Detailed information for compound 1409885

Basic information

Technical information
  • TDR Targets ID: 1409885
  • Name: 6-diethylamino-N,N-diethyl-5,6-dihydrobenzo[b ][1]benzazepine-11-carboxamide
  • MW: 365.512 | Formula: C23H31N3O
  • H donors: 0 H acceptors: 1 LogP: 4.22 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)N1c2ccccc2C(Cc2c1cccc2)N(CC)CC)CC
  • InChi: 1S/C23H31N3O/c1-5-24(6-2)22-17-18-13-9-11-15-20(18)26(23(27)25(7-3)8-4)21-16-12-10-14-19(21)22/h9-16,22H,5-8,17H2,1-4H3
  • InChiKey: DUXONKOEFSZBRM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000038087
  • A3367/0142962
  • SMR000037022

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0177 0.0227
Schistosoma mansoni hypothetical protein 0.0164 0.203 0.2613
Echinococcus granulosus expressed conserved protein 0.009 0.1084 0.1396
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0074
Echinococcus multilocularis pyruvate kinase 0.0313 0.395 0.395
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0255 0.3205 0.4122
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0043 0.0056
Brugia malayi hypothetical protein 0.0009 0.0043 0.0056
Brugia malayi CXXC zinc finger family protein 0.0028 0.0284 0.0366
Trypanosoma brucei pyruvate kinase 1 0.061 0.7767 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0222 0.0271
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0177 0.0227
Loa Loa (eye worm) pyruvate kinase 0.0128 0.1577 0.203
Brugia malayi nuclear receptor RXR 0.001 0.0058 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0169 0.0218
Echinococcus multilocularis protein dispatched 1 0.0047 0.0529 0.0529
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Trichomonas vaginalis pyruvate kinase, putative 0.061 0.7767 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0177 0.0227
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0043 0.0056
Chlamydia trachomatis PTS system PEP phosphotransferase 0.0255 0.3205 0.4013
Echinococcus granulosus GPCR family 2 0.0019 0.0169 0.0218
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0177 0.0213
Brugia malayi beta-lactamase family protein 0.0035 0.0376 0.0484
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0043 0.0056
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.0477
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.2175 0.2801
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0043 0.0056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0376 0.047
Schistosoma mansoni thyroid hormone receptor 0.002 0.0177 0.0227
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0177 0.0213
Schistosoma mansoni hypothetical protein 0.0019 0.0169 0.0218
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0014 0.0018
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0376 0.047
Plasmodium vivax pyruvate kinase 2, putative 0.0313 0.395 0.5078
Schistosoma mansoni hypothetical protein 0.004 0.0435 0.056
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0058 0.0074
Brugia malayi steroid hormone receptor 0.002 0.0177 0.0227
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1159 0.1492
Loa Loa (eye worm) hypothetical protein 0.0425 0.5394 0.6945
Loa Loa (eye worm) hypothetical protein 0.0023 0.0222 0.0285
Brugia malayi conserved hypotetical protein 0.0009 0.0043 0.0056
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0146 0.0174
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0719 0.0925
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1689 0.2174
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0363 0.0453
Brugia malayi nuclear hormone receptor 0.0009 0.0043 0.0056
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Loa Loa (eye worm) pyruvate kinase 0.061 0.7767 1
Brugia malayi tailless protein 0.0009 0.0043 0.0056
Echinococcus granulosus pyruvate kinase 0.061 0.7767 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0189
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0363 0.0652
Schistosoma mansoni pyruvate kinase 0.0313 0.395 0.5085
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0376 0.0477
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.047
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0376 0.047
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0074
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0222 0.0271
Mycobacterium leprae Probable lipase LipE 0.0035 0.0376 0.047
Loa Loa (eye worm) pyruvate kinase 0.061 0.7767 1
Brugia malayi TAR-binding protein 0.0062 0.0719 0.0925
Brugia malayi CHE-14 protein 0.0041 0.0454 0.0585
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0376 0.047
Echinococcus multilocularis cpg binding protein 0.003 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0096 0.1159 0.1492
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0014 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0177 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0158
Onchocerca volvulus 0.0035 0.0376 0.047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0177 0.0227
Mycobacterium leprae Probable pyruvate kinase PykA 0.061 0.7767 1
Brugia malayi isocitrate dehydrogenase 0.0015 0.0122 0.0158
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0255 0.3205 0.4122
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0222 0.039
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0122 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0122 0.0122
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0586 0.0748
Giardia lamblia Pyruvate kinase 0.0313 0.395 0.4725
Echinococcus multilocularis transcription factor btf3 0.0034 0.0363 0.0363
Echinococcus multilocularis geminin 0.0164 0.203 0.203
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0043 0.0041
Loa Loa (eye worm) beta-lactamase 0.0035 0.0376 0.0484
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0305 0.0393
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0043 0.0043
Onchocerca volvulus 0.0035 0.0376 0.047
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.2809 0.3607
Echinococcus granulosus pyruvate kinase 0.061 0.7767 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0177 0.0227
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0222 0.039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0376 0.047
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0177 0.0227
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0043 0.0043
Onchocerca volvulus Pyruvate kinase homolog 0.061 0.7767 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0376 0.047
Loa Loa (eye worm) hypothetical protein 0.006 0.0699 0.0899
Entamoeba histolytica pyruvate kinase, putative 0.0425 0.5394 1
