Detailed information for compound 1513488

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 418.485 | Formula: C20H23FN4O3S
  • H donors: 2 H acceptors: 2 LogP: 2.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(N2CC[C@H](C2)[C@@H](N)C)c(F)cc2c1n(C1CC1)c1c(c2=O)c(=O)[nH]s1
  • InChi: 1S/C20H23FN4O3S/c1-9(22)10-5-6-24(8-10)16-13(21)7-12-15(18(16)28-2)25(11-3-4-11)20-14(17(12)26)19(27)23-29-20/h7,9-11H,3-6,8,22H2,1-2H3,(H,23,27)/t9-,10+/m0/s1
  • InChiKey: OEFVEGDPRVNFMP-VHSXEESVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Staphylococcus aureus DNA gyrase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium berghei DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein Get druggable targets OG5_129568 All targets in OG5_129568
Treponema pallidum DNA gyrase, subunit A (gyrA) Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Chlamydia trachomatis DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium knowlesi DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium vivax DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium ulcerans DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) Get druggable targets OG5_129568 All targets in OG5_129568
Theileria parva DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium falciparum DNA gyrase subunit A Get druggable targets OG5_129568 All targets in OG5_129568
Babesia bovis DNA gyrase A subunit, putative Get druggable targets OG5_129568 All targets in OG5_129568
Plasmodium yoelii DNA gyrase subunit a-related Get druggable targets OG5_129568 All targets in OG5_129568
Neospora caninum DNA gyrase subunit A, putative Get druggable targets OG5_129568 All targets in OG5_129568
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Dictyostelium discoideum DNA topoisomerase II DNA gyrase   644 aa 655 aa 23.8 %
Leishmania mexicana mitochondrial DNA topoisomerase II DNA gyrase   644 aa 620 aa 23.4 %
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative DNA gyrase   644 aa 615 aa 22.6 %
Neospora caninum hypothetical protein DNA gyrase   644 aa 693 aa 24.1 %
Echinococcus granulosus DNA topoisomerase 2 alpha DNA gyrase   644 aa 613 aa 25.9 %
Leishmania mexicana DNA topoisomerase ii DNA gyrase   644 aa 668 aa 23.1 %
Toxoplasma gondii DNA topoisomerase 2, putative DNA gyrase   644 aa 664 aa 24.1 %
Trypanosoma brucei DNA topoisomerase II alpha, putative DNA gyrase   644 aa 676 aa 23.4 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) DNA gyrase   644 aa 667 aa 53.1 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB DNA gyrase   644 aa 561 aa 50.4 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.7 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 617 aa 24.8 %
Onchocerca volvulus DNA gyrase   644 aa 624 aa 25.8 %
Leishmania major DNA topoisomerase ii DNA gyrase   644 aa 672 aa 23.4 %
Leishmania major mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.1 %
Leishmania braziliensis mitochondrial DNA topoisomerase II DNA gyrase   644 aa 622 aa 23.8 %
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) DNA gyrase   644 aa 661 aa 53.0 %
Brugia malayi DNA topoisomerase II, alpha isozyme DNA gyrase   644 aa 659 aa 24.3 %
Trypanosoma brucei DNA topoisomerase ii DNA gyrase   644 aa 619 aa 25.7 %
Echinococcus multilocularis DNA topoisomerase 2 alpha DNA gyrase   644 aa 612 aa 25.8 %
Leishmania infantum mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Mycobacterium ulcerans DNA gyrase subunit B DNA gyrase   644 aa 663 aa 54.0 %
Leishmania donovani mitochondrial DNA topoisomerase II DNA gyrase   644 aa 624 aa 23.2 %
Plasmodium berghei DNA gyrase subunit B, putative DNA gyrase   644 aa 662 aa 36.3 %
Theileria parva DNA gyrase subunit B, putative DNA gyrase   644 aa 638 aa 37.1 %
Entamoeba histolytica DNA topoisomerase II, putative DNA gyrase   644 aa 544 aa 25.0 %
Babesia bovis DNA topoisomerase II, putative DNA gyrase   644 aa 587 aa 22.7 %
Trypanosoma cruzi DNA topoisomerase II, putative DNA gyrase   644 aa 674 aa 23.0 %
Loa Loa (eye worm) TOPoisomerase family member DNA gyrase   644 aa 668 aa 26.2 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 619 aa 25.7 %
Leishmania braziliensis DNA topoisomerase ii DNA gyrase   644 aa 675 aa 23.0 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 666 aa 23.4 %
Theileria parva DNA topoisomerase II, putative DNA gyrase   644 aa 683 aa 23.9 %
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein DNA gyrase   644 aa 548 aa 25.7 %
Plasmodium falciparum DNA topoisomerase 2 DNA gyrase   644 aa 647 aa 23.2 %
Trypanosoma brucei gambiense DNA topoisomerase II, putative DNA gyrase   644 aa 676 aa 23.4 %
Onchocerca volvulus DNA gyrase   644 aa 618 aa 26.5 %
Chlamydia trachomatis DNA gyrase subunit B DNA gyrase   644 aa 561 aa 55.3 %
Candida albicans DNA topoisomerase II similar to S. cerevisiae TOP2 (YNL088W) DNA gyrase   644 aa 625 aa 25.6 %
Onchocerca volvulus Ectoderm-expressed 4 homolog DNA gyrase   644 aa 673 aa 24.1 %
Trypanosoma brucei DNA topoisomerase II beta, putative DNA gyrase   644 aa 570 aa 24.0 %
Leishmania infantum DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.6 %
Leishmania donovani DNA topoisomerase ii DNA gyrase   644 aa 666 aa 23.4 %
Brugia malayi Probable DNA topoisomerase II DNA gyrase   644 aa 672 aa 25.9 %
Plasmodium knowlesi DNA gyrase subunit B, putative DNA gyrase   644 aa 517 aa 36.0 %
Schistosoma mansoni DNA topoisomerase II DNA gyrase   644 aa 633 aa 24.3 %
