoma brucei DNA topoisomerase II beta, putative DNA gyrase   644 aa 570 aa 24.0 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Onchocerca volvulus Ectoderm-expressed 4 homolog DNA gyrase   644 aa 673 aa 24.1 %
Chlamydia trachomatis DNA gyrase subunit B DNA gyrase   644 aa 561 aa 55.3 %
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB DNA gyrase   644 aa 561 aa 50.4 %
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) DNA gyrase   644 aa 667 aa 53.1 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Trypanosoma brucei DNA topoisomerase II alpha, putative DNA gyrase   644 aa 676 aa 23.4 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 617 aa 24.8 %
Onchocerca volvulus DNA gyrase   644 aa 624 aa 25.8 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.7 %
Dictyostelium discoideum DNA topoisomerase II DNA gyrase   644 aa 655 aa 23.8 %
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Toxoplasma gondii DNA topoisomerase 2, putative DNA gyrase   644 aa 664 aa 24.1 %
Leishmania mexicana DNA topoisomerase ii DNA gyrase   644 aa 668 aa 23.1 %
Leishmania mexicana mitochondrial DNA topoisomerase II DNA gyrase   644 aa 620 aa 23.4 %
Echinococcus granulosus DNA topoisomerase 2 alpha DNA gyrase   644 aa 613 aa 25.9 %
Neospora caninum hypothetical protein DNA gyrase   644 aa 693 aa 24.1 %
Loa Loa (eye worm) TOPoisomerase family member DNA gyrase   644 aa 668 aa 26.2 %
Leishmania donovani mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Leishmania infantum mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Plasmodium berghei DNA gyrase subunit B, putative DNA gyrase   644 aa 662 aa 36.3 %
Mycobacterium ulcerans DNA gyrase subunit B DNA gyrase   644 aa 663 aa 54.0 %
Leishmania major mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.1 %
Leishmania major DNA topoisomerase ii DNA gyrase   644 aa 672 aa 23.4 %
Echinococcus multilocularis DNA topoisomerase 2 alpha DNA gyrase   644 aa 612 aa 25.8 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 619 aa 25.7 %
Entamoeba histolytica DNA topoisomerase II, putative DNA gyrase   644 aa 544 aa 25.0 %
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) DNA gyrase   644 aa 661 aa 53.0 %
Leishmania braziliensis mitochondrial DNA topoisomerase II DNA gyrase   644 aa 622 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0105 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1521 0.185
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0216 0.1457 0.1768
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.5867 1
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0145 0.0913 0.1683
Schistosoma mansoni hypothetical protein 0.0114 0.0673 0.0649
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.1813
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Trypanosoma cruzi DNA polymerase eta, putative 0.0159 0.1017 0.3253
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0145 0.0911 0.113
Loa Loa (eye worm) hypothetical protein 0.0114 0.0673 0.083
Echinococcus multilocularis glycoprotein Antigen 5 0.0115 0.0683 0.1124
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Brugia malayi RNA binding protein 0.0069 0.0331 0.0391
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0123 0.0204
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0698 0.0861
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0135 0.0832 0.0864
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Trypanosoma brucei NADH dehydrogenase 0.0038 0.0099 0.0048
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0128 0.0313
Giardia lamblia Fructose-bisphosphate aldolase 0.0594 0.4339 1
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0331 0.0391
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Plasmodium falciparum DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.1268 0.4107
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0038 0.0099 0.0112
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0093
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0145 0.0911 0.2645
Echinococcus granulosus lamin 0.003 0.0032 0.001
Onchocerca volvulus 0.0151 0.0955 0.1043
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0145 0.0911 0.113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Loa Loa (eye worm) solute carrier family 6 member 4 0.0249 0.1705 0.2153
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.2063 0.6819
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0064 0.0291 0.0525
Mycobacterium ulcerans dehydrogenase 0.0038 0.0099 0.0112
Mycobacterium tuberculosis Probable dehydrogenase 0.0954 0.7084 0.8962
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0064 0.0291 0.0304
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Echinococcus granulosus GPCR family 2 0.0053 0.0207 0.0343
Plasmodium vivax ferrodoxin reductase, putative 0.0038 0.0099 0.0224
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0074 0.0034
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0122
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0115 0.0683 0.0842
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0007
Brugia malayi Thioredoxin reductase 0.0418 0.2996 0.3809
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0072 0.0352 0.0596
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0115 0.0683 0.1124
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.4964 0.4951
