TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 597.747 | Formula: C35H43N5O4
H donors: 4 H acceptors: 3 LogP: 5.1 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: NC(=O)CN1CCN(CC1)C(=O)Oc1ccc2c(c1)c(CCNCCCCc1ccc(cc1)O)c([nH]2)c1cc(C)cc(c1)C
InChi: 1S/C35H43N5O4/c1-24-19-25(2)21-27(20-24)34-30(12-14-37-13-4-3-5-26-6-8-28(41)9-7-26)31-22-29(10-11-32(31)38-34)44-35(43)40-17-15-39(16-18-40)23-33(36)42/h6-11,19-22,37-38,41H,3-5,12-18,23H2,1-2H3,(H2,36,42)
InChiKey: CIEKCFNXAVVFGT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Gonadotropin-releasing hormone receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	GnHR receptor homolog	Get druggable targets OG5_131719	All targets in OG5_131719

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	ORL1-like opioid receptor	Gonadotropin-releasing hormone receptor	327 aa	293 aa	20.8 %
Loa Loa (eye worm)	hypothetical protein	Gonadotropin-releasing hormone receptor	327 aa	334 aa	21.6 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	19.0 %
Echinococcus granulosus	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	284 aa	22.9 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Gonadotropin-releasing hormone receptor	327 aa	263 aa	23.2 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Gonadotropin-releasing hormone receptor	327 aa	343 aa	21.6 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Gonadotropin-releasing hormone receptor	327 aa	305 aa	24.9 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	19.1 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	24.3 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	284 aa	19.4 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	292 aa	19.5 %
Echinococcus multilocularis	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	20.9 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	336 aa	20.8 %
Echinococcus multilocularis	allatostatin A receptor	Gonadotropin-releasing hormone receptor	327 aa	279 aa	23.7 %
Onchocerca volvulus		Gonadotropin-releasing hormone receptor	327 aa	271 aa	20.7 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Gonadotropin-releasing hormone receptor	327 aa	272 aa	23.2 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Gonadotropin-releasing hormone receptor	327 aa	290 aa	19.7 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Gonadotropin-releasing hormone receptor	327 aa	288 aa	27.8 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Gonadotropin-releasing hormone receptor	327 aa	283 aa	20.1 %
Schistosoma mansoni	neuropeptide receptor	Gonadotropin-releasing hormone receptor	327 aa	263 aa	24.0 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Gonadotropin-releasing hormone receptor	327 aa	273 aa	19.8 %
Echinococcus granulosus	tm gpcr rhodopsin	Gonadotropin-releasing hormone receptor	327 aa	299 aa	23.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	putative S-adenosyl-L-homocysteine hydrolase SahH	0.0131	0.082	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.017	0.1356	0.5077
Loa Loa (eye worm)	phosphatidylinositol 3	0.0099	0.0388	0.0499
Onchocerca volvulus		0.0641	0.7771	1
Brugia malayi	phosphofructokinase	0.0108	0.0505	0.065
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0099	0.0388	0.1377
Mycobacterium leprae	conserved hypothetical protein	0.0099	0.0388	0.3747
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0176	0.1437	1
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0162	0.1241	0.4474
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0131	0.082	0.2268
Entamoeba histolytica	hypothetical protein	0.0099	0.0388	0.1377
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0505	0.1906
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0641	0.7771	1
Leishmania major	S-adenosylhomocysteine hydrolase	0.0131	0.082	0.2268
Entamoeba histolytica	adenosylhomocysteinase, putative	0.0131	0.082	0.3333
Entamoeba histolytica	hypothetical protein	0.0099	0.0388	0.1377
Echinococcus granulosus	thymidylate synthase	0.0105	0.0463	0.0102
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0505	0.0614
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.2294	1
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0505	0.065
Toxoplasma gondii	adenosylhomocysteinase, putative	0.0131	0.082	0.3404
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.6121
Giardia lamblia	Phosphatidylinositol 4-kinase	0.017	0.1356	0.9227
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.2294	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0176	0.1437	0.5502
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0099	0.0388	0.0294
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0105	0.0463	0.4831
Toxoplasma gondii	S-Adenosyl homocysteine hydrolase	0.0131	0.082	0.3404
Brugia malayi	6-phosphofructokinase	0.0108	0.0505	0.065
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0099	0.0388	0.1377
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0099	0.0388	0.0499
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0176	0.1437	0.5502
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0099	0.0388	0.0499
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0099	0.0388	0.1377
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0105	0.0463	0.0383
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.6121
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0239	0.2294	1
Loa Loa (eye worm)	adenosylhomocysteinase	0.0131	0.082	0.1056
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0641	0.7771	0.7681
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0148	0.1045	0.6267
