Detailed information for compound 1558491

Basic information

Technical information
  • TDR Targets ID: 1558491
  • Name: 7-[(3S)-3-(2-aminopropan-2-yl)pyrrolidin-1-yl ]-9-cyclopropyl-6-fluoro-8-methoxy-[1,2]thiaz olo[5,4-b]quinoline-3,4-dione
  • MW: 432.512 | Formula: C21H25FN4O3S
  • H donors: 2 H acceptors: 2 LogP: 2.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(N2CC[C@@H](C2)C(N)(C)C)c(F)cc2c1n(C1CC1)c1c(c2=O)c(=O)[nH]s1
  • InChi: 1S/C21H25FN4O3S/c1-21(2,23)10-6-7-25(9-10)16-13(22)8-12-15(18(16)29-3)26(11-4-5-11)20-14(17(12)27)19(28)24-30-20/h8,10-11H,4-7,9,23H2,1-3H3,(H,24,28)/t10-/m0/s1
  • InChiKey: CECJUHKZSOSOJJ-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[(3S)-3-(1-amino-1-methyl-ethyl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-isothiazolo[5,4-b]quinoline-3,4-dione
  • 7-[(3S)-3-(1-amino-1-methylethyl)-1-pyrrolidinyl]-9-cyclopropyl-6-fluoro-8-methoxyisothiazolo[5,4-b]quinoline-3,4-dione
  • 7-[(3S)-3-(1-amino-1-methyl-ethyl)pyrrolidin-1-yl]-9-cyclopropyl-6-fluoro-8-methoxy-isothiazolo[5,4-b]quinoline-3,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0145 0.0911 0.2728
Brugia malayi Trypsin-like protease protein 5 0.0115 0.0683 0.0842
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Mycobacterium ulcerans monoxygenase 0.0038 0.0099 0.0112
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0073 0.0088
Loa Loa (eye worm) programmed cell death 8 0.0038 0.0099 0.0093
Loa Loa (eye worm) RNA binding protein 0.0069 0.0331 0.0391
Loa Loa (eye worm) norepinephrine transporter 0.0249 0.1705 0.2153
Echinococcus multilocularis GPCR, family 2 0.0053 0.0207 0.031
Onchocerca volvulus 0.0038 0.0099 0.0082
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0331 0.0391
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0331 0.0522
Brugia malayi jmjC domain containing protein 0.0095 0.0529 0.0644
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Mycobacterium ulcerans ferredoxin reductase 0.0038 0.0099 0.0112
Plasmodium falciparum transporter, putative 0.0042 0.0128 0.0313
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Onchocerca volvulus 0.0115 0.0683 0.0738
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0145 0.0911 0.1135
Trypanosoma brucei polo-like protein kinase 0.0094 0.0521 0.061
Chlamydia trachomatis DNA gyrase subunit A 0.0454 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.1124
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0038 0.0099 0.0032
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0145 0.0911 0.0887
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Echinococcus granulosus transmembrane protease serine 3 0.0115 0.0683 0.1246
Onchocerca volvulus 0.003 0.0032 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Chlamydia trachomatis DNA gyrase subunit A 0.0047 0.0165 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0074 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Onchocerca volvulus 0.0115 0.0683 0.0738
Brugia malayi MH2 domain containing protein 0.0117 0.0698 0.0861
Leishmania major NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0595 0.0596
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0193
Brugia malayi Probable DNA topoisomerase II 0.0073 0.036 0.0428
Loa Loa (eye worm) hypothetical protein 0.006 0.026 0.03
Echinococcus multilocularis enteropeptidase 0.0115 0.0683 0.1124
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0106 0.0618 0.0758
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0521 0.1063
Plasmodium vivax amine transporter, putative 0.0042 0.0128 0.0313
Toxoplasma gondii NADPH-glutathione reductase 0.0145 0.0911 0.2786
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0038 0.0099 0.0122
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0207 0.0232
Trypanosoma brucei trypanothione reductase 0.0418 0.2996 0.3907
Echinococcus granulosus dna polymerase kappa 0.0135 0.0832 0.153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.1268 0.2125
Plasmodium falciparum glutathione reductase 0.0145 0.0911 0.2728
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0454 0.327 0.7478
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Toxoplasma gondii peptidylprolyl isomerase 0.0064 0.0291 0.0889
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) beta-lactamase 0.0035 0.0074 0.0061
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0261 0.0302
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0075
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Loa Loa (eye worm) hypothetical protein 0.0151 0.0955 0.1192
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0038 0.0099 0.0093
Trypanosoma brucei inositol phosphorylceramide synthase 0.1018 0.757 1
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Brugia malayi beta-lactamase 0.0035 0.0074 0.0061
Echinococcus granulosus Mastin 0.0115 0.0683 0.1246
Brugia malayi TAR-binding protein 0.0069 0.0331 0.0391
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0042 0.0128 0.0174
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0042 0.0128 0.013
Echinococcus granulosus tumor protein p63 0.0328 0.2309 0.4333
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0145 0.0911 0.2728
Schistosoma mansoni terminal deoxycytidyl transferase 0.0109 0.0635 0.0611
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0065 0.0303 0.0354
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0421 0.3015 0.5672
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0038 0.0099 0.0032
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0323