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0376 0.047
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0719 0.0925
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0177 0.0177
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0014 0.0018
Loa Loa (eye worm) oxidoreductase 0.0007 0.0012 0.0015
Mycobacterium ulcerans beta-lactamase 0.0035 0.0376 0.047
Echinococcus granulosus FTZ F1 alpha 0.002 0.0177 0.0227
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0454 0.0454
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0177 0.0227
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0058 0.0074
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0043 0.0056
Trypanosoma brucei pyruvate phosphate dikinase 0.0255 0.3205 0.4117
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0586 0.0755
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0719 0.0925
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0454 0.0584
Chlamydia trachomatis pyruvate kinase 0.061 0.7767 1
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0043 0.0056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0043 0.0056
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0012 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0177 0.0227
Mycobacterium ulcerans pyruvate kinase 0.061 0.7767 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0363 0.046
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0222 0.0271
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0284 0.0366
Schistosoma mansoni coup transcription factor 0.002 0.0177 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0158
Brugia malayi ecdysteroid receptor 0.002 0.0177 0.0227
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0719 0.0925
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0376 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.0041 0.0454 0.0585
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0012 0.0015
Schistosoma mansoni hypothetical protein 0.004 0.0435 0.056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0012 0.0015
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0222 0.0271
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0169 0.0218
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0363 0.0453
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Echinococcus multilocularis pyruvate kinase 0.061 0.7767 0.7767
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0662 0.0838
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0074
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0043 0.0056
Echinococcus multilocularis pyruvate kinase 0.061 0.7767 0.7767
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0169 0.0169
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0177 0.0177
Schistosoma mansoni pyruvate kinase 0.061 0.7767 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0376 0.0484
Loa Loa (eye worm) hypothetical protein 0.0023 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Leishmania major basic transcription factor 3a, putative 0.0034 0.0363 0.0453
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0185 0.2297 0.2958
Trichomonas vaginalis pyruvate kinase, putative 0.061 0.7767 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.061 0.7767 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0012 0.0007
Brugia malayi Pyruvate kinase, muscle isozyme 0.061 0.7767 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0169 0.0218
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0177 0.0227
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0043 0.0056
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0255 0.3205 0.4117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0222 0.0285
Loa Loa (eye worm) pyruvate kinase 0.061 0.7767 1
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0363 0.0453
Schistosoma mansoni hypothetical protein 0.004 0.0435 0.056
Mycobacterium ulcerans hypothetical protein 0.0255 0.3205 0.4117
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0363 0.0453
Echinococcus multilocularis expressed conserved protein 0.009 0.1084 0.1084
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0699 0.0899
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1159 0.1492
Schistosoma mansoni hypothetical protein 0.0019 0.0169 0.0218
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0034 0.0044
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0177 0.0227
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0012 0.0015
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.0477
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0376 0.047
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0177 0.0227
Echinococcus granulosus dnaJ subfamily B 0.0399 0.5054 0.6506
Loa Loa (eye worm) pyruvate kinase-PB 0.0425 0.5394 0.6945
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0531 0.0965
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0222 0.0271
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0719 0.0719
Brugia malayi hypothetical protein 0.0009 0.0043 0.0056
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0222 0.0271
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.2112 0.272
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0146 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0177 0.0227
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0122 0.0143
Schistosoma mansoni hypothetical protein 0.0041 0.0454 0.0584
Brugia malayi nuclear receptor NHR-88 0.002 0.0177 0.0227
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0164 0.203 0.2613
Echinococcus granulosus geminin 0.0164 0.203 0.2613
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0122 0.0143
Giardia lamblia Pyruvate kinase 0.061 0.7767 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0177 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0454 0.0578
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0586 0.0741
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0376 0.0484
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.047
Schistosoma mansoni nuclear hormone receptor 0.002 0.0177 0.0227
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0376 0.047
Onchocerca volvulus 0.0009 0.0043 0.0041
Toxoplasma gondii ABC1 family protein 0.0035 0.0376 0.047
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0014 0.0014
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0009 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0015
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1159 0.2132
Trypanosoma cruzi pyruvate phosphate dikinase, putative 0.0255 0.3205 0.4117
Mycobacterium tuberculosis Conserved protein 0.0035 0.0376 0.047