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0247	0.2404	1
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0148	0.1045	0.3448
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0505	0.0614
Loa Loa (eye worm)	phosphatidylinositol 3	0.0099	0.0388	0.0499
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.017	0.1356	0.1441
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.017	0.1356	0.9227
Trichomonas vaginalis	DNA-3-methyladenine glycosylase, putative	0.0162	0.1241	0.4474
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0641	0.7771	1
Echinococcus multilocularis	Zinc finger, PHD finger	0.0176	0.1437	0.1091
Onchocerca volvulus		0.0105	0.0463	0.0596
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0176	0.1437	0.142
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0099	0.0388	0.1377
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0176	0.1437	0.5502
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0176	0.1437	0.142
Brugia malayi	Adenosylhomocysteinase	0.0131	0.082	0.1056
Brugia malayi	GnHR receptor homolog	0.0575	0.6867	0.8837
Echinococcus multilocularis	6 phosphofructokinase	0.0108	0.0505	0.0122
Entamoeba histolytica	protein kinase rad3, putative	0.0099	0.0388	0.1377
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0131	0.082	0.3333
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0239	0.2294	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0099	0.0388	0.1377
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.017	0.1356	0.5755
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0099	0.0388	0.1377
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0099	0.0388	0.1377
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0239	0.2294	0.2553
Loa Loa (eye worm)	phosphatidylinositol 3	0.0176	0.1437	0.1849
Mycobacterium ulcerans	6-phosphofructokinase	0.0108	0.0505	0.054
Brugia malayi	6-phosphofructokinase	0.0108	0.0505	0.065
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0176	0.1437	0.5502
Loa Loa (eye worm)	6-phosphofructokinase	0.0108	0.0505	0.065
Trypanosoma cruzi	S-adenosylhomocysteine hydrolase, putative	0.0131	0.082	0.3333
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0388	0.0499
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0176	0.1437	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0099	0.0388	0.0499
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.0182	0.1517	0.1953
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0108	0.0505	0.5
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.017	0.1356	0.9227
Plasmodium vivax	adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative	0.0131	0.082	0.4123
Mycobacterium ulcerans	DNA-3-methyladenine glycosylase I TagA	0.0162	0.1241	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0099	0.0388	0.1377
Echinococcus multilocularis	thymidylate synthase	0.0105	0.0463	0.0078
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.037	0.4075	0.5244
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0148	0.1045	0.4341
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0148	0.1045	0.435
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0641	0.7771	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0099	0.0388	0.0499
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	1
Loa Loa (eye worm)	thymidylate synthase	0.0105	0.0463	0.0596
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0239	0.2294	0.2581
Brugia malayi	thymidylate synthase	0.0105	0.0463	0.0596
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.017	0.1356	0.1311
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0505	0.0614
Plasmodium falciparum	adenosylhomocysteinase	0.0131	0.082	0.4123
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0176	0.1437	0.1849
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.6121
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0176	0.1437	0.142
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0505	0.0433
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0108	0.0505	0.5439
Loa Loa (eye worm)	phosphatidylinositol 3	0.0641	0.7771	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0099	0.0388	0.1377
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0505	0.1906
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0099	0.0388	0.1377
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0108	0.0505	0.5439
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0176	0.1437	0.1091
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0176	0.1437	0.6121
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0176	0.1437	0.5502
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0176	0.1437	0.6121
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0176	0.1437	0.6121
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0176	0.1437	0.1091
Echinococcus multilocularis	peptidyl glycine alpha amidating monooxygenase	0.037	0.4075	0.3836
Entamoeba histolytica	hypothetical protein	0.0176	0.1437	0.6121
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0099	0.0388	0.0294
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0176	0.1437	0.5502
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0105	0.0463	0.4831
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein	0.037	0.4075	0.5244
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0176	0.1437	0.1537
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0099	0.0388	0.1377
Schistosoma mansoni	dopamine-beta-monooxygenase	0.07	0.8577	1
Brugia malayi	Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein	0.0188	0.1593	0.2049