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0138
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0418 0.2996 0.3736
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus multilocularis thioredoxin glutathione reductase 0.0421 0.3015 0.5117
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0115 0.0683 0.1246
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.2063 0.2664
Schistosoma mansoni alpha glucosidase 0.0039 0.0105 0.008
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0124
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Onchocerca volvulus 0.0115 0.0683 0.0738
Toxoplasma gondii hypothetical protein 0.0103 0.0595 0.1819
Trichomonas vaginalis rotamase, putative 0.0064 0.0291 0.0253
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0521 0.0939
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0529 0.0954
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0099 0.0048
Schistosoma mansoni spingomyelin synthetase-related 0.0103 0.0595 0.057
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.0684 0.2118
Echinococcus multilocularis geminin 0.072 0.5296 0.9021
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.036 0.0686
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0038 0.0099 0.0036
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.036 0.1028
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.029 0.202 0.2488
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1158 0.1451
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0215 0.0242
Brugia malayi Pre-SET motif family protein 0.0151 0.0955 0.1192
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0521 0.0634
Echinococcus granulosus transcription factor btf3 0.0034 0.0067 0.0077
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0042 0.0128 0.0092
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0072 0.0352 0.0355
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0184 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Giardia lamblia DINP protein human, muc B family 0.0115 0.0684 0.1526
Onchocerca volvulus 0.0042 0.0128 0.0114
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0521 0.0634
Entamoeba histolytica disulphide oxidoreductase, putative 0.0038 0.0099 0.0075
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0249 0.1705 0.1684
Plasmodium vivax sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0038 0.0099 0.0224
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni rotamase 0.0065 0.0303 0.0277
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1158 0.2148
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0445 0.136
Onchocerca volvulus 0.0042 0.0128 0.0114
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Schistosoma mansoni hypothetical protein 0.0038 0.0099 0.0073
Entamoeba histolytica hypothetical membrane-spanning protein 0.0103 0.0595 0.1236
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0995 0.1177
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Schistosoma mansoni sodium/chloride dependent transporter 0.0042 0.0128 0.0102
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.036 0.0571
Schistosoma mansoni disulfide oxidoreductase 0.0038 0.0099 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Brugia malayi hypothetical protein 0.0159 0.102 0.1274
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Echinococcus granulosus expressed protein 0.0371 0.2633 0.4947
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0521 0.0847
Trichomonas vaginalis DNA polymerase eta, putative 0.0135 0.0832 0.0864
Echinococcus granulosus jumonji domain containing protein 0.004 0.0113 0.0164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0048
Treponema pallidum fructose-bisphosphate aldolase 0.0594 0.4339 1
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Mycobacterium ulcerans glutamate synthase subunit beta 0.0038 0.0099 0.0112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0109 0.0635 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0038 0.0099 0.0075
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.0635 0.0718
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0074 0.0034
Echinococcus granulosus tar DNA binding protein 0.0069 0.0331 0.0579
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi intermediate filament protein 0.003 0.0032 0.0007
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Echinococcus multilocularis expressed protein 0.0065 0.0303 0.0473
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0427 0.0402
Mycobacterium ulcerans hypothetical protein 0.0115 0.0683 0.1934
Echinococcus granulosus serotonin transporter 0.0249 0.1705 0.3187
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0418 0.2996 0.9156
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0065 0.03 0.0316
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0521 0.0496
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.1268 0.3877
Schistosoma mansoni DNA polymerase eta 0.0159 0.1017 0.0993
Trichomonas vaginalis set domain proteins, putative 0.1196 0.8931 1
Leishmania major DNA polymerase eta, putative 0.0159 0.1017 0.3253
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399
Onchocerca volvulus 0.0115 0.0683 0.0738
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0207 0.0232
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0151 0.0955 0.1591