Trypanosoma congolense DNA topoisomerase II, putative DNA gyrase   644 aa 678 aa 22.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1075 0.1345
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.031
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0074 0.0015
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Schistosoma mansoni transcription factor btf3 0.0034 0.0067 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0115 0.0684 0.078
Mycobacterium ulcerans DNA gyrase subunit B 0.0072 0.0352 0.09
Brugia malayi latrophilin 2 splice variant baaae 0.0114 0.0673 0.083
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) hypothetical protein 0.0159 0.1017 0.1271
Mycobacterium ulcerans DNA gyrase subunit A 0.0454 0.327 1
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0065 0.0303 0.0354
Giardia lamblia NADH oxidase lateral transfer candidate 0.0145 0.0911 0.2051
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.1075 0.1345
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0074 0.009
Schistosoma mansoni jumonji domain containing protein 0.0075 0.038 0.0355
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Plasmodium falciparum thioredoxin reductase 0.0145 0.0911 0.2728
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Giardia lamblia Glutamate synthase 0.0038 0.0099 0.0168
Brugia malayi hypothetical protein 0.0042 0.0128 0.013
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Trichomonas vaginalis maltase-glucoamylase, putative 0.0039 0.0105 0.0044
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0038 0.0099 0.0032
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0038 0.0099 0.0124
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0138
Trichomonas vaginalis glutathione reductase, putative 0.0145 0.0911 0.0952
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1051 0.7824 1
Echinococcus multilocularis transcription factor btf3 0.0034 0.0067 0.0069
Leishmania major alpha glucosidase II subunit, putative 0.0039 0.0105 0.0145
Trichomonas vaginalis mercuric reductase, putative 0.0145 0.0911 0.0952
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0038 0.0099 0.0138
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.029 0.202 0.2488
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0065 0.03 0.0316
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1679
Giardia lamblia DNA damage repair protein 0.0034 0.0063 0.0085
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0151 0.0955 0.1591
Echinococcus multilocularis glutamate synthase 0.0038 0.0099 0.0124
Onchocerca volvulus 0.0042 0.0128 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Trypanosoma brucei DNA polymerase kappa, putative 0.0115 0.0684 0.0828
Entamoeba histolytica deoxycytidyl transferase, putative 0.0109 0.0635 0.1331
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0427 0.0686
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.4964 0.8454
Giardia lamblia DNA topoisomerase II 0.0069 0.0334 0.0713
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0038 0.0099 0.0168
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Onchocerca volvulus 0.0035 0.0074 0.0054
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0106 0.0618 0.0758
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0038 0.0099 0.0032
Toxoplasma gondii thioredoxin reductase 0.0418 0.2996 0.9163
Toxoplasma gondii hypothetical protein 0.0042 0.0128 0.0391
Loa Loa (eye worm) serotonin transporter b 0.0249 0.1705 0.2153
Brugia malayi jmjC domain containing protein 0.0035 0.0073 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0145 0.0911 0.2786
Trichomonas vaginalis esterase, putative 0.0035 0.0074 0.0008
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Brugia malayi glutamate synthase 0.0038 0.0099 0.0093
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0038 0.0099 0.0302
Onchocerca volvulus 0.0249 0.1705 0.1886
Loa Loa (eye worm) thioredoxin reductase 0.0418 0.2996 0.3809
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Loa Loa (eye worm) trypsin family protein 0.0115 0.0683 0.0842
Brugia malayi polk-prov protein 0.006 0.026 0.03
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.2063 0.6819
Echinococcus granulosus glycoprotein Antigen 5 0.0115 0.0683 0.1246
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0122
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Plasmodium falciparum DNA gyrase subunit A 0.0454 0.327 1
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0073 0.036 0.0375
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0073 0.006
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0099 0.0036
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.106 0.7896 1
Mycobacterium ulcerans NADH dehydrogenase 0.0038 0.0099 0.0112
Plasmodium vivax DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.0343
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Leishmania major mitochondrial DNA topoisomerase II 0.0073 0.036 0.1012
Brugia malayi glutathione reductase 0.0418 0.2996 0.3809
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0038 0.0099 0.0032
Onchocerca volvulus 0.0035 0.0074 0.0054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major DNA polymerase eta, putative 0.0084 0.0445 0.1302
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Trypanosoma brucei DNA topoisomerase ii 0.0073 0.036 0.0395
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0115 0.0683 0.1246
