TDR Targets

Basic information

Technical information

TDR Targets ID: 1411215
Name: (E)-3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano- N-(oxolan-2-ylmethyl)prop-2-enamide
MW: 379.205 | Formula: C16H15BrN2O4
H donors: 1 H acceptors: 2 LogP: 2.46 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N#C/C(=C\c1cc2OCOc2cc1Br)/C(=O)NCC1CCCO1
InChi: 1S/C16H15BrN2O4/c17-13-6-15-14(22-9-23-15)5-10(13)4-11(7-18)16(20)19-8-12-2-1-3-21-12/h4-6,12H,1-3,8-9H2,(H,19,20)/b11-4+
InChiKey: APRXORKCNSEWGN-NYYWCZLTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(oxolan-2-ylmethyl)prop-2-enamide
(E)-3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(tetrahydrofuran-2-ylmethyl)prop-2-enamide
3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(tetrahydrofuran-2-ylmethyl)prop-2-enamide
3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(2-tetrahydrofuranylmethyl)prop-2-enamide
(E)-3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(2-tetrahydrofuranylmethyl)prop-2-enamide
3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(tetrahydrofurfuryl)acrylamide
(E)-3-(6-bromo-1,3-benzodioxol-5-yl)-2-cyano-N-(tetrahydrofurfuryl)acrylamide
(E)-3-(6-Bromo-benzo[1,3]dioxol-5-yl)-2-cyano-N-(tetrahydro-furan-2-ylmethyl)-acrylamide
MLS000779567
SMR000419751
STK182571

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	esterase, putative	0.0037	0.0306	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0702	0.6956	0.6955
Echinococcus granulosus	pyruvate kinase	0.1006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0181	0.0178
Trypanosoma brucei	pyruvate phosphate dikinase	0.0421	0.4147	0.4141
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0061	0.0058
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0012	0.0008
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0585	0.0582
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0181	0.0171
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.01	0.0097
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0061	0.0058
Trypanosoma cruzi	pyruvate kinase 2, putative	0.1006	1	1
Plasmodium falciparum	pyruvate kinase 2	0.0516	0.5103	0.5098
Plasmodium vivax	pyruvate kinase, putative	0.1006	1	1
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0883	0.088
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0306	0.0301
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.011	0.011
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0061	0.0058
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0306	0.0297
Echinococcus granulosus	pyruvate kinase	0.0516	0.5103	0.5101
Echinococcus multilocularis	pyruvate kinase	0.0794	0.788	0.788
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0181	0.0181
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.0554	0.0545
Echinococcus multilocularis	dnaJ subfamily B	0.0417	0.4113	0.4111
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0016	0.01	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0061	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0018	0.012	0.0116
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0306	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0007
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0554	0.0545
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0061	0.0058
Echinococcus granulosus	pyruvate kinase	0.0516	0.5103	0.5101
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0061	0.0058
Plasmodium vivax	pyruvate kinase 2, putative	0.0516	0.5103	0.5098
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0585	0.0582
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.0554	0.0545
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.003	0.0026
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.0061	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0467	0.0464
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0232	0.0229
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0306	0.0301
Mycobacterium ulcerans	hypothetical protein	0.0421	0.4147	0.4141
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0012	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Loa Loa (eye worm)	pyruvate kinase	0.1006	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0306	0.0306
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0061	0.0058
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0306	0.0301
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0061	0.0058
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.01	0.0097
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.01	0.0097
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0181	0.0171
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0181	0.0178
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0306	0.0297
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0421	0.4147	0.4147
Schistosoma mansoni	coup transcription factor	0.0012	0.0061	0.0058
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.01	0.009
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0061	0.0058
Brugia malayi	RNA binding protein	0.0065	0.0585	0.0582
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.0944	0.0941
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0061	0.0058
Treponema pallidum	pyruvate phosphate dikinase	0.0421	0.4147	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0012	0.0008
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0585	0.0582
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0306	0.0297
Leishmania major	pyruvate phosphate dikinase, putative	0.0421	0.4147	0.4141
Loa Loa (eye worm)	hypothetical protein	0.0018	0.012	0.0116
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0012	0.0008
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.01	0.009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0061	0.0058
Loa Loa (eye worm)	oxidoreductase	0.0007	0.001	0.0007
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0061	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0585	0.0582
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.01	0.009