Plasmodium vivax SET domain protein, putative 0.0151 0.0955 0.2865
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0038 0.0099 0.0112
Trichomonas vaginalis hypothetical protein 0.0103 0.0595 0.0596
Echinococcus granulosus dna polymerase eta 0.0159 0.1017 0.188
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0105 0.015
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0521 0.1561
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Mycobacterium ulcerans hypothetical protein 0.0035 0.0074 0.0034
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0074 0.0061
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0038 0.0099 0.0302
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0454 0.327 0.4086
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0038 0.0099 0.0093
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0145 0.0911 0.2728
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.029 0.202 0.6104
Toxoplasma gondii hypothetical protein 0.0048 0.0169 0.0518
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0123 0.008
Toxoplasma gondii selenide, water dikinase 0.0038 0.0099 0.0302
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.036 0.0633
Echinococcus multilocularis lamin dm0 0.003 0.0032 0.0009
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0954 0.7084 0.8962
Mycobacterium ulcerans lipase LipD 0.0035 0.0074 0.0034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.036 0.0428
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.0343
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0074 0.0061
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Echinococcus multilocularis lamin 0.003 0.0032 0.0009
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0105 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1017 0.1271
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Brugia malayi beta-NAC-like protein 0.0034 0.0067 0.0052
Plasmodium falciparum glutathione reductase 0.0418 0.2996 0.9156
Onchocerca volvulus 0.1196 0.8931 1
Schistosoma mansoni kinase 0.0048 0.0169 0.0143
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0032 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0883 0.1099
Trypanosoma brucei glucosidase, putative 0.0039 0.0105 0.0057
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0105 0.0136
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Plasmodium vivax sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0521 0.0556
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1158 0.1451
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0072 0.0352 0.0797
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0249 0.1705 0.2153
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0073 0.008
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0193
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0192 0.0441
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0063 0.0192
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Plasmodium vivax glutathione reductase, putative 0.0418 0.2996 0.9156
Mycobacterium ulcerans hypothetical protein 0.0156 0.0995 0.2905
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0103 0.0595 0.0709
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0174
Trypanosoma brucei DNA polymerase eta, putative 0.0159 0.1017 0.1271
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Echinococcus multilocularis expressed protein 0.0371 0.2633 0.4463
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.036 0.0428
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0032 0.0007
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0427 0.076
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Brugia malayi hypothetical protein 0.0115 0.0683 0.0842
Schistosoma mansoni DNA topoisomerase II 0.0073 0.036 0.0334
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0145 0.0911 0.107
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0454 0.327 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0331 0.0391
Loa Loa (eye worm) hypothetical protein 0.0081 0.0427 0.0514
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Echinococcus granulosus histone lysine methyltransferase setb 0.0151 0.0955 0.1763
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Treponema pallidum NADH oxidase 0.0145 0.0911 0.1915
Leishmania major basic transcription factor 3a, putative 0.0034 0.0067 0.0013
Plasmodium falciparum amino acid transporter, putative 0.0042 0.0128 0.0313
Echinococcus granulosus enteropeptidase 0.0115 0.0683 0.1246
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Loa Loa (eye worm) hypothetical protein 0.0166 0.1075 0.1345
Onchocerca volvulus 0.0081 0.0427 0.045
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0064 0.0291 0.0777
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Trypanosoma brucei unspecified product 0.0128 0.0783 0.096
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0038 0.0099 0.0032
Echinococcus multilocularis musashi 0.003 0.0032 0.0009
Echinococcus multilocularis transmembrane protease serine 3 0.0115 0.0683 0.1124
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0067 0.0052
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0174
Plasmodium falciparum ferrodoxin reductase-like protein 0.0038 0.0099 0.0224
Toxoplasma gondii ABC1 family protein 0.0035 0.0074 0.0226
