Detailed information for compound 820917

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 461.528 | Formula: C27H28FN3O3
  • H donors: 2 H acceptors: 3 LogP: 3.75 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(C=CCN2CCc3c(C2)cnc(c3CNC(=O)c2ccccc2F)C)ccc1O
  • InChi: 1S/C27H28FN3O3/c1-18-23(16-30-27(33)22-7-3-4-8-24(22)28)21-11-13-31(17-20(21)15-29-18)12-5-6-19-9-10-25(32)26(14-19)34-2/h3-10,14-15,32H,11-13,16-17H2,1-2H3,(H,30,33)/b6-5+
  • InChiKey: ZGQWGHIFYBEETH-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.009 0.5802
Plasmodium falciparum phosphodiesterase gamma, putative 0.0027 0.009 0.5802
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0148 0.0133
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0119 0.0898 0.0898
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0111 0.0111
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0061 0.0384 0.0384
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0027 0.009 0.0852
Echinococcus granulosus neuropeptide s receptor 0.0464 0.3925 0.3925
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.009 0.0075
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0086 0.0605 0.059
Loa Loa (eye worm) hypothetical protein 0.0033 0.0145 0.014
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.5802
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Loa Loa (eye worm) hypothetical protein 0.0038 0.0186 0.018
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.1157 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0075
Toxoplasma gondii hypothetical protein 0.0033 0.0145 0.2013
Leishmania major hypothetical protein, conserved 0.0027 0.009 0.0852
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0048 0.0048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0062 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Echinococcus multilocularis phosphoenolpyruvate carboxykinase 0.1157 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0111 0.1494
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0027 0.009 0.0852
Loa Loa (eye worm) hypothetical protein 0.0049 0.0286 0.028
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.0898 0.0884
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0145 0.013
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0061 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.007 0.0467 0.0462
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0027 0.009 0.009
Giardia lamblia hypothetical protein 0.0027 0.009 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0371 0.0371
Mycobacterium tuberculosis Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase 0.1157 1 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.0384 0.0379
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0015 0.001
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.0898 1
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1914 0.1901
Loa Loa (eye worm) hypothetical protein 0.0034 0.0148 0.0143
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Loa Loa (eye worm) hypothetical protein 0.0527 0.4478 0.4475
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0286 0.0271
Mycobacterium leprae PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE 0.1157 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.026 0.026
Brugia malayi Pre-SET motif family protein 0.003 0.0111 0.0096
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0659 0.0645
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Giardia lamblia Hypothetical protein 0.0027 0.009 0.0075
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0027 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0034 0.0148 0.0148
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.5802
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0062 0.073
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Plasmodium vivax SET domain protein, putative 0.003 0.0111 0.7421
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0027 0.009 0.0852
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0015
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Brugia malayi Bromodomain containing protein 0.0038 0.0185 0.017
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0075
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0015 0.5
Toxoplasma gondii hypothetical protein 0.0092 0.0659 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0061 0.0384 0.0369
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0027 0.009 0.009
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0027 0.009 0.0852
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.1157 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0145 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0164 0.0164
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Leishmania major cAMP-specific phosphodiesterase, putative 0.0027 0.009 0.0852
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0027 0.009 0.009
Echinococcus multilocularis neuropeptide receptor A26 0.0464 0.3925 0.3925
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0027 0.009 0.009
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0898 1
Schistosoma mansoni zinc finger protein 0.0019 0.0022 0.0022
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0075
Brugia malayi PHD-finger family protein 0.0025 0.0068 0.0053
Schistosoma mansoni bromodomain containing protein 0.0063 0.0402 0.0402
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Onchocerca volvulus 0.0235 0.1914 0.216
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0048 0.0048
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0164 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.009 0.009
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0062 0.0533
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0075
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.026 0.026
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0062 0.0047
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.1157 1 1
Brugia malayi phosphoenolpyruvate carboxykinase [GTP] 0.1157 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.026 0.0255
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0062 0.0062
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0062 0.0062
Plasmodium falciparum phosphodiesterase delta, putative 0.0027 0.009 0.5802
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.009 0.5802
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0201
Brugia malayi Bromodomain containing protein 0.0074 0.0504 0.049
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0027 0.009 0.009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0371 0.0371
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0852
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0659 0.0645
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0119 0.0898 0.0898
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0898 1
Giardia lamblia Phosphoenolpyruvate carboxykinase 0.1157 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.009 0.0852
