Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tubulin subunit delta | 0.0102 | 0.3953 | 0.3953 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0012 | 0.0012 |
Trichomonas vaginalis | tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.4611 | 0.4611 |
Schistosoma mansoni | tubulin subunit beta | 0.0102 | 0.3953 | 0.3953 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0132 | 0.5359 | 0.2326 |
Mycobacterium tuberculosis | Cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.3589 | 0.3589 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3907 | 0.3907 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0101 | 0.3907 | 0.3907 |
Brugia malayi | Tubulin alpha chain | 0.0102 | 0.3953 | 0.3953 |
Wolbachia endosymbiont of Brugia malayi | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Onchocerca volvulus | 0.0132 | 0.5359 | 1 | |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.5359 | 0.5359 |
Brugia malayi | Cation transporter family protein | 0.0101 | 0.3907 | 0.3907 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0132 | 0.5359 | 0.2326 |
Echinococcus granulosus | tubulin delta chain | 0.0102 | 0.3953 | 0.3953 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0824 | 0.0824 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.4611 | 0.4611 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1525 | 0.1525 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0132 | 0.5359 | 0.5359 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0012 | 0.0012 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Loa Loa (eye worm) | tubulin beta chain | 0.0102 | 0.3953 | 0.3953 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0132 | 0.5359 | 0.2326 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0012 | 0.0012 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Brugia malayi | Cell division protein ftsZ | 0.0102 | 0.3953 | 0.3953 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.3907 | 0.3907 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0012 | 0.0012 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Schistosoma mansoni | tubulin subunit alpha | 0.0102 | 0.3953 | 0.3953 |
Brugia malayi | Tubulin beta chain | 0.0132 | 0.5359 | 0.5359 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1525 | 0.1525 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.4611 | 0.4611 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0824 | 0.0824 |
Trichomonas vaginalis | tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0101 | 0.3907 | 0.3907 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0824 | 0.0824 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0012 | 0.0012 |
Trypanosoma brucei | alpha tubulin, putative | 0.0132 | 0.5359 | 0.2326 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0102 | 0.3953 | 0.3953 |
Mycobacterium ulcerans | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Treponema pallidum | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0132 | 0.5359 | 0.5359 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.5359 | 0.5359 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0132 | 0.5359 | 0.2326 |
Onchocerca volvulus | 0.0101 | 0.3907 | 0.7289 | |
Brugia malayi | Tubulin beta chain | 0.0102 | 0.3953 | 0.3953 |
Mycobacterium leprae | cell division protein FtsZ | 0.0102 | 0.3953 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.3953 | 0.3953 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0012 | 0.0012 |
Echinococcus multilocularis | tubulin delta chain | 0.0102 | 0.3953 | 0.3953 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 6.04 | Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR | ChEMBL. | 23083093 |
Emax (functional) | > 90 % | Agonist activity at rat alpha7 nAchR expressed in rat GH4C1 cells assessed as stimulation of calcium flux by FLIPR relative to nicotine | ChEMBL. | 23083093 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.