Plasmodium falciparum thioredoxin reductase 0.0418 0.2996 0.9156
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0698 0.0861
Schistosoma mansoni DNA polymerase IV / kappa 0.0034 0.0063 0.0037
Giardia lamblia Thioredoxin reductase 0.0038 0.0099 0.0168
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0145 0.0911 0.2728
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Leishmania major DNA topoisomerase ii 0.0065 0.03 0.0809
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0954 0.7084 0.8962
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.106 0.7896 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Loa Loa (eye worm) glutathione reductase 0.0418 0.2996 0.3809
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Loa Loa (eye worm) hypothetical protein 0.0159 0.102 0.1274
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0074 0.0147
Echinococcus multilocularis tumor protein p63 0.0328 0.2309 0.3909
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0151 0.0955 0.0932
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0067 0.0125
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Schistosoma mansoni intermediate filament proteins 0.003 0.0032 0.0006
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Mycobacterium ulcerans hypothetical protein 0.0038 0.0099 0.0112
Brugia malayi Glycosyl hydrolases family 31 protein 0.0039 0.0105 0.0102
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0427 0.0514
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0151 0.0955 0.2922
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0103 0.0595 0.0974
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.106 0.7896 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0529 0.086
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1075 0.1345
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Loa Loa (eye worm) TOPoisomerase family member 0.0073 0.036 0.0428
Onchocerca volvulus 0.0115 0.0683 0.0738
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.013
Loa Loa (eye worm) hypothetical protein 0.0048 0.0172 0.0187
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0303 0.0266
Onchocerca volvulus 0.0103 0.0588 0.0631
Onchocerca volvulus 0.003 0.0032 0.0006
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.1268 0.2356
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0207 0.0232
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0099 0.0138
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0874 0.108
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Trypanosoma brucei DNA polymerase IV, putative 0.0128 0.0783 0.096
Toxoplasma gondii DNA topoisomerase 2, putative 0.0073 0.036 0.11
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Loa Loa (eye worm) latrophilin receptor protein 2 0.0053 0.0207 0.0232
Plasmodium falciparum DNA gyrase subunit B 0.0072 0.0352 0.1003
Trichomonas vaginalis apoptosis inducing factor, putative 0.0038 0.0099 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Echinococcus granulosus sphingomyelin synthase protein 1 0.0103 0.0595 0.1079
Echinococcus multilocularis Mastin 0.0115 0.0683 0.1124
Trichomonas vaginalis rotamase, putative 0.0065 0.0303 0.0266
Echinococcus multilocularis dna polymerase kappa 0.0135 0.0832 0.138
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0067 0.0204
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.0883 0.1099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1156
Mycobacterium tuberculosis Probable oxidoreductase 0.106 0.7896 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0103 0.0595 0.0729
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.0883 0.1468
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Loa Loa (eye worm) intermediate filament protein 0.003 0.0032 0.0007
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Schistosoma mansoni sodium/chloride dependent transporter 0.0249 0.1705 0.1684
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Brugia malayi Pre-SET motif family protein 0.1051 0.7824 1
Echinococcus granulosus expressed protein 0.0065 0.0303 0.0524
Trypanosoma cruzi DNA polymerase eta, putative 0.0084 0.0445 0.1302
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0073 0.036 0.1012
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0099 0.0048
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0138
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0048 0.0172 0.0164
Echinococcus granulosus glutamate synthase 0.0038 0.0099 0.0138
Treponema pallidum sodium- and chloride- dependent transporter 0.0249 0.1705 0.3788
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0038 0.0099 0.0112
Schistosoma mansoni glutamate synthase 0.0038 0.0099 0.0073
Echinococcus granulosus lamin dm0 0.003 0.0032 0.001
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0145 0.0911 0.2561
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Leishmania major hypothetical protein, conserved 0.0035 0.0074 0.0037
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Echinococcus granulosus intermediate filament protein 0.003 0.0032 0.001
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans beta-lactamase 0.0035 0.0074 0.0034
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0113 0.0148
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.1268 0.1526
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0454 0.327 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Brugia malayi Cytochrome P450 family protein 0.0054 0.0215 0.0242