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0306	0.0306
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.01	0.0097
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0016	0.01	0.009
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0061	0.0058
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.01	0.0097
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0061	0.0058
Echinococcus granulosus	expressed conserved protein	0.0094	0.0883	0.088
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0181	0.0171
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0061	0.0058
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0061	0.0058
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0306	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.001	0.001
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0181	0.0246
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0061	0.0058
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0061	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0585	0.0582
Onchocerca volvulus		0.0037	0.0306	0.0297
Loa Loa (eye worm)	hypothetical protein	0.1006	1	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0061	0.0058
Trypanosoma brucei	pyruvate kinase 1	0.1006	1	1
Onchocerca volvulus		0.0037	0.0306	0.0297
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0585	0.0582
Trichomonas vaginalis	pyruvate kinase, putative	0.1006	1	1
Echinococcus multilocularis	geminin	0.0205	0.1986	0.1983
Loa Loa (eye worm)	pyruvate kinase	0.1006	1	1
Echinococcus granulosus	pyruvate kinase	0.1006	1	1
Schistosoma mansoni	patched 1	0.0043	0.037	0.0367
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.012	0.011
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.01	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0043	0.037	0.0367
Schistosoma mansoni	hypothetical protein	0.0205	0.1986	0.1983
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0306	0.0297
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0061	0.0058
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0554	0.0549
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0306	0.0306
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.01	0.009
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0306	0.0303
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.0944	0.1344
Echinococcus granulosus	Niemann Pick C1 protein	0.0144	0.1375	0.1372
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.01	0.0097
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0554	0.0549
Schistosoma mansoni	hypothetical protein	0.0042	0.0354	0.0351
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0554	0.0551
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0181	0.0178
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0306	0.0306
Mycobacterium tuberculosis	Probable pyruvate, phosphate dikinase PpdK	0.0421	0.4147	0.4147
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0296	0.0292
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0181	0.0171
Onchocerca volvulus	Pyruvate kinase homolog	0.1006	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.012	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Mycobacterium ulcerans	lipase LipD	0.0037	0.0306	0.0297
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0306	0.0303
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0181	0.0246
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0306	0.0297
Brugia malayi	ecdysteroid receptor	0.0012	0.0061	0.0058
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.0061	0.0051
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0296	0.0292
Mycobacterium leprae	Probable lipase LipE	0.0037	0.0306	0.0297
Brugia malayi	TAR-binding protein	0.0065	0.0585	0.0582
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0028	0.0025
Mycobacterium ulcerans	pyruvate kinase	0.1006	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0585	0.0582
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.037	0.0365
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0296	0.0291
Schistosoma mansoni	hypothetical protein	0.0042	0.0354	0.0351
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0306	0.0306
Brugia malayi	beta-NAC-like protein	0.0036	0.0296	0.0292
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0061	0.0058
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.0554	0.0545
Brugia malayi	nuclear hormone receptor	0.0012	0.0061	0.0058
Trypanosoma cruzi	pyruvate phosphate dikinase, putative	0.0421	0.4147	0.4141
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.0421	0.4147	0.4144
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0554	0.0549
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.0554	0.0549
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.011	0.011
Onchocerca volvulus		0.0012	0.0061	0.0051
Wolbachia endosymbiont of Brugia malayi	pyruvate phosphate dikinase	0.0421	0.4147	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0061	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.001	0.001
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.037	0.0367
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0061	0.0058
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0181	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0007
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0306	0.0303
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.001	0.0007
Chlamydia trachomatis	pyruvate kinase	0.1006	1	1
Brugia malayi	beta-lactamase family protein	0.0037	0.0306	0.0303
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0235	0.2286	0.2286
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Toxoplasma gondii	pyruvate kinase PyK1	0.1006	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.1006	1	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0306	0.0306
Brugia malayi	steroid hormone receptor	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0306	0.0306
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0181	0.0171
Brugia malayi	beta-lactamase family protein	0.0037	0.0306	0.0303
