Target list

Search results for query: T. brucei targets - composite weighted query (DSR)

  • Score for genes in query #2 (T. brucei enzymes): 100
  • Score for genes in query #6 (T. brucei, NOT human): 25
  • Score for genes in query #29 (Druggability precedent (>0.6)): 35
  • Score for genes in query #7 (Essential (in any organism)): 40
  • Score for genes in query #30 (Compound desirability (>0.3)): 35
  • Score for genes in query #36 (T. brucei 3D structures): 50
  • Score for genes in query #27 (T. brucei <100kDa): 20
  • Score for genes in query #33 (T. brucei no TM domains): 20
  • Score for genes in query #4 (T. brucei models): 30
  • Score for genes in query #35 (T. brucei lethal (KO or KD)): 50
  • Score for genes in query #34 (T. brucei published): 35
  • Score for genes in query #5 (Present in all TriTryps): 25

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8361 records found | Showing page 3 of 335 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. brucei   Tb927.7.2420   OG5_161869   glycogen synthase kinase-3 alpha, putative 325
T. brucei   Tb927.11.8170   OG5_143121   Mitogen-activated protein kinase 8, putative 325
T. brucei   Tb927.11.5360   OG5_150082   aldo/keto reductase, putative 325
T. brucei   Tb927.3.4670   OG5_151756   cdc2-related kinase 10, putative 325
T. brucei   Tb927.11.5340   OG5_148668   Cell division protein kinase, putative 325
T. brucei   Tb927.10.10390   OG5_126785   trypanothione reductase 320
T. brucei   Tb11.v5.0356   OG5_126851   cytidine triphosphate synthase, putative 320
T. brucei   Tb927.4.1330   OG5_127702   DNA topoisomerase IB, large subunit 320
T. brucei   Tb927.3.3270   OG5_126758   ATP-dependent 6-phosphofructokinase, glycosomal 320
T. brucei   Tb927.11.5520   OG5_127002   triosephosphate isomerase 320
T. brucei   Tb927.6.4410   OG5_128279   S-adenosylmethionine decarboxylase 315
T. brucei   Tb427.10.6950     No group sterol 24-c-methyltransferase, putative 310
T. brucei   Tb927.1.870   OG5_127351   deoxyhypusine synthase 305
T. brucei   Tb927.10.14070   OG5_128252   mevalonate diphosphate decarboxylase 305
T. brucei   Tb927.11.7840   OG5_126839   ribonucleoside-diphosphate reductase large chain 305
T. brucei   Tb927.10.13560   OG5_128252   mevalonate-diphosphate decarboxylase 305
T. brucei   Tb927.9.4360   OG5_145811   KREL1 305
T. brucei   Tb927.11.9590   OG5_127233   S-adenosylhomocysteine hydrolase, putative 305
T. brucei   Tb927.11.8220   OG5_127024   aurora B kinase 305
T. brucei   Tb927.10.1500   OG5_127468   methionyl-tRNA synthetase, putative 305
T. brucei   Tb927.4.1950   OG5_128819   NADPH-dependent diflavin oxidoreductase 1 305
T. brucei   Tb927.11.12800   OG5_126823   ribonucleoside-diphosphate reductase small chain 305
T. brucei   Tb927.10.3210   OG5_128522   delta-1-pyrroline-5-carboxylate dehydrogenase, putative 305
T. brucei   Tb927.10.13630   OG5_126880   glucosidase, putative 305
T. brucei   Tb927.10.2560   OG5_127145   mitochondrial malate dehydrogenase 305

Showing page 3 (records 51-75) of 335