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0038 0.0099 0.0112
Trypanosoma cruzi trypanothione reductase, putative 0.0145 0.0911 0.2891
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0954 0.7084 0.8962
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0172 0.0146
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0145 0.0911 0.2891
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Leishmania major trypanothione reductase 0.0418 0.2996 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Giardia lamblia Kinase, PLK 0.0094 0.0521 0.1147
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.013 0.0104
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0038 0.0099 0.0112
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0323
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0038 0.0099 0.0032
Onchocerca volvulus 0.0159 0.102 0.1116
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0065 0.0303 0.0354
Schistosoma mansoni terminal deoxycytidyl transferase 0.0109 0.0635 0.0611
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0099 0.0032
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0038 0.0099 0.0032
Echinococcus granulosus thioredoxin glutathione reductase 0.0421 0.3015 0.5672
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0145 0.0911 0.2728
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Brugia malayi TAR-binding protein 0.0069 0.0331 0.0391
Echinococcus granulosus Mastin 0.0115 0.0683 0.1246
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0042 0.0128 0.013
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0042 0.0128 0.0174
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Echinococcus granulosus tumor protein p63 0.0328 0.2309 0.4333
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0074 0.0008
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0038 0.0099 0.0093
Loa Loa (eye worm) hypothetical protein 0.0151 0.0955 0.1192
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi beta-lactamase family protein 0.0035 0.0074 0.0061
Trypanosoma brucei inositol phosphorylceramide synthase 0.1018 0.757 1
Brugia malayi beta-lactamase 0.0035 0.0074 0.0061
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0261 0.0302
Loa Loa (eye worm) beta-lactamase 0.0035 0.0074 0.0061
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0038 0.0099 0.0075
Trypanosoma brucei trypanothione reductase 0.0418 0.2996 0.3907
Brugia malayi Latrophilin receptor protein 2 0.0053 0.0207 0.0232
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0124
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Echinococcus granulosus dna polymerase kappa 0.0135 0.0832 0.153
Plasmodium falciparum glutathione reductase 0.0145 0.0911 0.2728
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.1268 0.2125
Toxoplasma gondii peptidylprolyl isomerase 0.0064 0.0291 0.0889
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0454 0.327 0.7478
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0521 0.1063
Plasmodium vivax amine transporter, putative 0.0042 0.0128 0.0313
Toxoplasma gondii NADPH-glutathione reductase 0.0145 0.0911 0.2786
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0038 0.0099 0.0122
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Loa Loa (eye worm) hypothetical protein 0.006 0.026 0.03
Brugia malayi Probable DNA topoisomerase II 0.0073 0.036 0.0428
Echinococcus multilocularis enteropeptidase 0.0115 0.0683 0.1124
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0106 0.0618 0.0758
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Brugia malayi MH2 domain containing protein 0.0117 0.0698 0.0861
Onchocerca volvulus 0.0115 0.0683 0.0738
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0595 0.0596
Leishmania major NADH dehydrogenase, putative 0.0038 0.0099 0.0122
Chlamydia trachomatis DNA gyrase subunit A 0.0047 0.0165 0.0209
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0074 0.0082
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0145 0.0911 0.0887
Echinococcus granulosus transmembrane protease serine 3 0.0115 0.0683 0.1246
Onchocerca volvulus 0.003 0.0032 0.0006
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.1124
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0038 0.0099 0.0032
Chlamydia trachomatis DNA gyrase subunit A 0.0454 0.327 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0145 0.0911 0.1135
Trypanosoma brucei polo-like protein kinase 0.0094 0.0521 0.061
Loa Loa (eye worm) hypothetical protein 0.0029 0.0028 0.0002
Echinococcus multilocularis lysosomal alpha glucosidase 0.0177 0.1158 0.1938
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0074 0.0008
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0331 0.0522
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0331 0.0391
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Brugia malayi jmjC domain containing protein 0.0095 0.0529 0.0644
Mycobacterium ulcerans ferredoxin reductase 0.0038 0.0099 0.0112
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Plasmodium falciparum transporter, putative 0.0042 0.0128 0.0313
Echinococcus multilocularis GPCR, family 2 0.0053 0.0207 0.031
Onchocerca volvulus 0.0038 0.0099 0.0082
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Loa Loa (eye worm) programmed cell death 8 0.0038 0.0099 0.0093
Loa Loa (eye worm) RNA binding protein 0.0069 0.0331 0.0391
