Detailed information for compound 1118887

Basic information

Technical information
  • TDR Targets ID: 1118887
  • Name: 5-tert-butyl-5-(2-hydroxyethyl)-2-sulfanylide ne-1,3-diazinane-4,6-dione
  • MW: 244.311 | Formula: C10H16N2O3S
  • H donors: 3 H acceptors: 3 LogP: 0.69 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1(C(=O)NC(=S)NC1=O)C(C)(C)C
  • InChi: 1S/C10H16N2O3S/c1-9(2,3)10(4-5-13)6(14)11-8(16)12-7(10)15/h13H,4-5H2,1-3H3,(H2,11,12,14,15,16)
  • InChiKey: XDJPALYFEGDZIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-tert-butyl-5-(2-hydroxyethyl)-2-thioxo-hexahydropyrimidine-4,6-dione
  • 5-tert-butyl-5-(2-hydroxyethyl)-2-thioxohexahydropyrimidine-4,6-dione
  • 5-tert-butyl-5-(2-hydroxyethyl)-2-thioxo-hexahydropyrimidine-4,6-quinone
  • NCIOpen2_005045
  • NSC85100

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax sphingomyelin synthase 2, putative 0.0106 0.0903 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.083
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0408 0.0519
Leishmania major hypothetical protein, conserved 0.0015 0.0023 0.0031
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.03 0.03
Plasmodium falciparum flap endonuclease 1 0.0026 0.0121 0.1116
Schistosoma mansoni hypothetical protein 0.0052 0.0379 0.0566
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.7569 1
Schistosoma mansoni hypothetical protein 0.0052 0.0379 0.0566
Toxoplasma gondii hypothetical protein 0.0106 0.0903 0.5028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.1774 0.6419
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0237 0.0345
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0062 0.0471 0.0709
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0379 0.0867
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0408 0.0937
Echinococcus multilocularis geminin 0.0548 0.5178 0.6834
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0026
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0023 0.0008
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0432 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0031
Mycobacterium ulcerans uracil-DNA glycosylase 0.0072 0.0566 0.1904
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0026
Mycobacterium ulcerans hypothetical protein 0.0031 0.0169 0.0421
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0379 0.048
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0494 0.0745
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0494 0.0631
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0112
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0106 0.0903 0.0903
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.1892 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0494 0.0631
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0023 0.0009
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0106 0.0903 0.0888
Treponema pallidum fructose-bisphosphate aldolase 0.0605 0.5726 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0096 0.0145
Brugia malayi Pre-SET motif family protein 0.0446 0.4196 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0057 0.0108
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0379 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0126 0.0109
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0023 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0432 0.0648
Loa Loa (eye worm) glutathione reductase 0.0037 0.0233 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0214
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0379 0.0867
Mycobacterium ulcerans hypothetical protein 0.0024 0.0106 0.0184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0408 0.0612
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0494 0.0745
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0106 0.0903 0.1174
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0432 0.1004
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.0411 0.0955
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0196 0.1774 0.2744
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0214
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0432 0.0648
Giardia lamblia Fructose-bisphosphate aldolase 0.0605 0.5726 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0026
Onchocerca volvulus 0.0064 0.0494 0.0698
Brugia malayi Cytochrome P450 family protein 0.0056 0.0411 0.0944
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0214
Schistosoma mansoni lamin 0.0031 0.0171 0.0241
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0023 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0106 0.0903 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0171 0.0369
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.03 0.1511
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0023 0.0009
Echinococcus granulosus GPCR family 2 0.0052 0.0379 0.0566
Brugia malayi Uracil-DNA glycosylase 0.0072 0.0566 0.1315
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0106 0.014
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0121 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0238 0.0221
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.1774 0.6419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.03 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0057 0.0214
Schistosoma mansoni hypothetical protein 0.0052 0.0379 0.0566
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Mycobacterium tuberculosis Probable uracil-DNA glycosylase Ung (UDG) 0.0041 0.027 0.0798
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0106 0.0477
Loa Loa (eye worm) hypothetical protein 0.0048 0.0343 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0408 0.0612
Loa Loa (eye worm) hypothetical protein 0.0313 0.2899 0.6902
Echinococcus multilocularis L aminoadipate semialdehyde 0.0082 0.0663 0.0855
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.1774 0.2744
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0233 0.0528
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.03 0.03