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0038 0.0099 0.0112
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.013 0.0104
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0038 0.0099 0.0032
Onchocerca volvulus 0.0159 0.102 0.1116
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Giardia lamblia Kinase, PLK 0.0094 0.0521 0.1147
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0172 0.0146
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0145 0.0911 0.2891
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Leishmania major trypanothione reductase 0.0418 0.2996 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Trypanosoma cruzi trypanothione reductase, putative 0.0145 0.0911 0.2891
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0954 0.7084 0.8962
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0113 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.1268 0.1526
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0454 0.327 1
Brugia malayi Cytochrome P450 family protein 0.0054 0.0215 0.0242
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0038 0.0099 0.0112
Leishmania major hypothetical protein, conserved 0.0035 0.0074 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans beta-lactamase 0.0035 0.0074 0.0034
Echinococcus granulosus intermediate filament protein 0.003 0.0032 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399
Echinococcus granulosus lamin dm0 0.003 0.0032 0.001
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0145 0.0911 0.2561
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Echinococcus granulosus glutamate synthase 0.0038 0.0099 0.0138
Treponema pallidum sodium- and chloride- dependent transporter 0.0249 0.1705 0.3788
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0038 0.0099 0.0112
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0445 0.1302
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0138
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0048
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0048 0.0172 0.0164
Schistosoma mansoni sodium/chloride dependent transporter 0.0249 0.1705 0.1684
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Echinococcus granulosus expressed protein 0.0065 0.0303 0.0524
Brugia malayi Pre-SET motif family protein 0.1051 0.7824 1
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) intermediate filament protein 0.003 0.0032 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1156
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Mycobacterium tuberculosis Probable oxidoreductase 0.106 0.7896 1
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0103 0.0595 0.0729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Echinococcus multilocularis dna polymerase kappa 0.0135 0.0832 0.138
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0067 0.0204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0883 0.1099
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0207 0.0232
Trichomonas vaginalis apoptosis inducing factor, putative 0.0038 0.0099 0.0036
Plasmodium falciparum DNA gyrase subunit B 0.0072 0.0352 0.1003
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Echinococcus multilocularis Mastin 0.0115 0.0683 0.1124
Trichomonas vaginalis rotamase, putative 0.0065 0.0303 0.0266
Echinococcus granulosus sphingomyelin synthase protein 1 0.0103 0.0595 0.1079
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0874 0.108
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0783 0.096
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.036 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Loa Loa (eye worm) hypothetical protein 0.0053 0.0207 0.0232
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.1268 0.2356
Onchocerca volvulus 0.003 0.0032 0.0006
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Loa Loa (eye worm) hypothetical protein 0.0048 0.0172 0.0187
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Onchocerca volvulus 0.0103 0.0588 0.0631
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0303 0.0266
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1075 0.1345
Onchocerca volvulus 0.0115 0.0683 0.0738
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.036 0.0428
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0529 0.086
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.106 0.7896 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0103 0.0595 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Schistosoma mansoni intermediate filament proteins 0.003 0.0032 0.0006
Mycobacterium ulcerans hypothetical protein 0.0038 0.0099 0.0112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0105 0.0102
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0427 0.0514
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0151 0.0955 0.2922
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0151 0.0955 0.0932
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Loa Loa (eye worm) hypothetical protein 0.0159 0.102 0.1274
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Echinococcus multilocularis tumor protein p63 0.0328 0.2309 0.3909
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0074 0.0147
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Leishmania major DNA topoisomerase ii 0.0065 0.03 0.0809
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.106 0.7896 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0954 0.7084 0.8962
Loa Loa (eye worm) glutathione reductase 0.0418 0.2996 0.3809