Loa Loa (eye worm) norepinephrine transporter 0.0249 0.1705 0.2153
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0145 0.0911 0.2728
Brugia malayi Trypsin-like protease protein 5 0.0115 0.0683 0.0842
Schistosoma mansoni hypothetical protein 0.0115 0.0683 0.0659
Mycobacterium ulcerans monoxygenase 0.0038 0.0099 0.0112
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0073 0.0088
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Schistosoma mansoni sodium/chloride dependent transporter 0.0042 0.0128 0.0102
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.1268 0.3756
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0073 0.036 0.0571
Schistosoma mansoni disulfide oxidoreductase 0.0038 0.0099 0.0073
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.1268 0.1245
Brugia malayi hypothetical protein 0.0159 0.102 0.1274
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Trypanosoma brucei DNA polymerase IV, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0249 0.1705 0.2153
Treponema pallidum fructose-bisphosphate aldolase 0.0594 0.4339 1
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0521 0.0847
Trichomonas vaginalis DNA polymerase eta, putative 0.0135 0.0832 0.0864
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0048
Echinococcus granulosus jumonji domain containing protein 0.004 0.0113 0.0164
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0039 0.0105 0.0044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.0883 0.086
Echinococcus granulosus expressed protein 0.0371 0.2633 0.4947
Mycobacterium tuberculosis Conserved hypothetical protein 0.0109 0.0635 0.0718
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0038 0.0099 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Mycobacterium ulcerans glutamate synthase subunit beta 0.0038 0.0099 0.0112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0109 0.0635 0.0611
Brugia malayi intermediate filament protein 0.003 0.0032 0.0007
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Loa Loa (eye worm) hypothetical protein 0.0103 0.0595 0.0729
Echinococcus granulosus tar DNA binding protein 0.0069 0.0331 0.0579
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0074 0.0034
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium ulcerans hypothetical protein 0.0115 0.0683 0.1934
Echinococcus granulosus serotonin transporter 0.0249 0.1705 0.3187
Echinococcus multilocularis expressed protein 0.0065 0.0303 0.0473
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0427 0.0402
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0521 0.0496
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0145 0.0911 0.113
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.0418 0.2996 0.9156
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0065 0.03 0.0316
Schistosoma mansoni spingomyelin synthetase-related 0.0103 0.0595 0.057
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0099 0.0048
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0521 0.0939
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0529 0.0954
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.0729
Trypanosoma cruzi DNA topoisomerase II, putative 0.0065 0.03 0.0809
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0038 0.0099 0.0036
Echinococcus multilocularis geminin 0.072 0.5296 0.9021
Entamoeba histolytica DNA topoisomerase II, putative 0.0073 0.036 0.0686
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0115 0.0684 0.2118
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0048
Brugia malayi Glycosyl hydrolases family 31 protein 0.0177 0.1158 0.1451
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.029 0.202 0.2488
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Plasmodium falciparum DNA topoisomerase 2 0.0073 0.036 0.1028
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0099 0.0075
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0042 0.0128 0.0092
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0072 0.0352 0.0355
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0521 0.0634
Echinococcus granulosus transcription factor btf3 0.0034 0.0067 0.0077
Brugia malayi Pre-SET motif family protein 0.0151 0.0955 0.1192
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0215 0.0242
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.016 0.0105
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Loa Loa (eye worm) hypothetical protein 0.005 0.0184 0.0202
Giardia lamblia DINP protein human, muc B family 0.0115 0.0684 0.1526
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0084 0.0445 0.136
Schistosoma mansoni rotamase 0.0065 0.0303 0.0277
Echinococcus granulosus lysosomal alpha glucosidase 0.0177 0.1158 0.2148
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0249 0.1705 0.1684
Plasmodium vivax sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0038 0.0099 0.0224
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0521 0.0634
Onchocerca volvulus 0.0042 0.0128 0.0114
Entamoeba histolytica disulphide oxidoreductase, putative 0.0038 0.0099 0.0075
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.1813
Onchocerca volvulus 0.0042 0.0128 0.0114
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.0995 0.1177
Entamoeba histolytica hypothetical membrane-spanning protein 0.0103 0.0595 0.1236
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Schistosoma mansoni hypothetical protein 0.0038 0.0099 0.0073