Schistosoma mansoni flap endonuclease-1 0.0023 0.0097 0.0125
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0408 0.0612
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0432 0.055
Schistosoma mansoni spingomyelin synthetase-related 0.0106 0.0903 0.1384
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0432 0.0648
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Plasmodium falciparum thioredoxin reductase 0.0037 0.0233 0.2386
Mycobacterium ulcerans glycosylase 0.0031 0.0169 0.0421
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0408 0.0948
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Echinococcus granulosus L aminoadipate semialdehyde 0.0082 0.0663 0.1008
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0693 0.2376
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.03 0.0429
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1046 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0213 0.0197
Brugia malayi Flap endonuclease-1 0.0026 0.0121 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0379 0.0566
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0106 0.0184
Mycobacterium tuberculosis Probable reductase 0.0085 0.0693 0.2376
Toxoplasma gondii aldehyde dehydrogenase 0.0196 0.1774 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0057 0.0063
Echinococcus multilocularis tumor protein p63 0.0331 0.308 0.4056
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0096 0.0096
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.03 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.016 0.0143
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0106 0.0477
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0121 0.0261
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0023 0.0009
Schistosoma mansoni lamin 0.0031 0.0171 0.0241
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0121 0.1116
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.0966 0.2271
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0057
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0096 0.0145
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0014
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0432 0.0648
Mycobacterium tuberculosis Probable uracil DNA glycosylase, UdgB 0.0031 0.0169 0.0421
Echinococcus granulosus lamin dm0 0.0031 0.0171 0.0241
Schistosoma mansoni hypothetical protein 0.0548 0.5178 0.8057
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0082 0.0663 0.1546
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0057 0.0053
Leishmania major hypothetical protein, conserved 0.0209 0.1892 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0408 0.0612
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0057 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0903 0.0888
Plasmodium vivax sphingomyelin synthase 1, putative 0.0106 0.0903 1
Schistosoma mansoni intermediate filament proteins 0.0031 0.0171 0.0241
Loa Loa (eye worm) hypothetical protein 0.0052 0.0379 0.0878
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.0784 0.2717
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0129 0.0112
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0693 0.2376
Mycobacterium leprae PROBABLE URACIL-DNA GLYCOSYLASE UNG (UDG) 0.0072 0.0566 0.1785
Trypanosoma brucei uracil-DNA glycosylase, putative 0.0072 0.0566 0.0566
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0693 0.2376
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0213 0.0197
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0171 0.038
Entamoeba histolytica hypothetical protein 0.0106 0.0903 0.1493
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0106 0.0903 0.0888
Giardia lamblia GTOR 0.0044 0.03 0.0429
Trypanosoma brucei inositol phosphorylceramide synthase 0.1046 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.0784 0.2717
Echinococcus multilocularis uracil DNA glycosylase 0.0072 0.0566 0.0728
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0026
Loa Loa (eye worm) hypothetical protein 0.0106 0.0903 0.2131
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.2324 0.5522
Brugia malayi intermediate filament protein 0.0031 0.0171 0.0369
Plasmodium vivax glutathione reductase, putative 0.0037 0.0233 0.2386
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0432 0.055
Loa Loa (eye worm) hypothetical protein 0.0015 0.0017 0.0013
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0023 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0113 0.0966 0.1482
Plasmodium falciparum glutathione reductase 0.0037 0.0233 0.2386
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Brugia malayi glutathione reductase 0.0037 0.0233 0.0517
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0033 0.0039
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0017 0.0012
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0023 0.0008
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0096 0.0421
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0058 0.0432 0.0993
Brugia malayi MH2 domain containing protein 0.0117 0.1007 0.2369
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0295 0.2733 1
Trypanosoma cruzi hypothetical protein, conserved 0.0209 0.1892 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0693 0.2376
Onchocerca volvulus 0.0313 0.2899 0.5903
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0343 0.0509
Echinococcus multilocularis dna polymerase eta 0.0019 0.0057 0.0053
Toxoplasma gondii uracil-DNA glycosylase 0.0072 0.0566 0.3104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0151 0.0134
Echinococcus multilocularis GPCR, family 2 0.0052 0.0379 0.048
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.1482 0.2836
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0106 0.0903 0.2121
Entamoeba histolytica hypothetical protein 0.0106 0.0903 0.1493
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.0784 0.261
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1007 0.2378