Brugia malayi	Pyruvate kinase, M2 isozyme	0.1006	1	1
Toxoplasma gondii	pyruvate kinase PyKII	0.0516	0.5103	0.5098
Brugia malayi	Pyruvate kinase, alpha/beta domain containing protein	0.0304	0.2983	0.2981
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0306	0.0297
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0296	0.0286
Schistosoma mansoni	pyruvate kinase	0.1006	1	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0306	0.0306
Schistosoma mansoni	pyruvate kinase	0.1006	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0061	0.0058
Leishmania major	basic transcription factor 3a, putative	0.0036	0.0296	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0585	0.0582
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0061	0.0058
Echinococcus multilocularis	pyruvate kinase	0.0516	0.5103	0.5101
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.0554	0.0545
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.001	0.0007
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.001	0.001
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0061	0.0058
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0061	0.0058
Mycobacterium ulcerans	pyruvate phosphate dikinase	0.0421	0.4147	0.4141
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.01	0.0097
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0102	0.0959	0.0956
Onchocerca volvulus		0.0037	0.0306	0.0297
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.001	0.001
Schistosoma mansoni	cpg binding protein	0.0031	0.0249	0.0245
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0306	0.0303
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0306	0.0301
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.01	0.0097
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0061	0.0058
Giardia lamblia	Pyruvate, phosphate dikinase	0.0421	0.4147	0.3804
Echinococcus multilocularis	cpg binding protein	0.0031	0.0249	0.0245
Entamoeba histolytica	pyruvate phosphate dikinase	0.0421	0.4147	0.5957
Echinococcus multilocularis	pyruvate kinase	0.0516	0.5103	0.5101
Onchocerca volvulus		0.0024	0.0181	0.0171
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.0421	0.4147	0.4144
Schistosoma mansoni	hypothetical protein	0.0417	0.4113	0.4111
Mycobacterium leprae	PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK	0.0421	0.4147	0.4141
Brugia malayi	CHE-14 protein	0.0043	0.037	0.0367
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0061	0.0058
Trichomonas vaginalis	pyruvate kinase, putative	0.1006	1	1
Echinococcus multilocularis	pyruvate kinase	0.1006	1	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0005
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0181	0.0178
Giardia lamblia	Pyruvate kinase	0.1006	1	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.0944	0.0941
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0232	0.0229
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.0296	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0018	0.012	0.0116
Loa Loa (eye worm)	pyruvate kinase	0.1006	1	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0181	0.0171
Echinococcus multilocularis	pyruvate kinase	0.1006	1	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.037	0.0367
Chlamydia trachomatis	PTS system PEP phosphotransferase	0.0421	0.4147	0.4076
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0061	0.0058
Trypanosoma cruzi	pyruvate phosphate dikinase, putative	0.0421	0.4147	0.4141
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.0554	0.0551
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.0554	0.0551
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0061	0.0058
Schistosoma mansoni	hypothetical protein	0.0042	0.0354	0.0351
Echinococcus granulosus	geminin	0.0205	0.1986	0.1983
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0061	0.0058
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.9733	0.9733
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.003	0.0026
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.0554	0.0545
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0181	0.0246
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0061	0.0058
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.037	0.0367
Brugia malayi	MAP kinase sur-1	0.0062	0.0554	0.0551
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0431	0.0428
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0561	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.001	0.0007
Echinococcus granulosus	cpg binding protein	0.0031	0.0249	0.0245
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Echinococcus multilocularis	pyruvate kinase	0.0516	0.5103	0.5101
Loa Loa (eye worm)	hypothetical protein	0.0018	0.012	0.0116
Brugia malayi	isocitrate dehydrogenase	0.0016	0.01	0.0097
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0296	0.0286
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0012	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0296	0.0291
Loa Loa (eye worm)	pyruvate kinase	0.0212	0.2059	0.2056
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.0554	0.0551
Schistosoma mansoni	cpg binding protein	0.0029	0.0232	0.0229
Leishmania major	pyruvate kinase	0.1006	1	1
Trypanosoma cruzi	pyruvate kinase 2, putative	0.1006	1	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0016	0.01	0.009
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0061	0.0058
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0585	0.0582
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0181	0.0171
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.003	0.0026
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0181	0.0171
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0061	0.0058
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0181	0.0181
Echinococcus multilocularis	Niemann Pick C1 protein	0.0144	0.1375	0.1372
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0061	0.0058
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.0061	0.0051