Brugia malayi beta-lactamase 0.0035 0.0376 0.0484
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0058 0.0074
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0146 0.0174
Loa Loa (eye worm) hypothetical protein 0.061 0.7767 1
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0454 0.0585
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0376 0.047
Brugia malayi RNA binding protein 0.0062 0.0719 0.0925
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.2175 0.2801
Mycobacterium tuberculosis Probable pyruvate, phosphate dikinase PpdK 0.0255 0.3205 0.4117
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0222 0.0271
Echinococcus granulosus pyruvate kinase 0.0313 0.395 0.5085
Brugia malayi hypothetical protein 0.001 0.0058 0.0074
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0177 0.0177
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0222 0.0271
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Brugia malayi nuclear receptor NHR-88 0.0009 0.0043 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0177 0.0227
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0177 0.0227
Leishmania major pyruvate kinase 0.061 0.7767 1
Plasmodium falciparum pyruvate kinase 2 0.0313 0.395 0.5078
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1159 0.1159
Leishmania major pyruvate kinase 0.061 0.7767 1
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0122 0.0143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0376 0.0484
Trichomonas vaginalis esterase, putative 0.0035 0.0376 0.0477
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0189
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0363 0.0467
Schistosoma mansoni hypothetical protein 0.0019 0.0169 0.0218
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0014 0.0014
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0177 0.0227
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0376 0.0484
Onchocerca volvulus 0.0009 0.0043 0.0041
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0043 0.0056
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0177 0.0227
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0376 0.047
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0177 0.0227
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0376 0.0484
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0586 0.0741
Schistosoma mansoni cpg binding protein 0.0028 0.0284 0.0366
Schistosoma mansoni zinc finger protein 0.0009 0.0043 0.0056
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0719 0.0925
Echinococcus multilocularis protein patched 0.0041 0.0454 0.0454
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0169 0.0169
Mycobacterium ulcerans hypothetical protein 0.0023 0.0222 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0719 0.0925
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0699 0.0899
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0177 0.0177
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0043 0.0056
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0177 0.0227
Brugia malayi nuclear receptor RXR 0.0009 0.0043 0.0056
Brugia malayi pyruvate kinase 0.0128 0.1577 0.203
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0122 0.0158
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0043 0.0056
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0531 0.067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0177 0.0227
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.2175 0.2175
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Entamoeba histolytica pyruvate phosphate dikinase 0.0255 0.3205 0.5933
Mycobacterium ulcerans lipase LipD 0.0035 0.0376 0.047
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0043 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Brugia malayi hypothetical protein 0.001 0.0058 0.0074
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0058 0.0074
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0043 0.0056
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0043 0.0056
Giardia lamblia Pyruvate, phosphate dikinase 0.0255 0.3205 0.3695
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0222 0.039
Trypanosoma cruzi pyruvate kinase 2, putative 0.061 0.7767 1
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0363 0.0453
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1178 0.1517
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0043 0.0056
Echinococcus granulosus pyruvate kinase 0.0313 0.395 0.5085
Treponema pallidum pyruvate phosphate dikinase 0.0255 0.3205 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0058 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0376 0.047
Schistosoma mansoni hypothetical protein 0.004 0.0435 0.056
Schistosoma mansoni transcription factor btf3 0.0034 0.0363 0.0467
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0222 0.0271
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0058 0.0074
Brugia malayi Pyruvate kinase, M2 isozyme 0.061 0.7767 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0177 0.0227
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0122 0.0158
Loa Loa (eye worm) acetyltransferase 0.0175 0.2175 0.2801
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0158
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0043 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0122 0.0122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0222 0.0271
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0043 0.0056
Trypanosoma brucei pyruvate kinase 1, putative 0.061 0.7767 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0043 0.0056
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0177 0.0227
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0222 0.0285
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0189
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0043 0.0056
Schistosoma mansoni cpg binding protein 0.003 0.0305 0.0393
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0177 0.0227
Onchocerca volvulus Pyruvate kinase homolog 0.061 0.7767 1
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0177 0.0227
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0586 0.0748
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0719 0.0925
Schistosoma mansoni pyruvate kinase 0.061 0.7767 1
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0363 0.046
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0454 0.0585
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.5054 0.5054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0255 0.3205 0.4117
Loa Loa (eye worm) hypothetical protein 0.0019 0.0169 0.0218