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.03 0.0442
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0106 0.0903 0.4727
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0237 0.0292
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.2324 0.5527
Echinococcus multilocularis musashi 0.0031 0.0171 0.0204
Echinococcus granulosus sphingomyelin synthase protein 1 0.0106 0.0903 0.1384
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0023 0.0026
Entamoeba histolytica hypothetical protein 0.0106 0.0903 0.1493
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0017 0.0001
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0121 0.0113
Trichomonas vaginalis hypothetical protein 0.0106 0.0903 0.0888
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Echinococcus granulosus uracil DNA glycosylase 0.0072 0.0566 0.0858
Trypanosoma cruzi uracil-DNA glycosylase 0.0072 0.0566 0.2929
Echinococcus multilocularis lamin 0.0031 0.0171 0.0204
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1007 0.2378
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1568 0.1554
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0494 0.0745
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.5726 0.5719
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0213 0.1048
Loa Loa (eye worm) hypothetical protein 0.0113 0.0966 0.228
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0171 0.038
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0121 0.0555
Leishmania major DNA polymerase eta, putative 0.0019 0.0057 0.0214
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0494 0.2689
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0096 0.0417
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0106 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0126 0.0109
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.0023 0.0008
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0191 0.0961
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0121 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0213 0.0197
Plasmodium vivax SET domain protein, putative 0.0064 0.0494 0.5349
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Chlamydia trachomatis uracil DNA glycosylase 0.0072 0.0566 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.03 0.0678
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0106 0.0118
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0057 0.004
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0121 0.0561
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0023 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0057 0.0057
Brugia malayi Pre-SET motif family protein 0.0064 0.0494 0.1141
Loa Loa (eye worm) hypothetical protein 0.0082 0.0663 0.1556
Echinococcus granulosus dna polymerase kappa 0.0019 0.0057 0.0063
Trichomonas vaginalis set domain proteins, putative 0.0508 0.4793 0.4784
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0106 0.0903 0.4727
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Schistosoma mansoni DNA polymerase eta 0.0019 0.0057 0.0063
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.1471 0.348
Echinococcus granulosus flap endonuclease 1 0.0026 0.0121 0.0163
Trypanosoma brucei unspecified product 0.0019 0.0057 0.0057
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0017 0.0017
Onchocerca volvulus 0.0508 0.4793 1
Echinococcus granulosus geminin 0.0548 0.5178 0.8057
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0233 0.0657
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0033 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Onchocerca volvulus 0.0082 0.0663 0.1064
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0106 0.0184
Plasmodium falciparum uracil-DNA glycosylase 0.0072 0.0566 0.6173
Echinococcus granulosus dna polymerase eta 0.0019 0.0057 0.0063
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0057 0.0096
Entamoeba histolytica hypothetical protein 0.0023 0.0096 0.0068
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0295 0.2733 1
Leishmania major uracil-DNA-glycosylase, putative 0.0072 0.0566 0.2929
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.03 0.1511
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0693 0.2264
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0096 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Trypanosoma brucei hypothetical protein, conserved 0.0209 0.1892 0.1892
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0082 0.0663 0.1008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0196 0.1774 0.6419
Brugia malayi Sphingomyelin synthase-related 1 0.0106 0.0903 0.2121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0169 0.0199
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.1471 0.348
Entamoeba histolytica uracil-DNA glycosylase, putative 0.0072 0.0566 0.0898
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0057 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0213 0.0197
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0106 0.0903 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0106 0.0903 0.0903
Schistosoma mansoni hypothetical protein 0.0052 0.0379 0.0566
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0057 0.0053
Leishmania major DNA polymerase kappa, putative 0.0019 0.0057 0.0214
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0057 0.0063
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0169 0.028
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0121 0.0104
Schistosoma mansoni aldehyde dehydrogenase 0.0196 0.1774 0.2744
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0106 0.0903 0.2121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.1471 0.3488
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0057 0.0063
Entamoeba histolytica hypothetical membrane-spanning protein 0.0106 0.0903 0.1493
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0408 0.0612
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0233 0.2386