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0115 0.0683 0.1246
Trypanosoma brucei DNA topoisomerase ii 0.0073 0.036 0.0395
Plasmodium falciparum thioredoxin reductase 0.0418 0.2996 0.9156
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0698 0.0861
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0145 0.0911 0.2728
Giardia lamblia Thioredoxin reductase 0.0038 0.0099 0.0168
Schistosoma mansoni DNA polymerase IV / kappa 0.0034 0.0063 0.0037
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Leishmania major mitochondrial DNA topoisomerase II 0.0073 0.036 0.1012
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0038 0.0099 0.0032
Brugia malayi glutathione reductase 0.0418 0.2996 0.3809
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Leishmania major DNA polymerase eta, putative 0.0084 0.0445 0.1302
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Onchocerca volvulus 0.0035 0.0074 0.0054
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Plasmodium vivax DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Mycobacterium ulcerans NADH dehydrogenase 0.0038 0.0099 0.0112
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.0343
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0073 0.036 0.0375
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0073 0.006
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.106 0.7896 1
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0122
Echinococcus granulosus glycoprotein Antigen 5 0.0115 0.0683 0.1246
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Plasmodium falciparum DNA gyrase subunit A 0.0454 0.327 1
Onchocerca volvulus 0.0249 0.1705 0.1886
Loa Loa (eye worm) thioredoxin reductase 0.0418 0.2996 0.3809
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Loa Loa (eye worm) trypsin family protein 0.0115 0.0683 0.0842
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Brugia malayi polk-prov protein 0.006 0.026 0.03
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0145 0.0911 0.2786
Trichomonas vaginalis esterase, putative 0.0035 0.0074 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0038 0.0099 0.0302
Brugia malayi glutamate synthase 0.0038 0.0099 0.0093
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Onchocerca volvulus 0.0035 0.0074 0.0054
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0106 0.0618 0.0758
Toxoplasma gondii thioredoxin reductase 0.0418 0.2996 0.9163
Loa Loa (eye worm) serotonin transporter b 0.0249 0.1705 0.2153
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0038 0.0099 0.0032
Brugia malayi jmjC domain containing protein 0.0035 0.0073 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Giardia lamblia DNA topoisomerase II 0.0069 0.0334 0.0713
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0038 0.0099 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0684 0.0828
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0427 0.0686
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Entamoeba histolytica deoxycytidyl transferase, putative 0.0109 0.0635 0.1331
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.4964 0.8454
Onchocerca volvulus 0.0042 0.0128 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0151 0.0955 0.1591
Echinococcus multilocularis glutamate synthase 0.0038 0.0099 0.0124
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0105 0.0145
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1051 0.7824 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0067 0.0069
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0038 0.0099 0.0138
Trichomonas vaginalis mercuric reductase, putative 0.0145 0.0911 0.0952
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.029 0.202 0.2488
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Giardia lamblia DNA damage repair protein 0.0034 0.0063 0.0085
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1679
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0065 0.03 0.0316
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0038 0.0099 0.0032
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0038 0.0099 0.0124
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0138
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Trichomonas vaginalis glutathione reductase, putative 0.0145 0.0911 0.0952
Giardia lamblia Glutamate synthase 0.0038 0.0099 0.0168
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Brugia malayi hypothetical protein 0.0042 0.0128 0.013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0105 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Schistosoma mansoni jumonji domain containing protein 0.0075 0.038 0.0355
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Plasmodium falciparum thioredoxin reductase 0.0145 0.0911 0.2728
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Giardia lamblia NADH oxidase lateral transfer candidate 0.0145 0.0911 0.2051
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0074 0.009
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.1075 0.1345
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Loa Loa (eye worm) hypothetical protein 0.0159 0.1017 0.1271
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0065 0.0303 0.0354
Mycobacterium ulcerans DNA gyrase subunit A 0.0454 0.327 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.0684 0.078
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Schistosoma mansoni transcription factor btf3 0.0034 0.0067 0.0041
Mycobacterium ulcerans DNA gyrase subunit B 0.0072 0.0352 0.09