Schistosoma mansoni nuclear receptor 0.0009 0.0043 0.0056
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0177 0.0227
Schistosoma mansoni thyroid hormone receptor 0.002 0.0177 0.0227
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0134 0.0158
Wolbachia endosymbiont of Brugia malayi pyruvate phosphate dikinase 0.0255 0.3205 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0177 0.0227
Brugia malayi pyruvate kinase, muscle isozyme 0.0128 0.1577 0.203
Echinococcus granulosus tar DNA binding protein 0.0062 0.0719 0.0925
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0222 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0177 0.0227
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0177 0.0227
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0146 0.0174
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0122 0.0143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0169 0.0218
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0122 0.0143
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0043 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0222 0.0285
Brugia malayi beta-NAC-like protein 0.0034 0.0363 0.0467
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0688 0.0886
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0376 0.0477
Loa Loa (eye worm) hypothetical protein 0.0041 0.0454 0.0584
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0177 0.0213
Loa Loa (eye worm) DR-78 0.0009 0.0043 0.0056
Brugia malayi ecdysone receptor 0.0009 0.0043 0.0056
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0454 0.0585
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0015
Echinococcus granulosus cpg binding protein 0.003 0.0305 0.0393
Trichomonas vaginalis phosphoenolpyruvate-protein phosphotransferase, putative 0.0255 0.3205 0.4122
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0222 0.0271
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0169 0.0218
Onchocerca volvulus 0.0035 0.0376 0.047
Echinococcus granulosus pyruvate kinase 0.0313 0.395 0.5085
Brugia malayi beta-lactamase family protein 0.0035 0.0376 0.0484
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0177 0.0227
Echinococcus multilocularis GPCR, family 2 0.0019 0.0169 0.0169
Echinococcus multilocularis pyruvate kinase 0.0313 0.395 0.395
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0222 0.0271
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0586 0.0741
Loa Loa (eye worm) hypothetical protein 0.0017 0.0146 0.0189
Schistosoma mansoni nuclear receptor 0.0009 0.0043 0.0056
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0699 0.0899
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0036 0.0046
Loa Loa (eye worm) hypothetical protein 0.005 0.0573 0.0738
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0177 0.0227
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0222 0.0271
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0122 0.0143
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0122 0.0143
Schistosoma mansoni hypothetical protein 0.0399 0.5054 0.6506
Echinococcus granulosus transcription factor btf3 0.0034 0.0363 0.0467
Plasmodium falciparum pyruvate kinase 0.061 0.7767 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0043 0.0043
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0719 0.0925
Onchocerca volvulus 0.0023 0.0222 0.0271
Schistosoma mansoni hypothetical protein 0.0019 0.0169 0.0218
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0122 0.0122
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0376 0.0477
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0122 0.0122
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0177 0.0227
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0177 0.0177
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0122 0.0143
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1689 0.1689
Onchocerca volvulus 0.0028 0.0284 0.0352
Mycobacterium ulcerans pyruvate phosphate dikinase 0.0255 0.3205 0.4117
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0177 0.0177
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0122 0.0158
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0376 0.047
Onchocerca volvulus 0.002 0.0177 0.0213
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0177 0.0227
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0363 0.0453
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0122 0.0122
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0376 0.047
Echinococcus multilocularis pyruvate kinase 0.0481 0.6115 0.6115
Toxoplasma gondii pyruvate kinase PyK1 0.061 0.7767 1
Plasmodium vivax pyruvate kinase, putative 0.061 0.7767 1
Onchocerca volvulus Pyruvate kinase homolog 0.061 0.7767 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0376 0.047
Entamoeba histolytica hypothetical protein 0.0034 0.0363 0.0652
Toxoplasma gondii pyruvate kinase PyKII 0.0313 0.395 0.5078
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0363 0.046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0177 0.0227
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0122 0.0158
Brugia malayi nuclear receptor NHR-67 0.0009 0.0043 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0222 0.0285
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0177 0.0227
Trichomonas vaginalis pyruvate, phosphate dikinase, chloroplast, putative 0.0255 0.3205 0.4122
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0012 0.0007
Schistosoma mansoni patched 1 0.0041 0.0454 0.0585
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0043 0.0056
Echinococcus multilocularis pyruvate kinase 0.0313 0.395 0.395
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0177 0.0227
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.061 0.7767 1
Leishmania major hypothetical protein, conserved 0.0035 0.0376 0.047
Brugia malayi nuclear hormone receptor 0.002 0.0177 0.0227
Loa Loa (eye worm) RNA binding protein 0.0062 0.0719 0.0925
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0122 0.0143
Mycobacterium leprae PROBABLE PYRUVATE, PHOSPHATE DIKINASE PPDK 0.0255 0.3205 0.4117
Loa Loa (eye worm) hypothetical protein 0.0009 0.0043 0.0056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0376 0.0484
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0177 0.0227
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0177 0.0177
Leishmania major pyruvate phosphate dikinase, putative 0.0255 0.3205 0.4117

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.631 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 7.3753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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