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.5502
Schistosoma mansoni	peptidyl-glycine monooxygenase	0.037	0.4075	0.4664
Echinococcus granulosus	peptidyl glycine alpha amidating monooxygenase	0.037	0.4075	0.4994
Loa Loa (eye worm)	phosphofructokinase	0.0108	0.0505	0.065
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0176	0.1437	0.1537
Trypanosoma brucei	S-adenosylhomocysteine hydrolase, putative	0.0131	0.082	0.2268
Entamoeba histolytica	hypothetical protein	0.0099	0.0388	0.1377
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0239	0.2294	1
Trichomonas vaginalis	adenosylhomocysteinase, putative	0.0131	0.082	0.2268
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.017	0.1356	0.1744
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0176	0.1437	0.5971
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0148	0.1045	0.6267
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0176	0.1437	0.1849
Loa Loa (eye worm)	phosphatidylinositol 3	0.0077	0.0084	0.0108
Toxoplasma gondii	FATC domain-containing protein	0.0099	0.0388	0.1604
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.5502
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0176	0.1437	0.1849
Echinococcus granulosus	6 phosphofructokinase	0.0108	0.0505	0.0158
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0099	0.0388	0.1604
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0505	0.0614
Mycobacterium ulcerans	S-adenosyl-L-homocysteine hydrolase	0.0131	0.082	0.4595
Schistosoma mansoni	6-phosphofructokinase	0.0108	0.0505	0.0433
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.2294	1
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0641	0.7771	0.7681
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0641	0.7771	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0176	0.1437	0.6121
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0641	0.7771	0.9045
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0099	0.0388	0.3747
Schistosoma mansoni	adenosylhomocysteinase	0.0131	0.082	0.0806
Entamoeba histolytica	hypothetical protein	0.0099	0.0388	0.1377
Mycobacterium tuberculosis	Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase)	0.0131	0.082	1
Entamoeba histolytica	phosphofructokinase, putative	0.0108	0.0505	0.1906
Echinococcus granulosus	adenosylhomocysteinase	0.0131	0.082	0.0586
Loa Loa (eye worm)	hypothetical protein	0.0641	0.7771	1
Schistosoma mansoni	peptidylglycine monooxygenase	0.037	0.4075	0.4664
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0099	0.0388	0.0294
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0641	0.7771	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0176	0.1437	0.1537
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0239	0.2294	0.2952
Echinococcus multilocularis		0.017	0.1356	0.1007
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0388	0.0499
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0148	0.1045	0.3448
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1437	0.1849
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0176	0.1437	0.5502
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0099	0.0388	0.1604
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0239	0.2294	0.2952
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0099	0.0388	0.0294
Leishmania major	phosphatidylinositol 4-kinase, putative	0.017	0.1356	0.5077
Loa Loa (eye worm)	phosphatidylinositol 3	0.0641	0.7771	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.017	0.1356	0.1744
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0239	0.2294	0.1983
Loa Loa (eye worm)	cyclin domain-containing protein	0.0254	0.2502	0.3219
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0176	0.1437	0.5502
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.017	0.1356	0.5755
Trypanosoma cruzi	target of rapamycin kinase 3	0.0099	0.0388	0.1377
Loa Loa (eye worm)	hypothetical protein	0.037	0.4075	0.5244
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0176	0.1437	0.5502
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.6121
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0108	0.0505	0.1906
Leishmania major	ATP-dependent phosphofructokinase	0.0108	0.0505	0.0614
Onchocerca volvulus		0.0641	0.7771	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.2294	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0099	0.0388	0.0294
Loa Loa (eye worm)	hypothetical protein	0.037	0.4075	0.5244
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0176	0.1437	0.6121
Schistosoma mansoni	hypothetical protein	0.0099	0.0388	0.0294
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0099	0.0388	0.0499
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0099	0.0388	0.1377
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0254	0.2502	0.3219
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0162	0.1245	0.5174
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0099	0.0388	0.1377
Echinococcus multilocularis	adenosylhomocysteinase	0.0131	0.082	0.045
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0099	0.0388	0.1604
Trichomonas vaginalis	phosphofructokinase, putative	0.0108	0.0505	0.0614
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0099	0.0388	0.1604

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 27 nM	Binding affinity to rat Gonadotropin-releasing hormone receptor.	ChEMBL.	11229760
IC50 (binding)	= 27 nM	Binding affinity to rat Gonadotropin-releasing hormone receptor.	ChEMBL.	11229760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 255360