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0673 0.083
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1075 0.1345
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.031
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0074 0.0015
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0105 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1017 0.1271
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Echinococcus multilocularis lamin 0.003 0.0032 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0074 0.0061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.0343
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.036 0.0428
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans lipase LipD 0.0035 0.0074 0.0034
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0954 0.7084 0.8962
Echinococcus multilocularis lamin dm0 0.003 0.0032 0.0009
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.036 0.0633
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0123 0.008
Toxoplasma gondii selenide, water dikinase 0.0038 0.0099 0.0302
Toxoplasma gondii hypothetical protein 0.0048 0.0169 0.0518
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.029 0.202 0.6104
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0038 0.0099 0.0093
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0145 0.0911 0.2728
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0454 0.327 0.4086
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0038 0.0099 0.0302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0074 0.0061
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Mycobacterium ulcerans hypothetical protein 0.0035 0.0074 0.0034
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0521 0.1561
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0105 0.015
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Echinococcus granulosus dna polymerase eta 0.0159 0.1017 0.188
Trichomonas vaginalis hypothetical protein 0.0103 0.0595 0.0596
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0038 0.0099 0.0112
Plasmodium vivax SET domain protein, putative 0.0151 0.0955 0.2865
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0207 0.0232
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0151 0.0955 0.1591
Onchocerca volvulus 0.0115 0.0683 0.0738
Leishmania major DNA polymerase eta, putative 0.0159 0.1017 0.3253
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399
Trichomonas vaginalis set domain proteins, putative 0.1196 0.8931 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Schistosoma mansoni DNA polymerase eta 0.0159 0.1017 0.0993
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.1268 0.3877
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0103 0.0595 0.0709
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Plasmodium vivax glutathione reductase, putative 0.0418 0.2996 0.9156
Mycobacterium ulcerans hypothetical protein 0.0156 0.0995 0.2905
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0063 0.0192
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0192 0.0441
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1043
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0193
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0073 0.008
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0249 0.1705 0.2153
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0072 0.0352 0.0797
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1158 0.1451
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0521 0.0556
Plasmodium vivax sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0105 0.0136
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0124
Trypanosoma brucei glucosidase, putative 0.0039 0.0105 0.0057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0883 0.1099
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0032 0.0007
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Schistosoma mansoni kinase 0.0048 0.0169 0.0143
Onchocerca volvulus 0.1196 0.8931 1
Plasmodium falciparum glutathione reductase 0.0418 0.2996 0.9156
Brugia malayi beta-NAC-like protein 0.0034 0.0067 0.0052
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.036 0.1028
Toxoplasma gondii ABC1 family protein 0.0035 0.0074 0.0226
Plasmodium falciparum ferrodoxin reductase-like protein 0.0038 0.0099 0.0224
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0174
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0067 0.0052
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Echinococcus multilocularis transmembrane protease serine 3 0.0115 0.0683 0.1124
Echinococcus multilocularis musashi 0.003 0.0032 0.0009
Trypanosoma brucei unspecified product 0.0128 0.0783 0.096
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0038 0.0099 0.0032
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0064 0.0291 0.0777
Onchocerca volvulus 0.0081 0.0427 0.045
Loa Loa (eye worm) hypothetical protein 0.0166 0.1075 0.1345
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Echinococcus granulosus enteropeptidase 0.0115 0.0683 0.1246
Plasmodium falciparum amino acid transporter, putative 0.0042 0.0128 0.0313
Leishmania major basic transcription factor 3a, putative 0.0034 0.0067 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Treponema pallidum NADH oxidase 0.0145 0.0911 0.1915
Echinococcus granulosus histone lysine methyltransferase setb 0.0151 0.0955 0.1763
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Loa Loa (eye worm) hypothetical protein 0.0081 0.0427 0.0514
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0331 0.0391