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.036 0.1028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0145 0.0911 0.2645
Plasmodium vivax DNA gyrase subunit B, putative 0.0072 0.0352 0.1003
Echinococcus granulosus geminin 0.072 0.5296 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0954 0.7084 0.8962
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0145 0.0911 0.2891
Echinococcus multilocularis serotonin transporter 0.0249 0.1705 0.2875
Trypanosoma cruzi trypanothione reductase, putative 0.0418 0.2996 1
Entamoeba histolytica thioredoxin reductase, putative 0.0038 0.0099 0.0075
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0038 0.0099 0.0224
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.004 0.0112 0.0342
Mycobacterium tuberculosis Probable reductase 0.0954 0.7084 0.8962
Schistosoma mansoni sodium-dependent amino acid transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0035 0.0074 0.0054
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0067 0.0005
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.031
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0145 0.0911 0.2645
Brugia malayi Sphingomyelin synthase-related 1 0.0103 0.0595 0.0729
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0038 0.0099 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0954 0.7084 0.8962
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus granulosus microtubule associated protein 2 0.0676 0.4964 0.9371
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0038 0.0099 0.0032
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Plasmodium vivax DNA gyrase subunit A, putative 0.0454 0.327 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Echinococcus multilocularis dna polymerase eta 0.0159 0.1017 0.1696
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1515
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.036 0.0331
Leishmania major DNA polymerase kappa, putative 0.0115 0.0684 0.2118
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0151 0.0955 0.2922
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0427 0.0514
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0105 0.0102
Mycobacterium ulcerans hypothetical protein 0.0038 0.0099 0.0112
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Schistosoma mansoni intermediate filament proteins 0.003 0.0032 0.0006
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0103 0.0595 0.0974
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.106 0.7896 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0529 0.086
Onchocerca volvulus 0.0115 0.0683 0.0738
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.036 0.0428
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1075 0.1345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0303 0.0266
Onchocerca volvulus 0.0103 0.0588 0.0631
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0172 0.0187
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Onchocerca volvulus 0.003 0.0032 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.1268 0.2356
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) hypothetical protein 0.0053 0.0207 0.0232
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.036 0.11
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0783 0.096
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0874 0.108
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.106 0.7896 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0073 0.036 0.0375
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0073 0.006
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Mycobacterium ulcerans NADH dehydrogenase 0.0038 0.0099 0.0112
Plasmodium vivax DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Onchocerca volvulus 0.0035 0.0074 0.0054
Leishmania major DNA polymerase eta, putative 0.0084 0.0445 0.1302
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Brugia malayi glutathione reductase 0.0418 0.2996 0.3809
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0038 0.0099 0.0032
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Leishmania major mitochondrial DNA topoisomerase II 0.0073 0.036 0.1012
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0145 0.0911 0.2728
Schistosoma mansoni DNA polymerase IV / kappa 0.0034 0.0063 0.0037
Giardia lamblia Thioredoxin reductase 0.0038 0.0099 0.0168
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0698 0.0861
Plasmodium falciparum thioredoxin reductase 0.0418 0.2996 0.9156
Trypanosoma brucei DNA topoisomerase ii 0.0073 0.036 0.0395
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0115 0.0683 0.1246
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Loa Loa (eye worm) glutathione reductase 0.0418 0.2996 0.3809
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0954 0.7084 0.8962
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.106 0.7896 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major DNA topoisomerase ii 0.0065 0.03 0.0809
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0074 0.0147
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Echinococcus multilocularis tumor protein p63 0.0328 0.2309 0.3909
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Loa Loa (eye worm) hypothetical protein 0.0159 0.102 0.1274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0151 0.0955 0.0932
Echinococcus multilocularis glutamate synthase 0.0038 0.0099 0.0124