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.037	0.0367
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Schistosoma mansoni	hypothetical protein	0.0042	0.0354	0.0351
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0061	0.0058
Echinococcus multilocularis	protein patched	0.0043	0.037	0.0367
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0181	0.0171
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0061	0.0058
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0181	0.0171
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.012	0.011
Giardia lamblia	Pyruvate kinase	0.0516	0.5103	0.4816
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.001
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0061	0.0058
Schistosoma mansoni	transcription factor btf3	0.0036	0.0296	0.0292
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0016	0.01	0.009
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0016	0.01	0.009
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0296	0.0291
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0061	0.0058
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0061	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0306	0.0303
Onchocerca volvulus	Pyruvate kinase homolog	0.1006	1	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0306	0.0301
Plasmodium falciparum	pyruvate kinase	0.1006	1	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0249	0.0245
Entamoeba histolytica	hypothetical protein	0.0036	0.0296	0.0411
Echinococcus granulosus	dnaJ subfamily B	0.0417	0.4113	0.4111
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0181	0.0178
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0306	0.0306
Leishmania major	pyruvate kinase	0.1006	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0181	0.0171
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0306	0.0297
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0016	0.01	0.01
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.012	0.012
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.0296	0.0286
Toxoplasma gondii	ABC1 family protein	0.0037	0.0306	0.0297
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0061	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0061	0.0058
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.001	0.0007
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0061	0.0058
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.011	0.011
Entamoeba histolytica	pyruvate kinase, putative	0.0702	0.6956	1
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0585	0.0582
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0181	0.0171
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.0554	0.0551
Schistosoma mansoni	hypothetical protein	0.0205	0.1986	0.1983
Schistosoma mansoni	pyruvate kinase	0.0516	0.5103	0.5101
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0181	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0061	0.0058
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0585	0.0582
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.0554	0.0545
Brugia malayi	pyruvate kinase, muscle isozyme	0.0212	0.2059	0.2056
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.011	0.011
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.012	0.011
Mycobacterium leprae	Probable pyruvate kinase PykA	0.1006	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0061	0.0058
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0306	0.0297
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0007
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.0944	0.0941
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.0554	0.0545
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0061	0.0058
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0296	0.0286
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0296	0.0286
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0061	0.0058
Brugia malayi	pyruvate kinase	0.0212	0.2059	0.2056
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.0944	0.0941
Trypanosoma brucei	protein kinase, putative	0.0062	0.0554	0.0545
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0061	0.0058
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0296	0.0286
Trichomonas vaginalis	pyruvate, phosphate dikinase, chloroplast, putative	0.0421	0.4147	0.4144
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0494	0.0485
Onchocerca volvulus	Pyruvate kinase homolog	0.1006	1	1
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.0554	0.0551
Mycobacterium leprae	conserved hypothetical protein	0.0037	0.0306	0.0297
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0061	0.0058
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0061	0.0058
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.001
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.001	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0061	0.0058
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.001	0.0007
Brugia malayi	beta-lactamase	0.0037	0.0306	0.0303
Loa Loa (eye worm)	pyruvate kinase-PB	0.0702	0.6956	0.6955
Echinococcus granulosus	pyruvate kinase	0.0516	0.5103	0.5101
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0061	0.0058
Trypanosoma brucei	pyruvate kinase 1, putative	0.1006	1	1
Onchocerca volvulus		0.0029	0.0232	0.0222
Echinococcus granulosus	transcription factor btf3	0.0036	0.0296	0.0292
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0306	0.0303
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0306	0.0303
Trichomonas vaginalis	phosphoenolpyruvate-protein phosphotransferase, putative	0.0421	0.4147	0.4144
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0005
Leishmania major	hypothetical protein, conserved	0.0037	0.0306	0.0297

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.1735 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 15.8489 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ]	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1549803

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1411215