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0454 0.327 1
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0145 0.0911 0.107
Schistosoma mansoni DNA topoisomerase II 0.0073 0.036 0.0334
Brugia malayi hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0427 0.076
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0032 0.0007
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.036 0.0428
Echinococcus multilocularis expressed protein 0.0371 0.2633 0.4463
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Trypanosoma brucei DNA polymerase eta, putative 0.0159 0.1017 0.1271
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0174
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Leishmania major DNA polymerase kappa, putative 0.0115 0.0684 0.2118
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.036 0.0331
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1515
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Echinococcus multilocularis dna polymerase eta 0.0159 0.1017 0.1696
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Plasmodium vivax DNA gyrase subunit A, putative 0.0454 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0038 0.0099 0.0032
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Echinococcus granulosus microtubule associated protein 2 0.0676 0.4964 0.9371
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0954 0.7084 0.8962
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0038 0.0099 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Brugia malayi Sphingomyelin synthase-related 1 0.0103 0.0595 0.0729
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0145 0.0911 0.2645
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.031
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0067 0.0005
Schistosoma mansoni sodium-dependent amino acid transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0035 0.0074 0.0054
Mycobacterium tuberculosis Probable reductase 0.0954 0.7084 0.8962
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.004 0.0112 0.0342
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0038 0.0099 0.0224
Entamoeba histolytica thioredoxin reductase, putative 0.0038 0.0099 0.0075
Trypanosoma cruzi trypanothione reductase, putative 0.0418 0.2996 1
Echinococcus multilocularis serotonin transporter 0.0249 0.1705 0.2875
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0145 0.0911 0.2891
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0954 0.7084 0.8962
Echinococcus granulosus geminin 0.072 0.5296 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0072 0.0352 0.1003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0145 0.0911 0.2645
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0064 0.0291 0.0525
Loa Loa (eye worm) solute carrier family 6 member 4 0.0249 0.1705 0.2153
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.2063 0.6819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0145 0.0911 0.113
Onchocerca volvulus 0.0151 0.0955 0.1043
Echinococcus granulosus lamin 0.003 0.0032 0.001
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0145 0.0911 0.2645
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0038 0.0099 0.0112
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.1268 0.4107
Plasmodium falciparum DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0331 0.0391
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Giardia lamblia Fructose-bisphosphate aldolase 0.0594 0.4339 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0128 0.0313
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Trypanosoma brucei NADH dehydrogenase 0.0038 0.0099 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0135 0.0832 0.0864
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0698 0.0861
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0123 0.0204
Brugia malayi RNA binding protein 0.0069 0.0331 0.0391
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Echinococcus multilocularis glycoprotein Antigen 5 0.0115 0.0683 0.1124
Loa Loa (eye worm) hypothetical protein 0.0114 0.0673 0.083
Trypanosoma cruzi DNA polymerase eta, putative 0.0159 0.1017 0.3253
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0145 0.0911 0.113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.1813
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Schistosoma mansoni hypothetical protein 0.0114 0.0673 0.0649
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0145 0.0913 0.1683
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.5867 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0105 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1521 0.185
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0216 0.1457 0.1768
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Trichomonas vaginalis rotamase, putative 0.0064 0.0291 0.0253
Toxoplasma gondii hypothetical protein 0.0103 0.0595 0.1819
Onchocerca volvulus 0.0115 0.0683 0.0738
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0124
Schistosoma mansoni alpha glucosidase 0.0039 0.0105 0.008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.2063 0.2664
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0115 0.0683 0.1246
Echinococcus multilocularis thioredoxin glutathione reductase 0.0421 0.3015 0.5117
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0418 0.2996 0.3736
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.4964 0.4951
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0115 0.0683 0.1124