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0151 0.0955 0.1591
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Onchocerca volvulus 0.0042 0.0128 0.0114
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.4964 0.8454
Entamoeba histolytica deoxycytidyl transferase, putative 0.0109 0.0635 0.1331
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0427 0.0686
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0684 0.0828
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0038 0.0099 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Giardia lamblia DNA topoisomerase II 0.0069 0.0334 0.0713
Brugia malayi jmjC domain containing protein 0.0035 0.0073 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Loa Loa (eye worm) serotonin transporter b 0.0249 0.1705 0.2153
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0038 0.0099 0.0032
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0106 0.0618 0.0758
Toxoplasma gondii thioredoxin reductase 0.0418 0.2996 0.9163
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Onchocerca volvulus 0.0035 0.0074 0.0054
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Brugia malayi glutamate synthase 0.0038 0.0099 0.0093
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0038 0.0099 0.0302
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Trichomonas vaginalis esterase, putative 0.0035 0.0074 0.0008
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0145 0.0911 0.2786
Brugia malayi polk-prov protein 0.006 0.026 0.03
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Loa Loa (eye worm) trypsin family protein 0.0115 0.0683 0.0842
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0249 0.1705 0.1886
Loa Loa (eye worm) thioredoxin reductase 0.0418 0.2996 0.3809
Plasmodium falciparum DNA gyrase subunit A 0.0454 0.327 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Echinococcus granulosus glycoprotein Antigen 5 0.0115 0.0683 0.1246
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0122
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0074 0.0015
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.031
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1075 0.1345
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0673 0.083
Mycobacterium ulcerans DNA gyrase subunit B 0.0072 0.0352 0.09
Schistosoma mansoni transcription factor btf3 0.0034 0.0067 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.0684 0.078
Mycobacterium ulcerans DNA gyrase subunit A 0.0454 0.327 1
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0065 0.0303 0.0354
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Loa Loa (eye worm) hypothetical protein 0.0159 0.1017 0.1271
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0074 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.1075 0.1345
Giardia lamblia NADH oxidase lateral transfer candidate 0.0145 0.0911 0.2051
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Plasmodium falciparum thioredoxin reductase 0.0145 0.0911 0.2728
Schistosoma mansoni jumonji domain containing protein 0.0075 0.038 0.0355
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0105 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Brugia malayi hypothetical protein 0.0042 0.0128 0.013
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Giardia lamblia Glutamate synthase 0.0038 0.0099 0.0168
Trichomonas vaginalis glutathione reductase, putative 0.0145 0.0911 0.0952
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0138
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0038 0.0099 0.0124
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0038 0.0099 0.0032
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1679
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0065 0.03 0.0316
Giardia lamblia DNA damage repair protein 0.0034 0.0063 0.0085
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.029 0.202 0.2488
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis mercuric reductase, putative 0.0145 0.0911 0.0952
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0038 0.0099 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1051 0.7824 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0067 0.0069
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0105 0.0145
Onchocerca volvulus 0.003 0.0032 0.0006
Echinococcus granulosus transmembrane protease serine 3 0.0115 0.0683 0.1246
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0145 0.0911 0.0887
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0038 0.0099 0.0032
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.1124
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0002
Chlamydia trachomatis DNA gyrase subunit A 0.0454 0.327 1
Trypanosoma brucei polo-like protein kinase 0.0094 0.0521 0.061
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0145 0.0911 0.1135
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Onchocerca volvulus 0.0115 0.0683 0.0738
Plasmodium falciparum transporter, putative 0.0042 0.0128 0.0313
Mycobacterium ulcerans ferredoxin reductase 0.0038 0.0099 0.0112
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Brugia malayi jmjC domain containing protein 0.0095 0.0529 0.0644
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0331 0.0522
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0331 0.0391
