pI: 4.7149 |
Length (AA): 490 |
MW (Da): 52005 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
17 | 489 | 1kbl (A) | 3 | 535 | 40.00 | 0 | 1 | 1.34911 | -0.32 |
23 | 489 | 1vbg (A) | 14 | 538 | 39.00 | 0 | 1 | 1.30586 | -0.11 |
369 | 463 | 3t05 (A) | 487 | 580 | 30.00 | 0.98 | 0.99 | 0.609678 | -0.37 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Dormant phase. | murphy |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Dormant phase. | hasan |
murphy | Identification of gene targets against dormant phase Mycobacterium tuberculosis infections. |
hasan | Prioritizing genomic drug targets in pathogens: application to Mycobacterium tuberculosis. |
Ortholog group members (OG5_127082)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G15530 | pyruvate, phosphate dikinase 1 |
Caenorhabditis elegans | CELE_T21C9.6 | Protein T21C9.6 |
Chlamydia trachomatis | CT_336 | PTS system PEP phosphotransferase |
Escherichia coli | b2416 | PEP-protein phosphotransferase of PTS system (enzyme I) |
Escherichia coli | b1702 | phosphoenolpyruvate synthase |
Escherichia coli | b2829 | fused PTS enzyme: PEP-protein phosphotransferase (enzyme I)/GAF domain containing protein |
Entamoeba histolytica | EHI_009530 | pyruvate phosphate dikinase |
Giardia lamblia | GL50803_9909 | Pyruvate, phosphate dikinase |
Leishmania braziliensis | LbrM.11.0800 | pyruvate phosphate dikinase, putative |
Leishmania donovani | LdBPK_111000.1 | pyruvate phosphate dikinase, putative |
Leishmania infantum | LinJ.11.1000 | pyruvate phosphate dikinase, putative |
Leishmania major | LmjF.11.1000 | pyruvate phosphate dikinase, putative |
Leishmania mexicana | LmxM.11.1000 | pyruvate phosphate dikinase, putative |
Mycobacterium leprae | ML0955c | PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK |
Mycobacterium tuberculosis | Rv1127c | Probable pyruvate, phosphate dikinase PpdK |
Mycobacterium ulcerans | MUL_0141 | pyruvate phosphate dikinase |
Oryza sativa | 4333181 | Os03g0432100 |
Oryza sativa | 4338750 | Os05g0405000 |
Schistosoma mansoni | Smp_113420 | pyruvate phosphate dikinase chloroplast |
Schmidtea mediterranea | mk4.000245.11 | |
Schmidtea mediterranea | mk4.034972.02 | |
Trypanosoma brucei gambiense | Tbg972.11.7080 | pyruvate phosphate dikinase, putative |
Trypanosoma brucei | Tb927.11.6280 | pyruvate phosphate dikinase |
Trypanosoma congolense | TcIL3000.11.6820 | pyruvate phosphate dikinase |
Trypanosoma cruzi | TcCLB.506297.190 | pyruvate phosphate dikinase, putative |
Trypanosoma cruzi | TcCLB.510101.140 | pyruvate phosphate dikinase, putative |
Treponema pallidum | TP0746 | pyruvate phosphate dikinase |
Trichomonas vaginalis | TVAG_585300 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_437410 | phosphoenolpyruvate-protein phosphotransferase, putative |
Trichomonas vaginalis | TVAG_073860 | phosphoenolpyruvate-protein phosphotransferase, putative |
Trichomonas vaginalis | TVAG_394650 | phosphoenolpyruvate-protein phosphotransferase, putative |
Trichomonas vaginalis | TVAG_178140 | phosphoenolpyruvate-protein phosphotransferase, putative |
Trichomonas vaginalis | TVAG_161270 | pyruvate, phosphate dikinase, chloroplast, putative |
Trichomonas vaginalis | TVAG_527480 | pyruvate, phosphate dikinase, chloroplast, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0209 | pyruvate phosphate dikinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1147 this record | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb11.02.4150 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.4150 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.4150 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.4150 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1702 | Escherichia coli | non-essential | goodall |
b2416 | Escherichia coli | essential | goodall |
b2829 | Escherichia coli | non-essential | goodall |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.