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0072 0.0352 0.0596
Brugia malayi Thioredoxin reductase 0.0418 0.2996 0.3809
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0007
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0115 0.0683 0.0842
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0074 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Plasmodium vivax ferrodoxin reductase, putative 0.0038 0.0099 0.0224
Echinococcus granulosus GPCR family 2 0.0053 0.0207 0.0343
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0064 0.0291 0.0304
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Mycobacterium tuberculosis Probable dehydrogenase 0.0954 0.7084 0.8962
Mycobacterium ulcerans dehydrogenase 0.0038 0.0099 0.0112
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0995 0.1177
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Entamoeba histolytica hypothetical membrane-spanning protein 0.0103 0.0595 0.1236
Schistosoma mansoni hypothetical protein 0.0038 0.0099 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Onchocerca volvulus 0.0042 0.0128 0.0114
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0445 0.136
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Schistosoma mansoni rotamase 0.0065 0.0303 0.0277
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1158 0.2148
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0038 0.0099 0.0224
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0249 0.1705 0.1684
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Plasmodium vivax sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Entamoeba histolytica disulphide oxidoreductase, putative 0.0038 0.0099 0.0075
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0521 0.0634
Onchocerca volvulus 0.0042 0.0128 0.0114
Giardia lamblia DINP protein human, muc B family 0.0115 0.0684 0.1526
Loa Loa (eye worm) hypothetical protein 0.005 0.0184 0.0202
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0072 0.0352 0.0355
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0042 0.0128 0.0092
Echinococcus granulosus transcription factor btf3 0.0034 0.0067 0.0077
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0521 0.0634
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0215 0.0242
Brugia malayi Pre-SET motif family protein 0.0151 0.0955 0.1192
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1158 0.1451
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.029 0.202 0.2488
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.036 0.1028
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0038 0.0099 0.0036
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.036 0.0686
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis geminin 0.072 0.5296 0.9021
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.0684 0.2118
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0099 0.0048
Schistosoma mansoni spingomyelin synthetase-related 0.0103 0.0595 0.057
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0529 0.0954
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0521 0.0939
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0521 0.0496
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0065 0.03 0.0316
Plasmodium vivax thioredoxin reductase, putative 0.0418 0.2996 0.9156
Echinococcus granulosus serotonin transporter 0.0249 0.1705 0.3187
Mycobacterium ulcerans hypothetical protein 0.0115 0.0683 0.1934
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0427 0.0402
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Echinococcus multilocularis expressed protein 0.0065 0.0303 0.0473
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Brugia malayi intermediate filament protein 0.003 0.0032 0.0007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0074 0.0034
Echinococcus granulosus tar DNA binding protein 0.0069 0.0331 0.0579
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.0635 0.0718
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0038 0.0099 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Mycobacterium ulcerans glutamate synthase subunit beta 0.0038 0.0099 0.0112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0109 0.0635 0.0611
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Treponema pallidum fructose-bisphosphate aldolase 0.0594 0.4339 1
Echinococcus granulosus jumonji domain containing protein 0.004 0.0113 0.0164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0048
Trichomonas vaginalis DNA polymerase eta, putative 0.0135 0.0832 0.0864
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0521 0.0847
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Echinococcus granulosus expressed protein 0.0371 0.2633 0.4947
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Brugia malayi hypothetical protein 0.0159 0.102 0.1274
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Schistosoma mansoni disulfide oxidoreductase 0.0038 0.0099 0.0073
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.036 0.0571
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Schistosoma mansoni sodium/chloride dependent transporter 0.0042 0.0128 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 61 uM Cytotoxicity against human Hep2 cells after 72 hrs by alamar blue assay ChEMBL. 21425851
MIC (functional) = 0.13 ug ml-1 Antibacterial activity against Escherichia coli ATCC25922 after 24 hrs by microdilution method ChEMBL. 21425851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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