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Onchocerca volvulus 0.0038 0.0099 0.0082
Echinococcus multilocularis GPCR, family 2 0.0053 0.0207 0.031
Loa Loa (eye worm) norepinephrine transporter 0.0249 0.1705 0.2153
Loa Loa (eye worm) RNA binding protein 0.0069 0.0331 0.0391
Loa Loa (eye worm) programmed cell death 8 0.0038 0.0099 0.0093
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0073 0.0088
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Mycobacterium ulcerans monoxygenase 0.0038 0.0099 0.0112
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Brugia malayi Trypsin-like protease protein 5 0.0115 0.0683 0.0842
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0145 0.0911 0.2728
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Echinococcus granulosus tumor protein p63 0.0328 0.2309 0.4333
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0042 0.0128 0.0174
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0042 0.0128 0.013
Brugia malayi TAR-binding protein 0.0069 0.0331 0.0391
Echinococcus granulosus Mastin 0.0115 0.0683 0.1246
Brugia malayi beta-lactamase 0.0035 0.0074 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Trypanosoma brucei inositol phosphorylceramide synthase 0.1018 0.757 1
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0038 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.0151 0.0955 0.1192
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0075
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0261 0.0302
Loa Loa (eye worm) beta-lactamase 0.0035 0.0074 0.0061
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Toxoplasma gondii peptidylprolyl isomerase 0.0064 0.0291 0.0889
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0454 0.327 0.7478
Plasmodium falciparum glutathione reductase 0.0145 0.0911 0.2728
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.1268 0.2125
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0124
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Echinococcus granulosus dna polymerase kappa 0.0135 0.0832 0.153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trypanosoma brucei trypanothione reductase 0.0418 0.2996 0.3907
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0207 0.0232
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0038 0.0099 0.0122
Toxoplasma gondii NADPH-glutathione reductase 0.0145 0.0911 0.2786
Plasmodium vivax amine transporter, putative 0.0042 0.0128 0.0313
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0521 0.1063
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0106 0.0618 0.0758
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Echinococcus multilocularis enteropeptidase 0.0115 0.0683 0.1124
Loa Loa (eye worm) hypothetical protein 0.006 0.026 0.03
Brugia malayi Probable DNA topoisomerase II 0.0073 0.036 0.0428
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0595 0.0596
Leishmania major NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Brugia malayi MH2 domain containing protein 0.0117 0.0698 0.0861
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0074 0.0082
Chlamydia trachomatis DNA gyrase subunit A 0.0047 0.0165 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Echinococcus granulosus intermediate filament protein 0.003 0.0032 0.001
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans beta-lactamase 0.0035 0.0074 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major hypothetical protein, conserved 0.0035 0.0074 0.0037
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0038 0.0099 0.0112
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Brugia malayi Cytochrome P450 family protein 0.0054 0.0215 0.0242
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0454 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.1268 0.1526
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0113 0.0148
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0954 0.7084 0.8962
Trypanosoma cruzi trypanothione reductase, putative 0.0145 0.0911 0.2891
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Leishmania major trypanothione reductase 0.0418 0.2996 1
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0172 0.0146
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0145 0.0911 0.2891
Giardia lamblia Kinase, PLK 0.0094 0.0521 0.1147
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Onchocerca volvulus 0.0159 0.102 0.1116
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0038 0.0099 0.0032
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.013 0.0104
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0038 0.0099 0.0112
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0323
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0038 0.0099 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0421 0.3015 0.5672
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0065 0.0303 0.0354
Schistosoma mansoni terminal deoxycytidyl transferase 0.0109 0.0635 0.0611
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0145 0.0911 0.2728
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Echinococcus granulosus sphingomyelin synthase protein 1 0.0103 0.0595 0.1079
Trichomonas vaginalis rotamase, putative 0.0065 0.0303 0.0266
Echinococcus multilocularis Mastin 0.0115 0.0683 0.1124
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Plasmodium falciparum DNA gyrase subunit B 0.0072 0.0352 0.1003
