TDR Targets

Basic information

Technical information

TDR Targets ID: 1290087
Name: 9-(3-bromo-4-hydroxyphenyl)-10-phenyl-3,4,6,7 ,9,10-hexahydro-1,8(2H,5H)-acridinedione
MW: 464.351 | Formula: C25H22BrNO3
H donors: 1 H acceptors: 3 LogP: 4.35 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCC2=C1C(c1ccc(c(c1)Br)O)C1=C(N2c2ccccc2)CCCC1=O
InChi: 1S/C25H22BrNO3/c26-17-14-15(12-13-20(17)28)23-24-18(8-4-10-21(24)29)27(16-6-2-1-3-7-16)19-9-5-11-22(30)25(19)23/h1-3,6-7,12-14,23,28H,4-5,8-11H2
InChiKey: WYYRSVLMNFELDT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

MLS000621718
SMR000299445
ZINC01134192

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	neuropeptide S receptor 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	neuropeptide s receptor	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Get druggable targets OG5_136011	All targets in OG5_136011
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	neuropeptide receptor A26	Get druggable targets OG5_136011	All targets in OG5_136011
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0019	0.017	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Schistosoma mansoni	dishevelled	0.0019	0.0174	0.1376
Brugia malayi	MH2 domain containing protein	0.0018	0.0144	0.0207
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.017	0.0098
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0019	0.017	0.5
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0174	0.0102
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0144	0.1015
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.5027	0.499
Echinococcus multilocularis	smad	0.0018	0.0144	0.0072
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0829	0.0762
Schistosoma mansoni	Smad4	0.0018	0.0144	0.1015
Echinococcus granulosus	segment polarity protein dishevelled	0.0019	0.0174	0.0102
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0019	0.0174	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0073	0.0104
Loa Loa (eye worm)	MH2 domain-containing protein	0.0259	0.4549	0.6527
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0018	0.0144	0.0072
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0014	0.0073	0.0104
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.0174	0.1376
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.017	1
Echinococcus granulosus	segment polarity protein dishevelled	0.0019	0.0174	0.0102
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0014	0.0073	0.5
Echinococcus multilocularis	isocitrate dehydrogenase	0.0019	0.017	0.0098
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.5027	0.499
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0174	0.0249
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0829	0.9334
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0174	0.0249
Brugia malayi	DIX domain containing protein	0.0019	0.0174	0.0249
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0073	0.0149
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0144	0.1015
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0018	0.0144	0.0072
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0014	0.0073	0.5
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0073	0.0104
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Echinococcus granulosus	Smad4	0.0018	0.0144	0.0072
Loa Loa (eye worm)	DIX domain-containing protein	0.0019	0.0174	0.0249
Echinococcus multilocularis	segment polarity protein dishevelled	0.0019	0.0174	0.0102
Brugia malayi	MH2 domain containing protein	0.0018	0.0144	0.0207
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0019	0.0174	0.0146
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0883	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0392	0.697	1
Brugia malayi	hypothetical protein	0.0286	0.5027	0.7211
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0019	0.0174	0.0102
Toxoplasma gondii	hypothetical protein	0.0019	0.0174	1
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0019	0.0174	0.0102
Schistosoma mansoni	ras GTP exchange factor	0.0014	0.0073	0.0149
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.017	0.5
Schistosoma mansoni	dishevelled	0.0019	0.0174	0.1376
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.0174	0.0249
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0014	0.0073	0.5
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0019	0.017	0.0098
Schistosoma mansoni	dep domain containing protein	0.0019	0.0174	0.1376
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0883	0.1267
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0014	0.0073	0.0104
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0019	0.017	0.5
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.017	0.0098
Echinococcus multilocularis	Smad4	0.0018	0.0144	0.0072
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0019	0.017	0.5
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0019	0.017	0.1327
Onchocerca volvulus		0.0058	0.0883	0.1175
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0018	0.0144	0.0072
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0.017	0.5
Brugia malayi	MH1 domain containing protein	0.0018	0.0144	0.0207
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0073	0.0149
Brugia malayi	isocitrate dehydrogenase	0.0019	0.017	0.0243
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0014	0.0073	0.0104
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Brugia malayi	N-terminal motif family protein	0.0392	0.697	1
Brugia malayi	hypothetical protein	0.0019	0.0174	0.0249
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0019	0.0174	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0286	0.5027	0.7211
Entamoeba histolytica	hypothetical protein	0.0014	0.0073	0.5
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0019	0.0174	0.0249
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0019	0.017	0.0098
Loa Loa (eye worm)	MH1 domain-containing protein	0.0018	0.0144	0.0207
Brugia malayi	MH1 domain containing protein	0.0018	0.0144	0.0207
Brugia malayi	RasGEF domain containing protein	0.0014	0.0073	0.0104
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0829	0.0762
Brugia malayi	MH2 domain containing protein	0.0259	0.4549	0.6527
Loa Loa (eye worm)	MH2 domain-containing protein	0.0018	0.0144	0.0207
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0174	0.0102
Brugia malayi	hypothetical protein	0.0019	0.0174	0.0249
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0018	0.0144	0.1015
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Brugia malayi	N-terminal motif family protein	0.0014	0.0073	0.0104
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0829	0.1189
Brugia malayi	Isocitrate dehydrogenase	0.0019	0.017	0.0243
Echinococcus multilocularis	segment polarity protein dishevelled	0.0019	0.0174	0.0102
Schistosoma mansoni	smad	0.0018	0.0144	0.1015
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.0174	0.0249
Echinococcus granulosus	smad	0.0018	0.0144	0.0072
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0829	0.0762
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0014	0.0073	0.0149
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0829	0.1189
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Brugia malayi	Smad1	0.0018	0.0144	0.0207
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0019	0.017	0.0098
Echinococcus granulosus	mothers against decapentaplegic 5	0.0018	0.0144	0.0072
Brugia malayi	N-terminal motif family protein	0.0014	0.0073	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0174	0.0249
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0829	0.0762
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.0174	0.1376
Schistosoma mansoni	smad1 5 8 and	0.0018	0.0144	0.1015
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.0174	0.0102
Loa Loa (eye worm)	transcription factor SMAD2	0.0259	0.4549	0.6527
Loa Loa (eye worm)	Smad1	0.0018	0.0144	0.0207
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0014	0.0073	0.0149
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0019	0.017	0.0243
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Brugia malayi	RasGEF domain containing protein	0.0014	0.0073	0.0104
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0829	0.9334
Loa Loa (eye worm)	hypothetical protein	0.0392	0.697	1
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.0174	0.0102
Schistosoma mansoni	hypothetical protein	0.0058	0.0883	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0829	0.9334
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0014	0.0073	0.5
Onchocerca volvulus		0.0019	0.0174	0.0146
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0019	0.017	0.5
Brugia malayi	RasGEF domain containing protein	0.0014	0.0073	0.0104

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 4.4668 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.6892 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Muscle isoform 2 Pyruvate Kinase. (Class of assay: confirmatory) [Related pubchem assays: 1379 ]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	125.8925 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1391246

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1290087