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0446 0.4196 1
Wolbachia endosymbiont of Brugia malayi uracil-DNA glycosylase 0.0031 0.0169 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0096 0.083
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0023 0.0009
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0196 0.1774 0.937
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0014
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0023 0.0023
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0213 0.1048
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.1568 0.1554
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0057 0.0214
Toxoplasma gondii thioredoxin reductase 0.0037 0.0233 0.12
Loa Loa (eye worm) hypothetical protein 0.003 0.0165 0.0367
Mycobacterium ulcerans hypothetical protein 0.0024 0.0106 0.0184
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.0023 0.0009
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0017 0.0001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0057 0.0108
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.6422 0.8482
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0605 0.5726 1
Treponema pallidum DNA polymerase 0.0031 0.0169 0.0131
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0693 0.2376
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0075 0.0075
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0106 0.009
Echinococcus granulosus lamin 0.0031 0.0171 0.0241
Echinococcus multilocularis lamin dm0 0.0031 0.0171 0.0204
Brugia malayi hypothetical protein 0.0313 0.2899 0.6898
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0106 0.0903 0.2121
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Onchocerca volvulus 0.0048 0.0343 0.0373
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0014
Trypanosoma brucei trypanothione reductase 0.0037 0.0233 0.0233
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.6422 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0605 0.5726 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0196 0.1774 0.2327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0213 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0196 0.1774 0.6419
Loa Loa (eye worm) hypothetical protein 0.0165 0.1471 0.3488
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0096 0.0145
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0023 0.0008
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0213 0.0213
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.03 0.0442
Loa Loa (eye worm) uracil-DNA glycosylase 0.0072 0.0566 0.1325
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0106 0.0903 0.2121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.03 0.0284
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0408 0.0519
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0106 0.0903 0.2121
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.03 0.1511
Loa Loa (eye worm) hypothetical protein 0.0031 0.0171 0.038
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0051 0.0051
Echinococcus granulosus microtubule associated protein 2 0.0676 0.6422 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0057 0.0057
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.03 0.069
Brugia malayi jmjC domain containing protein 0.0015 0.0023 0.0014
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0057 0.0214
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0121 0.0555
Schistosoma mansoni G/t mismatch-specific thymine DNA glycosylase 0.0031 0.0169 0.0238
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0024 0.0106 0.0184
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.03 0.1511
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0379 0.0878
Echinococcus granulosus intermediate filament protein 0.0031 0.0171 0.0241
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0295 0.2733 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0494 0.0745
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.0784 0.2717
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0233 0.1151
Mycobacterium tuberculosis Conserved protein 0.0024 0.0106 0.0184
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0121 0.0138
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0106 0.0903 1
Entamoeba histolytica hypothetical protein 0.0106 0.0903 0.1493
Schistosoma mansoni uracil-DNA glycosylase 0.0072 0.0572 0.0866
Schistosoma mansoni hypothetical protein 0.0548 0.5178 0.8057
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0494 0.0745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0087
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0191 0.0174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0379 0.0566
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.03 0.0429
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0023 0.0009
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.1482 0.1467
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0106 0.0903 0.4727
Brugia malayi Thioredoxin reductase 0.0037 0.0233 0.0517
Plasmodium vivax uracil-DNA glycosylase, putative 0.0072 0.0566 0.6173
Brugia malayi jmjC domain containing protein 0.0058 0.0432 0.0993
Loa Loa (eye worm) hypothetical protein 0.0064 0.0494 0.1152
Trichomonas vaginalis uracil DNA glycosylase, putative 0.0072 0.0566 0.055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.03 0.0284
Entamoeba histolytica hypothetical protein 0.0106 0.0903 0.1493
Echinococcus granulosus tumor protein p63 0.0331 0.308 0.4783
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0106 0.0903 0.0903
Echinococcus granulosus phd:f box containing protein 0.0015 0.0023 0.0009
Leishmania major trypanothione reductase 0.0037 0.0233 0.1151
Loa Loa (eye worm) hypothetical protein 0.0015 0.0023 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.2324 0.2312
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0024 0.0106 0.0184

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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