Plasmodium vivax ferrodoxin reductase, putative 0.0038 0.0099 0.0224
Echinococcus granulosus GPCR family 2 0.0053 0.0207 0.0343
Trypanosoma brucei unspecified product 0.0075 0.0378 0.0419
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0064 0.0291 0.0304
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0042 0.0128 0.0102
Mycobacterium ulcerans dehydrogenase 0.0038 0.0099 0.0112
Mycobacterium tuberculosis Probable dehydrogenase 0.0954 0.7084 0.8962
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0115 0.0683 0.0842
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0038 0.0099 0.0122
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0074 0.0034
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0072 0.0352 0.0596
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0331 0.0306
Loa Loa (eye worm) hypothetical protein 0.003 0.0032 0.0007
Brugia malayi Thioredoxin reductase 0.0418 0.2996 0.3809
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0038 0.0099 0.0138
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0521 0.0512
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0418 0.2996 0.3736
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.4964 0.4951
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0115 0.0683 0.1124
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0122
Schistosoma mansoni alpha glucosidase 0.0039 0.0105 0.008
Echinococcus multilocularis thioredoxin glutathione reductase 0.0421 0.3015 0.5117
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0074 0.0037
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0115 0.0683 0.1246
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.2063 0.2664
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0038 0.0099 0.0124
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0042 0.0128 0.0391
Trichomonas vaginalis rotamase, putative 0.0064 0.0291 0.0253
Toxoplasma gondii hypothetical protein 0.0103 0.0595 0.1819
Brugia malayi Trypsin family protein 0.0115 0.0683 0.0842
Onchocerca volvulus 0.0115 0.0683 0.0738
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0099 0.0122
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0103 0.0595 0.1813
Schistosoma mansoni hypothetical protein 0.0114 0.0673 0.0649
Mycobacterium leprae Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0216 0.1457 0.1768
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0039 0.0105 0.0102
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1521 0.185
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0145 0.0913 0.1683
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0103 0.0595 0.1753
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.5867 1
Loa Loa (eye worm) hypothetical protein 0.0114 0.0673 0.083
Echinococcus multilocularis glycoprotein Antigen 5 0.0115 0.0683 0.1124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0135 0.0832 0.2623
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0145 0.0911 0.113
Trypanosoma cruzi DNA polymerase eta, putative 0.0159 0.1017 0.3253
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0099 0.0073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0123 0.0204
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0099 0.0036
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0698 0.0861
Brugia malayi RNA binding protein 0.0069 0.0331 0.0391
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Schistosoma mansoni hypothetical protein 0.0053 0.0207 0.0181
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0099 0.0122
Trypanosoma brucei NADH dehydrogenase 0.0038 0.0099 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0135 0.0832 0.0864
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0042 0.0128 0.0193
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0039 0.0105 0.0091
Plasmodium falciparum DNA repair protein REV1, putative 0.0034 0.0063 0.0113
Schistosoma mansoni lamin 0.003 0.0032 0.0006
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0331 0.0391
Giardia lamblia Fructose-bisphosphate aldolase 0.0594 0.4339 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0128 0.0313
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0038 0.0099 0.0112
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.1268 0.4107
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0145 0.0911 0.113
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Echinococcus granulosus lamin 0.003 0.0032 0.001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0093
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0145 0.0911 0.2645
Onchocerca volvulus 0.0151 0.0955 0.1043
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0064 0.0291 0.0525
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.2063 0.6819
Loa Loa (eye worm) solute carrier family 6 member 4 0.0249 0.1705 0.2153
Plasmodium vivax DNA gyrase subunit B, putative 0.0072 0.0352 0.1003
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0145 0.0911 0.2645
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0105 0.0145
Chlamydia trachomatis DNA gyrase subunit B 0.0072 0.0352 0.0797
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0954 0.7084 0.8962
Echinococcus granulosus geminin 0.072 0.5296 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0038 0.0099 0.0224
Entamoeba histolytica thioredoxin reductase, putative 0.0038 0.0099 0.0075
Echinococcus multilocularis serotonin transporter 0.0249 0.1705 0.2875