Trichomonas vaginalis apoptosis inducing factor, putative 0.0038 0.0099 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0207 0.0232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0883 0.1099
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0067 0.0204
Echinococcus multilocularis dna polymerase kappa 0.0135 0.0832 0.138
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0103 0.0595 0.0729
Mycobacterium tuberculosis Probable oxidoreductase 0.106 0.7896 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1156
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) intermediate filament protein 0.003 0.0032 0.0007
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Brugia malayi Pre-SET motif family protein 0.1051 0.7824 1
Echinococcus granulosus expressed protein 0.0065 0.0303 0.0524
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Schistosoma mansoni sodium/chloride dependent transporter 0.0249 0.1705 0.1684
Onchocerca volvulus 0.0048 0.0172 0.0164
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0048
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0138
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0445 0.1302
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0038 0.0099 0.0112
Treponema pallidum sodium- and chloride- dependent transporter 0.0249 0.1705 0.3788
Echinococcus granulosus glutamate synthase 0.0038 0.0099 0.0138
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0145 0.0911 0.2561
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Echinococcus granulosus lamin dm0 0.003 0.0032 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 9 uM Cytotoxicity against human Hep2 cells after 72 hrs by alamar blue assay ChEMBL. 21425851
IC50 (binding) = 0.68 uM Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay ChEMBL. 21425851
IC50 (binding) = 2.9 uM Inhibition of DNA supercoiling activity of wild type Mycobacterium tuberculosis DNA gyrase A ChEMBL. 20516287
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 2 ChEMBL. 20516287
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 6 ChEMBL. 20516287
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against multidrug-resistant Mycobacterium tuberculosis isolate 19 ChEMBL. 20516287
MIC (functional) = 0.03 ug ml-1 Antimicrobial activity against multidrug drug-resistant Mycobacterium tuberculosis isolate 20 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis ATCC 35802 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 1 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 3 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 4 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 5 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 7 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against multidrug-resistant Mycobacterium tuberculosis isolate 9 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against Mycobacterium tuberculosis isolate 13 isolated from Beijing ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against pansusceptible Mycobacterium tuberculosis isolate 14 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antimicrobial activity against isoniazid-resistant Mycobacterium tuberculosis isolate 15 ChEMBL. 20516287
MIC (functional) = 0.06 ug ml-1 Antibacterial activity against Escherichia coli ATCC25922 after 24 hrs by microdilution method ChEMBL. 21425851
MIC (functional) = 0.125 ug ml-1 Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 10 ChEMBL. 20516287
MIC (functional) = 0.125 ug ml-1 Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 18 ChEMBL. 20516287
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against streptomycin-resistant Mycobacterium tuberculosis isolate 8 ChEMBL. 20516287
MIC (functional) = 0.25 ug ml-1 Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 11 ChEMBL. 20516287
MIC (functional) = 0.5 ug ml-1 Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 16 ChEMBL. 20516287
MIC (functional) = 1 ug ml-1 Antimicrobial activity against quinolone-resistant Mycobacterium tuberculosis isolate 12 ChEMBL. 20516287
MIC (functional) = 1 ug ml-1 Antimicrobial activity against extensively drug-resistant Mycobacterium tuberculosis isolate 17 ChEMBL. 20516287
MIC50 (functional) = 0.06 ug ml-1 Antimicrobial activity against isoniazid and rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
MIC50 (functional) = 0.0625 ug ml-1 Antimicrobial activity against isoniazid and rifampin-susceptible Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
MIC50 (functional) = 0.12 ug ml-1 Antimicrobial activity against isoniazid or rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
MIC90 (functional) = 0.12 ug ml-1 Antimicrobial activity against isoniazid and rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
MIC90 (functional) = 0.12 ug ml-1 Antimicrobial activity against isoniazid or rifampin-resistant Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
MIC90 (functional) = 0.125 ug ml-1 Antimicrobial activity against isoniazid and rifampin-susceptible Mycobacterium tuberculosis clinical isolates after 7 days by broth microdilution assay ChEMBL. 20231398
Ratio pIC50 (binding) = 0.09 Ratio of ciprofloxacin IC50 to compound IC50 for wild-type Staphylococcus aureus DNA gyrase ChEMBL. 21425851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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