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0062 0.0062
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.6911 0.6911
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0075
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.009 0.009
Onchocerca volvulus 0.0981 0.8456 1
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0062 0.3628
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0119 0.0898 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.0606 0.5171 0.5164
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0027 0.009 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.0981 0.8456 0.8453
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Plasmodium falciparum GAF domain-related protein, putative 0.0033 0.0145 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0119 0.0898 0.0884
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0119 0.0898 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0111 0.0111
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0027 0.009 0.0075
Loa Loa (eye worm) hypothetical protein 0.1157 1 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0062 0.0533
Schistosoma mansoni hypothetical protein 0.002 0.0031 0.0031
Leishmania major hypothetical protein, conserved 0.0027 0.009 0.0852
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.009 0.0852
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0027 0.009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0042 0.0223 0.0218
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0033 0.0145 0.013
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.1663 0.1659
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0062 0.0062
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0086 0.0605 0.059
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0062 0.0047
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0062 0.0057
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0085
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0033 0.0145 0.013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0015 0.0015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0102 0.0102
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0062 0.0062
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0286 0.0271
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.009 0.009
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.5802
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0659 0.0645
Trichomonas vaginalis chaperonin, putative 0.0024 0.0062 0.0047
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0033 0.0145 0.013
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0062 0.3628
Echinococcus granulosus neuropeptide receptor A26 0.0464 0.3925 0.3925
Mycobacterium ulcerans putative regulatory protein 0.0033 0.0145 0.013
Plasmodium vivax phosphodiesterase gamma, putative 0.0027 0.009 0.5802
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0061 0.0384 0.0369
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0027 0.009 0.0852
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0061 0.0384 0.0369
Brugia malayi hypothetical protein 0.043 0.3627 0.3617
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Loa Loa (eye worm) hypothetical protein 0.0555 0.4717 0.4714
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0061 0.0384 0.0384
Brugia malayi Pre-SET motif family protein 0.0207 0.1663 0.1651
Echinococcus granulosus phosphoenolpyruvate carboxykinase 0.1157 1 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Loa Loa (eye worm) phosphoenolpyruvate carboxykinase 0.1157 1 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0119 0.0898 0.0884
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0061 0.0384 0.0369
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0027 0.009 0.009
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.026 0.026
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0062 0.0047
Toxoplasma gondii hypothetical protein 0.0033 0.0145 0.2013
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.009 0.009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.026 0.026
Schistosoma mansoni ap endonuclease 0.0019 0.0015 0.0015
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.1157 1 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0031 0.0026
Schistosoma mansoni phosphoenolpyruvate carboxykinase 0.1157 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.5802
Chlamydia trachomatis phosphoenolpyruvate carboxykinase 0.1157 1 0.5
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.1157 1 1
Echinococcus granulosus zinc finger protein 0.0019 0.0022 0.0022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Treponema pallidum phosphoenolpyruvate carboxykinase 0.1157 1 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0119 0.0898 0.0898
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Toxoplasma gondii GAF domain-containing protein 0.0033 0.0145 0.2013
Loa Loa (eye worm) PDE1B protein 0.0027 0.009 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.5802
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0111 0.0111
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0145 0.013
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0085
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.009 0.0852
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0027 0.009 0.0085
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.009 0.0075
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0027 0.009 0.009
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0555 0.4717 0.4709
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0286 0.028
Echinococcus multilocularis zinc finger protein 0.0019 0.0022 0.0022
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0062 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0027 0.009 0.009
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.009 0.009
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.009 0.1168
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0027 0.009 0.009
Mycobacterium ulcerans phosphoenolpyruvate carboxykinase 0.1157 1 1
Echinococcus multilocularis neuropeptide s receptor 0.0464 0.3925 0.3925
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0062 0.0533
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0048 0.0048
Loa Loa (eye worm) phosphoenolpyruvate carboxykinase cytosolic family member 0.1157 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.009 0.0852
Trichomonas vaginalis phosphoenolpyruvate carboxykinase, putative 0.0981 0.8456 0.8453
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0061 0.0384 0.0369
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.009 0.0852
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0075
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0086 0.0605 0.6677
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0119 0.0898 0.0884

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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