Trypanosoma cruzi trypanothione reductase, putative 0.0418 0.2996 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0145 0.0911 0.2891
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium tuberculosis Probable reductase 0.0954 0.7084 0.8962
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.004 0.0112 0.0342
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0042 0.0128 0.0102
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0145 0.0911 0.2645
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0053 0.0207 0.031
Schistosoma mansoni sodium-dependent amino acid transporter 0.0042 0.0128 0.0102
Onchocerca volvulus 0.0035 0.0074 0.0054
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0067 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Trypanosoma brucei DNA polymerase kappa, putative 0.0081 0.0427 0.0484
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0038 0.0099 0.0075
Brugia malayi Sphingomyelin synthase-related 1 0.0103 0.0595 0.0729
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0073 0.036 0.0375
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0038 0.0099 0.0032
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0954 0.7084 0.8962
Entamoeba histolytica hypothetical protein 0.0103 0.0595 0.1236
Echinococcus granulosus microtubule associated protein 2 0.0676 0.4964 0.9371
Leishmania major DNA polymerase kappa, putative 0.0115 0.0684 0.2118
Trichomonas vaginalis DNA topoisomerase II, putative 0.0073 0.036 0.0331
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0145 0.0911 0.1515
Brugia malayi ImpB/MucB/SamB family protein 0.0109 0.0635 0.0781
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0145 0.0911 0.2891
Echinococcus multilocularis dna polymerase eta 0.0159 0.1017 0.1696
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Plasmodium vivax DNA gyrase subunit A, putative 0.0454 0.327 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0145 0.0911 0.2891
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0074 0.0048
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0042 0.0128 0.0174
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0032 0.0007
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0073 0.036 0.0428
Echinococcus multilocularis expressed protein 0.0371 0.2633 0.4463
Trypanosoma brucei DNA polymerase eta, putative 0.0159 0.1017 0.1271
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0099 0.0093
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0067 0.0013
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0122
Brugia malayi hypothetical protein 0.0115 0.0683 0.0842
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0145 0.0911 0.107
Schistosoma mansoni DNA topoisomerase II 0.0073 0.036 0.0334
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0145 0.0911 0.2561
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0427 0.076
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0099 0.0302
Loa Loa (eye worm) hypothetical protein 0.0081 0.0427 0.0514
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0454 0.327 1
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0331 0.0391
Echinococcus granulosus enteropeptidase 0.0115 0.0683 0.1246
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.008
Leishmania major basic transcription factor 3a, putative 0.0034 0.0067 0.0013
Plasmodium falciparum amino acid transporter, putative 0.0042 0.0128 0.0313
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Treponema pallidum NADH oxidase 0.0145 0.0911 0.1915
Echinococcus granulosus histone lysine methyltransferase setb 0.0151 0.0955 0.1763
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0038 0.0099 0.0032
Trypanosoma brucei unspecified product 0.0128 0.0783 0.096
Loa Loa (eye worm) hypothetical protein 0.0115 0.0683 0.0842
Onchocerca volvulus 0.0081 0.0427 0.045
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0064 0.0291 0.0777
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Loa Loa (eye worm) hypothetical protein 0.0166 0.1075 0.1345
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0103 0.0595 0.0709
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0064 0.0291 0.0777
Echinococcus multilocularis transmembrane protease serine 3 0.0115 0.0683 0.1124
Echinococcus multilocularis musashi 0.003 0.0032 0.0009
Plasmodium vivax DNA topoisomerase II, putative 0.0073 0.036 0.1028
Toxoplasma gondii ABC1 family protein 0.0035 0.0074 0.0226
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.0883 0.1627
Plasmodium falciparum ferrodoxin reductase-like protein 0.0038 0.0099 0.0224
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0174
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0067 0.0052
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0032 0.0007
Schistosoma mansoni kinase 0.0048 0.0169 0.0143
Schistosoma mansoni alpha-glucosidase 0.0153 0.097 0.0946
Onchocerca volvulus 0.1196 0.8931 1
Plasmodium falciparum glutathione reductase 0.0418 0.2996 0.9156
Brugia malayi beta-NAC-like protein 0.0034 0.0067 0.0052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0039 0.0105 0.0136
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0038 0.0099 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0074 0.0061
Trypanosoma brucei glucosidase, putative 0.0039 0.0105 0.0057
Loa Loa (eye worm) hypothetical protein 0.0042 0.0128 0.013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.0883 0.1099
Trichomonas vaginalis sphingomyelin synthetase, putative 0.1018 0.757 0.8465
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0521 0.0556
Schistosoma mansoni cercarial elastase (S01 family) 0.0115 0.0683 0.0659
Plasmodium vivax sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0103 0.0595 0.0729
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0177 0.1158 0.1451
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0072 0.0352 0.0797
Echinococcus granulosus sodium and chloride dependent glycine 0.0042 0.0128 0.0193
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0042 0.0128 0.0193
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0073 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.026 0.0262
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0123 0.0204
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0249 0.1705 0.2153
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0034 0.0063 0.0192
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0192 0.0441
Loa Loa (eye worm) hypothetical protein 0.0047 0.0165 0.0178
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0109 0.0635 0.1043
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0874 0.2765
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0103 0.0595 0.0709
Plasmodium vivax glutathione reductase, putative 0.0418 0.2996 0.9156
Mycobacterium ulcerans hypothetical protein 0.0156 0.0995 0.2905
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0099 0.0036
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0103 0.0595 0.0596
Plasmodium vivax SET domain protein, putative 0.0151 0.0955 0.2865
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0053 0.0207 0.0232
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0151 0.0955 0.1591
Onchocerca volvulus 0.0115 0.0683 0.0738
Trichomonas vaginalis alpha-glucosidase, putative 0.0039 0.0105 0.0044
Schistosoma mansoni DNA polymerase eta 0.0159 0.1017 0.0993
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.1268 0.3877
Trichomonas vaginalis set domain proteins, putative 0.1196 0.8931 1
Leishmania major DNA polymerase eta, putative 0.0159 0.1017 0.3253
Mycobacterium ulcerans DNA polymerase IV 0.0135 0.0832 0.2399
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0099 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0135 0.0832 0.1025
Echinococcus granulosus neutral alpha glucosidase AB 0.0039 0.0105 0.015
Echinococcus granulosus dna polymerase eta 0.0159 0.1017 0.188
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0521 0.1561
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0038 0.0099 0.0112
Trichomonas vaginalis hypothetical protein 0.0103 0.0595 0.0596
Mycobacterium ulcerans hypothetical protein 0.0035 0.0074 0.0034
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0521 0.1561
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0099 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0073 0.0047
Schistosoma mansoni hypothetical protein 0.072 0.5296 0.5283
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0103 0.0595 0.1753
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0151 0.0955 0.0932
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0074 0.0061
Toxoplasma gondii selenide, water dikinase 0.0038 0.0099 0.0302
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0123 0.008
Toxoplasma gondii hypothetical protein 0.0048 0.0169 0.0518
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0145 0.0911 0.2728
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0038 0.0099 0.0093
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.029 0.202 0.6104
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0594 0.4339 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0038 0.0099 0.0302
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0454 0.327 0.4086
Mycobacterium ulcerans lipase LipD 0.0035 0.0074 0.0034
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0115 0.0683 0.0659
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0954 0.7084 0.8962
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0073 0.036 0.0633
Echinococcus multilocularis lamin dm0 0.003 0.0032 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0074 0.0061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0053 0.0207 0.0343
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0073 0.036 0.0428
Echinococcus multilocularis sodium and chloride dependent glycine 0.0042 0.0128 0.0174
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0099 0.0124
Brugia malayi ImpB/MucB/SamB family protein 0.0159 0.1017 0.1271
Trichomonas vaginalis sucrase-isomaltase, putative 0.0039 0.0105 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0594 0.4339 0.482
Echinococcus multilocularis lamin 0.003 0.0032 0.0009
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0099 0.0122

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 6 uM Cytotoxicity against human Hep2 cells after 72 hrs by alamar blue assay ChEMBL. 21425851
IC50 (binding) = 0.68 uM Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay ChEMBL. 21425851
MIC (functional) = 0.008 ug ml-1 Antibacterial activity against Escherichia coli ATCC25922 after 24 hrs by microdilution method ChEMBL. 21425851
Ratio IC50 (binding) = 0.06 Ratio of ciprofloxacin IC50 to compound IC50 for wild-type Staphylococcus aureus DNA gyrase ChEMBL. 21425851

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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